Prostate cancer aurora kinases. Medical search. Frequent questions

Aurora kinase inhibitors are a putative drug class for treating cancer. (wikipedia.org)
The Aurora kinase enzymes could be potential targets for novel small-molecule enzyme inhibitors. (wikipedia.org)
So far three Aurora-kinase inhibitors have been described: ZM447439, hesperadin and VX-680. (wikipedia.org)
Clinical studies have shown that subsets of patients with cancer achieve a significant benefit from Aurora kinase inhibitors, suggesting an urgent need to identify biomarkers for predicting drug response. (figshare.com)
Here, we show that CHD1 promotes the susceptibility of prostate cancer cells to inhibitors targeting Aurora kinases, while depletion of CHD1 impairs their efficacy in vitro and in vivo. (figshare.com)
Pan-cancer drug sensitivity analyses revealed that high expression of CHD1 was associated with increased sensitivity to Aurora kinase A (AURKA) inhibitors. (figshare.com)
Mechanistically, KPNA2 served as a direct target of CHD1 and suppressed the interaction of AURKA with the coactivator TPX2, thereby rendering cancer cells more vulnerable to AURKA inhibitors. (figshare.com)
Mount Sinai researchers have developed a novel method to identify aggressive early-stage lung cancers and target drugs known as aurora kinase inhibitors to tumors that are especially likely to respond. (bio-itworld.com)
The Mount Sinai team used a genomics network model to measure tumor invasiveness-distinguishing aggressive tumors from so-called "indolent" ones, which often cannot be told apart via chest CT scan-and identify those that will respond to aurora kinase inhibitors, molecules that can inhibit gene signature regulators. (bio-itworld.com)
They identified and tested aurora kinase inhibitors, including AMG900, as an effective treatment to intercept lung cancer progression in the models. (bio-itworld.com)
Although immune checkpoint inhibitors (ICIs), in particular blockade of PD-1/PD-L1, show promising therapy response in some cancers, they are less effective in PCa which may be poor infiltration of cytotoxic T-cells [ 7 - 9 ]. (thno.org)
Nowadays, Checkpoint inhibitors for cancer therapy have shown great benefits. (cancer-research-network.com)
Therefore, the altered capacity of cancer cells to repair and/or replicate DNA is the basis of many classical therapies, such as platinum-based agents, and also recently introduced or upcoming therapies, such as PARP inhibitors or ATR inhibitors (reviewed in refs. (nature.com)
ORIC discovered novel, potent, orally bioavailable small molecule inhibitors of PLK4 that are highly selective, including against the closely related aurora kinases and PLK1-3. (oricpharma.com)
Cell viability assessment across a cancer cell line panel revealed that the highly selective ORIC PLK4 inhibitors showed greater potency in TRIM37 high cancer cell lines as compared to TRIM37 low cell lines. (oricpharma.com)
Importantly, cell potency in TRIM37 high cancer cells was rescued with knockdown of TRIM37, illustrating that selective PLK4 inhibitors are synthetic lethal with TRIM37 amplification. (oricpharma.com)
PI3K inhibitors block the PI3K/AKT/mTOR pathway and thus slow down cancer growth. (pi3k-inhibitors.com)

Furthermore, Aurora kinases are known to be oncogenic and overexpressed in various forms of cancerous growth, including leukemia, colon cancer, prostate cancer and breast cancer tumors. (wikipedia.org)
Exceptional responders were identified, including complete resolution of liver metastases and prolonged stable disease, with tumors suggestive of N-myc and Aurora-A overactivity. (unitn.it)
A genomic network model is used to identify aurora kinase inhibitor-sensitive lung tumors, new Illumina Accelerator start-ups are announced, AI algorithms are being used to improve prostate cancer identification and treatment, and a blood-based DNA methylation test can detect liver cancer. (bio-itworld.com)
We use translational approaches using cell lines derived from thyroid tumors to understand why some tumors are sensitive or resistant to different kinase-directed therapies, with the goal of identifying predictive biomarkers of response, and improving clinical responses. (cuanschutz.edu)

Phosphatase 1 Nuclear Targeting Subunit (PNUTS) Regulates Aurora Kinases and Mitotic Progression. (nih.gov)
The research team used a genetically engineered mouse model to define the role of aurora kinases in early progression of the disease. (bio-itworld.com)
A key feature of prostate cancer progression is the induction and activation of survival proteins, including the Inhibitor of Apoptosis (IAP) family member survivin. (oncotarget.com)
Hepatocyte growth factor (HGF) is associated with tumour progression and increases the invasiveness of prostate carcinoma cells. (silverchair.com)
In breast cancer, CD44+CD24- cells possess stem cell-like features and contribute to disease progression, and we previously described a CD44+CD24-pSTAT3+ breast cancer cell subpopulation that is dependent on JAK2/STAT3 signaling. (bvsalud.org)
Aurora kinases control multiple events during cell cycle progression and are essential for mitotic and meiotic bipolar spindle assembly and function. (cancer-research-network.com)
The tumor microenvironment (TME) promotes BCSC survival and cancer progression, and targeting the TME can aid in successful immunotherapy. (hindawi.com)
Notably, expressions of some lncRNAs undergo significant changes in the initiation and progression of cancers. (oncotarget.com)
Notably, increasing data suggests that lncRNAs may play an irreplaceable role in the progression of autoimmune diseases and cancers [ 16 , 17 ]. (oncotarget.com)

Consistent with previous research reporting that loss of PTEN elevates CHD1 levels, studies in a genetically engineered mouse model, patient-derived organoids, and patient samples showed that PTEN defects are associated with a better response to AURKA inhibition in advanced prostate cancer. (figshare.com)
2016 ) Icaritin suppresses development of neuroendocrine differentiation of prostate cancer through inhibition of IL-6/STAT3 and Aurora kinase A pathways in TRAMP mice. (neurotree.org)
Because APE1/Ref-1 is expressed and elevated in prostate cancer, we sought to characterize APE1/Ref-1 expression and activity in human prostate cancer cell lines and determine the effect of selective reduction-oxidation (redox) function inhibition on prostate cancer cells in vitro and in vivo . (oncotarget.com)
Due to the role of oncogenic transcriptional activators NFĸB and STAT3 in survivin protein expression, and APE1/Ref-1 redox activity regulating their transcriptional activity, we assessed selective inhibition of APE1/Ref-1's redox function as a novel method to halt prostate cancer cell growth and survival. (oncotarget.com)
Our study demonstrates that survivin and APE1/Ref-1 are significantly higher in human prostate cancer specimens compared to noncancerous controls and that APE1/Ref-1 redox-specific inhibition with small molecule inhibitor, APX3330 and a second-generation inhibitor, APX2009, decreases prostate cancer cell proliferation and induces cell cycle arrest. (oncotarget.com)
Immune checkpoint inhibition combined with chemotherapy is currently approved as first-line treatment for patients with advanced PD-L1-positive triple-negative breast cancer (TNBC). (bvsalud.org)
Auora kinase inhibitor MLN8054 binds to and inhibits Aurora kinase A, resulting in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregration, and inhibition of cell proliferation. (xcessbio.com)
40-fold more selective inhibitory activity for Aurora A compared with Aurora B. In vitro, MLN8054 exhibits the activity of growth inhibition across various cell lines from diverse tissue origins with IC50 values ranging from 0.11 μM to 1.43 μM. (xcessbio.com)
BCL2L11 Induction Mediates Sensitivity to Src and MEK1/2 Inhibition in Thyroid Cancer. (cuanschutz.edu)

MLN8054 is an aurora kinase inhibitor MLN8054, which is an orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A kinase with potential antineoplastic activity. (xcessbio.com)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells. (stembook.org)
Induction of apoptosis and autophagy via sirtuin1- and PI3K/Akt/mTOR-mediated pathways by plumbagin in human prostate cancer cells. (stembook.org)
The investigational Aurora kinase A inhibitor alisertib (MLN8237) induces cell cycle G2/M arrest, apoptosis, and autophagy via p38 MAPK and Akt/mTOR signaling pathways in human breast cancer cells. (stembook.org)
HNK controls various intracellular signaling pathways involved in cancer, including those related to nuclear factor kappa B (NF- B), signal transducers and activators of transcription 3 (STAT3), epidermal growth factor receptor (EGFR), and mammalian targets of rapamycin (mTOR) [ 12 ]. (hindawi.com)
The goals of Dr. Rebecca Schweppe's lab are to understand the regulation and function of deregulated kinase pathways in thyroid cancer in order to develop more effective therapies. (cuanschutz.edu)
Targeting specific pathways which are aberrant in cancer cells relative to normal cells is ideally a good approach at therapeu- tic dosages. (pi3k-inhibitors.com)
2015). Therefore, effective che- motherapeutic drugs require multiple molecular/cellular tar- gets/pathways to control cancer cell survival/proliferation. (pi3k-inhibitors.com)

The hinge (yellow), glycine-rich loop (blue), and activation loop (red) are key features of the protein kinase fold involved in binding adenosine. (wikipedia.org)
The protein backbone atoms of residues Glu-211, Ala-213 in the hinge region of Aurora-2, and the sidechain of residue Trp-277, located in the activation loop, bind adenosine through specific hydrogen bonds. (wikipedia.org)
Residues Lys-162 and Asp-274 are essential for Aurora-2 kinase activity but do not hydrogen bond to each other as seen in crystal structures of several other protein kinases. (wikipedia.org)
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. (cancerindex.org)
The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. (cancerindex.org)
The deregulation of protein kinases plays a major role in promoting tumorigenesis in the majority of human cancers, including thyroid cancer, and targeting this deregulated activity has led to major breakthroughs in cancer therapy. (cuanschutz.edu)
Bae KM, Wang H, Jiang G, Chen MG, Lu L, Xiao L. Protein kinase C epsilon is overexpressed in primary human non-small cell lung cancers and functionally required for proliferation of non-small cell lung cancer cells in a p21/Cip1-dependent manner. (famri.org)
Combinatorial effect of QUE and resveratrol has been found to be antiproliferative via suppression of oncogenic microRNA-27a and induction of zinc finger protein ZBTB10 against HT-29 colon cancer (Del Follo-Martinez et al. (pi3k-inhibitors.com)

2017. Kinase-Independent Phosphoramidate S1P1 Receptor Agonist Benzyl Ether Derivatives . (lsrnw.ac.uk)

citation needed] Kinome Cyclin-dependent kinase Signal transduction Andrews, Paul D. (wikipedia.org)

Aurora kinases belong to serine/threonine kinases. (cancer-research-network.com)

There are three mammalian aurora kinase genes, encoding aurora A, B and C. Intense investigation has focused on aurora A and B as they appear to play a role in oncogenesis with aurora A identified as a low penetrance tumor susceptibility gene in mice and humans. (wikipedia.org)
They performed molecular profiling of early-stage lung cancer samples with RNA sequencing and identified signature genes associated with tumor invasiveness. (bio-itworld.com)
A panel of genes has been identified whose cancer genome alterations may predict whether non-metastatic prostate cancer would go on to metastasize. (mdpi.com)
The activity of these genes may help to guide treatment decision for non-metastatic cancer with the choice for non-aggressive versus debilitating aggressive options. (mdpi.com)

Metastatic prostate cancer is incurable and lethal. (mdpi.com)

However, when the disease progresses to castration-resistant prostate cancer (CRPC), there are limited treatments for those patients and lead to dissatisfied outcomes [ 2 , 3 ]. (thno.org)
2020. Phase I trial of docetaxel plus lutetium-177-labeled anti-prostate-specific membrane antigen monoclonal antibody J591 (Lu-J591) for metastatic castration-resistant prostate cancer. . (cornell.edu)

Upregulation of Phosphatase 1 Nuclear-Targeting Subunit (PNUTS) Is an Independent Predictor of Poor Prognosis in Prostate Cancer. (nih.gov)

Advanced prostate cancer (PCa) has limited treatment regimens and shows low response to chemotherapy and immunotherapy, leading to poor prognosis. (thno.org)
Breast cancer stem cells (BCSCs) play a critical role in chemoresistance, metastasis, and poor prognosis of breast cancer. (hindawi.com)
Breast cancer stem cells (BCSCs) are one of the main factors driving chemoresistance, thereby contributing to poor prognosis and clinical outcomes [ 3 - 5 ]. (hindawi.com)

A new approach to inhibiting cancer growth that shows great promise for structure-based drug development is targeting enzymes central to cellular mitosis. (wikipedia.org)
Aurora A localizes in mitosis to the spindle poles and to spindle microtubules and is thought to regulate spindle assembly. (xcessbio.com)
Mitosis is usually a dynamic process controlled by the activity of multiple kinases with attendant modification of proteins facilitating rigid checkpoint control. (ap26113.com)
GSK1904529A Aurora A is found at centrosomes in early mitosis and controls centrosome maturation centriole separation and chromosome alignment (33) whereas accurate targeting of Aurora B to the chromosomes and then to the spindle midzone and midbody is essential for maintaining microtubule/kinetochore attachments and therefore faithful chromosomal segregation (34). (ap26113.com)
GR phosphorylation by an Aurora kinase-dependent pathway provides the mechanism explaining the tight coupling GSK1904529A of ligand-independent GR phosphorylation to cell cycle phase because the maximal activity of these kinases occurs in mitosis. (ap26113.com)

Purpose: Neuroendocrine prostate cancer (NEPC) is an aggressive variant of prostate cancer that may develop de novo or as a mechanism of treatment resistance. (unitn.it)
However, there is limited research on the immune microenvironment of adeno-neuroendocrine prostate cancer (NEPC). (biomedcentral.com)

4D Q-plasia OncoReader Breast provides histopathologists with an adjunct technology to potentially improve diagnostic accuracy of breast cancer features (invasiveness, grade, ki-67 status, etc.) solely from digitized histopathology images obtained via biopsies or resections. (bio-itworld.com)
Inflammatory breast cancer (IBC) is a difficult-to-treat disease with poor clinical outcomes due to high risk of metastasis and resistance to treatment. (bvsalud.org)
Reply to "Can Patients with Multiple Breast Cancers in the Same Breast Avoid Mastectomy by Having Multiple Lumpectomies to Achieve Equivalent Rates of Local Breast Cancer Recurrence? (cornell.edu)
2020. Public health insurance and cancer-specific mortality risk among patients with breast cancer: A prospective cohort study in China. . (cornell.edu)
The pan-inhibitor of Aurora kinases danusertib induces apoptosis and autophagy and suppresses epithelial-to-mesenchymal transition in human breast cancer cells. (stembook.org)
is known to exert anticancer effects, such as inducing cell cycle arrest, inhibiting metastasis, and overcoming immunotherapy resistance in breast cancer cells. (hindawi.com)
Breast cancer was the most prevalent cancer in 2020 (in terms of new cases) and the leading cause of cancer-related deaths among females [ 1 ]. (hindawi.com)
According to the World Health Organization, breast cancer has the highest incidence rate in Indonesia, with a mortality rate of 22,692 cases per year [ 1 ]. (hindawi.com)
Chemoresistance, or the insensitivity of cancer cells to drug therapy, is a major factor in the failure of chemotherapy against breast cancer. (hindawi.com)
The presentations will also introduce a new program targeting a synthetic lethality pathway in breast cancer. (oricpharma.com)
Research: Ashton's research with Debabrata (Dev) Mukhopadhyay, Ph.D. focused on designing a targeted nanoparticle formulation for drug-resistant breast cancer stem cells. (mayo.edu)

Aurora kinases regulate cell cycle transit from G2 through cytokinesis, and thus are targets in cancer therapy. (wikipedia.org)
Aurora kinases, so named because the scattered mitotic spindles generated by mutant forms resemble the Aurora Borealis, have gained a great deal of attention as possible anticancer drug targets. (wikipedia.org)
Long non-coding RNAs (lncRNAs) can exhibit cell-type and cancer-type specific expression profiles, making them highly attractive as therapeutic targets. (researchgate.net)

Mol Cancer Ther (2005) 4 (11): 1810-1819. (aacrjournals.org)

There were no sex-related differences in GR expression ( SI Appendix Fig. S19 A ) and no correlation between GR and estrogen receptor (ERα) expression across all breast malignancy subtypes or GSK1904529A with androgen receptor (AR) expression in prostate cancer ( SI Appendix Fig. S19 B ). Discussion The GR plays a key role in energy metabolism immunity and cell fate determination. (ap26113.com)

Tumor growth is initially reduced by radiation, surgery, or hormone therapy and later, by pairing them with chemotherapy for advanced cancer. (mdpi.com)
Cancer Biology: targeting therapy to maximize benefit and minimize side effects - What are VEGF, erbb2 and BCR-ABL? (powershow.com)
The aim of this article is to summarize topics discussed at this workshop and highlight conclusions as to the immediate and long-term future of epigenetic therapy in cancer. (aacrjournals.org)

Cancer Epidemiol Biomarkers Prev. (famri.org)
Use of urine biomarkers in the initial diagnosis of bladder cancer is controversial. (medscape.com)
Overall, genetic urinary biomarkers are a very heterogeneous group of tests that currently cannot replace cystoscopy and cytology, which remain the gold standard for surveillance of non-muscle-invasive bladder cancer (NMIBC). (medscape.com)

We herein demonstrated that CADM1 interacts with Hippo pathway core kinases and enhances the phosphorylation of YAP1, and also that the membranous co-expression of CADM1 and LATS2 predicts a favorable prognosis in lung adenocarcinoma. (cancerindex.org)

Frameshift mutation of MAPRE3, a microtubule-related gene, in gastric and colorectal cancers with microsatellite instability. (nih.gov)
Anderson C, Ellenhorn J, Hellan M, Pigazzi A. Pilot series of robot-assisted laparoscopic subtotal gastrectomy with extended lymphadenectomy for gastric cancer. (famri.org)

Alisertib inhibits the interaction between N-myc and its stabilizing factor Aurora-A, inhibiting N-myc signaling, and suppressing tumor growth. (unitn.it)
Patient organoids exhibited concordant responses to alisertib and allowed for the dynamic testing of Aurora-N-myc complex disruption. (unitn.it)
Conclusions: Although the study did not meet its primary endpoint, a subset of patients with advanced prostate cancer and molecular features supporting Aurora-A and N-myc activation achieved significant clinical benefit from single-agent alisertib. (unitn.it)

Cancers (Basel) 13(19), 2021. (mdanderson.org)

Is 6 Months the Optimal Duration of Adjuvant Chemotherapy for Pancreatic Cancer? (cancerdiagnosisprognosis.org)
Pancreatic cancer (PC) is one of the most common causes of cancer-related death. (oncotarget.com)
Pancreatic cancer (PC) is a malignant neoplasm with a high mortality rate. (oncotarget.com)

Bardoxolone methyl induces apoptosis and autophagy and inhibits epithelial-to-mesenchymal transition and stemness in esophageal squamous cancer cells. (stembook.org)

Researchers from Sema4 used novel genomic networking approaches to identify key network regulators and therapeutic drugs to demonstrate that targeting the signaling pathway reduces lung cancer spread and improves survival. (bio-itworld.com)
HSP90AA1 Aurora kinases are grasp regulators of both centrosome and checkpoint control function. (ap26113.com)

The Aurora enzymes are particularly significant because they are involved in a direct path to the nucleosome by phosphorylating histone H3. (wikipedia.org)

Cancer and Metastasis Reviews. (wikipedia.org)

During her second year of SPARK in 2019, Ashton's work focused on drug delivery and metastatic cancer, furthering her drug delivery system research from the previous year. (mayo.edu)

Background & Aims: Measurements of α-fetoprotein (AFP) detect hepatocellular carcinoma (HCC) with low levels of sensitivity and specificity and are therefore not recommended for use in liver cancer surveillance. (biomasswars.com)
Urine cytology is still the most accurate noninvasive test for bladder cancer that is in routine clinical use, with a sensitivity of 80-90% and a specificity of 98-100% for detection of high-grade lesions and carcinoma in situ (CIS). (medscape.com)
For more information, see Bladder Cancer , as well as Cystoscopy in Bladder Carcinoma and Surveillance for Recurrent Bladder Cancer . (medscape.com)

Here we show that Lin28b/let-7 pathway is indispensable for modulating the expression of Wnt5a in tumor epithelium, which could be secreted and then up-regulates Lin28b in cancer-associated fibroblasts (CAFs). (bvsalud.org)
Jones D, Noble M, Wedge SR, Robson CN, Gaughan L. Aurora A regulates expression of AR-V7 in models of castrate resistant prostate cancer . (ncl.ac.uk)

Aberrant expression of Aurora kinases occurs in a wide variety of cancers, including colon and breast cancers. (xcessbio.com)

CHD1 plays a critical role in controlling AURKA activation and promoting Aurora kinase inhibitor sensitivity, providing a potential clinical biomarker to guide cancer treatment. (figshare.com)
Because cancer therapeutics often target DNA synthesis or repair, we asked if mutational signatures make useful markers of drug sensitivity. (nature.com)
Because mutational signatures describe the state of the DNA repair machinery of a cancer cell, they may be able to serve as a drug sensitivity marker. (nature.com)

PS 1145 dihydrochloride is a selective I κ B kinase (IKK) inhibitor (IC 50 = 100 nM). (tocris.com)
In contrast, less selective compounds, including from the clinical literature, did not display differential potency in TRIM37 high versus low cancer cell lines. (oricpharma.com)

These observations demonstrate that CHD1 plays an important role in modulating Aurora kinases and drug sensitivities, providing new insights into biomarker-driven therapies targeting Aurora kinases for future clinical studies. (figshare.com)

Recent innovations have helped to develop prescription drugs against certain prostate cancer types, showing gene alterations that prevent the repair of damaged DNA or activate the body's anti-cancer natural immune defense. (mdpi.com)
Recent advances in understanding the role that epigenetics plays in cancer pathogenesis and understanding the mechanisms through which these processes regulate gene expression have stimulated considerable interest in developing clinically viable antineoplastic agents that target enzymatic components of transcriptional regulatory complexes responsible for the establishment of pathologic epigenetic modifications that lead to deregulated gene expression in cancer. (aacrjournals.org)
Although genetics have played a dominant role in cancer research, epigenetics (heritable changes in gene function that do not involve alterations in DNA sequence) has become equally important in this field. (aacrjournals.org)

Molecular Cancer Therapeutics 2015, 14 (1), 48-58. (ncl.ac.uk)

Cancer precision medicine draws on the presence of somatically acquired changes in the tumor, which serve as predictive markers of response to drugs and other therapies. (nature.com)
The investigation of molecular mechanisms and targeted therapies is critical to help us understand the causes of thyroid cancer, how the tumor grows and spreads, and how we can find new ways to treat advanced disease for which there is currently no cure. (cuanschutz.edu)
Ultimately, these studies will identify rational and more specific therapies for patients with advanced thyroid cancer. (cuanschutz.edu)

We demonstrate FIPRESCI enables the generation of approximately 100,000 single-cell transcriptomes from E10.5 whole mouse embryos in a single-channel experiment, and simultaneous identification of subpopulation differences and T cell receptor signatures of peripheral blood T cells from 12 cancer patients. (bvsalud.org)
Dr. Multani has extensive expertise in the field of Human and Mammalian Cytogenetics, and specializes in the evaluation of genetic instability and complex chromosomal rearrangements in cancer cells, telomere dysfunction, characterization of embryonic stem cells, and authentication of cell lines. (mdanderson.org)
In addition, MLN8054 selectively inhibits Aurora A over Aurora B in cultured cells, and inhibits cell proliferation by promoting G2/M accumulation and spindle defects in multiple cultured human tumor cells lines. (xcessbio.com)
2018. Small molecules targeted to the microtubule-HEC1 interaction inhibit cancer cell growth through microtubule stabilization . (lsrnw.ac.uk)
We detect mutational signatures in cancer cell line exomes (where matched healthy tissues are not available) by adjusting for the confounding germline mutation spectra across ancestries. (nature.com)
Genetics of Human Thyroid Cancer Cell Lines-Response. (cuanschutz.edu)
Comprehensive Genetic Characterization of Human Thyroid Cancer Cell Lines: A Validated Panel for Preclinical Studies. (cuanschutz.edu)
Establishment and Characterization of Four Novel Thyroid Cancer Cell Lines and PDX Models Expressing the RET/PTC1 Rearrangement, BRAFV600E, or RASQ61R as Drivers. (cuanschutz.edu)

Accurate assessment of treatment response and residual disease is indispensable for the evaluation of cancer treatment efficacy. (researchgate.net)

We now report that DU145 human prostate cancer cells with reduced levels of PAK4 expression are unable to successfully migrate in response to HGF, have prominent actin stress fibres, and an increase in the size and number of focal adhesions. (silverchair.com)

Anatomy14

Organisms3

Diseases24

Chemicals and Drugs107

Analytical, Diagnostic and Therapeutic Techniques and Equipment54

Phenomena and Processes53

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Information Science6

Health Care23

Geographicals1

Inhibitors17

Tumors4

Progression9

Inhibition9

Small-molecule1

Pathways8

Protein8

20171

Cyclin-Depend1

Serine1

Genes4

Metastatic prostate cancer1

Castration-resistant prostate2

Subunit1

Poor Prognosis3

Mitosis5

Neuroendocrine2

Breast cancer11

Targets3

Ther1

Expression in prostate cancer1

Therapy3

Biomarkers3

Phosphorylation1

Gastric2

Alisertib3

20211

Pancreatic cancer3

Apoptosis1

Regulators2

Enzymes1

Metastasis1

20191

Carcinoma3

Regulates2

Colon1

Sensitivity3

Selective2

Targeting1

Gene3

Molecular Cancer Therapeutics1

Therapies3

Cell8

Efficacy1

Human prostate cancer1