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  • protein
  • The release of prostaglandin has now also been shown to be mediated by a specific transporter, namely the multidrug resistance protein 4 (MRP4, ABCC4), a member of the ATP-binding cassette transporter superfamily. (wikipedia.org)
  • human
  • Prostaglandins differ from endocrine hormones in that they are not produced at a specific site but in many places throughout the human body. (wikipedia.org)
  • levels
  • The classic dogma is as follows: COX-1 is responsible for the baseline levels of prostaglandins. (wikipedia.org)
  • However, while COX-1 and COX-2 are both located in the blood vessels, stomach and the kidneys, prostaglandin levels are increased by COX-2 in scenarios of inflammation and growth. (wikipedia.org)
  • research
  • The biochemists Sune K. Bergström, Bengt I. Samuelsson and John R. Vane jointly received the 1982 Nobel Prize in Physiology or Medicine for their research on prostaglandins. (wikipedia.org)
  • reduce
  • Will ibuprofen, 600 mg three times daily, reduce prostaglandin E concentrations in the alveolar portion of BAL fluid in subjects with emphysema to those present in smoking, former smoking and healthy non-smoking controls? (clinicaltrials.gov)
  • Will ibuprofen 600 mg three times daily, reduce prostaglandin E concentrations in the bronchial portion of BAL fluid in subjects with emphysema compared to placebo? (clinicaltrials.gov)