Loading...
  • Cyclooxygenases
  • Its abundant production during blood clotting, the presence of cyclooxygenases and to a lesser extent thromboxane synthase in a wide range of cell types and tissue, and its production by other pathways imply that 12-HHT has one or more important bioactivities relevant to clotting and, perhaps, other responses. (wikipedia.org)
  • Acids
  • Also in a series of studies, they found that leukotrienes, HETEs (hydroxyeicosatetraenoic acids), inositol lipids and prostaglandins are key molecules in the communication between retinal pigment epithelial cells and photoreceptors. (wikipedia.org)
  • These acids can be turned into some anti-inflammatory prostacyclins by COX instead of pro-inflammatory prostaglandins. (wikipedia.org)
  • NSAIDs
  • The most frequent adverse effect of NSAIDs is irritation of the gastric mucosa as prostaglandins normally have a protective role in the gastrointestinal tract. (wikipedia.org)
  • carbon
  • The 11-peroxyl radical cyclizes at carbon 9 and the carbon-centered radical generated at C-8 cyclizes at carbon 12, generating the endoperoxide . (wikipedia.org)
  • cyclooxygenases
  • Its abundant production during blood clotting, the presence of cyclooxygenases and to a lesser extent thromboxane synthase in a wide range of cell types and tissue, and its production by other pathways imply that 12-HHT has one or more important bioactivities relevant to clotting and, perhaps, other responses. (wikipedia.org)
  • expression
  • The fever response has also been clearly associated with a rapid induction of COX-2 expression and an associated increase in prostaglandin E2 production, with no role for COX-1 or a COX-1 gene product (e.g. (wikipedia.org)
  • cyclizes
  • The 11-peroxyl radical cyclizes at carbon 9 and the carbon-centered radical generated at C-8 cyclizes at carbon 12, generating the endoperoxide. (wikipedia.org)
  • fever
  • Like its ability to control pain, aspirin's ability to control fever is due to its action on the prostaglandin system through its irreversible inhibition of COX. (wikipedia.org)
  • role
  • During the 1960s, a U.K. research team, headed by Professor John Vane, began to explore the role of prostaglandins in anaphylaxis and respiratory diseases. (wikipedia.org)