Loading...
  • cancers
  • The principle behind the company's business is based on the emerging field of adoptive immunotherapy , or biological therapy, which has been successfully used around the world to treat a wide variety of cancers and chronic viral infections. (thefreedictionary.com)
  • According to the growing developments and improvements of cancer immunotherapies, nowadays, special attention has been paid to the immunotherapies of various types of cancers. (ac.ir)
  • The potential for adoptive cell immunotherapy as a treatment against cancers has been demonstrated by the remarkable response in some patients with hematological malignancies using autologous T cells endowed with chimeric antigen receptors (CARs) specific for CD19. (biomedcentral.com)
  • The article describes how adoptive transfer of receptor-engineered T cells has produced "impressive results in treating B-cell leukemias and lymphomas," but that effective treatment of solid cancers using a similar approach based upon pursuing shared tumor antigens is unlikely. (cnbc.com)
  • Along with other technologies developed with our partners and collaborators, it has the potential to play a key role accessing tumor-associated antigens at the individual level thereby translating the enormous promise of adoptive cell therapy to all cancers. (cnbc.com)
  • METHODS: We summarise different cancer vaccines and targeted drugs and highlight the scientific rationale of using immunotherapy for targeting GI cancers, in addition to the potential strategies for improving immunotherapeutic efficacy. (salford.ac.uk)
  • subsets
  • Although pulse zoledronate stimulation with IL-15 preserved early memory subsets, adoptive immunotherapy with IL-15-derived Vγ2Vδ2 cells equally inhibited PC-3 tumor growth as those derived with IL-2. (springer.com)
  • Previous attempts to stimulate and expand these cells have therefore focused on stimulation using ligands of the Vγ9Vδ2 receptor, whereas relatively little is known about variant blood γδT subsets and their potential role in cancer immunotherapy. (aacrjournals.org)
  • tumor cells
  • Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer," Journal of Immunotherapy , vol. 36, no. 7, pp. 382-389, 2013. (hindawi.com)
  • metastatic
  • Phase 2 trial of single agent ipilimumab (Anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma," Journal of Immunotherapy , vol. 33, no. 8, pp. 828-833, 2010. (hindawi.com)
  • poorly
  • So far, examples of HPV16-specific CTLs mainly represent poorly characterized, mostly bulk cultures with limited value for adoptive CTL therapy ( 6 , 7 , 8 , 14 ). (jimmunol.org)
  • However, this prospect is limited by the current cDCs culture system which are poorly amenable to immunotherapy. (jedns-bio.fr)
  • therapeutic
  • Cancer immunotherapy is becoming an appealing and attractive strategy among different therapeutic options over the past years and has showed its power against malignancies ( Figure 1 ) [ 3 , 6 - 9 ]. (jcancer.org)