Prostatic NeoplasmsMonoclonal antibodiesNeuroendocrine neoplasmsMyeloproliferative neoplasmMyeloidClinicalCohort studyPancytokeratin antibodyLymphomaAntigenSquamousMetastaticMPNsProstateSmall Cell LungSerumTiterIgG1InfliximabPatientsTitresImmunohistochemistryTumorImmunizationBiomarkersDefectiveCheckpointMulticenterSeroconversionChronicDiagnosisMortalityAntigensInfectionsCancerStudiesVaccineReceptorResponseStudyInjection
Prostatic Neoplasms1
- Prognosis --Several studies have demonstrated that a large proportion of neuroendocrine differentiated prostatic neoplasms are positive for neuron-specific enolase and chromogranin A [4,6]. (cancernetwork.com)
Monoclonal antibodies3
- The only currently approved BH3-mimetic, the selective BCL2 inhibitor venetoclax, is highly efficacious in chronic lymphocytic leukemia and has rapidly advanced to an approved standard of care in frontline and relapsed disease in combination with anti-CD20 monoclonal antibodies. (biomedcentral.com)
- In this multicentre retrospective study of Gruppo Italiano Malattie EMatologiche dell'Adulto (GIMEMA), we collected data from 91 paucisymptomatic HM patients treated with anti-spike neutralizing monoclonal antibodies (nMoAbs) to determine time to viral clearance, referencing it to the expected value of 28 days from an historical group of untreated paucisymptomatic patients. (bvsalud.org)
- In cases in which response is inadequate, TNF blockers such infliximab or monoclonal antibodies such as vedolizumab can be used. (medscape.com)
Neuroendocrine neoplasms4
- Streptozocin-Based Chemotherapy in Patients with Advanced Neuroendocrine Neoplasms--Predictive and Prognostic Markers for Treatment Stratification. (cancerindex.org)
- Chemotherapy with streptozocin (STZ) in combination with 5-FU or doxorubicin (Dox) represents a standard of care for patients with metastatic pancreatic neuroendocrine neoplasms (pNEN). (cancerindex.org)
- STZ-based chemotherapy is an effective and well-tolerated treatment option in patients with well differentiated neuroendocrine neoplasms. (cancerindex.org)
- Since the pioneering use of 131 I in differentiated thyroid cancer in the 1940s, remarkable achievements in nuclear medicine endoradiotherapy have been demonstrated, mainly in the treatment of neuroendocrine neoplasms by using 177 Lu-labeled somatostatin analogs or in the treatment of advanced prostate cancer using prostate-specific membrane antigen-directed radionuclide therapy. (snmjournals.org)
Myeloproliferative neoplasm1
- Myelofibrosis (MF) is a hematopoietic stem cell malignancy classified as a myeloproliferative neoplasm (MPN). (cancernetwork.com)
Myeloid4
- however, the mRNA-1273 SARS CoV-2 vaccine induces a strong antibody response in patients with acute myeloid leukemia (AML) or with myelodysplastic syndrome (MDS). (jhoponline.com)
- Of the 338 patients with hematologic malignancies, 67% had myeloid neoplasms and 33% had lymphoid neoplasms. (jhoponline.com)
- In addition, 2 (21.4%) patients had myeloid neoplasms and 4 (7.1%) had autoimmune disease. (jhoponline.com)
- Only 1 of 101 patients with chronic myeloid leukemia had no antibody response. (jhoponline.com)
Clinical7
- Our aim was to establish whether neuronal antibodies, independent of clinical neurological features, correlate with SCLC survival. (ox.ac.uk)
- The Ventana CAP/CLIA lab is a full-service histopathology lab that employs automated staining platforms and validated assays for IHC and ISH staining of retrospective and prospective clinical samples. (azbio.org)
- WHO grading of human brain tumors extends beyond a strictly histological grading system by providing a basis predictive for the clinical behavior of the respective neoplasm. (health-atlas.de)
- IgG subclass determination is of limited value in assessing patients with clinical immunodeficiency because functional antibody deficiency may be present despite normal IgG subclass levels. (medscape.com)
- Cancer therapy based on recombinant antibodies against tumor associated target molecules or checkpoint inhibitors have resulted in a number of clinical trials, aiming at improved treatment options for the patients. (lu.se)
- This is a phase 1, open-label study evaluating the safety, clinical pharmacology and clinical activity of AMG 340, a PSMA x CD3 T-cell engaging bispecific antibody, in subjects with metastatic castrate-resistant prostate cancer (mCRPC) who have received 2 or more pr. (mountsinai.org)
- This prospective clinical trial (PRostate Imaging using Mri +/- contrast Enhancement (PRIME)) aims to assess whether biparametric MRI (bpMRI) is non-inferior to multiparametric mpMRI (mpMRI) in the detection of clinically significant prostate cancer. (mountsinai.org)
Cohort study6
- We conducted a prospective cohort study with long-term follow-up to evaluate the relevance of BMM as a prognostic factor for disease free (DFS) and overall survival (OS) in stage I-III colon cancer patients. (nih.gov)
- In this prospective multicenter cohort study 144 stage I-III colon cancer patients underwent bone marrow aspiration from both iliac crests prior to open oncologic resection. (nih.gov)
- Using baseline data from a prospective cohort study of reproductive-aged Black women (N=751), we characterized profiles of EDC mixtures and identified correlates of exposure. (cdc.gov)
- We identified biomarker profiles and correlates of exposure to EDC mixtures in a cross-sectional analysis of data from a prospective cohort study of 749 Black women aged 23-35 years. (cdc.gov)
- A single arm prospective cohort study was conducted at a tertiary referral centre. (turkjsurg.com)
- We sequenced the isocitrate dehydrogenase 1 gene (IDH1) at codon 132 in 382 patients with anaplastic astrocytoma and glioblastoma from the NOA-04 trial and from a prospective translational cohort study of the German Glioma Network. (health-atlas.de)
Pancytokeratin antibody2
- The bone marrow aspirates were stained with the pancytokeratin antibody A45-B/B3 and analyzed for the presence of epithelial tumor cells. (nih.gov)
- SLNs underwent conventional hematoxylin and eosin (H & E) staging with additional serial sectioning and immunohistochemistry for pancytokeratin antibody (ultra-staging). (turkjsurg.com)
Lymphoma1
- Venetoclax combination with standard regimens in follicular lymphoma, multiple myeloma and aggressive B cell neoplasms has shown some promise, but further studies are required to optimize dose and scheduling to mitigate increased myelosuppression and infection risk, and to find validated biomarkers of venetoclax sensitivity. (biomedcentral.com)
Antigen4
- In a prospective pilot study nested in the EPIC-Oxford cohort, we examined the seroprevalence of antibodies against the L1 antigen of 38 human papilloma virus (HPV) types among 39 cases of cutaneous squamous cell carcinoma (SCC) for whom plasma was collected prior to diagnosis (incident) and 80 controls. (ox.ac.uk)
- In children who have completed immunizations with diphtheria, pertussis, and tetanus (DPT) or Hib-conjugated vaccines, the antibody response to protein antigens can be tested in adults and older children by measuring IgG antibodies to tetanus or diphtheria toxoid and H influenzae type b (Hib) polysaccharide antigen. (medscape.com)
- Alternatively antibody response to typhoid-Vi antigen can be measured following typhoid vaccine administration. (medscape.com)
- Antibodies blocking the immune checkpoint cytotoxic T lymphocyte antigen-4 (CTLA-4), programmed death-1 (PD-1), and programmed death-1-ligand 1 (PD-L1) antigens have been tested in several gastrointestinal malignancies. (medscape.com)
Squamous2
- A prospective pilot study of antibodies against human papillomaviruses and cutaneous squamous cell carcinoma nested in the Oxford component of the European Prospective Investigation into Cancer and Nutrition. (ox.ac.uk)
- Squamous cell carcinomas (SCCs) are among the malignancies most commonly diagnosed affecting the oral cavity, accounting for 90% of all cases of neoplasms. (bvsalud.org)
Metastatic1
- report a case of a patient with metastatic gastric cancer with a meaningful response to the anti-programmed death-ligand 1 (PD-L1) antibody avelumab. (medscape.com)
MPNs1
- The myeloproliferative neoplasms (MPNs) are a heterogeneous group of chronic hematological malignancies that are generally divided into the Philadelphia chromosome-positive (Ph-positive) MPNs, which refers to chronic myelogenous leukemia (CML) and the Philadelphia chromosome-negative (Ph-negative) MPNs. (cancernetwork.com)
Prostate2
- Neuroendocrine differentiation has been foundin 50% to 100% of prostate neoplasms of all stages. (cancernetwork.com)
- However, the proportion of neuroendocrine differentiation was found to be much higher in follow-up studies and it is now thought that 50% to 100% of all prostate neoplasms (including benign prostatic tissue) contain at least some neuroendocrine cells [3,5]. (cancernetwork.com)
Small Cell Lung2
- Novel Humoral Prognostic Markers in Small-Cell Lung Carcinoma: A Prospective Study. (ox.ac.uk)
- PURPOSE: Favourable small cell lung carcinoma (SCLC) survival outcomes have been reported in patients with paraneoplastic neurological disorders (PNDs) associated with neuronal antibodies (Neur-Abs), but the presence of a PND might have expedited diagnosis. (ox.ac.uk)
Serum2
- The overal prevalence of positive tion was found between C. trachomatis C. trachomatis );and2)Giemsastaining serum antibodies for C. trachomatis in- and cervical neoplasia [ 4 ]. (who.int)
- A diagnosis of common variable immunodeficiency (CVID) is based on defective functional antibody formation, usually accompanied by decreased (not absent) serum immunoglobulin (Ig)G and IgA levels, generally (not invariably) decreased serum IgM, and exclusion of other known causes of antibody deficiency. (medscape.com)
Titer2
- Positive seroconversion, defined as ≥0.8 U/mL antibody titer, was demonstrated for 85% of patients, with a mean titer value of 197 U/mL. (jhoponline.com)
- Of the patients with a positive antibody titer, 89 (28%) had a response between 0.8 U/mL and 250 U/mL. (jhoponline.com)
IgG11
- Anti-PD-L1 IgG1 monoclonal antibody. (medscape.com)
Infliximab1
- Infliximab, an antibody to human tumor necrosis factor alpha, has proved successful in the treatment of severe refractory disease and generally causes only mild side effects. (aafp.org)
Patients14
- their median survival time was longer still (15.0 months, P = 0.0048), contrasting with the survival time in patients with non-neuronal anti-nuclear antibodies (detected using HEp-2 cells, n = 23 (10%), 9.25 months). (ox.ac.uk)
- Negative seroconversion occurred predominantly in patients with lymphoid neoplasms. (jhoponline.com)
- Of the 56 patients with no seroconversion, 40 (72%) had lymphoid neoplasms, which "reflects 36% of all patients with lymphoid diseases," said Dr Rotterdam. (jhoponline.com)
- For example, among the 6 patients with MPN, 5 patients received ruxolitinib therapy, and all 5 had no antibody response. (jhoponline.com)
- A substantial number of patients with hematologic diseases do not have adequate antibody response, and might therefore not have sufficient protection from vaccination," said Dr Rotterdam. (jhoponline.com)
- This study showed a strong antibody to mRNA vaccines in patients with AML and MDS. (jhoponline.com)
- Antibody levels increased dramatically following the second vaccine dose, which indicated the potential utility of serial vaccination, with good efficacy in poorly responsive patients after the first vaccine dose," Dr Lancet said. (jhoponline.com)
- Antibody titres before and after a third dose of the SARS-CoV-2 BNT162b2 vaccine in patients with cancer. (sciensano.be)
- Episodic memory for visual scenes suggests compensatory brain activity in breast cancer patients: a prospective longitudinal fMRI study. (starrcancer.org)
- Being aware of the benefits that the correct systemic therapy provides to patients with advanced breast cancer, the Spanish Breast Cancer Research Group (GEICAM) performed a prospective, observational study to determine the conversion rate of receptor status (ER, PR and HER2) between the primary tumor and the recurrent lesion. (springer.com)
- Antibody titers for Rickettsia japonica and Orientia tsutsugamushi in the patients with nonrickettsial diseases. (cdc.gov)
- The sera of 22 (42%) of the 52 hemophilia-associated AIDS patients have been tested for antibody to antigens of the AIDS virus using Western blot analysis (2). (hemophiliafed.org)
- Methods: Medical records of 130 patients treated with neoadjuvant chemotherapy were reviewed and divided into two groups: 90 samples to train the network and 40 samples to perform prospective testingand validate the results obtained by the Artificial intelligence method. (bvsalud.org)
- Anti-PD-1 or PD-L1 antibodies alone or in combination with CTLA-4 were shown to induce objective responses in approximately 10% to 20% of patients with gastric and gastroesophageal adenocarcinoma in small nonrandomized trials. (medscape.com)
Titres1
- antibody in blood samples (titres of wereover40yearsold. (who.int)
Immunohistochemistry1
- Immunohistochemistry using a mutation-specific antibody recognizing the R132H mutation yielded similar results. (health-atlas.de)
Tumor4
- This might suggest that if HPV is involved in the aetiology of SCC, the process occurs close to the time of diagnosis, or that the antibody response observed in people with SCC is a consequence of tumor formation. (ox.ac.uk)
- Meanwhile, sintilimab is a human immunoglobulin G4 (IgG4) monoclonal antibody that specifically binds to the programmed death-1 (PD-1) molecule on the surface of T-cells, consequently blocking the tumor immune tolerance-inducing PD-1/programmed death-ligand 1 (PD-L1) pathway, reactivating the antitumor activities of lymphocytes, and inhibiting tumors [ 9 ]. (hindawi.com)
- En los casos, se recogió información clínica y se dispone de muestras de tumor fresco o parafinado a través de los biobancos de los hospitales. (isciii.es)
- The selected biomarkers are defined with antibodies directed against cancer associated markers released by the tumor (the secretome) or immuno regulatory proteins, as part of a systematic response. (lu.se)
Immunization2
- This assessment can also be done by measuring antibody responses following active immunization with protein or polysaccharide antigens. (medscape.com)
- Obtain blood 4 weeks after the last immunization and determine IgG antibodies. (medscape.com)
Biomarkers1
Defective1
- Defective antibody production and low circulating numbers of B cells were described in some female infants and in males in whom no Btk abnormalities were detected. (medscape.com)
Checkpoint1
- Application of anti-PD-1/PD-L1 antibodies as checkpoint inhibitors is rapidly becoming a promising therapeutic approach in treating tumors, and some of them have successfully been commercialized in the past few years [ 10 ]. (hindawi.com)
Multicenter1
- This was a multicenter, prospective, observational study coordinated by GEICAM and performed by the Medical Oncology departments in 31 hospitals. (springer.com)
Seroconversion1
- Immunogenicity outcomes of interest were seroconversion, geometric mean titers (GMTs), or antibody avidity. (cdc.gov)
Chronic1
- Participants encouraged prospective cohort studies of persons with chronic liver diseases in which the use of various screening modalities and regimens could be assessed and suggested that cost-effectiveness studies of AFP screening could be useful in decision-making. (cdc.gov)
Diagnosis1
- Today, the pilot platform includes up to 500 antibodies and well-conceived bioinformatics has been developed for selection of the orthogonal markers generating the optimal signature for maximum specificity and sensitivity for a particular diagnosis. (lu.se)
Mortality1
- Diesel exhaust exposure and mortality among males in the American Cancer Society prospective study. (cdc.gov)
Antigens5
- Eighteen (82%) of these specimens contained antibody to one or more antigens (2,3). (hemophiliafed.org)
- Assessment of the ability to produce functional antibodies can be obtained by measuring antibody responses to natural antigens or those antigens to which the population commonly is exposed. (medscape.com)
- Isohemagglutinins are IgM antibodies to ABO blood group antigens that are polysaccharide. (medscape.com)
- Approximately 80% of children have detectable antibodies to these antigens after 3 immunizations during their first year of life. (medscape.com)
- Therefore, antibody responses should be measured to polysaccharide antigens that are not present in the protein-conjugated pneumococcal vaccine. (medscape.com)
Infections1
- There were no statistically significant differences in the seroprevalence of antibodies against any of the HPV types examined between incident cases and controls, nor was there a difference in the seroprevalence of multiple infections. (ox.ac.uk)
Cancer2
Studies4
- Further and larger prospective studies are needed to clarify the role of HPV in the aetiology of cutaneous SCC. (ox.ac.uk)
- Those preliminary findings need validation in larger studies, with a prospective design and longer follow-up. (hindawi.com)
- The Ventana Companion Diagnostics (CDx) Pharma Services Team provides customers with a comprehensive suite of services in prototype assay development and validation, including antibody screening, analytical performance studies, validation report and IHC/ISH slide scoring by pathologists. (azbio.org)
- Our findings of a link between vitamin D intake and reduced risk for colitis could potentially impact practice if validated in future prospective studies," senior author Osama Rahma, MD, said in a press release. (medscape.com)
Vaccine2
- Three doses of BNT162b2 vaccine confer neutralising antibody capacity against the SARS-CoV-2 Omicron variant. (sciensano.be)
- Protein conjugated pneumococcal vaccine elicit antibody responses that are T-cell dependent. (medscape.com)
Receptor2
- The availability of an anti-androgen receptor (AR) monoclonal antibody has allowed the identification of both AR-positive and AR-negative neuroendocrine subpopulations in both benign and malignant tumors [5]. (cancernetwork.com)
- Se evaluó la expresión de los receptores hormonales (receptor de estrógeno (RE) y de progesterona (RP)), HER2, Ki67 y GRB7, mediante inmunohistoquímica (IHQ), y a partir de estos, se clasificaron los tumores en subtipos intrínsecos. (bvsalud.org)
Response1
- Distinct Requirements of CHD4 during B Cell Development and Antibody Response. (starrcancer.org)
Study3
- Participants study, participants were selected from negative for anti- Chlamydia antibody thetotalof609womenvisitingthegy- Statistical methods also had a negative evaluation for C. tra- naecology clinic in our hospital between Categorical variables were summarized chomatis inclusion bodies. (who.int)
- In an earlier prospective study among pre- and postmenopausal women not using exogenous hormones, we obs. (biomedcentral.com)
- Faust H, Andersson K, Ekström J, Hortlund M, Robsahm TE, Dillner J. Prospective study of Merkel cell polyomavirus and risk of Merkel cell carcinoma. (medscape.com)
Injection2
- If the child's antibody level is low, administer 1 booster injection, then measure for antibodies 4 weeks later. (medscape.com)
- take a blood sample 4 weeks after the last injection and determine antibody level (usually by virus neutralization). (medscape.com)