Proscillaridin is a cardiac glycoside, a kind of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). (wikipedia.org)
The compound is called Proscillaridin A, a cardiac glycoside that is known for treating congestive heart failure and cardiac arrhythmia. (promegaconnections.com)
A study published in the Journal of Experimental and Clinical Cancer Research has found that a cardiotonic, known as proscillaridin A, primarily used to treat heart failure or cardiac arrhythmia is showing promise in treating patients with leukemia. (contemporaryclinic.com)
Drug4
A repurposed drug, known as proscillaridin A, has been found to show potential in fighting the MYC gene mutation in patients with leukemia. (contemporaryclinic.com)
Using proscillaridin A to treat leukemia is a major advancement in drug repositioning, or using drugs designed for certain therapeutic indications for other disease. (contemporaryclinic.com)
Heart failure drug proscillaridin A targets MYC overexpressing leukemia through global loss of lysine acetylation. (contemporaryclinic.com)
Then we detected hHub-DEGs guided top-ranked nine candidate drug agents (Digoxin, Avermectin, Simeprevir, Nelfinavir Mesylate, Proscillaridin, Linifanib, Withaferin, Amuvatinib, Atazanavir) by molecular docking and cross-validation for treatment of SARS-CoV-2 infections. (edu.au)
Authors2
Next, the authors wanted to determine how Proscillaridin A impacts tumor cell viability. (promegaconnections.com)
According to the study authors, proscillaridin A drugs have passed critical toxicology, safety, and pharmacokinetics testing and can be fast tracked for use in clinical trials. (contemporaryclinic.com)
Found1
Using this assay, they found that Proscillaridin A induced apoptosis at earlier time points and higher rates in 3D spheroids expressing oncogenic KRAS compared with wild-type KRAS. (promegaconnections.com)
Candidate1
This means that Proscillaridin A would not have been identified as a candidate if the screen was done using only 2D cultures. (promegaconnections.com)