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  • hypothyroidism
  • The present study induced varying degrees of developmental hypothyroidism by administration of low doses of the thyroidhormone synthesis inhibitor, propylthiouracil (PTU 0, 1, 2 and 3 ppm) to the drinking water of pregnant rats. (epa.gov)
  • Varying degrees of developmental hypothyroidism were induced by administration of low doses of the TH synthesis inhibitor, propylthiouracil (PTU 0, 1,2 and 3 ppm) to the drinking water of pregnant rats at concentrations 200-fold lower than those traditionally used in standard hypothyroid models. (epa.gov)
  • 3. Serum T 4 and T 3 concentrations of mice were found to rise immediately before the onset of muscle necrosis in the mdx mouse, and induction of hypothyroidism by treatment of animals with propylthiouracil was found to delay the onset of muscle necrosis. (clinsci.org)
  • iodine
  • Propylthiouracil is for use only if your condition cannot be treated with another thyroid medication, or when surgery or radioactive iodine are not good treatment options for you. (cigna.com)
  • day of propylthiouracil continuously,Lugols iodine daily for the first 7 days and tamoxifen 240 mg/day. (aacrjournals.org)
  • symptoms
  • The following is a report of hypoprothrombinemia which occurred during propylthiouracil administration in a case whose presenting symptoms were hematuria and purpura. (annals.org)
  • drug
  • The drug was subjected to forced degradation under acidic and basic condtiions, and the method proved to be stability indicating for propylthiouracil. (ijpc.com)
  • While the prescribing information for this drug clearly states that women should never breastfeed while taking it, other reliable sources state that propylthiouracil is compatible with breastfeeding. (emedtv.com)