Poloxamers, also called Pluronic, belong to a unique class of synthetic tri-block copolymers containing central hydrophobic chains of poly(propylene oxide) sandwiched between two hydrophilic chains of poly(ethylene oxide). (mostwiedzy.pl)
Amphiphilic triblock copolymers of ethylene oxide and propylene oxide (Pluronic) significantly enhanced expression of plasmid DNA in the skeletal muscle. (nebraska.edu)
The polymer moieties such as poly(ethylene glycol) (PEG), chitosan (CTS), hyaluronic acid, pullulan, poly(ethylene oxide) (PEO), poly(propylene oxide) (PPO) protect DDS from degradation. (eurekaselect.com)
Glycol3
Poloxamer 407 is a triblock copolymer consisting of a central hydrophobic block of polypropylene glycol flanked by two hydrophilic blocks of polyethylene glycol (PEG). (wikipedia.org)
The approximate lengths of the two PEG blocks is 101 repeat units, while the approximate length of the propylene glycol block is 56 repeat units. (wikipedia.org)
The objective of this study is to summarize existing evidence on short- and long-term outcomes of patients following toxic alcohol poisonings, including methanol, ethylene glycol, isopropanol, propylene glycol, and diethylene glycol. (biomedcentral.com)
Copolymers1
Poloxamer 407 is a hydrophilic non-ionic surfactant of the more general class of copolymers known as poloxamers. (wikipedia.org)
Poloxamers1
Some chemical characteristics of poloxamers such as temperature-dependent self-assembly and thermo-reversible behavior along with biocompatibility and physiochemical properties make poloxamer-based biomaterials. (mostwiedzy.pl)
BASF1
This particular compound is also known by the BASF trade name Pluronic F-127 or by the Croda trade name Synperonic PE/F 127. (wikipedia.org)
Toxic1
reported that aqueous solutions of poloxamer 188 and poloxamer 407 sonicated in the presence or absence of multi-walled carbon nanotubes (MWNTs) can become highly toxic to cultured cells. (wikipedia.org)
Solution1
In a 30% solution by weight, poloxamer 407 forms a gel solid at room temperature but liquifies when chilled to 4 °C (39 °F). This allows poloxamer 407 to serve as a removable support material, particularly for creating hollow channels or cavities inside hydrogels. (wikipedia.org)
Unique1
Poloxamer 407 is used in bioprinting applications due to its unique phase-change properties. (wikipedia.org)
Presence1
In the presence of Pluronic P85 (P85) high levels of expression of a reporter gene (luciferase) were sustained for at least 40 days and the area under the gene expression curve increased by at least 10 times compared to the DNA alone. (nebraska.edu)
Properties2
Most of the common uses of poloxamer 407 are related to its surfactant properties. (wikipedia.org)
Poloxamer 407 can also be used for its thermogelling properties in aqueous media. (wikipedia.org)
Ethylene Oxide2
Poloxamers are based on a poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) structure, which is also typically expressed as PEOa-PPOb-PEOa (a = 75 and b = 30). (medscape.com)
It is made of low molecular compounds consisting of active hydrogen such as (alcohols, amines) as the beginning representative, as well as under the activity of a driver, it is integrated with ethylene oxide (EO), propylene oxide (PO), butylene oxide (BO) It is developed by ring-opening polymerization. (zhishangchemical.com)
Polyoxyethylene1
The product produced by German BASF company is called Pluronic, in which the polyoxyethylene chain is relatively hydrophilic, and the polyoxypropylene chain is relatively lipophilic, so it is a non-ionic polymer surfactant. (zhishangchemical.com)
Hydrophilic1
Poloxamer 407 is a hydrophilic non-ionic surfactant of the more general class of copolymers known as poloxamers. (wikipedia.org)
Sigma-Aldrich1
For the synthesis of nanoemulsions, poloxamer P188 and sunflower oil were purchased from Sigma-Aldrich. (medscape.com)
Copolymer1
Poloxamer is a nonproprietary name for polyether polyol copolymer. (zhishangchemical.com)
Formulations1
Poloxamer 407-based sterile injectable formulations serve to be a good candidate for drug delivery. (sigmaaldrich.com)
Concentration1
Poloxamer 407 (P407) exhibits reversible gelation properties above a particular polymer concentration and temperature. (sigmaaldrich.com)
Applications2
Poloxamer 407 is used in bioprinting applications due to its unique phase-change properties. (wikipedia.org)
Abstract In this review, we have highlighted different types of Pluronic® polymers for prominent photodynamic therapy (PDT) applications. (pharmaexcipients.com)