Prophylaxis chemotherapy induced febrile neutropenia. Medical search. Frequent questions

3 . Aapro MS et al: 2010 update of EORTC guidelines for the use of granulocyte-colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphoproliferative disorders and solid tumours. (trillium.de)
Impact of primary prophylaxis with granulocyte colony-stimulating factor on febrile neutropenia and mortality in adult cancer patients receiving chemotherapy: A systematic review. (trillium.de)
Acute myeloid leukemia or myelodysplastic syndrome in randomized controlled clinical trials of cancer chemotherapy with granulocyte colony-stimulating factor: A systematic review. (trillium.de)
The impact of the granulocyte colony-stimulating factor on chemotherapy dose intensity and cancer survival: A systematic review and meta-analysis of randomized controlled trials. (trillium.de)
Granulocyte colony-stimulating factor in the treatment of high-risk febrile neutropenia: A multicenter randomized trial. (trillium.de)
Treatment with granulocyte colony-stimulating factor is used to stimulate neutrophil production and prevent bacterial infections after cancer chemotherapy and with severe chronic neutropenia. (msdmanuals.com)
The current system of management of febrile neutropenia involves administration of prophylactic antimicrobials and hematopoietic growth factor supplements (granulocyte colony stimulating factor G-‐ CSF). (biomedgrid.com)

The objective of this protocol was to develop a reference tool for the evaluation and management of febrile neutropenia in a fourth-level cancer hospital in Ecuador and provide a guideline for a timely and adequate care of cancer patients. (ijpsonline.com)
The diagnosis and management of febrile neutropenia and fever will be directed by the Consultant/Associate Specialist or a senior member of the medical team. (scot.nhs.uk)

The low incidence of adverse effects and chemotherapy dose changes, delays, and withdrawals supports the use of lenograstim as effective primary prophylaxis in South African patients being treated with a docetaxel-based regimen. (hindawi.com)
Based on this evidence, guidelines published by the American Society of Clinical Oncology and the European Organisation for Research and Treatment of Cancer state that when the overall risk of FN is 20% or greater, especially on "dose dense" regimens, primary prophylaxis with G-CSFs is justified [ 10 , 13 ]. (hindawi.com)
OBJECTIVES: To examine the cost-effectiveness of lipegfilgrastim versus pegfilgrastim as primary prophylaxis in women with early stage breast cancer. (edu.au)
CONCLUSIONS: Lipegfilgrastim was likely to be a cost-effective alternative to pegfilgrastim as primary prophylaxis. (edu.au)

The causes of neutropenia can be divided between problems that are transient and those that are chronic. (wikipedia.org)

Patients who are under-prophylacted are at higher risk for disturbances to their chemotherapy regimens. (unibas.ch)
Docetaxel-based chemotherapy regimens have substantially improved survival and recurrence rates for cancer patients. (hindawi.com)
Safety profile of docetaxel regimens includes toxicities, particularly a high risk of neutropenia and febrile neutropenia. (hindawi.com)
Systemic adjuvant chemotherapy with anthracycline- and taxane-containing regimens has become the standard first line treatment for early and metastatic breast cancer [ 5 ], with large phase III randomized trials showing extremely high long-term disease-free survival and overall survival rates (resp. (hindawi.com)
In fact, reducing the planned dose intensity of systemic adjuvant chemotherapy regimens by as little as 15% has been shown to significantly reduce time to progression and overall survival rates in women with metastatic breast cancer [ 5 ]. (hindawi.com)
G-CSFs have been shown to reduce overall mortality risk [ 8 , 11 ], reduce the incidence of other adverse events (grade 2 or greater anaemia, asthenia, anorexia, myalgia, nail disorders, and oral mucositis) associated with docetaxel-based chemotherapy regimens, and increase health related quality of life and consequently treatment compliance [ 8 , 12 ]. (hindawi.com)
3 Alternatively, R-CHOP alone or with consolidation XRT is also used for the management of PMBCL, although the latter is preferred given the survival benefit associated with the XRT consolidation, 4 pending the results of phase 3 randomized study looking into the role of consolidation XRT ( NCT01599559 ) following rituximab-containing chemotherapy regimens. (silverchair.com)
[ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
Despite regimens with acceptable toxicity profiles are needed, with increasing evidence that the appropriate management of fit increasing attention toward patient convenience and quality patients should be with systemic chemotherapy, nocombination has yet emerged as the standard of care. (aboutdrugspdf.com)

Febrile Neutropenia (FN) is a common complication of chemotherapy and a main cause of morbidity and mortality in cancer patients[ 1 ]. (ijpsonline.com)
Chemotherapy is still the current standard treatment for hematological malignancy and febrile neutropenia is a common complication of chemotherapy in most patients [ 1 ]. (biomedcentral.com)

After transplantation, most febrile episodes require in-patient treatment and observation until profound neutropenia and clinically significant infection resolves. (medscape.com)

Antimicrobial prophylaxis and outpatient management of fever and neutropenia in adults treated for malignancy: American Society of Clinical Oncology clinical practice guideline. (trillium.de)
An overview of the concepts related to neutropenic fever, including definitions of fever and neutropenia and categories of risk are reviewed here. (ukessays.com)
This topic also provides a general approach to the management of neutropenic fever syndromes in cancer patients at high and low risk for complications, and the prophylaxis of infections in such patients. (ukessays.com)
The definition of fever as an indicator of infection in patients with neutropenia has varied. (ukessays.com)
If fever is present, infection is presumed, and immediate, empiric broad-spectrum antibiotics are necessary, especially if the neutropenia is severe. (msdmanuals.com)
Patients having fever or febrile neutropenia (FN) then attend hospital and undergo assessment including a complete blood cell count (CBC). (biomedgrid.com)
The critical element in reducing neutropenia related mortality is early diagnosis before the onset of infection and fever resulting in reduced need for hospitalisation and a faster neutrophil recovery. (biomedgrid.com)
Infections lead to fever known as febrile neutropenia (FN). (biomedgrid.com)
If fever persists 72-96 hours after treatment with broad-spectrum antibacterial antibiotics during neutropenia, invasive fungal infection may be suspected and treated empirically with antifungal agents [ 1 - 3 ]. (biomedcentral.com)
Management of neutropenia with a fever, including an antibiotic, anti-viral and anti-fungal policy for this group of patients. (scot.nhs.uk)
Children with neutropenia and fever, especially children with haematological and/ oncology conditions. (scot.nhs.uk)

MONITOR-GCSF is a prospective, observational study of 1447 evaluable patients from 140 cancers centers in 12 European countries treated with myelosuppressive chemotherapy for up to 6 cycles receiving biosimilar GCSF prophylaxis. (unibas.ch)
Myeloid growth factors (MGFs) are given as supportive care to patients receiving myelosuppressive chemotherapy to reduce the incidence of neutropenia. (jnccn.org)

Neutropenia can be divided into congenital and acquired, with severe congenital neutropenia (SCN) and cyclic neutropenia (CyN) being autosomal dominant and mostly caused by heterozygous mutations in the ELANE gene (neutrophil elastase). (wikipedia.org)
ELA2 mutation, GATA2 deficiency Barth syndrome Copper deficiency Vitamin B12 deficiency Pearson syndrome Some types of Hermansky-Pudlak syndrome Transient neutropenia: Typhoid Tuberculosis Chemotherapy Cytomegalovirus Influenza Human Immunodeficiency Virus Propylthiouracil Levamisole Penicillamine Trimethoprim/sulfamethoxazole Clozapine Valproate Vaccination Venetoclax Severe bacterial infections, especially in people with underlying hematological diseases or alcoholism, can deplete neutrophil reserves and lead to neutropenia. (wikipedia.org)
The congenital neutropenia (severe and cyclic type) is autosomal dominant, with mutations in the ELA2 gene (neutrophil elastase) as the most common genetic reason for this condition. (wikipedia.org)
Based upon the level of ANC, neutropenia is categorized as mild, moderate or severe. (ukessays.com)
Acute, severe neutropenia, particularly if another factor (eg, cancer) is present, significantly impairs the immune system and can lead to rapidly fatal infections. (msdmanuals.com)
RESULTS: From the first chemotherapy model, lipegfilgrastim was associated with fewer episodes of severe neutropenia (SN) (N = 142 per 1000 patients treated), febrile neutropenia (FN) (N = 29 per 1000 patients treated), infection (N = 17 per 1000 patients treated) and chemotherapy delayed (N = 170 per 1000 patients treated) and lower cost ($116.88 less per patient treated). (edu.au)
Severe or life-threatening neutropenia may occur. (trodelvyhcp.com)
Severe, life-threatening, or fatal neutropenia can occur and may require dose modification. (trodelvyhcp.com)
Key words: advanced gastric cancer, chemotherapy, oxaliplatin, pemetrexed, phase II trial addition, cisplatin-based combinations are difficult toadminister in this often-debilitated population and have the Patients suffering from advanced gastric cancer (AGC) remain potential for severe toxicity. (aboutdrugspdf.com)

The European Society for Medical Oncology (ESMO, 2016) reported an incidence of approximately 8 cases of FN per 1000 patients who received chemotherapy[ 1 ]. (ijpsonline.com)
Granotax was a prospective, open label, multicentre, national phase IV study that evaluated the incidence and severity of neutropenia in adult patients with solid tumors being treated with a docetaxel-based regimen while receiving the GCSF lenograstim. (hindawi.com)
Among the 394 enrolled patients the incidence of grade 3-4 neutropenia was 16.2% and of febrile neutropenia was 1.5%, far lower than the reported 85-100% and 30-40% incidence without G-CSFs. (hindawi.com)
Neutrophils play a vital role in protecting against infection, so the duration and severity of neutropenia directly correlate with the total incidence of all infections, including those that are life threatening. (medscape.com)
The duration and severity of neutropenia directly correlate with the total incidence of all infections and of those infections that are life threatening. (medscape.com)
The primary outcome of the study was to assess the incidence of bacteremia during periods of neutropenia. (jhoponline.com)
The use of levofloxacin prophylaxis did not result in a significant reduction in the incidence of bacteremia compared with the control group but did show a trend towards the reduction of bacteremia. (jhoponline.com)

[ 3 ] Major causes of acquired neutropenia are infection, drugs (through direct toxicity or immune effects), and autoimmunity. (medscape.com)
These symptoms may exist because individuals with neutropenia often have infection. (wikipedia.org)
Tuberculosis (see the image below) is one type of infection that may cause neutropenia. (medscape.com)
With the increasing use of myelo-suppressive agents in the treatment of neoplastic and nonneoplastic diseases, the increased rate of infection in patients with neutropenia has been clearly established 3. (ukessays.com)
However, neutropenia is detected in these patients only after the onset of infection limiting the efficacy of these therapeutic interventions. (biomedgrid.com)

Cytotoxic chemotherapy often induces febrile neutropenia and may lead to serious complications including mortality. (ijpsonline.com)
Reprogramming is a promising treatment, which redifferentiates T-induced pluripotent stem cells (T-IPSCs) into naïve and cytotoxic T cells or dedifferentiates within their own lineage [ 13 ]. (hindawi.com)

Neutropenia can be acute (temporary) or chronic (long lasting). (wikipedia.org)
Treatment for patients with acute myeloid leukemia involves intensive chemotherapy to destroy the leukemic cell population as rapidly as possible and to prevent the emergence of a resistant clone. (medscape.com)
Hospitalization is necessary in patients with acute myeloid leukemia for managing chemotherapy and for treating complications related to the disease and its treatment, usually infections or febrile neutropenic episodes. (medscape.com)
Prophylactic antibiotics are often used in pediatric patients for the treatment of acute myeloid leukemia (AML) and relapsed acute lymphoblastic leukemia (ALL), and for those undergoing hematopoietic stem cell transplant (HSCT) who are receiving intensive chemotherapy. (jhoponline.com)
Prompt Initiation of Conventional Chemotherapy to Avoid Early Death in Patients with Newly Diagnosed Acute Promyelocytic Leukemia. (u-tokyo-hemat.com)
ONUREG is indicated for continued treatment of adult patients with acute myeloid leukemia who achieved first complete remission (CR) or complete remission with incomplete blood count recovery (CRi) following intensive induction chemotherapy and are not able to complete intensive curative therapy. (guidelinecentral.com)

Causes can be divided into these groups: Chronic neutropenia: Aplastic anemia Evans syndrome. (wikipedia.org)
Nutritional deficiencies, such as deficiency in vitamin B12, folate, copper or protein-calorie malnutrition are associated with chronic neutropenia. (wikipedia.org)

Patients with prolonged neutropenia after hematopoietic stem cell transplantation or chemotherapy and patients receiving broad-spectrum antibiotics and high doses of corticosteroids are predisposed to fungal infections. (msdmanuals.com)
Hematopoietic growth factors, including erythrocyte stimulating agents (ESAs), granulocyte colony-stimulating factors, and thrombopoietin mimetics, can mitigate anemia, neutropenia, and thrombocytopenia resulting from chemotherapy for the treatment of cancer. (jnccn.org)
Heterozygous Dnmt3a R878C induces expansion of quiescent hematopoietic stem cell pool. (u-tokyo-hemat.com)

In the MONITOR-GCSF study of chemotherapy-induced (febrile) neutropenia with biosimilar filgrastim, 56.6% of patients were prophylacted according to amended EORTC guidelines, but 17.4% were prophylacted below and 26.0% above guideline recommendations. (unibas.ch)
Comparison of pegfilgrastim with filgrastim on febrile neutropenia, grade IV neutropenia and bone pain: A meta-analysis of randomized controlled trials. (trillium.de)
Pegfilgrastim prophylaxis is associated with a lower risk of hospitalization of cancer patients than filgrastim prophylaxis: A retrospective United States claims analysis of granulocyte colony-stimulating factors (G-CSF). (trillium.de)

This selection from the NCCN Guidelines for MGFs focuses on the evaluation of regimen- and patient-specific risk factors for the development of febrile neutropenia (FN), the prophylactic use of MGFs for the prevention of chemotherapy-induced FN, and assessing the risks and benefits of MGF use in clinical practice. (jnccn.org)

List medications that can cause neutropenia and thrombocytopenia, and state drugs that are useful for neutropenia. (ashp.org)
When considering the differential diagnosis, it is important to include diseases that may cause neutropenia. (termedia.pl)

Other causes of congenital neutropenia are Shwachman-Diamond syndrome, Cyclic neutropenia, bone marrow failure syndromes, cartilage-hair hypoplasia, reticular dysgenesis, and Barth syndrome. (wikipedia.org)
21 , 22 Patients with cyclic neutropenia have oscillations in blood neutrophils usually at 3-week intervals, measured from nadir to nadir. (jnccn.org)

These are: Bacterial or fungal sepsis Necrotizing enterocolitis, circulating neutrophil population depleted due to migration into the intestines and peritoneum Alloimmune neonatal neutropenia, the mother produces antibodies against fetal neutrophils Inherited autoimmune neutropenia, the mother has autoimmune neutropenia Autoimmune neutropenia of infancy, the sensitization to self-antigens The pathophysiology of neutropenia can be divided into congenital and acquired. (wikipedia.org)

Where neutropenia is significant, it is associated with an increased risk of systemic infections that lead to sepsis and death (1,2,3,7,9). (biomedgrid.com)

Neutropenia is a decrease in circulating (ie, nonmarginal) neutrophils in the blood. (medscape.com)
Neutropenia is an abnormally low concentration of neutrophils (a type of white blood cell) in the blood. (wikipedia.org)
Though the body can manufacture a normal level of neutrophils, in some cases the destruction of excessive numbers of neutrophils can lead to neutropenia. (wikipedia.org)
Neutropenia is a decrease in circulating neutrophils in the nonmarginal pool, which constitutes 4-5% of total body neutrophil stores. (medscape.com)
Chemotherapy treatments for cancer are well-‐ known to be associated with a depletion of white blood cells, in particular neutrophils, causing a condition known as chemotherapy-‐ induced neutropenia (CIN), as described in Figure 1. (biomedgrid.com)
These diseases can be categorized into congenital and acquired conditions ( Table I ). Neutropenia can arise from various causes, including impaired production of neutrophils ( Table II ), increased destruction of granulocytes in the peripheral blood ( Table II ), and improper distribution of granulocytes in the peripheral blood. (termedia.pl)

Concurrent anemia, thrombocytopenia, and/or an abnormal result on a peripheral blood smear from a patient with neutropenia suggest an underlying hematologic disorder. (medscape.com)
Most common grade 3/4 toxic effects were neutropenia in 41% of patients (19% of cycles) and thrombocytopenia in 11% of patients (4% of cycles). (aboutdrugspdf.com)

Thus, several measurements may be needed when determining the severity of neutropenia. (msdmanuals.com)
The risk increases with the duration and severity of the neutropenia. (biomedgrid.com)
The frequency and severity of infective episodes correlates inversely with the degree and duration of neutropenia and is particularly marked in children whose neutrophil count is below 0.5 x 10 9 /l. (scot.nhs.uk)

However, the DCF regimen induced treatment of patients with AGC [5-9]. (aboutdrugspdf.com)
Patients were randomized so that half pursued no set exercise regimen during chemotherapy, and the other half were instructed to follow a specific home-based, personalized prescription of aerobic walking and anaerobic resistance band training known as EXCAP (Exercise for Cancer Patients) for 6 weeks. (oncnursingnews.com)

Background: Despite a potentially curative treatment, the prognosis after upfront surgery and adjuvant chemotherapy for patients with resectable pancreatic ductal adenocarcinoma (PDAC) is poor. (unav.edu)

Academic and clinical research in collaboration with Northwestern University and University of Chicago, under Professor Everett E. Vokes, regarding the combination of chemotherapy and radiotherapy in advanced Head and Neck cancer. (mitera.gr)
Traditionally, the treatment of hematological malignancies is administrated by chemotherapy, radiotherapy, and stem cell transplantation. (hindawi.com)

It is also crucial to assess the risk of serious complications in patients with febrile neutropenia, since this assessment will dictate the approach to therapy, including the need for inpatient admission, IV antibiotics, and prolonged hospitalization 2. (ukessays.com)
Numerous changes in antibiotics may be necessary until infections and neutropenia resolve. (medscape.com)

This document compiles updated information available on the definition, risk factors, evaluation methods, treatment and special situations in cancer patients with febrile neutropenia. (ijpsonline.com)
Furthermore, lenograstim may increase the patient's exposure to chemotherapy allowing patients to receive optimal dosing and duration of treatment, benefitting survival. (hindawi.com)
Furthermore, they can lead to delays and dose reductions in chemotherapy treatment, thereby potentially compromising the efficacy of chemotherapy and, consequently, patient outcome [ 10 ]. (hindawi.com)
There is strong and consistent clinical evidence to show that granulocyte-colony stimulating factors (G-CSFs) reduce the risk of chemotherapy-induced neutropenia and therefore complicated neutropenia and can be used to maintain chemotherapy at the desired dose intensity or density and minimize delays in treatment [ 11 ]. (hindawi.com)
See "Major side effects of low-dose methotrexate" and "Hepatotoxicity associated with chronic low-dose methotrexate for nonmalignant disease" and "Methotrexate-induced lung injury" and "Initial treatment of rheumatoid arthritis in adults" and "Treatment of rheumatoid arthritis in adults resistant to initial conventional synthetic (nonbiologic) DMARD therapy" . (medilib.ir)
A retrospective review sought to better understand the relationship between bortezomib and lenalidomide therapy and treatment-induced skin rash in multiple myeloma. (cancertherapyadvisor.com)
Transfer to a pediatric cancer center is usually necessary for initial diagnostic studies and is mandatory for management of chemotherapy and treatment-related complications. (medscape.com)
Repeated infections results in prolonged periods of hospitalisation, delay in treatment and chemotherapy dose reductions. (biomedgrid.com)
Trodelvy is also approved in the U.S. under the accelerated approval pathway for the treatment of adult patients with locally advanced or metastatic urothelial cancer (UC) who have previously received a platinum-containing chemotherapy and either programmed death receptor-1 (PD-1) or programmed death-ligand 1 (PD-L1) inhibitor. (montanadigitalnews.com)
Initiate anti-infective treatment in patients with febrile neutropenia without delay. (trodelvyhcp.com)
It is important to know about the diagnosis, differentiation and treatment of neutropenia and the prevention of febrile neutropenia. (termedia.pl)
Risk of inflammation and cognitive impairment due to chemotherapy,often called "chemobrain", may be reduced by maintaining physical activity during treatment, according to a University of Rochester (UR) Medical Center study presented at the 2015 ASCO Annual Meeting. (oncnursingnews.com)
If a patient continues to experience febrile neutropenia after dose reduction, reduce the treatment duration by 7 days. (guidelinecentral.com)

People with neutropenia are more susceptible to bacterial infections and, without prompt medical attention, the condition may become life-threatening (neutropenic sepsis). (wikipedia.org)

Kourlaba G, Gourzoulidis G, Aravantinos G, Athanasiadis I, Lyman GH, Villa G, Papagiannopoulou V, Tritaki G, Maniadakis N. Cost-Effectiveness Analysis Of Granulocyte Colony-Stimulating Factors For The Prophylaxis Of Chemotherapy-Induced Febrile Neutropenia In Patients With Breast Cancer In Greece. (mitera.gr)
Colony-stimulating factors for febrile neutropenia during cancer therapy. (trillium.de)
Prophylaxis of infectious complications with colony-stimulating factors in adult cancer patients undergoing chemotherapy - evidence-based guidelines from the Infectious Diseases Working Party AGIHO of the German Society for Haematology and Medical Oncology (DGHO). (trillium.de)
Granulocyte colony-stimulating factors for febrile neutropenia prophylaxis following chemotherapy: Systematic review and meta-analysis. (trillium.de)
Efficacy, effectiveness and safety of long-acting granulocyte colony-stimulating factors for prophylaxis of chemotherapy-induced neutropenia in patients with cancer: A systematic review. (trillium.de)

Neutropenia has a wide range of causes, both hereditary and acquired (see Etiology ). (medscape.com)
Furthermore, emerging research suggests neutropenia without an identifiable etiology (idiopathic neutropenia) may be the result of a low-grade, chronic inflammatory process with an abnormal excessive production of myelosuppressive cytokines in a study conducted in the island of Crete. (wikipedia.org)

An absolute neutrophil count between 1000 and 1500/microL corresponds to mild neutropenia. (ukessays.com)
Neutropenia is a reduction in the blood neutrophil count. (msdmanuals.com)
To establish the diagnosis of FS, it is necessary to meet the classification criteria for RA and have the presence of neutropenia, indicated by a neutrophil count in the peripheral blood below 1.5 × 10 3 /μl [ 1 ]. (termedia.pl)

She underwent a myeloablative HSCT using a matched unrelated donor, conditioning with BuCy (busulfan and cyclophosphamide), and GvHD (graft vs. host disease) prophylaxis with ATG (thymoglobulin), tacrolimus and methotrexate. (bvsalud.org)
Give lymphodepleting chemotherapy (cyclophosphamide 300mg/m 2 /day IV + fludarabine 30mg/m 2 /day IV) for 3 days. (empr.com)

Predicting individual risk of neutropenic complications in patients receiving cancer chemotherapy. (trillium.de)

Febrile neutropenia is a common and serious complication of cancer chemotherapy. (ijpsonline.com)
Despite recent therapeutic advances, febrile neutropenia is still a major cause of morbidity and mortality among cancer patients in Latin America and worldwide. (ijpsonline.com)
Mortality, morbidity, and cost associated with febrile neutropenia in adult cancer patients. (trillium.de)
Filling in the gaps: Reporting of concurrent supportive care therapies in breast cancer chemotherapy trials. (trillium.de)
Impact of pegfilgrastim on early all-cause mortality in patients receiving cancer chemotherapy. (trillium.de)
For many years, most children in the United States were treated with chemotherapy protocols developed by the Children's Cancer Group and the Pediatric Oncology Group. (medscape.com)
One of the major side effects of cancer chemotherapy is myelosuppression leading to an obligate period of neutropenia. (biomedgrid.com)
Neutropenia is a serious adverse effect frequently associated with cancer chemotherapy (1,7). (biomedgrid.com)
The randomized, multicenter, phase III study accrued 619 patients with early-stage cancer who were beginning chemotherapy. (oncnursingnews.com)
The benefits shown in this study are very promising for early-stage cancer patients undergoing chemotherapy, said Mustian. (oncnursingnews.com)

Conclusions: Pharmacokinetically-guided dose adjustment of standard chemotherapy treatments might improve survival outcomes in patients with pancreatic ductal adenocarcinoma. (unav.edu)

3 Patients receiving intensive chemotherapy for AML or ALL and those undergoing HSCT have an increased risk for serious bacterial infections. (jhoponline.com)

Because of the patient's need for intense chemotherapy and supportive care, guaranteed venous access is critical. (medscape.com)

When neutropenia is present, the inflammatory response to such infections is blunted. (msdmanuals.com)

Study Investigating How Physicians Assess the Risk of Patients Developing Febrile Neutropenia During Chemotherapy. (brainandnervecenter.com)

thus, any impairment of glomerular filtration rate (GFR) will result in sustained serum levels of the drug that may induce bone marrow or other toxicities. (medilib.ir)

9 Therefore, with the conventional approach, the chemotherapy intensity has been raised to the limit of tolerance, and further improvements in outcomes and reduction of adverse effects will require novel therapeutic approaches. (haematologica.org)

These protocols, which used different multiagent chemotherapies, were associated with improved results as therapy was intensified. (medscape.com)

1. Wang W, Balu S, Campbell K. Cost-minimization analysis for biosimilar pegfilgrastim in the prophylaxis of chemotherapy induced (Febrile) neutropenia and expanded access based on budget neutral basis. (centerforbiosimilars.com)
The post-chemotherapy model indicated lipegfilgrastim led to higher gains in both life years (18.72 versus 18.61) and quality-adjusted life years (17.28 versus 17.18) in comparison to pegfilgrastim. (edu.au)

Antiemetic prophylaxis may be omitted after 2 cycles if there has been no nausea and vomiting. (guidelinecentral.com)

Additionally, the positive data from the ECHELON-2 trial demonstrated that in patients with previously untreated CD30-positive peripheral T-cell lymphoma, ADCETRIS in combination with chemotherapy was superior to the control arm for progression-free survival and overall survival, representing an important milestone for ADCETRIS as a potential therapy in this setting where standard of care has not changed in several decades. (covaipost.com)

Grade 3-4 neutropenia occurred in 49% of patients. (trodelvyhcp.com)
Grade 3-4 neutropenia occurred in 15.1% of patients and one (1.9%) of them presented febrile neutropenia. (biomedcentral.com)

To induce a diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus. (nih.gov)

METHODS: Two Markov models including a chemotherapy and a post-chemotherapy models were constructed with a time horizon of 12 weeks and 30 years, respectively. (edu.au)

Although, historically, chemotherapy was used for palliation of symptoms, during the last few years the median overall survival of patients with advanced CRC has been substantially increased from 12 months to about 21-22 months when all of the available chemotherapeutic agents are administered [ 3 ]. (biomedcentral.com)

If febrile neutropenia reoccurs after dose and schedule reduction, discontinue ONUREG. (guidelinecentral.com)

Myelotoxicity and dose intensity of chemotherapy: Reporting practices from randomized clinical trials. (trillium.de)

A triad of symptoms characterises Felty's syndrome: seropositive rheumatoid arthritis (RA), splenomegaly and neutropenia. (termedia.pl)
It is characterised by a triad of symptoms: seropositive rheumatoid arthritis (RA), splenomegaly and neutropenia. (termedia.pl)

These improvements in outcome are very welcome, yet they do have associated substantial toxicities, especially a moderate-to-high risk of neutropenia or febrile neutropenia (FN) [ 8 ]. (hindawi.com)

Anatomy3

Diseases80

Chemicals and Drugs83

Analytical, Diagnostic and Therapeutic Techniques and Equipment70

Phenomena and Processes10

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Humanities1

Information Science3

Named Groups1

Health Care39

Geographicals2

Granulocyte-colony7

Management of febrile neutropenia2

Primary Prophylaxis4

Causes of neutropenia1

Regimens9

Common complication of chemotherapy2

Profound neutropenia1

Fever11

Myelosuppressive chemotherapy2

Severe9

Incidence7

Infection5

Cytotoxic2

Acute6

Chronic neutropenia2

Hematopoietic3

Filgrastim3

Prophylactic1

Cause neutropenia2

Cyclic neutropenia2

Autoimmune neutropenia1

Systemic1

Neutrophils6

Thrombocytopenia2

Severity3

Regimen2

Adjuvant chemotherapy1

Radiotherapy2

Antibiotics2

Treatment13

Neutropenic sepsis1

Colony-stimula5

Etiology2

Neutrophil count3

Cyclophosphamide2

Complications1

Cancer10

Standard Chemotherapy1

Intensive chemotherapy1

Supportive care1

Infections1

Assess the Risk1

Bone1

Outcomes1

Multiagent1

Pegfilgrastim2

Cycles1

Peripheral1

Grade2

Idiopathic1

Methods1

Chemotherapeutic1

Reduction1

Clinical Trials1

Rheumatoid2

Toxicities1