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  • mRNA
  • RNA localization is mediated by specific cis-regulatory elements usually found in mRNA 3'UTRs. (mdc-berlin.de)
  • Therefore, processes that generate alternative 3'UTRs-alternative splicing and polyadenylation-have the potential to diversify mRNA localization patterns in neurons. (mdc-berlin.de)
  • Using reporter assays and 3'UTR swapping experiments, we have identified the role of alternative 3'UTRs and mRNA transport in differential localization of alternative CDC42 protein isoforms. (mdc-berlin.de)
  • Sxl controls sex determination and sexual behavior by inducing the use of a female-specific 3′ splice site in the first intron of transformer ( tra ) pre-mRNA. (genetics.org)
  • Mitochondrial mRNA editing in Trypanosoma brucei requires the specific interaction of a guide RNA with its cognate mRNA. (jove.com)
  • By characterizing a number of different gRNA/mRNA interactions, we may be able to define a "bank" of RNA editing substrates with different putative chaperone and other co-factor requirements. (jove.com)
  • Previous studies suggested that Zfrp8 functions in the formation of mRNP (mRNA ribonucleoprotein) complexes and also controls RNA of select Transposable Elements (TEs). (sdbonline.org)
  • These results suggest that Zfrp8/PDCD2 functions at late stages of ribosome assembly and may regulate the binding of specific mRNA-RNPs to the small ribosomal subunit ultimately controlling their cytoplasmic localization and translation. (sdbonline.org)
  • The id of specific paracrine indicators that get the cell-fate decision of the multipotent progenitors, as well as the advancement of novel methods to deliver these indicators cell-fate Rabbit Polyclonal to Ezrin change for individual ESC-derived Isl1-ECs, we founded a book strategy using revised mRNA like a system for transient chemically, however efficient manifestation of paracrine elements in cardiovascular progenitors extremely. (welbourneprimary.com)
  • RNAi
  • The first category includes RNA interference (RNAi) and antisense oligonucleotides that aim at the destruction of transcribed lncRNA. (biomedcentral.com)
  • 1996
  • Even though autoantibody production may be an epiphenomenon of autoimmune diseases, autoantibody targets in scleroderma are very specific ( White, 1996 ). (rupress.org)
  • knockout
  • Transgenic mice carrying site-specific genome modifications (knockout, knock-in) are of vital importance for dissecting complex biological systems as well as for modeling human diseases and testing therapeutic strategies. (jove.com)
  • chromosomes
  • After pre-meiotic DNA replication, germ cells enter an extended G2 cell cycle phase, termed meiotic prophase, during which homologous chromosomes pair and interact, and an extensive, cell type-specific transcription program turns on to set up gamete differentiation. (biologists.org)
  • antigens
  • By investigating the multiple ways AIRE function can be compromised, recent research has uncovered the steadfast mechanisms explaining how AIRE is expressed in mTECs, how AIRE transactivates tissue-specific antigens (TSAs), and how those TSAs are presented to T cells by both medullary thymic epithelial cells (mTECs) and bone marrow-derived antigen-presenting cells. (jyi.org)
  • mechanism
  • Substantial progress has been made in determining the mechanism of mitochondrial RNA editing in trypanosomes. (jove.com)
  • CRISPR
  • Recent advances in the use of designer nucleases such as zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) 9 system for site-specific genome engineering open the possibility to perform rapid targeted genome modification in virtually any laboratory species without the need to rely on embryonic stem (ES) cell technology. (jove.com)
  • important
  • The evident diversification of CIDs may be neutral or may be important for plant adaptation to the environment and for acquisition of specific traits during evolution. (biomedcentral.com)
  • functional
  • With the increasing discovery of long noncoding RNAs (lncRNAs), the application of functional techniques that could have very specific, efficient, and robust effects and readouts is necessary. (biomedcentral.com)
  • found
  • A sampling of the introductory information found in Ambion's newly available RNA Interference Research Guide. (thermofisher.com)
  • location
  • This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. (genecards.org)
  • several
  • Various synthetic nucleoside analogs related to guanosine protect mice in several models of RNA viral infection by induction of type I IFN via TLR7 stimulation ( 8 , 9 ). (pnas.org)
  • activity
  • Pharmacologic inhibitors of the enzyme inosine monophosphate dehydrogenase (IMPDH), including ribavirin and mizoribine, have been reported to have activity against RNA viruses ( 18 - 20 ). (pnas.org)
  • Loss of the Sigma Activity of RNA Polymerase of Bacillus Subtilis During Sporulation Proceedings of the National Academy of Sciences of the United States of America. (jove.com)
  • approach
  • We developed a triple staining approach, combining DNA-FISH with RNA-FISH and immunofluorescence, using peroxidase based signal amplification to accommodate each staining requirement. (jove.com)