Chronic pain enhances this cortico-cortical connection, as manifested by an increased number of ACC neurons that respond to S1 inputs and the magnified contribution of these neurons to the nociceptive response in the ACC. (iasp-pain.org)
A 'wave' of ATP was seen spreading through the brain after neurons were stimulated with a small electric pulse, mimicking a sudden migraine or stroke. (elifesciences.org)
Activity-dependent regulation of excitability in rat visual cortical neurons. (auth.gr)
Effects of dopaminergic modulation of persistent sodium currents on the excitability of prefrontal cortical neurons: A computational study. (auth.gr)
The release of tau from cortical neurons is therefore a physiological process that can be regulated by neuronal activity. (neurosciencenews.com)
In these experiments, Amy Pooler, the lead author, revealed that molecules such as potassium chloride, glutamate or an AMPA receptor agonist could release tau from cortical neurons in an active physiological process that is, at least partially, dependent on pre-synaptic vesicle secretion. (neurosciencenews.com)
Our cortex model is constrained by relevant experimental data about cortical neurons, synapses, modularity, and connectivity. (eneuro.org)
Seizure Propagation1
Stafstrom, CE 2020, ' Stopped At the Border: Cortical Spreading Depolarization Blocks Seizure Propagation ', Epilepsy Currents , vol. 20, no. 3, pp. 171-172. (johnshopkins.edu)
Depolarization6
Segregation of Seizures and Spreading Depolarization Across Cortical Layers Zakharov A, Chernova K, Burkhanova G, Holmes GL, Khazipov R. Epilepsia. (johnshopkins.edu)
Results: Spreading depolarization occurred in half of the flurothyl-evoked seizures. (johnshopkins.edu)
Spreading depolarization always started from the superficial layers and spread downward either through all cortical layers or stopping at the L4/L5 border. (johnshopkins.edu)
Spreading depolarization may represent a novel mechanism for delayed fluctuating neurological deficit after chronic subdural hematoma evacuation. (unm.edu)
Spreading depolarization in acute brain injury inhibited by ketamine: a prospective, randomized, multiple crossover trial. (unm.edu)
Epileptic3
However, the cross-layer dynamics of SD during seizures and the effect of SD on epileptic activity across cortical layers remain largely unknown. (johnshopkins.edu)
Further propagation of SD to deep layers resulted in a wave of transient suppression of epileptic activity through the entire cortical column. (johnshopkins.edu)
Barth DS, Di S, Baumgartner C (1989) Laminar cortical interactions during epileptic spikes studied with principal component analysis and physiological modeling. (springer.com)
Prefrontal1
Here, we investigate these using a novel multiarea spiking neural network model of prefrontal cortex (PFC) and two parietotemporal cortical areas based on macaque data. (eneuro.org)
Acute2
For episodic migraine with aura we outline model-based design strategies toward preventive and acute therapies using stereotactic cortical neuromodulation. (reading.ac.uk)
The continuum of spreading depolarizations in acute cortical lesion development: Examining Leão's legacy. (unm.edu)
Stroke2
This phenomenon has been recognized as playing an important role in migraine, stroke and other cortical pathology, and her contributions established the role of the extracellular movement of potassium ions in propagation of spreading depression. (sfn.org)
Mechanisms of brain injury and stroke, including cortical spreading depolarizations and cerebral blood flow physiology, and refining treatments and techniques to make treatment of brain pathology more safe and effective. (unm.edu)
Cerebral3
This depression is a reaction in the cerebral cortex that can be induced by touch or electric shock, although, more significantly, it occurs spontaneously in migraine and to some extent in epilepsy. (wikipedia.org)
This suggestion was tested on the rat's brain, and the FUS possibility of inducing a negative shift of direct current potential (reflecting ionic changes in brain tissues) and to initiate SD in cortical and sub-cortical structures (cerebral cortex, caudate nucleus, thalamus, and hippocampus) were confirmed [ 10 - 12 ]. (biomedcentral.com)
Pathology1
Secreted tau could therefore be involved in the propagation of tau pathology in tauopathies, a group of neurodegenerative diseases associated with the accumulation of tau proteins in the brain," commented Diane Hanger, Reader in the Department of Neuroscience at King's College London. (neurosciencenews.com)
Mechanisms1
Cortical mechanisms of sensory and affective integration, however, remain poorly defined. (iasp-pain.org)
Spikes1
During partial SD, epileptiform activity persisted in deep layers throughout the entire seizure, with positive signals at the cortical surface reflecting passive sources of population spikes generated in deeper cortical layers. (johnshopkins.edu)
Extracellular1
Modeling extracellular space electrodiffusion during Leao's spreading depression. (reading.ac.uk)
Migraine2
To this end, we regard a localized spreading depression (SD) wave segment as a central element in migraine pathophysiology. (reading.ac.uk)
Familial Hemiplegic Migraine (FHM) is an autosomal dominantly inherited form of migraine with aura (MA, as opposed to migraine without aura, MO), in which the accompanying aura symptom of the typical half-sided headache is transient motor weakness (hemiparesis) that is frequently accompanied by other cortical symptoms. (frontiersin.org)
Functional1
Alonso BD, Lowe AS, Dear JP, Lee KC, Williams SC, Finnerty GT (2008) Sensory inputs from whisking movements modify cortical whisker maps visualized with functional magnetic resonance imaging. (springer.com)
Occurs2
Cortical spreading depression occurs during elective neurosurgical procedures. (unm.edu)
If the [Ca 2+ ] rises above a critical threshold for depression (θ D ) , LTD occurs and the synaptic strength is decreased. (eneuro.org)
Define2
Our results thus define a cortical circuit that plays a potentially important role in integrating sensory and affective pain signals. (iasp-pain.org)
To describe nucleation and propagation features of the SD wave segment, we define the new concepts of cortical hot spots and labyrinths, respectively. (reading.ac.uk)
Structures1
We conclude with discussing further anatomical factors, such as areal, laminar, and cellular heterogeneity, that in addition to and in relation to Gaussian curvature determine the generalized concept of cortical hot spots and labyrinths as target structures for neuromodulation. (reading.ac.uk)
Interactions1
Here we present a large-scale biologically detailed spiking neural network model accounting for three connected cortical areas to study dynamic STM-LTM interactions that reflect the underlying theoretical concept of memory indexing, adapted to support distributed cortical WM. (eneuro.org)
Her thesis work was on the mechanism of cortical spreading depression, which appears as a wave of decreased electrical activity advancing slowly over the grey matter. (sfn.org)
Clinical2
These simulations should predict the clinical data and therefore can also serve as a test bed for exploring stereotactic cortical neuromodulation. (reading.ac.uk)
Direct current electrocorticography for clinical neuromonitoring of spreading depolarizations. (unm.edu)
High-frequency1
Local cortical injections of glutamate and noradrenaline alter high-frequency (245 Hz) neuronal activity in rat cortex. (auth.gr)
Autism1
We further assess evidence linking dysbiosis of the gut microbiota to neurobehavioral diseases, such as autism spectrum disorder and major depression, drawing upon findings from animal models and human trials. (deepdyve.com)
Networks1
D'Esposito and Postle, 2015 ), there is accumulated evidence for the involvement of other cortical regions, particularly parietotemporal networks associated with long-term memory (LTM) correlates. (eneuro.org)
Surface1
In particular, we firstly focus exclusively on curvature-induced dynamical properties by studying a generic reaction-diffusion model of SD on the folded cortical surface. (reading.ac.uk)
Brain2
Which Spreading Depolarizations Are Deleterious To Brain Tissue? (unm.edu)
In addition to intracellular aggregation, recent experiments have shown that tau is released from neuronal cells and taken up by neighboring cells, which allows the spread of aggregated tau across the brain. (neurosciencenews.com)
Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group. (unm.edu)
Local1
Einevoll GT, Kayser C, Logothetis NK, Panzeri S (2013) Modelling and analysis of local field potentials for studying the function of cortical circuits. (yale.edu)
Relevant1
At this stage, the only relevant factor that can modulate nucleation and propagation paths is the Gaussian curvature, which has the advantage of being rather readily accessible by MRI. (reading.ac.uk)
Results2
Significance: Our results point to the importance of vertical SD spread in the SD-related depression of epileptiform activity across cortical layers. (johnshopkins.edu)
The final results suggesExtracellular electrophysiology and two-photon calcium supplements image tend to be trusted options for calibrating physical exercise together with single-cell solution across large populations involving cortical nerves. (epoxomicininhibitor.com)
Lead1
Apart from endangering the health of individuals, drug addiction can also lead to crime and violence, and speed up the spread of infectious diseases, seriously affecting social stability and safety [ 3 ]. (degruyter.com)