• Infiltration versus metastasis is one of the most characteristic biological properties of tumors [ 5 ]. (hindawi.com)
  • Generally, it is believed that there are four main pathways between tumor invasion and metastasis, including local invasion, blood, lymphatic, and seeding metastasis [ 6 ]. (hindawi.com)
  • In addition to these four pathways, tumors can undergo infiltration around nerve fibers and metastasis along nerves, that is, perineural invasion (PNI), which refers to the phenomenon of perineural invasion by tumor cells filling the perineurial space, wrapping around nerves in a continuous concentric sheath-like pattern, infiltration, and metastasis of extension along nerves around nerve fibers or into perineurium within the perineurium [ 7 ]. (hindawi.com)
  • AXL significantly promotes tumour cell migration, invasion and metastasis, as well as angiogenesis. (cancerindex.org)
  • To evaluate the mechanisms underlying the role of AXL signalling in tumour metastasis, we screened a phage display library to generate a novel human monoclonal antibody, named DAXL-88, that recognizes both human and murine AXL. (cancerindex.org)
  • Interleukin 17 (IL-17)-producing γδ T cells (γδ17 T cells) have been recently found to promote tumor growth and metastasis formation. (crick.ac.uk)
  • Cancer stem-like cells (CSCs) are associated with cancer progression, metastasis, and recurrence, and may also represent a subset of circulating tumor cells (CTCs). (biorxiv.org)
  • Combined, these data indicate that CD117 expression potentially promotes tumor initiation and metastasis. (biorxiv.org)
  • This model however, attributes tumorigenesis, metastasis and chemoresistance to a distinct cell population with a stem-like phenotype that can be identified using selective markers. (tmc.edu)
  • Importantly, increasing numbers of novel reports suggest that the GFRα-mediated signaling pathway acts as an oncogenic promoter related to tumor proliferation, invasion, and metastasis as well as treatment resistance. (medsci.org)
  • Upregulated miR-143 in CSCs differentiation promotes prostate cancers cells SCH58261 metastasis by modulating FNDC3B appearance. (exposed-skin-care.net)
  • Leveraging the inverse relationship between cell pluripotency and miR-145 expression, we successfully separated highly tumorigenic, metastasis-prone (miR-145low) cells from poorly tumorigenic, nonmetastatic (miR-145high) counterparts. (visualsonics.com)
  • Gene expression and functional studies of the two cell populations identified the EPHB2 receptor as a prognostic biomarker in patients with EwS and a major promoter of metastasis. (visualsonics.com)
  • DCs and macrophages are thought to play important role in cancer by modulating host-immune responses against the tumor cells, promoting metastasis, angiogenesis, etc. (upenn.edu)
  • Noninvasive prediction of axillary lymph node breast cancer metastasis using morphometric analysis of nodal tumor microvessels in a contrast-free ultrasound approach. (medscape.com)
  • It is within the cell-autonomous context that ST6GAL1 involvement in cancer progression has been interpreted. (nature.com)
  • Cancer cell-extrinsic mechanisms, which are poorly understood, are also believed to contribute to disease progression and the heterogeneous genetic mutations with diverse presentations. (nature.com)
  • We demonstrated the induction of CSC-like cells, a potential driving force of tumor initiation and progression, from human lung epithelial cells by chronic exposure to SWCNT, as evaluated by tumor spheres side population. (cdc.gov)
  • We demonstrate that in human CRC, increased PTPN2 expression and activity correlated with disease progression and decreased immune responses in tumor tissues. (jci.org)
  • Some studies showed that blocking cell cycle progression ameliorated fibrosis. (nature.com)
  • These results demonstrate that ChoK plays an essential role in both normal human mammary epithelial cell proliferation and breast tumor progression. (aacrjournals.org)
  • Recent evidence also suggests involvement of innate immunity, including dendritic cells (DC), in the initiation and maintenance as well as progression of MS [ 11 ]. (hindawi.com)
  • The molecular biology underlying renal cell carcinoma (RCC) development and progression has been a key milestone in the management of this type of tumor. (cancerindex.org)
  • Modulation of mitochondrial function thus represents a primary target to rewire metabolism and counteract tumour progression and chemotherapy resistance. (europa.eu)
  • Understanding the importance of the tumor microenvironment in cancer progression has also directed our focus to the manipulation of the immune cells surrounding cancerous tumors. (a-star.edu.sg)
  • Further, in cell lines, CD117 activation by SCF promotes faster proliferation and invasiveness, while blocking CD117 activation with tyrosine kinase inhibitors (TKIs) decreased progression in a context-dependent manner. (biorxiv.org)
  • Currently, use of cannabinoids is limited to improve adverse effects of chemotherapy and their palliative administration during treatment is curiously concomitant with improved prognosis and regressed progression in patients with different tumor types. (frontiersin.org)
  • Recent studies demonstrated that piperine potentiates curcumin's inhibitory effect on tumor progression via enhancing its delivery and therapeutic activity. (frontiersin.org)
  • In the local tumour microenvironment, elevated glucose levels, the presence of tumour-associated stellate cells and macrophages are hypothesised to promote the tumour progression and invasion. (lu.se)
  • Further compounding this conundrum is the difficulty in accurately assessing response, as an increase in contrast enhancement on standard post-contrast MRI can be seen in treatment-related changes and true tumor progression. (abta.org)
  • The observation of this intercellular communication and that MM cells modify the microenvironment is highly suggestive that one of the first biologically relevant changes necessary for progression of MGUS or SMM to MM is for a member(s) of the clone to evolve and acquire the molecular changes needed to reprogram its immediate microenvironment into a supportive, growth-promoting microenvironment. (oncotarget.com)
  • Malignancy stem-like cells (CSCs) or tumor initiating stem cells are a sub-population of tumor cells and play pivotal tasks in malignancy initiation progression recurrence and chemoresistance [2]-[5]. (exposed-skin-care.net)
  • The availability of a sophisticated genetic tool box makes Drosophila an excellent genetic model well suited to studying the biology of Lunasin and its effect on tumor progression in an in vivo model organism. (weeksmd.com)
  • Propidium iodide staining and flow cytometry analysis of Annexin V binding was utilized to measure the progression of the cell cycle and the induction of apoptosis. (techscience.com)
  • In the current study, we investigated the effects of pinealectomy on oral squamous cell carcinoma (OSCC) occurrence and progression in rats. (unesp.br)
  • Sreekumar A . Uridine Diphosphate Glucuronosyl Transferase 2B28 (UGT2B28) Promotes Tumor Progression and Is Elevated in African American Prostate Cancer Patients. (viictr.org)
  • The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)
  • Mechanistically, an upregulation of PDL-1 in chemotherapy-treated CAFs led to an increase in hepatocyte growth factor (HGF) secretion, which stimulates cancer progression, cell invasion, and stemness of lung cancer cells, while inhibiting apoptosis. (cdc.gov)
  • How such γδ17 T-cell responses may be regulated in the tumor microenvironment remains, however, largely unknown. (crick.ac.uk)
  • Tumor-associated neutrophils inhibited the proliferation of murine CD27- Vγ6+ γδ17 T cells via induction of oxidative stress, thereby preventing them from constituting the major source of pro-tumoral IL-17 in the tumor microenvironment. (crick.ac.uk)
  • This work thus identifies an unanticipated, immunosuppressive yet antitumoral, neutrophil/ROS/γδ17 T-cell axis in the tumor microenvironment. (crick.ac.uk)
  • Cancer cells display an altered metabolism as a result of genetic mutations, changes in the tumour microenvironment, and interactions with other cell types. (europa.eu)
  • The present study investigated the influence by the microenvironment on pancreatic cancer cell invasion in vitro. (lu.se)
  • Our preliminary and published studies uncovered a remarkably better response to standard care in female glioblastoma patients than in male patients as well as sex-specific differences in signaling networks and interactions in the tumor microenvironment. (abta.org)
  • Over the last decade, significant investigation in the MM field has demonstrated that the interaction of malignant PCs with BM stromal cells within the microenvironment is essential for survival of the PC clone [ 5 , 6 ]. (oncotarget.com)
  • γδ T cells recruited into the tumor microenvironment can act as effector cells to mediate cancer immune surveillance. (explorationpub.com)
  • Therefore, an in-depth understanding of γδ T cells that play conflicting roles in the tumor microenvironment is necessary. (explorationpub.com)
  • Specifically, we study the mononuclear phagocyte system (MPS) with an emphasis on their role in the tumor microenvironment. (upenn.edu)
  • A major focus in our laboratory is to understand the role of MPS within the microenvironment of a group of solid tumors known as sarcomas. (upenn.edu)
  • Vimentin expression in human malignant glioma cells depends on cellular density, algorithms of drug delivery and chemo/radio treatment. (whispermovie.com)
  • Calebin-A induced death of malignant peripheral nerve sheath tumor cells by activation of histone acetyltransferase. (cancerindex.org)
  • This malignant vascular tumour can develop in cases of long-standing chronic lymphoedema. (medicaljournals.se)
  • Ovarian carcinoma ranks fifth in the leading causes of cancer-relevant deaths among the female, with the highest fatality rate in all gynecological malignant tumors and the rising incidence worldwide. (iospress.com)
  • Multiple myeloma (MM) is characterized by the clonal expansion of malignant plasma cells within the bone marrow. (oncotarget.com)
  • In summary, this study demonstrates the significance of MV shedding and MV-mediated intercellular communication on malignant plasma cell proliferation, and identifies the role of MV-enriched CD147 in this process. (oncotarget.com)
  • Numerous vectors have been engineered for the sole purpose of killing cancer cells, and some have successfully suppressed malignant tumours. (weeksmd.com)
  • It is involved in the proliferation, invasion, apoptosis and epithelial mesenchymal transformation of malignant tumor cells. (techscience.com)
  • Breast metastatic tumors in lung can be substituted by lung-derived malignant cells transformed by alternative splicing H19 lncRNA. (medscape.com)
  • Inactivation of tumor suppressor genes, whose products normally provide negative control of cell proliferation, contributes to malignant transformation in various cell types. (medscape.com)
  • Also, the term "primary cutaneous CD4 + small/medium T-cell lymphoma" was changed to "primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder" because of its indolent clinical behavior and uncertain malignant potential. (medscape.com)
  • Pexidartinib (PLX-3397) induces cell apoptosis and has anti-tumor activity. (medchemexpress.com)
  • Cabozantinib disrupts tumor vasculature and promotes tumor and endothelial cell apoptosis . (medchemexpress.com)
  • The power of the thiol proteinases to cleave a multitude of substrates in response to calcium mineral activation allows their involvement in a variety of cell processes offering cell motility, sign transduction, apoptosis, cell differentiation and legislation of the cytoskeleton (3). (exposed-skin-care.net)
  • The molecular systems in charge of the suppression be engaged from the anticancer activity of Akt, PI3K, MAPK, JNK, ROS, NF-KB, and additional pathways, advertising of inhibition and apoptosis of cell routine, and proliferation. (unscburma.org)
  • Potential synergistic effects of various combinations including these compounds were tested by measuring cancer cell proliferation and apoptosis. (frontiersin.org)
  • Mechanistically, mouse or human CD4+ CAR T-cell-derived IFN-γ diffused extensively to act on tumor cells at distance selectively killing tumors sensitive to cytokine-induced apoptosis, including antigen-negative variants. (pasteur.fr)
  • In accordance, CIGB-300 decreases the viability and proliferation of CLL cell lines, promotes apoptosis of primary leukemia cells and displays antitumor efficacy in a xenograft mouse model of human CLL. (oncotarget.com)
  • The present study certified that inhibition of SNHG8 executed suppressive activities in ovarian carcinoma by obstructing cell proliferation, migration, EMT process and stemness as well as driving cell apoptosis. (iospress.com)
  • Lately we have discovered miR-200b as an integral regulator of chemoresistance and repair of miR-200b considerably reverses chemoresistance of docetaxel (DTX)-resistant LAD cells by inducing cell routine arrest and apoptosis improvement [19]. (exposed-skin-care.net)
  • Oxaliplatin causes cell-cycle arrest promotes accelerated senescence and induces apoptosis in Bexarotene (LGD1069) cancer cells7 8 9 The p53 protein is involved in many biological processes the best known of which are cell-cycle arrest and DNA repair10 11 p53 also regulates apoptosis after exposure to hypoxia and cytotoxic drugs and is one of the most commonly mutated genes in many types of cancer12. (immune-source.com)
  • Abstract Fos-related antigen 1 (Fra-1) is a nuclear transcription factor that regulates cell growth, differentiation, and apoptosis. (techscience.com)
  • Fra-1 is highly expressed in gastric cancer (GC), affects the cycle distribution and apoptosis of GC cells, and participates in GC occurrence and development. (techscience.com)
  • The TP53 gene is also capable of stimulating apoptosis of cells containing damaged DNA. (medscape.com)
  • TP53 activates the expression of genes involved in apoptosis, cell cycle regulation (p21), and MDM2. (medscape.com)
  • Role of PDL-1 in NSCLC chemoresistance was assessed using CRISPR/Cas9 knockdown and various functional assays including MTT, cell invasion, sphere formation, and cell apoptosis. (cdc.gov)
  • Expression is particularly high in the pancreas where it is thought to play a role in the differentiation of pancreatic beta cells. (embl.de)
  • Signalling through c-Kit plays a role in cell survival, proliferation, and differentiation. (medchemexpress.com)
  • DC are professional antigen-presenting cells with the unique capacity to polarize the differentiation of T cells, thereby regulating the balance between inflammation and tolerance [ 12 ]. (hindawi.com)
  • In summary, co-culture with TPSCs induced molecular changes associated with EMT in pancreatic cancer cells, regardless of differentiation status, and the organotypic model demonstrated the influence of microenvironmental factors, such as glucose, stellate cells and macrophages, on pancreatic cancer cell invasion. (lu.se)
  • Glial cell line-derived neurotrophic factor family receptor alpha (GFRα) members have been widely connected to the mechanisms contributing to cell growth, differentiation, cell migration and tissue maturation. (medsci.org)
  • The glial cell line-derived neurotrophic factors (GDNFs), a family of neurotrophic factors, were initially thought to be able to regulate the growth, survival, and differentiation of neural-derived cell types. (medsci.org)
  • Based on whether it cooperates with the second receptor RET, GFRα has also been widely linked to the mechanisms that contribute to cell growth, differentiation and migration and tissue maturation. (medsci.org)
  • Here we show that cell differentiation suppresses tumor formation. (amegroups.org)
  • Cells were transfected with the early B-cell factor-2 (EBF2) to activate progenitor cell differentiation and gauged the tumorigenic potentials of the derived cell subsets. (amegroups.org)
  • Here we show that the brown adipose differentiation gene, EBF2, activates differentiation-associated signals in the cancer progenitor cells in culture and CSC transplantation models. (amegroups.org)
  • Expression of EBF2 in the PDX1 and E-cadherin-expressing and organoid forming pancreatic epithelial CSCs indeed induced ductal and acinar-like structural differentiation in vivo in tumors resulting in tumor suppression. (amegroups.org)
  • This study reveals a previously unrecognized function of EBF2 in regulating PDAC progenitor cell differentiation and tumor suppression. (amegroups.org)
  • Cyclin-dependent kinase 5 (CDK5) phosphorylated DRP1 to improve its activity in BTICs whereas Ca2+-calmodulin-dependent proteins kinase 2 (CAMK2) inhibited DRP1 in non-BTICs recommending tumor cell differentiation induces a regulatory change in mitochondrial morphology. (biopaqc.com)
  • Regular neural progenitor cells (NPCs) are functionally described by self-renewal and differentiation into relevant lineages7. (biopaqc.com)
  • BTICs talk about these features but are recognized by their regularity proliferation aberrant appearance of differentiation markers chromosomal abnormalities and tumor development. (biopaqc.com)
  • Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation to Promote Immune Suppression Cell. (upenn.edu)
  • Cylindromas are appendage tumors previously thought to be of apocrine differentiation. (medscape.com)
  • miR-203 drives breast cancer cell differentiation. (medscape.com)
  • The proliferative ability of MCF-7 cells treated with lovastatin was reduced compared to normal, and further decreased in the presence of excess BRCA1, detected by methyl thiazolyl tetrazolium and flow cytometry techniques in vitro or by 5-bromodeoxyuridine incorporation in vivo. (nih.gov)
  • Subsequently, we used a model of neuroinvasion in nude mice to assess the effect of NGF in vivo on tumor nerve invasion as well as on nociceptive transmission. (hindawi.com)
  • In vivo tumorigenesis experiments, Tanezumab markedly alleviated nerve invasion of PC cells as well as relieved nociceptive conduction in animal models. (hindawi.com)
  • The objective of this study was to develop an in vitro model for lung cancer risk assessment of CNT and to evaluate the in vivo tumorigenicity of chronic CNT-exposed human lung cells. (cdc.gov)
  • Overexpression of Cav-1 further promoted the CSC induction, cell motility, and in vivo tumorigenesis. (cdc.gov)
  • While much is known about the ErbB receptor binding characteristics of BTC and its effect on a variety of cultured cells under different conditions, the challenge that lies ahead is to determine the role of BTC in vivo. (embl.de)
  • In particular, stage II and III tumors displayed enhanced PTPN2 protein expression in tumor-infiltrating T cells, and increased PTPN2 levels negatively correlated with expression of PD-1, CTLA4, STAT1, and granzyme A. In vivo, T cell- and DC-specific PTPN2 deletion reduced tumor burden in several CRC models by promoting CD44+ effector/memory T cells, as well as CD8+ T cell infiltration and cytotoxicity in the tumor. (jci.org)
  • In direct relevance to CRC treatment, T cell-specific PTPN2 deletion potentiated anti-PD-1 efficacy and induced antitumor memory formation upon tumor rechallenge in vivo. (jci.org)
  • Consistently, superoxide deficiency, or the administration of a glutathione precursor, rescued CD27- Vγ6+ γδ17 T-cell proliferation in vivo. (crick.ac.uk)
  • MITIG capitalizes on the recent reported ability of gliomas to import exogenous mitochondria, either isolated or transferred from surrounding neural cells in the brain, to foster tumour development and malignancy in vivo. (europa.eu)
  • MITIG will target both paths for mitochondrial importation to remodel organelle content and address i) how incorporation of exogenous mitochondria impacts respiratory metabolism in GBM cells and iii) the relevance of this metabolic rewiring for tumour development in vivo. (europa.eu)
  • Red Blood Cell Metabolism In Vivo and In Vitro. (ucdenver.edu)
  • In vivo, both local and systemic administration of CIGB-300 elicited significant antitumor effects in murine syngeneic cancers and human tumors xenografted in nude mice [ 21 ]. (oncotarget.com)
  • These results strongly circumscribe the possible mechanisms of PINK1 action in the mitochondrial life cycle and also raise the possibility that mitochondrial turnover events that occur in cultured embryonic axons might be restricted to the cell body in vivo, in the intact nervous system. (sdbonline.org)
  • NK activation was evaluated, and its tumoricidal activity was assessed using in vitro and in vivo tumor models. (weeksmd.com)
  • In addition, NK cells stimulated with lunasin plus cytokines displayed higher tumoricidal activity than those stimulated with cytokines alone using in vitro and in vivo tumor models. (weeksmd.com)
  • Moreover, The use of animals as surrogate rine host, can provide a platform for animal models for tumour viruses in hosts for the study of human tu- in vivo infection. (who.int)
  • In vivo experiments were conducted using a co-implantation xenograft mouse model with live cell imaging and immunohistochemistry. (cdc.gov)
  • Distinct pathways of cell migration and antiapoptotic response to epithelial injury: structure-function analysis of human intestinal trefoil factor. (embl.de)
  • Primary colorectal carcinomas display aberrant expression of vimentin, and have activated Notch and TGFbeta signaling pathways. (whispermovie.com)
  • Recent studies have revealed that AXL contributes to leukaemic phenotypes through activation of oncogenic signalling pathways that lead to increased cell migration and proliferation. (cancerindex.org)
  • While all tumor cells display dysregulation of metabolic pathways the differential growth patterns of BTICs suggest that these tumor subpopulations have metabolic features that distinguish them from your tumor bulk17-20. (biopaqc.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Using a combination of advanced genetically engineered mouse models in conjunction with patient-derived samples, we aim to uncover the molecular pathways underlying tumor-MPS interaction with the overarching goal of targeting them for therapeutic purposes. (upenn.edu)
  • The melatonin suppression caused by the pinealectomy might contribute to oral cancer development by acting on ERK1/2 and p53 pathways and regulating tumor inflammation. (unesp.br)
  • Mucin 1 lies on the tubular cell apical surface and has a role in signal transduction pathways. (medscape.com)
  • Dasatinib and Trametinib Promote Anti-Tumor Metabolic Activity. (ucdenver.edu)
  • While BTICs stay controversial because of unresolved problems over cell-of-origin and purification BTICs possess generated substantial curiosity because of their resistance to typical therapies evasion of anti-tumor immune system responses advertising of tumor angiogenesis and invasion into regular tissue8-11. (biopaqc.com)
  • Immunostimulatory cytokines can enhance anti-tumor immunity and are part of the therapeutic armamentarium for cancer treatment. (weeksmd.com)
  • Over the years, Rolny and colleagues have demonstrated that reprogramming the pro-tumor phenotype of TAMs into an anti-tumor Page 2(3) phenotype represents a promising anti-cancer strategy. (lu.se)
  • We set out to investigate the functional role of PTPN2 in the pathogenesis of human colorectal carcinoma (CRC), as its role in immune-silent solid tumors is poorly understood. (jci.org)
  • MiR-200b a significant person in miR-200 families is situated at miR-200b/c/429 gene cluster serves as a tumor suppressor in a number of individual solid tumors and gets the capacity for inhibiting CSCs development and reversing the EMT phenotype of CSCs [17] [18]. (exposed-skin-care.net)
  • Now, we are developing a number of approaches to test the effects of antibody-directed depletion of tumor-promoting macrophages in cancer models. (a-star.edu.sg)
  • The combined presence of TPSCs and M2-like macrophages induced invasion of the non-invasive BxPC-3 cells. (lu.se)
  • MPS is part of the innate immune system and comprises of monocytes, macrophages, and dendritic cells (DC). (upenn.edu)
  • Tumor-associated macrophages (TAMs) are dynamic cells displaying a spectrum of states and phenotypes ranging from antitumor/immunostimulating (often termed M1-like) to protumor/immunosuppressive (also known as M2-like). (lu.se)
  • Pinealectomized rats showed higher mean number of tumor-associated macrophages and eosinophils in the invasive front of OSCC. (unesp.br)
  • that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)
  • At infection sites, activated T cells secrete cytokines (eg, interferon-gamma [IFN-gamma]) that induce production of macrophage migration inhibitory factor, preventing macrophages from leaving. (msdmanuals.com)
  • Macrophages are phagocytic cells present in tissues throughout the body. (msdmanuals.com)
  • Western blotting was employed to determine NGF level in PC and paracarcinoma tissues and in PC cell lines as well as pancreatic ductal epithelial cells. (hindawi.com)
  • NGF level was preeminently higher in PC tissues and cell lines than in paracarcinoma tissues and normal pancreatic epithelial cell lines. (hindawi.com)
  • Her research group is particularly interested in developing biomaterials and cell-based therapeutics to improve regeneration of various musculoskeletal tissues including bone, cartilage, tendon, blood vessels etc. (stanford.edu)
  • Emerging evidence has demonstrated that these factors are expressed in tissues outside of the nervous system and represent a widespread signal transduction system that is involved in the regulation of motility and adhesion in different cell types. (tam-receptor.com)
  • In this study we show that plexin-B1 is usually overexpressed in tissues and cell lines from neurotropic malignancies and is attracted to nerves that express its ligand semaphorin 4D in a Rho/Rho kinase-dependent manner. (tam-receptor.com)
  • Finally Suz-12 was inversely correlated with miR-200b positively correlated with HDAC1 and up-regulated in docetaxel-resistant LAD cells compared with docetaxel-sensitive tissues. (exposed-skin-care.net)
  • This enzyme is detected in all tissues, especially in embryonic tissues and immune cells ( https://www.proteinatlas.org/ ) ( Figures 1B,C ). The full-length human RNase T2 has 256 amino acids (AA) and a predicted size of 29 kD ( Table 1 ). (frontiersin.org)
  • The evolutionary conservation structure of RNase T2 and distribution of RNASET2 in human tissues and immune cells. (frontiersin.org)
  • Here, we reported that mammalian target of rapamycin complex 2 (mTORC2) kinase is overexpressed in pancreatic cancer tissues and promotes pancreatic cancer cell growth and invasion. (techscience.com)
  • Tissues and Cells. (lu.se)
  • genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)
  • Dendritic cells are present in the skin (as Langerhans cells), lymph nodes, and tissues throughout the body. (msdmanuals.com)
  • Another study of mice lacking STARD13, found it may promote blood vessel formation (angiogenesis), especially by tumor cells. (wikipedia.org)
  • Although, non-psychoactive cannabidiol (CBD) and cannabigerol (CBG) display antineoplastic effects by repressing tumor growth and angiogenesis both in cell line and animal models, their use as chemotherapeutic agents is awaiting further investigation. (frontiersin.org)
  • 2014). With regards to antitumor, most research possess reported that they exert powerful growth inhibition, solid cytotoxicity against different tumor cell lines, and powerful antiangiogenic activity on endothelial cells (Kim et al. (unscburma.org)
  • Herein we show that nerve cell lines migrate toward PC3 cells and exhibit extended nerve processes in a Sema4D/plexin-B1-dependent manner a response also blocked by Rho/ROK inhibition. (tam-receptor.com)
  • Recently, we and others have shown that leukemia cells from CLL patients display higher CK2 expression and activity than normal B cells, leading to inhibition of PTEN and activation of PI3K signaling pathway [ 9 , 10 ], which is required for CLL cell survival [ 11 - 13 ]. (oncotarget.com)
  • Oxaliplatin treatment upregulates p53 and activated p53 enhances growth inhibition in CRC cells treated with oxaliplatin. (immune-source.com)
  • This study is the first to report that inhibition of oxaliplatin-induced cell growth may be dependent on p53 and may involve increased expression of cytochrome enzymes (CYP2S1) in CRC cells. (immune-source.com)
  • Results Inhibition of CRC cell growth by oxaliplatin is usually associated with Bexarotene (LGD1069) the presence of wild-type p53 To investigate the cytotoxicity of the anticancer agent oxaliplatin in CRC cells CCK8 assays were performed using HCT116 SW480 and HT29 cells treated with various concentrations of oxaliplatin for 24?h. (immune-source.com)
  • Body 1 Inhibition of colorectal tumor cell development by oxaliplatin. (immune-source.com)
  • These cells may be a key factor ultimately mediating the deviation of the antagonistic response between tumor inhibition and tumor promotion. (explorationpub.com)
  • consequently, genes encoding some of these proteins are being used to design constructs for the inhibition of multiplying cancer cells. (weeksmd.com)
  • Vimentin and detyrosinated microtubules provide structural support for the extensive microtentacles observed in detached tumor cells and a mechanism to promote successful metastatic spread. (whispermovie.com)
  • Tumors with high Her4 expression have higher probability of developing metastatic disease. (tmc.edu)
  • Oxaliplatin displays a wide spectrum of antitumor activities and is widely used in the treatment of metastatic colorectal Bexarotene (LGD1069) cancer (CRC). (immune-source.com)
  • Previous research has demonstrated that TAMs located in close proximity to tumor vessels (perivascular TAMs) promote vessel abnormalization and facilitate metastatic dissemination. (lu.se)
  • This study evaluates the effect of A. montana leaves hexane extract on several signaling cascades and gene expression in metastatic breast cancer cells upon insulin-like growth factor-1 (IGF-1) stimulation. (techscience.com)
  • To perform this function, DC are capable of capturing antigens, processing them, and presenting them on the cell surface complexed to major histocompatibility (MHC) molecules, for example, human leukocyte antigen- (HLA-) DR. Along with that, context-dependent expression of costimulatory molecules, such as CD80 and CD86, and secretion of cytokines occurs. (hindawi.com)
  • We also use combinatorial phage display technology to discover antibodies against human disease antigens, including cytokines and tumor markers on cancer stem cells. (a-star.edu.sg)
  • With the goal of further improving cytokine-based immunotherapy, we examined the effects of a soybean peptide called lunasin that synergistically works with cytokines on natural killer (NK) cells. (weeksmd.com)
  • The combination of lunasin and cytokines (IL-12 plus IL-2) was capable of restoring IFNγ production by NK cells from post-transplant lymphoma patients. (weeksmd.com)
  • Human infl uenza infections with subtype H5N1 various proinfl ammatory cytokines, such as tumor necrosis viruses are often fatal. (cdc.gov)
  • In recent years, much has been learned of the characteristics of immune responses to skin sensitizing chemicals and of the roles played by dendritic cells, cytokines and chemokines. (cdc.gov)
  • In addition, antibodies function via unique mechanisms, such as antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC), which are unachievable with small molecule drugs. (a-star.edu.sg)
  • With the help of functional intravital imaging, we report that interferon (IFN)-γ production but not perforin-mediated cytotoxicity was the dominant mechanism for tumor elimination by anti-CD19 CD4+ CAR T cells. (pasteur.fr)
  • CYP2S1 knockdown conferred a cell survival advantage after oxaliplatin treatment to cells harboring wild-type p53 and cytotoxicity and antitumor activity. (immune-source.com)
  • Adding lunasin to IL-12- or IL-2-stimulated NK cells demonstrated synergistic effects in the induction of IFNG and GZMB involved in cytotoxicity. (weeksmd.com)
  • However, potentially erroneous characterization of cytotoxicity and cell proliferation can arise if verification of baseline interaction of test article with method employed is neglected. (cdc.gov)
  • Non-tumorigenic Beas-2B cells were treated with graded concentrations of benzo[a]pyrene (B[a]P) for 24 and 48h prior to cytotoxicity and proliferation assessment with commonly used MTT, MTS, WST1, and Alamar Blue assays. (cdc.gov)
  • In an effort to explain tumoral heterogeneity, the tumor initiating cell model (TIC) states that tumors are composed of cells that form the majority of the tumor and are terminally differentiated. (tmc.edu)
  • However, the metastable nature of tumor heterogeneity, which allows cells to transition between strong and weak tumorigenic phenotypes, and the lack of reliable markers of tumor-promoting properties hamper identification of the most relevant cells. (visualsonics.com)
  • γδ T cells express unique T cell receptor (TCR) γ and TCR δ chains, with structural and functional heterogeneity. (explorationpub.com)
  • At present, the phenotypic heterogeneity and functional variation of human γδ T cells are increasing. (explorationpub.com)
  • It selectively activates RhoA and CDC42 and suppresses cell growth by inhibiting actin stress fiber assembly. (wikipedia.org)
  • It is suggested that curcumin can selectively kill tumor cells through its multifaceted metabolic effects, that culminate in its anti-oxidant and anti-inflammatory activities ( Hewlings and Kalman, 2017 ). (frontiersin.org)
  • One such peptide, Lunasin , has been shown to selectively act on newly transformed cells while having no cytotoxic effect on non-tumorigenic or established cancer cell lines. (weeksmd.com)
  • Metronidazole selectively radiosensitizes hypoxic cells without influencing the radiation response of normal well-oxygenated cells [5,7-9]. (who.int)
  • Here, we show that CIGB-300 promotes activation of the tumor suppressor PTEN and abrogates PI3K-mediated downstream signaling in CLL cells. (oncotarget.com)
  • In addition, these alterations affect 3 principal categories of genes, as follows: proto-oncogenes, tumor suppressor genes, and DNA repair genes. (medscape.com)
  • This article briefly discusses tumor suppressor genes and then focuses on the role of proto-oncogenes in childhood cancer. (medscape.com)
  • [ 1 ] His prediction was subsequently supported by the cloning of the retinoblastoma tumor suppressor gene ( RB1 ) and by functional studies of the retinoblastoma protein, Rb. (medscape.com)
  • Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
  • Another important class of tumor suppressor genes involved in cell cycle control and in the generation of human cancers is the cyclin-dependent kinase (CDK) inhibitors. (medscape.com)
  • Our data suggest a role for PTPN2 in suppressing antitumor immunity and promoting tumor development in patients with CRC. (jci.org)
  • Overall, we proven that PG-mediated downregulation of PD-1 on the top of Compact disc8+ T cells represents a guaranteeing technique to locally enhance T-cell reactions and improve antitumor immunity. (unscburma.org)
  • Despite the fact that study on PG as well as the main components is becoming significantly in-depth, it continues to be unfamiliar whether PG enables to accomplish antitumor results through immune rules, aswell as the system(s) of how PG promotes antitumor immunity. (unscburma.org)
  • Our data indicate that extracellular ST6GAL1 from remote sources can compensate for cellular ST6GAL1-mediated aggressive tumor cell proliferation and invasive behavior and has great clinical potential for extracellular ST6GAL1 as these molecules are in the extracellular space should be easily accessible targets. (nature.com)
  • Targeting of the most aggressive tumor cell subpopulations is key for effective management of most solid malignancies. (visualsonics.com)
  • To reveal that the NGF-TrkA signaling pathway was closely associated with PC PNI, in vitro neuroinvasion model was established by using MiaPaCa-2 cells via coculturing DRG cells in Matrigel. (hindawi.com)
  • We found that shRNA knockdown of intrinsic ST6GAL1 expression resulted in decreased ST6GAL1 cargo in the exosome-like vesicles as well as decreased breast tumor cell growth and invasive behavior in 3D in vitro cultures. (nature.com)
  • Dr. Yang has extensive expertise in developing novel biomaterials and stem cell-based therapeutics for musculoskeletal tissue engineering, or engineering 3D in vitro cancer models for drug screening and mechanistic discovery. (stanford.edu)
  • This receptor is induced and required to survive stressors, like anchorage independence, serum starvation and chemotherapy treatment, which are similar in vitro conditions used to enrich for cells with tumor initiating potential. (tmc.edu)
  • CLL cells rely on overexpression and hyperactivation of the ubiquitous serine/threonine protein kinase CK2 for their viability in vitro. (oncotarget.com)
  • These in vitro, and their expression in these human tumour virus. (who.int)
  • The in vitro effects of metronidazole on the production of reactive oxygen species by polymorphonuclear (PMN) cells were studied by means of nitroblue tetrazolium and luminol-dependent chemiluminescence. (who.int)
  • Using xenograft limiting dilution assays and serial tumor initiation assays, we show that CD117+ cells represent a CSC population. (biorxiv.org)
  • This research will be the first of its kind, improving our understanding of brain tumor initiation but also in providing the basis for developing sensitive methods for detecting incipient tumors where no manifestation is evident. (abta.org)
  • Choline kinase (ChoK) is increased in human mammary tumors with high incidence, and this activation is associated with clinical variable indicators of greater malignancy. (aacrjournals.org)
  • Therefore mitochondria fission may be related to stem cell biology beneficial for malignancy and harmful in normal mind. (biopaqc.com)
  • Many malignancy therapies including chemotherapies that destroy the bulk of malignancy cells may ultimately fail as they do not get rid of CSCs that then cause a relapse of tumors [10]. (exposed-skin-care.net)
  • However, how to promote the sensitivity of statins to mammary cancer is yet to be completely deciphered. (nih.gov)
  • The purpose of this study was to investigate whether breast cancer susceptibility gene 1 (BRCA1) overexpression sensitizes mammary cancer cells to statins. (nih.gov)
  • MCF-7 cells, which have only one wild-type BRCA1 allele, were transfected with pcDNA3-beta-HA-hsBRCA1 plasmids via liposomes to reconstitute BRCA1 overexpression human breast cancer cell line, and tumoral xenografts with BRCA1 overexpression were subsequently established in BALB/c nude mice. (nih.gov)
  • Then, the inhibitory activity of lovastatin on cancer cells and tumoral xenografts, and the underlying mechanism involving in cell-cycle regulatory proteins were analyzed. (nih.gov)
  • Our results suggest that BRCA1 overexpression sensitizes cancer cells to lovastatin via regulation of cyclin D1-CDK4-p21WAF1/CIP1 pathway, which will provide an innovative experimental framework to study control of breast cancer cell proliferation. (nih.gov)
  • Extracellular ST6GAL1, present in cancer exosomes or the freely soluble recombinant sialyltransferase, compensates for insufficient intrinsic ST6GAL1 by boosting cancer cell proliferation and increasing invasiveness. (nature.com)
  • Aggressive breast cancer is a highly heterogeneous disease caused by a variety of distinct cell-intrinsic genetic alterations in mammary epithelial cells, leading to vastly heterogenic disease manifestation in individual patients and predominantly affecting patient prognosis and treatment options [ 14 ]. (nature.com)
  • This observation has led to the 'cancer stem cell' (CSCs) hypothesis, stating that a subpopulation of cancer cells survive therapy and lead to tumor relapse. (mdpi.com)
  • Due to its key role in the eukaryotic cell cycles, Plk1 has been one of the most validated drug targets for cancer treatment. (nature.com)
  • Breast cancer is still one of the most important tumors among women in industrialized countries. (aacrjournals.org)
  • Here, we have investigated the role of ChoK in the development of breast cancer and found that ChoK is both necessary and sufficient for growth factor-induced proliferation in primary human mammary epithelial cells and an absolute requirement for the specific mitogenic response to heregulin in breast tumor-derived cells. (aacrjournals.org)
  • PURPOSE: This review discusses the histology, MR technique, diagnosis, staging, and treatment of anal cancer, with a particular focus on the differences in TNM staging between anal squamous-cell carcinoma (ASCC) and rectal adenocarcinoma. (bvsalud.org)
  • Ablation of vimentin expression inhibits migration and invasion of colon and breast cancer cell lines. (whispermovie.com)
  • Clear cell renal cell carcinoma (ccRCC) is the seventh most frequently diagnosed tumor in adults in Europe and represents approximately 2.5% of cancer deaths. (cancerindex.org)
  • Moreover, human Vδ1+ γδ T cells, which contain most γδ17 T cells found in cancer patients, also displayed low glutathione levels and were potently inhibited by ROS. (crick.ac.uk)
  • Emerging evidence indicates that cancer cells incorporate mitochondrial genes or whole mitochondria to maintain their bioenergetic state. (europa.eu)
  • To determine how CD117 expression and activation by its ligand stem cell factor (SCF, kit ligand, steel factor) alter prostate cancer aggressiveness, we used LNCaP-C4-2 and PC3-mm human prostate cancer cells, which contain a CD117+ subpopulation. (biorxiv.org)
  • herb, reduced the expression of PD-1 on the surface of CD8+ T cells to exert antitumor effects in non-small cell lung cancer (NSCLC). (unscburma.org)
  • After co-culture with tumour-associated pancreatic stellate cells (TPSCs), pancreatic cancer cells displayed up to 8-fold reduction in levels of epithelial-mesenchymal transition (EMT) markers E-cadherin and ZO-1, while β-catenin and vimentin levels were increased. (lu.se)
  • A 3D organotypic model showed that TPSCs stimulated pancreatic cancer cell. (lu.se)
  • A 3D organotypic model showed that TPSCs stimulated pancreatic cancer cell invasion, both as single cell (PANC-1) and cohort (MIAPaCa-2) invasion. (lu.se)
  • High glucose conditions further enhanced changes in EMT markers as well as the cancer cell invasion. (lu.se)
  • PNI promotes cancer cell survival and severely limits the ability NOS2A to establish local control of disease. (tam-receptor.com)
  • The prostate cancer cell lines PC3 and Du-145 migrate toward nerve cell lines expressing Sema4D a response abrogated when plexin-B1 or Sema4D is usually knocked down through RNA interference (RNAi) or when signaling of RhoA and its downstream effector Rho kinase (ROK) is usually inhibited. (tam-receptor.com)
  • Cancer stem cells (CSCs) and poorly differentiated progenitor cells in pancreatic ductal adenocarcinoma (PDAC) exacerbate hierarchical tissue organization contributing to cell hyperproliferation and therapy resistance. (amegroups.org)
  • Mechanistically, EBF2 uniformly activates Pparγ-expression in pancreatic cancer cells and limits cell proliferation, whereas oncogenic drivers are expressed differentially in the progenitor cell subsets. (amegroups.org)
  • Studies have also identified other contender genes and genomic disruptions in human pancreatic exocrine tumors classified patients into different subclasses based on tumor histotypes and cancer-specific chromosomal rearrangements ( 7 - 9 ). (amegroups.org)
  • Our preliminary data suggest that young healthy people already harbor cells in their brain showing mutations that we know drive brain cancer. (abta.org)
  • The current presence of cancer stem-like cells (CSCs) is one of the mechanisms responsible for chemoresistance that has been a major hindrance towards lung adenocarcinoma (LAD) treatment. (exposed-skin-care.net)
  • MiR-21 regulates EMT phenotype and hypoxia-inducible aspect-1α appearance in third-sphere developing breast SCH58261 cancer SCH58261 tumor stem cell-like cells. (exposed-skin-care.net)
  • catenin signaling and cytochromeP450 enzymes (CYP51A1) were correlated to oxaliplatin sensitivity in 21 colorectal cancer cell lines24. (immune-source.com)
  • Additionally, the ability of these cells to regulate lymphocyte function makes them an important determinant in the success of cancer immunotherapy. (upenn.edu)
  • Eukaryotic expression vectors containing genes encoding plant proteins for killing of cancer cells. (weeksmd.com)
  • Gene therapy has attracted attention for its potential to specifically and efficiently target cancer cells with minimal toxicity to normal cells. (weeksmd.com)
  • We have now identified a unique pathway that regulates the pro-tumor functions of TAMs, offering potential for the development of novel anti-cancer targets. (lu.se)
  • Fruits and seed extracts of Annona montana have significant cytotoxic potential in several cancer cells. (techscience.com)
  • MTT assay was performed to determine the proliferation of cancer cells. (techscience.com)
  • SCR-6852, an oral and highly brain-penetrating estrogen receptor degrader (SERD), effectively shrinks tumors both in intracranial and subcutaneous ER + breast cancer models. (medscape.com)
  • Correction: Changes in the tumor oxygenation but not in the tumor volume and tumor vascularization reflect early response of breast cancer to neoadjuvant chemotherapy. (medscape.com)
  • arations verified the presence of cancer cells in all samples. (lu.se)
  • An important development in cancer research over the past 2 decades has been the recognition that genetic changes drive the pathogenesis of tumors of both adulthood and childhood. (medscape.com)
  • One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
  • Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
  • Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)
  • Hypoxic cancer cells are known to be relatively resistant to radiation killing compared with well oxygenated healthy cells [2,3,7-9]. (who.int)
  • Metronidazole (Flagyl) is a drug used to treat infections and has been studied in the treatment of cancer [10,11] as a radiosensitizer drug, especially for hypoxic cells [9]. (who.int)
  • In this study, we investigated programmed death-ligand 1 (PDL-1) as a potential biomarker for CAF-induced chemoresistance and evaluated its role and the underlying mechanisms of chemoresistance in non-small cell lung cancer (NSCLC). (cdc.gov)
  • Silencing PDL-1 expression suppressed CAFs' ability to promote stem cell-like properties and invasiveness of lung cancer cells, favoring chemoresistance. (cdc.gov)
  • c-Kit (Mast/stem cell growth factor receptor, SCFR or CD117) is a proteinthat in humans is encoded by the KIT gene. (medchemexpress.com)
  • This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. (cancerindex.org)
  • Emerging models of PNI strongly suggest that interactions between tumor cells and nerves induce tumor cell migration and stimulate nerve growth or axonogenesis. (tam-receptor.com)
  • Although studies have identified unique transcription factors in the selection of normal pancreatic lineages, the cells of origin and molecular mechanisms arbitrating PDAC growth are poorly defined. (amegroups.org)
  • In contrast, Akt-phosphorylation, β-catenin, and c-Myc are repressed in the cells, presumably inhibiting tumor growth. (amegroups.org)
  • however, the tumor growth rate was significantly reduced. (amegroups.org)
  • Herein we present clear evidence that not only do both patient MM cells and human MM cell lines (HMCLs) release MVs, but that these MVs stimulate MM cell growth. (oncotarget.com)
  • As shown in Fig. 1A oxaliplatin inhibited cell growth in these three CRC cell lines in a Bexarotene (LGD1069) dose-dependent manner with HCT116 cells being more sensitive to oxaliplatin than SW480/HT29 cells (Fig. 1A). (immune-source.com)
  • Moreover, pro-tumor TAMs contribute to tumor growth by inhibiting tumor-infiltrating lymphocytes (TILs) that target tumor cells. (lu.se)
  • Since recent evidence supports a crucial role of dendritic cells (DC) in the pathogenesis of MS, we investigated the effect of a 12-week combined exercise program in MS patients on the number and function of DC. (hindawi.com)
  • Dendritic cells in the skin act as sentinel APCs, taking up antigen, then traveling to local lymph nodes where they can activate T cells. (msdmanuals.com)
  • Follicular dendritic cells are a distinct lineage (a different cell type than conventional dendritic cells), do not express class II MHC molecules, and therefore do not present antigen to Th cells. (msdmanuals.com)
  • Mechanisms of skin sensitization and allergic epidermal Langerhans cells (LC), although other cuta- contact dermatitis neous (dermal) dendritic cells (DC) may also contrib- ute. (cdc.gov)
  • In this study, we explored the role of Plk1 in the classical kidney fibrosis model, UUO, and cultured fibroblast and renal tubular epithelial cells by using specific Plk1 inhibitors, genetic silencing, and heterozygous global knockout mice. (nature.com)
  • 2017). Additionally, they considerably inhibit tumor development in mice bearing liver organ tumor cells (Li et al. (unscburma.org)
  • We verified the result of PG on LLC tumor-bearing mice, and it had indeed slowed markedly. (unscburma.org)
  • We observed neurite GSK369796 outgrowth in a co-culture of PC3 cells with wild-type DRG but not from DRG harvested from plexin-B1 knockout mice or in which Sema4D was silenced in the PC3 cells. (tam-receptor.com)
  • Antigen-specific Th1 but not Th2 cells provide protection from lethal Trypanosoma cruzi infection in mice. (southernbiotech.com)
  • Tumors that developed in mice deficient in INK4A were enhanced by the topical application of carcinogens and ultraviolet light. (medscape.com)
  • For other human tumour virus- primate species are related to the hu- tween data in humans and in experi- es, the use of humanized severe man tumour viruses, the incidence of mental animals is not obvious. (who.int)
  • Tumor-native ST6GAL1 promotes tumor cell behaviors such as invasion and resistance to cell stress and chemo- and radio-treatments. (nature.com)
  • the 5-year patient survival is about 8% ( 1 ) due to the late-stage disease diagnosis, tangible tumor resistance to therapy ( 2 ) and aberrant post-treatment tumor relapse ( 3 ). (amegroups.org)
  • We discovered that PG includes a significant inhibitory influence on a number of tumor cell lines, as well as the Rabbit polyclonal to ALS2CL Lewis lung tumor (LLC) cell range may be the most delicate to its impact. (unscburma.org)
  • Mechanistically, NGF could upregulate TDE-miR-21-5p levels, and DRG cells took up TDE to activate the Warburg effect and stimulate nociceptor gene expression. (hindawi.com)
  • Mechanistically, we found that low expression of the antioxidant glutathione in CD27- γδ17 T cells renders them particularly susceptible to neutrophil-derived reactive oxygen species (ROS). (crick.ac.uk)
  • Mechanistically, PG increased the infiltration GW841819X and killing activity of CD8+ T cells, which was related to the decrease of PD-1+ CD8+ T cells. (unscburma.org)
  • These pDC display an activated phenotype, as evidenced by increased numbers of circulating CD62L + and CD80 + pDC. (hindawi.com)
  • Taken collectively the HDAC1/miR-200b/Suz-12-E-cadherin signaling might account SCH58261 for maintenance of CSCs and formation of chemoresistant phenotype in docetaxel-resistant LAD cells. (exposed-skin-care.net)
  • In anti-CD19 CAR T-cell-treated patients exhibiting elevated CAR CD4:CD8 ratios, strong induction of serum IFN-γ was associated with increased survival. (pasteur.fr)
  • Mitochondrial dynamics are tightly coordinated in association with the cell cycle and state with complex structural and practical interactions leading SGX-523 to fusion and fission of mitochondria to alter the balance of oxidative-phosphorylation get rid of damaged mitochondrial parts (e.g. mtDNA) SGX-523 and regulate reactive oxygen species (ROS)22. (biopaqc.com)
  • Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)
  • Perineural invasion (PNI) is normally a tropism of tumor cells for nerve bundles located in the surrounding stroma. (tam-receptor.com)
  • Many carcinomas display perineural invasion (PNI) a tropism of tumor cells for surrounding nerve bundles. (tam-receptor.com)
  • Interestingly, the number of CD80 + pDC positively correlates with the presence of IL-10-producing regulatory type 1 cells (Tr1), an important cell type for maintaining peripheral tolerance to self-antigens. (hindawi.com)
  • Although some antigens (Ags) can stimulate the immune response directly, T cell-dependent acquired immune responses typically require antigen-presenting cells (APCs) to present antigen-derived peptides within major histocompatibility complex (MHC) molecules. (msdmanuals.com)
  • Intracellular antigens (eg, viruses) can be processed and presented to CD8 cytotoxic T cells by any nucleated cell because all nucleated cells express class I MHC molecules. (msdmanuals.com)
  • Extracellular antigens (eg, from many bacteria) that are phagocytosed or endocytosed can be processed into peptides and complexed with surface class II MHC molecules on professional APCs, which specialize in presenting antigens to CD4 helper T (Th) cells. (msdmanuals.com)
  • Inhibitors of mitochondrial fission [e.g. mitochondrial division inhibitor-1 (Mdivi-1)] may ameliorate neurodegenerative diseases and reduce the cardiotoxicity of chemotherapy36 37 Here we interrogated the role of mitochondrial form and functional SGX-523 control within the cellular hierarchy of the most common primary intrinsic brain tumor glioblastoma using validated and well characterized. (biopaqc.com)
  • Research in our laboratory is at the intersection of innate immune system and solid tumor biology. (upenn.edu)
  • BT-474 cells, obtained expression of the receptor has important implications for their biology from American Type Culture Collection, were maintained in RPMI 1640 and therapy (1). (lu.se)
  • Microarrays were prepared in tumor biology. (lu.se)
  • The sialyltransferase ST6GAL1 that adds α2-6 linked sialic acids to N-glycans of cell surface and secreted glycoproteins is prominently associated with many human cancers. (nature.com)
  • Many cancers re-emerge after treatment, despite the sensitivity of the bulk of tumor cells to treatments. (mdpi.com)
  • A common feature in GBM, as in many other cancers, is their escape to the retrograde signalling and metabolic regulation exerted by mitochondria -the bioenergetic central of the cell. (europa.eu)
  • Li Q, Cao Z, Zhao S. The Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRα) in Cancers. (medsci.org)
  • Like most cancers glioblastomas display derangement of rate of metabolism to promote a shift towards glycolysis known as the Warburg effect16. (biopaqc.com)
  • CIGB-300 is a cell-permeable selective CK2 inhibitor peptide undergoing clinical trials for several cancers. (oncotarget.com)
  • Role of Caveolin-1 in carbon nanotube -induced stem-like cells and tumorigenesis. (cdc.gov)
  • She is the Director and PI for Stem Cells and Biomaterials Engineering Laboratory at Stanford University, jointly supported by Departments of Orthopaedic Surgery and Bioengineering. (stanford.edu)
  • c-Kit is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. (medchemexpress.com)
  • c-Kit is a receptor tyrosine kinase type III, which binds to stem cell factor. (medchemexpress.com)
  • When c-Kit binds to stem cell factor (SCF) it forms adimer that activates its intrinsic tyrosine kinase activity, that in turn phosphorylates and activates signal transduction molecules that propagate the signal in the cell. (medchemexpress.com)
  • OS appears to follow this model where OS cells with tumor initiating potential can be identified by expression of Stro1, CD117 and embryonic stem cell transcription factors such as Sox2, Nanog and Oct3/4. (tmc.edu)
  • Additionally, OS stem-like cells display high aldehyde dehydrogenase activity and sarcosphere formation under limited nutrient media and anchorage independence. (tmc.edu)
  • In this dissertation, we demonstrate that Her4 expression is induced by conditions that enrich stem-like cells and its expression correlates with the ability to upregulate various OS TIC markers. (tmc.edu)
  • The GDNF family ligands (GFLs) function through a glycosyl-phosphatidylinositol-(GPI) anchored coreceptor, GDNF family receptor alpha (GFRα), and rearranged during transfection (RET), a well-known receptor tyrosine kinase involved in kidney development, spermatogonial stem cell maintenance, and the development and maintenance of the sympathetic, parasympathetic, and enteric nervous systems [ 1 , 2 ]. (medsci.org)
  • Recent studies suggest that the molecular machinery of nutrient sensation instructs the behavior of stem cells particularly embryonic and hematopoietic stem cells21. (biopaqc.com)
  • RESULTS: We demonstrated that chemotherapy-stimulated CAFs promoted tumorigenic and stem cell-like properties of NSCLC cells, which contribute to their chemoresistance. (cdc.gov)
  • CONCLUSION: Our results show that PDL-1-positive CAFs modulate stem cell-like properties of NSCLC cells by secreting elevated HGF, thereby promoting chemoresistance. (cdc.gov)
  • Activated γδ T cells exhibit strong cytotoxic activity and cytokine secretion functions and are effective antitumor lymphocytes with simple and direct recognition modes and rapid responses. (explorationpub.com)
  • Cutaneous T-cell lymphoma (CTCL) (see the image below) is a heterogeneous group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin, with no evidence of extracutaneous disease at the time of diagnosis. (medscape.com)
  • The development of skin sensitization is associated with, and requires, the activation and clonal expansion of allergen responsive T lymphocytes and it is these cells that orchestrate the cutaneous allergic reaction. (cdc.gov)
  • Histopathology with immunochemistry showed extensive infiltration of the dermis by atypical cells positive for CD31 and negative on pan-cytokeratin and human herpesvirus-8 staining. (medicaljournals.se)
  • d) Immunochemistry, ×10 magnification: infiltration of dermis by CD31 + cells. (medicaljournals.se)
  • We studied tumor cell signaling in the cell subsets to understand the tumor-inhibitory potentials of EBF2. (amegroups.org)
  • It is of great significance to gain insight into the classification of γδ T cell subsets. (explorationpub.com)
  • These cells are functionally, phenotypically, and developmentally heterogeneous with many distinct subsets. (upenn.edu)
  • BSS has been described as an autosomal dominant disease characterized by the development of multiple skin appendage tumors such as cylindromas, trichoepitheliomas, and spiradenomas, with a variable preponderance of any of the aforementioned subsets. (medscape.com)
  • Nevertheless whether miR-200b regulates CSCs produced from docetaxel-resistant LAD cells continues to be poorly realized and must become further elucidated. (exposed-skin-care.net)
  • In contrast silencing p53 significantly decreases the inhibitory effects of oxaliplatin suggesting an important role for p53 in this process13 14 The p53 protein regulates a group Bexarotene (LGD1069) of cytochrome P450 (CYP) genes in human and mouse liver cells and influences the efficacy of chemotherapeutic treatment regimens15 16 However a role for p53 in regulating CYP450 genes in the intestinal tract has not yet been reported. (immune-source.com)
  • Diaz AV, Stephenson D, Nemkov T, D'Alessandro A, Reis T. Spenito-dependent metabolic sexual dimorphism intrinsic to fat storage cells. (ucdenver.edu)
  • Mind tumor initiating cells (BTICs) coopt the neuronal high affinity GLUT3 blood sugar transporter to withstand metabolic tension. (biopaqc.com)
  • Metabolic adjustments aren't merely a consequence of oncogenesis as mutations in essential enzymes are principal tumor initiating lesions13. (biopaqc.com)
  • MiaPaCa-2 and CFPAC-1 cells were treated with 100 ng/ml of NGF or the NGF inhibitor Tanezumab for 24 h, CCK-8 and Transwell assays were employed to test cell proliferation, invasion, and migration, respectively. (hindawi.com)
  • NGF promoted MiaPaCa-2 and CFPAC-1 cell invasion and migration, while Tanezumab treatment showed the opposite results. (hindawi.com)
  • TrkA blocking-up could restrain NGF induced PC cell migration and neural invasion. (hindawi.com)
  • These CSC-like cells, which express a high level of Cav-1, displayed increased cell migration and invasion, compared with their non-CSC counterpart. (cdc.gov)
  • A novel human anti-AXL monoclonal antibody attenuates tumour cell migration. (cancerindex.org)
  • We demonstrate that CD117+ cells display increased proliferation and migration. (biorxiv.org)
  • In addition, overexpression of ZYX in hepatoma cell lines (PLC/PRF/5, HCCLM3) enhanced their proliferation, migration and invasion, whereas ZYX knockdown had the opposite effects (SK HEP-1, Huh-7). (techscience.com)
  • RIP assay was performed to validate NGF and miR-21 binding ability in MiaPaCa-2 cells. (hindawi.com)
  • To overcome these obstacles, we designed a functional microRNA (miR)-based live-cell reporter assay to identify highly tumorigenic cells in xenotransplants of primary Ewing sarcoma (EwS) 3D cultures. (visualsonics.com)
  • Blood cell count and results of haemostasis, liver and renal function tests were within normal limits. (medicaljournals.se)
  • Based on previous efforts focusing on the role of the adaptive immune system in the pathogenesis of MS, it is currently well established that autoreactive T helper type 1 (Th1) and Th17 cells mediate the inflammatory processes in the CNS [ 10 ]. (hindawi.com)
  • This review further emphasizes the diversified cross-talk between γδ T cells and other immune cells. (explorationpub.com)
  • It is hoped that the host immune status can be accurately predicted and gradually advance γδ T cell precise individualized medicine. (explorationpub.com)
  • Overview of the Immune System The immune system distinguishes self from nonself and eliminates potentially harmful nonself molecules and cells from the body. (msdmanuals.com)
  • they have receptors for the crystallizable fragment (Fc) region of immunoglobulin (Ig) G and for complement, which enable them to bind with immune complexes and present the complex to B cells in germinal centers of secondary lymphoid organs. (msdmanuals.com)
  • We isolated CSCs from low passage PDAC cell lines derived from human tumors and commercially available cell lines. (amegroups.org)
  • that are comes from human being docetaxel-resistant LAD cells. (exposed-skin-care.net)
  • To the very best of our understanding there were no reviews about HDAC1/miR-200b/Suz-12/E-cadherin regulatory network in regulating CSCs maintenance and chemoresistance in human being LAD cells and the existing work provides a novel. (exposed-skin-care.net)
  • (C) Expressions of RNASET2 in 18 types of human blood cells and total peripheral blood mononuclear cells (PBMC) were analyzed in the Blood Atlas database. (frontiersin.org)
  • For example CYP2S1 which is usually most highly expressed in intestinal tract epithelial cells may be involved in metabolizing aromatic hydrocarbons and other xenobiotic substrates20 21 Madanayake also identified that human CYP2S1 is an important enzyme in the metabolism of COX-derived prostaglandins at nanomolar concentrations and the authors suggested that CYP2S1 may play an important role in modulating the inflammatory process23. (immune-source.com)
  • In this review, we use the Heilig nomenclature to describe human γδ T cells [ 1 ]. (explorationpub.com)
  • Although carcinogenic roles for the INK4B, INK4C, INK4D, CIP1, KIP1, and KIP2 genes appear to be limited, INK4A is among the most commonly mutated genes in human tumors. (medscape.com)
  • Antibodies against endothelial cells are the stain of choice (4). (medicaljournals.se)
  • This development occurs under the influence of macrophage colony-stimulating factor (M-CSF), which is secreted by various cell types (eg, endothelial cells, fibroblasts). (msdmanuals.com)
  • In both 2D and 3D cultures, stemness marker gene expression is higher in CD117+ cells. (biorxiv.org)
  • The underlying mechanism responsible for the effects of lunasin on NK cells is likely due to epigenetic modulation on target gene loci. (weeksmd.com)
  • Despite variable phenotypic expressions of a predominant tumor in BSS, the gene responsible for multiple cylindromas, CYLD , is localized to band 16q12-q13. (medscape.com)
  • For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)
  • Indeed cisplatin-resistant colorectal tumors are responsive to oxaliplatin4. (immune-source.com)
  • Our experiments confirm and extend the involvement of CYP2S1 as a potential therapeutic target for enhancing oxaliplatin efficacy in colorectal epithelial cells. (immune-source.com)
  • Brain metastases (BM) are the most common tumor within the brain and carry a poor prognosis due to limitations in current treatment options. (abta.org)
  • Funded by the Marie Skłodowska-Curie Actions programme, the MITIG project aims to understand how this process affects metabolism and tumour development of glioblastoma multiforme (GBM), a common and aggressive brain tumour in adults. (europa.eu)
  • Further, exosomes were extracted from PC cells and identified by examining the levels of specific markers for exosomes. (hindawi.com)
  • CSCs derived from both CSCs and non-CSCs give rise to tumors through self-renewal and are able to differentiate into multiple cell types [6]-[9]. (exposed-skin-care.net)
  • For instance miR-34a repression causes digestive tract CSCs to execute asymmetric cell department and promotes little girl cells to stay digestive tract CSCs by regulating Notch signaling. (exposed-skin-care.net)
  • Other lesions reported with BSS include parotid basal cell adenomas, organoid nevi, syringomas, and basal cell carcinomas. (medscape.com)
  • Triple treatment showed synergism in terms of exhibiting anti-tumorigenic effects by activating the Hippo YAP signaling pathway in the HCT116 cell line. (frontiersin.org)