Promotes receptors vitronectin. Medical search. Frequent questions

It functions as a receptor for Tenascin, Fibronectin, and Vitronectin and can promote attachment, cell spreading, and neurite outgrowth. (kactusbio.com)
The platelet integrin GP IIb-IIIa (also referred to as α IIb-β) is a calcium-dependent heterodimer complex that can bind fibronectin, fibrinogen, vWF, and vitronectin. (medscape.com)
No colocalisation of mast cells was found with fibronectin or vitronectin. (bmj.com)
This consists of fibronectin vitronectin thrombospondins and tenascins. (bio-cavagnou.info)
These chondrocyte/ECM interactions are regulated by a large family of transmembrane glycoproteins whereby beta 1 integrins are the most widely expressed and interact with several matrix proteins such as collagen, fibronectin, vitronectin and laminin [ 4 ]. (biomedcentral.com)
Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. (biossantibodies.com)

Integrin αIIbβ3 can also bind other proteins on platelets and in the blood as well as proteins within the intricate lattice that forms in the space between cells (extracellular matrix) to ensure proper clot formation and promote wound healing. (medlineplus.gov)
During central nervous system development extracellular matrix (ECM) receptors and their ligands enjoy key Flavopiridol HCl element roles as guidance molecules informing neurons where so when to send out axonal and dendritic projections create connections and form synapses between pre- and postsynaptic cells. (bio-cavagnou.info)
Receptors with α5 α8 and α(V) subunits are believed "RGD" receptors because they acknowledge IL18 antibody an Arg-Gly-Asp binding theme within many extracellular ligands. (bio-cavagnou.info)
CD47 is a 50 kDa membrane receptor that has extracellular N-terminal IgV domain , five transmembrane domains , and a short C-terminal intracellular tail. (wikidoc.org)
Vitronectin is an abundantglycoprotein found in serum and the extracellular matrix and promotes celladhesion and spreading, inhibits the membrane-damaging effect of the terminalcytolytic complement pathway, and binds to several serpin serine protease inhibitors. (creativebiomart.net)
To investigate the role of the extracellular receptors in OPN signaling, we have examined the spatio-temporal regulation of CD44 and integrin αvβ3 receptor in OPN-induced Akt activation in PC3 cells. (biomedcentral.com)

Tyrosine kinase receptors and integrins play essential roles in tumor cell invasion and metastasis. (biotech-angels.com)
Integrins are heterodimeric, transmembrane receptors that function as mechanosensors, adhesion molecules and signal transduction platforms in a multitude of biological processes. (thno.org)
Integrins are heterodimeric cell surface receptors found in nearly all metazoan cell types, composed of non-covalently linked α and β subunits. (thno.org)
Integrins are not constitutively active but rather exist in multiple activation states wherein ligand binding stability is related to the activation status of the receptor. (thno.org)
Integrins with α1 α2 α10 and α11 are collagen receptors that identify the peptide sequence "GFOGER. (bio-cavagnou.info)
Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. (biossantibodies.com)

There are specific receptor proteins like integrin on the external surface of focal attachments. (omicsonline.org)
And the internal surface has actin filaments such as talin, paxillin, vinculin, tensin and proteins that provide interactions between membrane receptor proteins [ 1 - 3 ]. (omicsonline.org)
Based on all the results, the increased resistance to trypsinization of C2C12, LF, HaCaT, and VSMC cells on amine PPs can be explained most probably by a non-specific cell adhesion such as electrostatic interaction between the cells and amine groups on the material surface, rather than by the receptor-mediated adhesion through serum-derived proteins adsorbed on the PPs. (nature.com)
HTR6 is a serotonin receptor whose activity is mediated by G proteins that stimulate adenylate cyclase. (abic2004.org)
Regarding function of these uremia-specific proteins, only SAA mimicked ESRD-HDL by promoting inflammatory cytokine production. (lww.com)
Somatomedins are a group of proteins that promote growth and cell division in response to stimulation by growth hormone (GH), also known as somatotropin (STH). (scopeheal.com)

SKI-606 suppressed EGF-induced Src phosphorylation in FG cells (Supplemental Fig. S2A) and obstructed EGF-mediated migration on vitronectin however HIF-C2 had no influence on EGF-independent migration on collagen (Fig. 2A). (biotech-angels.com)

A specific inhibitor of PKCd, rottlerin, completely abrogated Go¨6976-dependent increase in PC12 cell adhesion to laminin as well as the activation of small GTPases, Rac1 and Cdc42, that are downstream of PKCd in adhesion receptor signaling. (mirnamimic.com)
Biological activities of laminin are mediated through binding to a subset of integrin family of cell adhesion receptors, a3b1, a6b1, a6b4, and a7b1 [2]. (mirnamimic.com)
In PC12 cells, we recently showed that the engagement of integrin a3b1 to a binding sequence within the human laminin a2 chain was sufficient to recruit PKCa and PKCd to the integrin receptor [6]. (mirnamimic.com)

Platelets adhere to sites of endothelial injury and then activate, aggregate, and secrete various chemicals designed to promote further platelet recruitment and aggregation. (medscape.com)
Approximately 80,000 GP IIb-IIIa receptors are present on the surface of each platelet. (medscape.com)
nuclear peculiar MWe exists the download the decline shifted by the manufactured formation distribution and creativity, and typically promotes into formation the secondary process for the platelet sleep( security is more human time, warmer questions less). (viotechsolutions.com)
In addition to its activity in the coagulation cascades, thrombin also promotes platelet activation, via activation of protease-activated receptors on the platelet. (gim-academy.com)

Each distinctive integrin receptor provides different ligand-binding specificities with some receptors binding to only 1 ligand among others binding to many. (bio-cavagnou.info)

CD36 (fatty acid translocase, FAT) is an 88 kDa ditopic glycosylated protein that belongs to the class B family of scavenger receptors. (exbio.cz)
Increased foam cell formation results from lack of VDR-SERCA2b interaction, causing SERCA dysfunction, activation of ER stress-CaMKII-JNKp-PPARγ signaling, and induction of the scavenger receptors CD36 and SR-A1. (regenerativemedicine.net)

Changing surface characteristics of scaffolds was a way to promote regeneration and ion implantation was one of the methods to modify surface properties which play a huge role in enhancing the proliferation and integration of cells. (omicsonline.org)
HGF is a well-established survival factor and viability assays and live/dead staining showed that it promoted the survival and proliferation of monocytes and osteoclasts in a manner similar to M-CSF. (ox.ac.uk)
Signals emanating from focal adhesions have been shown to promote survival, differentiation and proliferation [ 5 ]. (thno.org)
The role of CD47 in promoting cell proliferation is heavily dependent on cell type as both activation and loss of CD47 can result in enhanced proliferation. (wikidoc.org)
Though the exact mechanism is unclear, it is likely that CD47 promotes proliferation via the PI3K/Akt pathway in cancerous cells but not normal cells. (wikidoc.org)
Shape 2 Mix of ACSL with SCD overexpression stimulates migration invasion and colony development without major results on proliferation Tumor cells often make use of metabolic ways of promote cell success and proliferation. (crispr-reagents.com)

Alessio M, Roggero S, Bussolino F, Saitta M, Malavasi F: Characterization of the murine monoclonal antibody NL07 specific for the human thrombospondin receptor (CD36 molecule). (exbio.cz)
CD47 is a high affinity receptor for thrombospondin-1 (TSP-1), a secreted glycoprotein that plays a role in vascular development and angiogenesis, and in this later capacity the TSP1-CD47 interaction inhibits nitric oxide signaling at multiple levels in vascular cells. (wikidoc.org)
Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. (biossantibodies.com)

Integrin alpha-5/beta-1 is a receptor for fibrinogen. (biossantibodies.com)

Kapinsky M, Torzewski M, Büchler C, Duong CQ, Rothe G, Schmitz G: Enzymatically degraded LDL preferentially binds to CD14(high) CD16(+) monocytes and induces foam cell formation mediated only in part by the class B scavenger-receptor CD36. (exbio.cz)

CD47 interacts with signal-regulatory protein alpha (SIRPα), an inhibitory transmembrane receptor present on myeloid cells . (wikidoc.org)

Here, we show that although this receptor is present on most vascular and blood cells, the key regulatory function in tumor and wound angiogenesis is performed by β 3 integrin on bone marrow-derived cells (BMDCs) recruited to sites of neovascularization. (rupress.org)
Bone regeneration is a complex and continuous process aiming at the anatomic and functional restoration and it can demand the use of biomaterials to promote a fast bone formation. (bvsalud.org)
In its presence, growth factors either adsorb or moisten the surface of the bone substitutes, promoting an adequate integration with the host bone 13 . (bvsalud.org)
Notwithstanding, to achieve the effectiveness and integration of the grafted tissue to the receptor site, it is necessary a strong cell adhesion, so that it demands many molecules interaction to induce cell differentiation and the bone matrix mineralization formed onto the graft. (bvsalud.org)
It is also involved in the anchoring of osteoclasts to the mineral of bone matrix via the vitronectin receptor, which has specificity for osteopontin. (crispr-reagents.com)
Hypoxia stimulates hypoxia inducible factor (HIF)-dependent expression of CXCL12 and KITL promoting mobilization from the bone marrow and recruitment to primary tumor and metastatic sites of CXCR4 + CD11b + bone marrow-derived cells and KITbCD11b + cells assisting vasculogenesis and metastasis respectively (Kuonen et al. (biomedcentral.com)

2001) and promotes hydrolysis of beta-lactams. (phosphorylaseinhibitors.com)

Results: Thrombin and protease-activated receptor-1 (PAR-1) agonist induced TGF-β1 activation and Smad3 phosphorylation. (ntu.edu.tw)

Hepatocyte growth factor (HGF) and M-CSF signal through tyrosine kinase receptors and phosphorylate common transducers and effectors such as Src, Grb2, and PI3-Kinase. (ox.ac.uk)
These findings demonstrate crosstalk between a tyrosine kinase receptor and an integrin involved in carcinoma cell invasion and metastasis and may explain in part how inhibitors of EGFR impact malignant disease. (biotech-angels.com)

The ITGB3 gene provides instructions for making the beta3 subunit of a receptor protein called integrin alphaIIb/beta3 (αIIbβ3), which is found on the surface of small cells called platelets. (medlineplus.gov)
After Metacore network evaluation of the 21 protein, eight appear inside the same network, keratins regulated by estrogen receptors primarily. (abic2004.org)
In mammalian cells, FAF2 protein directly interacts with and negatively regulates neurofibromin by promoting its ubiquitin-dependent proteolysis. (abic2004.org)

Here, we observed that HDL isolated from healthy individuals inhibited the production of inflammatory cytokines by peripheral monocytes stimulated with a Toll-like receptor 2 agonist. (lww.com)

In contrast, while some studies have suggested a tumor promoting activity of plakoglobin in a cell/malignancy specific context, it generally acts as a tumor/metastasis suppressor. (oncotarget.com)

Stimulates growth and regulates the differentiation of various tissues, shows activities similar to insulin, and promotes cartilage growth. (scopeheal.com)

Knockdown of Rap1b expression in FG cells selectively blocked EGF-induced migration on vitronectin (Fig. 1B) supporting a role for Rap1 in the β5/EGF-mediated cell migratory response. (biotech-angels.com)
Since αvβ5 requires activation to promote cell migration we considered whether EGF and integrin αvβ5 could coordinately influence the spontaneous metastasis of FG HIF-C2 cells in vivo. (biotech-angels.com)
Src activation downstream of EGFR is required for αvβ5-mediated carcinoma cell invasion and metastasis EGF receptor ligation and Src activation have been linked to the growth and malignant properties of many tumors (2 4 To assess whether HIF-C2 EGF-mediated migration was Src-dependent FG cells had been treated using a Src kinase inhibitor (SKI-606) ahead of EGF excitement. (biotech-angels.com)
Concentrated growth factor promotes Schwann cell migration partly through the integrin β1-mediated activation of the focal adhesion kinase pathway. (biossantibodies.com)

2013 Notably either deletion of cell adhesion molecules or inhibition of their relationships with function-blocking antibodies promotes structural and practical maturation of dendritic spines (Matsuno et al. (bio-cavagnou.info)

Innate immune function between newborns and elderly is extremely different and large quantities of IL-6 after stimulation of receptors, such as TLR, by term newborns are indicated [117]. (mayabouchenaki.com)

We demonstrate that deletion of the macrophage vitamin D receptor (VDR) in mice (KODMAC) is sufficient to induce insulin resistance by promoting M2 macrophage accumulation in the liver as well as increasing cytokine secretion and hepatic glucose production. (regenerativemedicine.net)

Osteopontin mediates biological function through signal transduction by binding to the cell surface receptors such as integrin αvβ3 and CD44 [ 5 ]. (biomedcentral.com)

We found that the HGF receptor, c-Met, is expressed by the CD14(+) monocyte fraction of human peripheral blood mononuclear cells (PBMC). (ox.ac.uk)
HGF was able to support monocyte-osteoclast differentiation in the presence of receptor activator for nuclear factor kappaB ligand as evidenced by the formation of numerous multinucleated tartrate-resistant acid phosphatase and vitronectin receptor positive cells which formed F-actin rings and were capable of lacunar resorption. (ox.ac.uk)

Previously, we documented the conversation involving kindlin-3 and the receptor for activated-C kinase (RACK1) [forty two]. (ack1inhibitor.com)

This last point is crucial, since it explains how upregulation of this receptor can contribute to an ascending spiral of RAGE-dependent cellular perturbation. (jci.org)
Such treatment was associated with upregulation of invasion- and inflammation-promoting soluble factors, such as matrix metalloproteinase 2 (MMP2), its activator MMP14, tissue inhibitors of matrix metalloproteinase 2 (TIMP2), chemokine ligand 2 (CCL2), and urokinase-type plasminogen activator (uPA), the latter two being linked to the recruitment of the monocytic cells. (biomedcentral.com)

Cardiovascular (CV) risk factors such as hypercholesterolemia, hyperglycaemia, obesity, hypertension, smoking, and aging promote vascular inflammation and endothelial activation [ 7 - 9 ]. (hindawi.com)
Novel vascular lesions in mice given a non-peptide vitronectin receptor antagonist. (southernbiotech.com)

Two novel human antitumor immunoconjugates, engineered by fusion of a single-chain antibody fragment against human ErbB2 receptor, termed Erbicin, with either a human RNase or the Fc region of a human IgG(1), are selectively cytotoxic for ErbB2-positive cancer cells in vitro and in vivo. (cnr.it)

Phagocytosis is a term coined from the Greek to describe the receptor-mediated engulfment and degradation of dead cells and microbes. (frontiersin.org)
107] demonstrated that IL-1 production and signaling from the IL-1 receptor are necessary components of Raf-induced transformation of NIH 3 T3 cells, which exclude other factors involvement in the vivo model [85]. (mayabouchenaki.com)
We found IL-17A receptor expression levels in LCH cells are important for defining LCH subclasses. (mayabouchenaki.com)
and in nonneuronal cells determining and characterizing ECM receptor connections in neurons from the central anxious system (CNS) possess proven more challenging. (bio-cavagnou.info)
2006 Hynes 2002 Within "RGD" receptors integrin αVβ3 offers been shown to interact with several different ECM ligands and counterreceptors on adjacent cells. (bio-cavagnou.info)
Up-regulation of Rho action has been claimed in integrin aVb3 expressing K562 cells plated Vps34-IN-1 on vitronectin, but the phorbol ester PMA was employed as the activating agent [seventy three]. (ack1inhibitor.com)
Our observations suggest that the activation of c-Raf-ERK cascade may promote cell cycle arrest in prostate cancer cells and OPN signaling has a role in the anti-apoptotic mechanism. (biomedcentral.com)

This chapter features several ECM receptors their assignments in the control of synapse framework and function as well as the impact of the receptors on synaptic Flavopiridol HCl plasticity and pet behavior. (bio-cavagnou.info)

Binding of these ligands to RAGE does not accelerate clearance or degradation but rather begins a sustained period of cellular activation mediated by receptor-dependent signaling. (jci.org)

This problems stems in huge part from having less extensive cellar membranes in the CNS producing the purification of huge amounts of ECM receptor complexes tough. (bio-cavagnou.info)

many HDL samples even promoted the production of inflammatory cytokines. (lww.com)

Background: Akira S, Yamamoto M, Takeda K. Role of adapters in toll-like receptor signalling. (mayabouchenaki.com)

Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. (biossantibodies.com)
Integrin alpha-4/beta-1 is a receptor for VCAM1. (biossantibodies.com)

FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling. (southernbiotech.com)

In order to assess whether additional granzymes might be important in promoting cell death in ALK+ ALCL, we examined whether other human granzymes were expressed in ALK+ ALCL cell lines using reverse-transcriptase PCR and western blotting. (biomedcentral.com)
Native humanmonomeric Vitronectin prepared from fresh human plasma using nondenaturingchromatography. (creativebiomart.net)

Here, our studies demonstrate that OPN can activate Akt either through the α V β 3 integrin or the CD44 cell surface receptor. (biomedcentral.com)

Taken together, these features of RAGE allow the receptor to propagate cellular dysfunction in a number of pathophysiologically relevant situations, most often dictated by the formation and persistence of ligands in the tissues. (jci.org)

Other unusual features of the receptor include its ability to engage classes of molecules, rather than individual ligands, and its enhanced surface expression in environments rich in RAGE ligands. (jci.org)

Anatomy2

Diseases1

Chemicals and Drugs30

Phenomena and Processes5

Information Science2

Fibronectin6

Extracellular6

Integrins6

Proteins6

Collagen1

Laminin3

Platelet4

Integrin receptor1

Scavenger receptors2

Proliferation6

Thrombospondin3

Fibrinogen1

CD361

Transmembrane1

Bone6

20011

Thrombin1

Tyrosine2

Protein3

Agonist1

Tumor1

Regulates1

Migration4

Inhibition1

Stimulation1

Macrophage1

Signal transduction1

Monocyte2

Rack11

Upregulation2

Vascular2

Antibody1

Cells7

Behavior1

Activation1

Amounts1

Inflammatory1

Role1

Beta2

Specific1

Human2

Demonstrate1

Tissues1

Surface1