Promotes lymphangiogenesis and lymphatic metastasis. Medical search. Frequent questions

Therefore, this complex regulatory network requires precise control of gene expression patterns at both transcriptional and post-transcriptional levels in order to ensure proper maturation, differentiation, and formation of blood and lymphatic vessels. (nature.com)
Absence of Lymphangiogenesis and Intratumoural Lymph Vessels in Human Metastatic Breast Cancer," The Journal of Pathology, Vol. 200, 2003, pp. 195-206. (scirp.org)
Lung destruction in LAM is a consequence of diffuse infiltration by neoplastic smooth muscle-like cells that invade all lung structures including the lymphatics, airway walls, blood vessels and interstitial spaces. (wikipedia.org)
In the cardiovascular system, the heart pumps new blood vessels and of lymphatic vessels from preexisting the blood through arteries into smaller arterioles and into ones, are involved in a number of physiological and patho- capillary beds. (sagepub.com)
e lymphatic network is composed of blind- in�ammation, increased blood �ow as a conse�uence of beginning thin-walled capillaries without pericyte coverage vesseldilationandedemaformationduetoincreasedperme- and with incomplete basal lamina as well as of collecting ability of the blood vessels. (sagepub.com)
MTC metastasizes through blood or lymphatic vessels. (fapesp.br)
However, this therapeutic regimen for ischemic limb using ADRCs did not affect remote melanoma growth nor the density of its feeder artery, angiogenesis and lymphatic vessels compared to the PBS group. (nagoya-u.ac.jp)
Spread can occur by local invasion into the surrounding tissue, by systemic metastasis via tumor-associated blood vessels to distant organs, or by lymphatic metastasis via tumor-associated lymphatic vessels to draining sentinel lymph nodes, then to distal lymph nodes and from there to distant organs. (dermatologytimes.com)
Dr. Detmar notes, 'It is tempting to speculate that the lymphangiogenic factors, in addition to increasing the mass of tumor-associated lymphatic vessels, might activate the lymphatic endothelium to express increased amounts of chemokines or adhesion molecules and receptors, which are involved in tumor cell-LEC interactions, thereby actively contributing to cancer dissemination. (dermatologytimes.com)
Lymphatic system consists of blind-ended lymphatic capillaries, lymphatic vessels, lymph nodes, lymphatic tissues, and red bone marrow . (turkupetcentre.net)
Collecting lymphatic vessels have valves which ensure that lymph flows unidirectionally. (turkupetcentre.net)
Collecting lymphatic vessels are surrounded by smooth muscle cells, pumping lymph against pressure gradient, with contraction rate of 1-15 cycles/min. (turkupetcentre.net)
Intraluminal valves, located 2-3 mm apart, ensure unidirectional lymphatics movement in lymphatic vessels towards the lymph nodes and further into large lymphatic trunks. (turkupetcentre.net)
White blood cells , which have migrated from blood into interstitial space, can return to the circulation via lymphatic vessels and lymph nodes. (turkupetcentre.net)
While lymphatic vessels provide an important route for disseminating tumor cells, they are also a crucial interface between a developing malignancy and the host immune response. (aacrjournals.org)
Rather than acting as passive conduits, lymphatic vessels directly regulate their transport function and facilitate leukocyte trafficking for efficient induction of adaptive immunity in downstream draining lymph nodes. (aacrjournals.org)
We recently published that in the absence of dermal lymphatic vessels, the tumor microenvironment of murine melanoma remains completely uninflamed and fails to induce a robust T-cell response (1). (aacrjournals.org)
We therefore hypothesize that lymphatic vessels are (A) required for induction of adaptive immunity but (B) acquire immunosuppressive activity as a function of the accumulation of local cytotoxic immunity. (aacrjournals.org)
There are two main routes by which tumor cells disseminate, through blood vessels (hematogenous spread) and through lymphatic vessels (lymphogenous spread). (harvard.edu)
Therapies targeted against lymphangiogenesis, the growth of new lymphatic vessels, are beginning to be explored. (harvard.edu)
Members of the vascular endothelial growth factor (VEGF) family, including VEGF-A and VEGF-C, stimulate the growth of blood vessels and lymphatic vessels. (harvard.edu)
A common receptor expressed on both adult blood vessels and lymphatic vessels is neuropilin 2 (NRP2). (harvard.edu)
In vivo, mock-transfected tumors are circumscribed with many large, open-lumened lymphatic vessels and contain intratumoral lymphatic vessels as well, while tumors overexpressing SEMA3F do not contain lymphatic vessels or have dilated surrounding lymphatics. (harvard.edu)
Angiogenesis (the formation of new blood vessels) and lymphangiogenesis (formation of new lymphatic vessels), i.e., neovasculogenesis, are key determinants for the survival, proliferation, and metastasis of cancer cells. (toppersonalhealth.com)
Increased formation of new blood and lymphatic vessels in the liver. (toppersonalhealth.com)
The ANGPT2 encodes the angiopoietin 2 protein, a growth factor that binds to receptors in blood and lymphatic vessels. (genengnews.com)
The fourth mutant demonstrated altered integrin binding and its expression in mouse skin, according to the authors, "promoted hyperplasia and dilation of cutaneous lymphatic vessels. (genengnews.com)
Corneal immunologic privilege is certainly linked with a accurate number of factors including the absence of blood and lymphatic vessels. (scienceexhibitions.org)
Lymphatic vasculature forms a network of vessels that drain interstitial fluid from tissues and return this fluid to the blood. (nii.ac.jp)
Lymphangiogesis, the formation of lymphatic vessels from preexisting lymphatic vessels, plays an important role in homeostasis of interstitial fluids and immunity. (nii.ac.jp)
At the heart of the pathogenesis of lymphedema lies the appearance of chronic high-protein edema, characterized by the pathological accumulation of intercellular fluid with large-molecule proteins in the interstitial space due to a defect in lymphatic drainage caused by congenital malformation (primary lymphedema), lymphatic obstruction or by the destruction of lymphatic vessels (secondary lymphedema). (biomedcentral.com)
Primary lymphedema is a disease caused by dysfunction of lymphatic vessels, their aplasia, dysplasia and hypoplasia. (biomedcentral.com)
Disturbance of drainage function of lymphatic vessels leads to accumulation of fluid rich in proteins under the epidermis. (biomedcentral.com)
We also found that NO mediates lymph-angiogenesis and metastasis as well as function of lymphatic vessels. (harvard.edu)
We recently uncovered that restoration of perivascular NO gradients improves structure and function of both blood and lymphatic vessels, and response to radiation. (harvard.edu)
In diverse vertebrate organs, lymphatic vessels display organotypic function and develop in an organ-specific manner. (shengsci.com)
The main interests of the Dr. Alitalo's group is to understand the mechanisms of development of blood vessels from preexisting ones in a process called angiogenesis and to learn analogous mechanisms of lymphangiogenesis. (euroacadti.eu)
They currently study angiogenesis and lymphatic vessels particularly in malignant tumors, focusing on the growth factor-receptor signaling and growth factor-mediated endothelial cell reprogramming. (euroacadti.eu)

Another lymphatic vessel growth factor, VEGF-C, is currently undergoing a clinical trial in combination with surgery for the treatment of lymphedema in patients whose lymph nodes in the armpit have been removed due to breast cancer metastasis. (genengnews.com)

The consensus clinical definition of LAM includes multiple symptoms:[citation needed] Fatigue Cough Coughing up blood (rarely massive) Chest pain Chylous complications arising from lymphatic obstruction, including Chylothorax Chylous ascites Chylopericardium Chyloptysis Chyluria Chyle in vaginal discharge Chyle in stool Angiomyolipomas (fatty kidney tumors) are present in about 30% of patients with sporadic LAM and up to 90% of patients with TSC-LAM. (wikipedia.org)
However, there is still a large knowledge gap whether treatment of ischemic diseases with angiogenic therapy using ADRCs would promote unfavorable angiogenesis associated with tumors in vivo. (nagoya-u.ac.jp)
Dr. Detmar and his team of researchers conducted a study consisting of 45 patients with primary cutaneous melanoma, where the extent of tumor lymphangiogenesis in the excised primary tumors and the presence of metastases in the sentinel lymph node biopsy samples were examined. (dermatologytimes.com)
Results showed that prominent 'hot spots' of increased lymphatic vessel density were seen in the primary melanomas of patients whose tumors had metastasized to the sentinel lymph nodes, as compared to nonmetastatic tumors. (dermatologytimes.com)
Dr. Detmar postulates that metastatic melanomas can therefore be characterized by increased lymphangiogenesis, as compared to non-metastatic tumors, and that the degree of tumor lymphangiogenesis can serve as a novel predictor of lymph node metastasis and overall patient survival, independent of tumor thickness. (dermatologytimes.com)
2005). Lymphangiogenesis is also important for tumors expansion, especially the for lymph node metastasis (Kadowaki et al . (vin.com)
Using experiments involving transgenic mice, they have successfully shown that dietary saturated/trans fats, but not cholesterol, can trigger hepatic angiogenesis and lymphangiogenesis, leading to the promotion of hepatic tumors. (toppersonalhealth.com)
criteria are the absence of extrahepatic metastasis and vascular invasion identifiable with preoperative images, a solitary tumor of 5 cm or less, or if there are multiple tumors, three or fewer tumors measuring 3 cm or less in diameter at a maximum (Milan criteria) (LF005401 level 2a). (hormonessignaling.com)
When combined with non-invasive PET/CT imaging, tumors and metastases can be clearly seen. (alfaoncology.com)
Our researchers are currently planning to develop nanoantibody technology for the treatment of tumors and metastases. (alfaoncology.com)
Primary tumors create a premetastatic niche (PMN) in secondary organs for subsequent metastases. (thno.org)

Inflammation and obesity induces lymphangiogenesis. (turkupetcentre.net)

This unequivocal requirement for a functional lymphatic vasculature in the priming of cutaneous immunity further supports the prediction that LVD may be a novel biomarker of immune reactivity within tumor parenchyma. (aacrjournals.org)

Angiosarcomas Express Mixed Endothelial Phenotypes of Blood and Lymphatic Capillaries: Podoplanin as a Specific Marker for Lymphatic Endothelium," American Journal of Pathology, Vol. 154, 1999, pp. 385-394. (scirp.org)

We determine a comprehensive map of lineage-specific lncRNAs in human dermal lymphatic and blood vascular endothelial cells (LECs and BECs), combining RNA-Seq and CAGE-Seq. (nature.com)

We studied tumour lymphangiogenesis and lymphatic invasion using D2-40 endothelial marker in 35 breast cancer patients treated by primary surgery and correlated it with various clinico-pathological prognostic parameters. (scirp.org)
Tumour Angiogenesis and Metastasis-Correlation in Invasive Breast Carcinoma," The New England Journal of Medicine, Vol. 324, No. 1, 1991, pp. 1-8. (scirp.org)
Suppression of Tumour Lymphangiogenesis and Lymph Node Metastasis by Blocking Vascular Endothelial Growth Factor Receptor 3 Signaling," Journal of the National Cancer Institute, Vol. 94, No. 11, 2002, pp. 819-825. (scirp.org)
Surprisingly, KIM-1 expression had no effect on cell proliferation or subcutaneous tumour growth in immune deficient (Rag1-/-) Balb/c mice, but inhibited cell invasion and formation of lung metastasis in the same model. (bvsalud.org)
Our findings reveal a novel role for KIM-1 in inhibiting metastasis of RCC and suggests that tumour-associated KIM-1 expression may be a favourable prognostic factor. (bvsalud.org)
Tumour growth can obstruct lymph flow, causing lymph reflux and lymphatic-venous shunting, which may promote metastasis formation. (turkupetcentre.net)
Studies have shown that a high expression of neuropilins (NRPs) promotes tumourigenesis and tumour malignancy. (hindawi.com)

Lymph is collected to large lymphatic trunks, including thoracic duct and right lymphatic duct, that lead the lymph into subclavian veins. (turkupetcentre.net)
My translational interests and contributions have spanned blood/lymphatic vascular endothelial cell biology and pathobiology in vitro and in vivo, hepatosplanchnic lymphatic/microcirculatory physiology, small animal models, in vivo lymphatic imaging, thoracic duct lymph drainage, lymphogenous cancer spread, and genomics/proteomics of lymphedema-angiodysplasia syndromes in man and experimental models, including defects, deficiency, and overexpression of human and murine lymphangio- gene-sis genes and their syndromic/phenotypic manifestations. (arizona.edu)

Lymphatic drainage fails in the advanced stages of the disease. (turkupetcentre.net)
To test the first part of this hypothesis (A), we have continued our published work and used a cutaneous model of viral infection to demonstrate the requirement for lymphatic vessel drainage in cutaneous immunity. (aacrjournals.org)
It is a chronic progressive disease characterized by high-protein edema of various parts of the body due to defects in lymphatic drainage. (biomedcentral.com)
Long existence of the high-protein edema causes chronic inflammation leading to the replacement of adipose tissue with connective tissue, increasing the volume of connective tissue matrix, which subsequently leads not only to an increase in size of body parts, but also to a secondary disturbance of lymphatic transport and drainage [ 2 ]. (biomedcentral.com)

Prognostic Value of Lymphatic and Blood Vessel Invasion in Neuroendocrine Tumours of the Lung," The American Journal of Surgical Pathology, Vol. 29, 2005, pp. 324-328. (scirp.org)
The reconstituted ECM creates a loose microenvironment for the proliferation and differentiation of tumor cells, resulting in high proliferation, low differentiation, invasion and metastasis of tumor cells. (alfaoncology.com)
Combined with molecular biology techniques, it was revealed that the changes of endogenous multiphoton signals of EMC in the process of tumor proliferation, invasion, metastasis, and epithelial-mesenchymal transition. (alfaoncology.com)

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. (nih.gov)

Our previous studies show that activation of the VEGF-C/VEGFR-3 axis promotes cancer metastasis and is associated with clinical progression in patients with lung cancer, indicating that VEGFR-3 is a potential target for cancer therapy. (oncotarget.com)
Therefore, we propose to investigate p.G533C mutation on gene RET associated to inherited MTC genesis modulating different VEGF isoforms, VEGFR, and other mediators involved on the process of angiogenesis and lymphangiogenesis on tumor progression. (fapesp.br)
Lymphatic vessel remodeling and lymphangiogenesis is correlated with melanoma progression and lymph node metastasis. (aacrjournals.org)
Analysis of interactions of these genes in the associative gene network of lymphedema can improve understanding of mechanisms of interaction between endothelial apoptosis and lymphangiogenesis, and shed light on the role of disturbance of these processes in the development of edema, chronic inflammation and connective tissue transformation during the progression of the disease. (biomedcentral.com)
Hypoxia, a condition of oxygen deprivation, is considered a hallmark of tumor microenvironment regulating several pathways and promoting cancer progression and resistance to therapy. (biomedcentral.com)
Moreover, semaphorins and their cognate receptors are involved in controlling cancer stem cell phenotype, contributing to tumor progression, resistance to therapies, and metastasis initiation [ 18 ]. (biomedcentral.com)

Relying on the technology platform of the Tumor Microenvironment Center, Alfa Oncology provides a full range of solutions for extracellular matrix changes during tumor metastasis, helping researchers successfully achieve their research goals. (alfaoncology.com)
At present, Alfa Oncology mainly uses multiphoton imaging technology, nanoantibody technology, multiplex immunohistochemistry , tissue decellularization technology , single cell sequencing and mass spectrometry to study the changes of extracellular matrix during tumor metastasis. (alfaoncology.com)

The elevated expression of several angiogenic factors, including vascular endothelial growth factor (VEGF), basic fibroblast growth factor (FGF) and interleukin-8, has been detected in primary cutaneous melanomas, and the importance of these mediators in promoting melanoma angiogenesis and metastasis has been confirmed in tumor xenotransplant models. (dermatologytimes.com)
Consistently, TCGA analysis of human cutaneous metastatic melanoma identified positive correlations between LEC gene expression and immune genes, including a T cell-inflamed signature, indicating a relationship between lymphatic vessel remodeling and local immunity. (aacrjournals.org)
Following cutaneous vaccinia infection we demonstrate that in the absence of lymphatic vessel transport, both cellular and humoral adaptive immune responses fail to initiate, leading to enhanced cutaneous immunopathology and persistent viral load. (aacrjournals.org)

M. A. Ansari, V. Pandey, V. Srivastava, M. Kumar, R. Mishra and A. Kumar, "Lymphangiogenesis as a Prognostic Marker in Breast Cancer Using D2-40 as Lymphatic Endothelial Marker-A Preliminary Study," Journal of Cancer Therapy , Vol. 3 No. 5A, 2012, pp. 814-821. (scirp.org)
Evidence for Lymphangiogenesis and Its Prognostic Implications in Head and Neck Squamous Cell Carcinoma," Journal of Pathology, Vol. 206, No. 2, 2005, pp. 170-177. (scirp.org)
He explains that the extent of tumor lymphangiogenesis is a highly sensitive (83 percent) and specific (89 percent) prognostic marker of lymph node metastasis. (dermatologytimes.com)
The lymphatic system is an important route for cancer dissemination, and lymph node metastasis (LNM) serves as a critical prognostic determinant in cancer patients. (nii.ac.jp)

More specifically, prior studies conducted on certain types of transgenic mice have shown that fat-rich diets comprising trans-fatty acid (TFA), saturated fatty acid (SFA), and cholesterol cause non-alcoholic fatty liver disease, which may then promote inflammation and tumor formation in the liver. (toppersonalhealth.com)
We found that lymphangiogenesis in chronic inflammation and secondary lymphedema was regulated by COX-2. (nii.ac.jp)

In contrast to this, however, many reports independently correlate peritumoral LVD with lymph node metastasis and some poor prognosis (3). (aacrjournals.org)
High CCL2 and CCL5 expression was associated with tumor metastasis and poor prognosis in BC patients. (thno.org)

Such metastases directly affect treatment choices and regimens as well as prognosis, according to Michael Detmar, M.D., professor of pharmacogenomics at the Institute of Pharmaceutical Sciences, Zurich, Switzerland, and associate professor of dermatology at Harvard Medical School. (dermatologytimes.com)
VEGF messenger RNA (mRNA) is widely overexpressed in tissues and is associated with metastasis, recurrence, and prognosis [ 2 ]. (hindawi.com)

Tumor metastasis refers to the process of tumor spread from the primary tumor to distant tissues and organs, and is a characteristic of tumor malignancy. (alfaoncology.com)

Vascular endothelial growth factor receptor 3 (VEGFR-3) supports tumor lymphangiogenesis. (oncotarget.com)
Despite the fact that it is well-known that Vascular Endothelial Growth Factor (VEGF) binds to its receptor VEGFR and initiates endothelial cell proliferation, almost nothing is known about their involvement and mechanisms in the process of MTC metastasis.Interestingly, RET (RET/PTC) gene rearrangement, present in papillary thyroid carciomas, modulates the expression of many genes that could be involved on tumor growth and angiogenesis, such as CXCL12 and CXCR4. (fapesp.br)
Says Prof. Tanaka, "Long-term feeding of SFA and TFA diets to HCVcpTg mice increased the expressions of vascular endothelial cell indicators like CD31 and TEK receptor tyrosine kinase, in addition to lymphatic vessel endothelial hyaluronan receptor 1. (toppersonalhealth.com)
Evolutionary Differences in the Vegf/Vegfr Code Reveal Organotypic Roles for the Endothelial Cell Receptor Kdr in Developmental Lymphangiogenesis. (shengsci.com)

Melanoma researchers have therefore been concentrating their efforts on learning more about angiogenesis, lymphangiogenesis and the nature of metastasis in order to better understand which types of melanomas have a tendency to metastasize. (dermatologytimes.com)
Dr. Detmar set out to investigate whether the extent of tumor lymphangiogenesis can predict melanoma metastasis to sentinel lymph nodes. (dermatologytimes.com)
Furthermore, our previous work demonstrated that vascular endothelial growth factor C (VEGFC)-driven lymphangiogenesis in the context of murine melanoma drove increased leukocyte infiltration but associated with poor CD8+ T cell priming in draining lymph nodes (4). (aacrjournals.org)
Recently we have demonstrated that one member of the class 3 semaphorins, Semaphorin 3F (SEMA3F), can inhibit human melanoma metastasis. (harvard.edu)
Melanoma is the most lethal skin cancer with most deaths occurring from distant metastases. (harvard.edu)

It was originally identified as a lymphangiogenic factor expressed in lymphatic endothelial cells. (oncotarget.com)
An ideal inhibitor may be one that is anti-angiogenic as well as anti-lymphangiogenic, thereby suppressing both routes of metastasis. (harvard.edu)

SEMA3F may inhibit angiogenesis and lymphangiogenesis by a novel mechanism, which is the repulsion of vascular and lymphatic endothelial cells (EC) expressing NRP2 similar to the way SEMA3F repels neurons. (harvard.edu)
In addition to their expression in neurons, Neuropilin 1 (NRP1) is expressed in epithelial cells and endothelial cells, while Neuropilin 2 (NRP2) is expressed in endothelial cells (both vascular and lymphatic) and visceral smooth muscle cells. (navbo.org)

Lymphatic capillaries consist of overlapping endothelial cells , and lack pericytes and smooth muscle cells. (turkupetcentre.net)
Endothelial junctions in lymphatic capillaries serve as a microvalve which allows the interstitial fluid and small particles (≤25 nm) to flow into the lumen, but reduces the leakage from lumen back into the interstitium. (turkupetcentre.net)

Lymphangiogenesis was quantified using lymphatic micro vessel density (LMVD) by counting the immunostained lymphatic microvessels at 200X. (scirp.org)
Furthermore, others have recently demonstrated that lymphatic vessel density (LVD) in combination with intratumoral T cell function stratified best overall survival in nonmetastatic and metastatic colorectal cancer (2). (aacrjournals.org)

In addition, no distant metastases were detected in any of the mice regardless the group. (nagoya-u.ac.jp)
Cancer cells can travel via lymphatic system to distant sites. (turkupetcentre.net)

The migrating tumor cells infiltrate the lymphatic or vascular system. (alfaoncology.com)

e lymphatic blood vascular endothelial cells are activated by several in�ammatory mediators (e.g., vascular endothelial growth capillariestakeupthisprotein-rich�uid,therebymaintaining factor- (VEGF-)A, tumor necrosis factor (TNF-) , inter- not only tissue �uid homeostasis but also exerting immune leukin (IL)-6, and IL-1), leading to the typical signs of surveillance. (sagepub.com)
It is also known that Tumor-Associated Macrophages (TAM) are attracted by CXCL12 and VEGF, and can promote angiogenesis and tumor metastasis. (fapesp.br)
VEGF is one of most important mediators of neoplastic angiogenesis and lymphangiogenesis (Hirakawa et al . (vin.com)
Lymphangiogenesis is regulated by VEGF-C and VEGF-D, and indirectly by NO. MMP-9 participates in lymphatic regeneration. (turkupetcentre.net)
According to Prof. Tanaka , "We demonstrated for the first time that hepatic angiogenesis and lymphangiogenesis were enhanced by saturated-fat- or trans-fat-rich diets, but not cholesterol-rich diets, mainly through the JNK-HIF1α-VEGF-C axis. (toppersonalhealth.com)
We possess previously uncovered HSV-1 elicits corneal lymphangiogenesis through a exclusive system regarding vascular endothelial development aspect (VEGF)-A indie of that defined for various other insults including transplantation or microbial infections. (scienceexhibitions.org)
As VEGF-A is certainly included in generating neovascularization linked with growth metastasis and development, protein that impact transcriptional control of VEGF-A may end up being useful in the advancement of adjunct therapy for such disparate illnesses as cancers and HSV-1 keratitis. (scienceexhibitions.org)
Most significantly, they have found that VEGF-C over-expression leads to lymphangiogenesis, intralymphatic tumor growth and lymph node metastasis in several tumor models. (euroacadti.eu)

Angiogenesis and lymphangiogenesis, the growth of structures. (sagepub.com)
In conclusion, local implantation of ADRCs promotes angiogenesis in response to tissue ischemia in the hind limb without promoting remote tumor growth and related angio/lymphangiogenesis. (nagoya-u.ac.jp)
The researchers then monitored the degree of hepatic angiogenesis and lymphangiogenesis and growth factor expression using a variety of techniques including quantitative mRNA measurement, immunoblot analysis, and immunohistochemistry. (toppersonalhealth.com)
A model of the angiopoietin 2 growth factor secretion from lymphatic endothelial cells and the effect of ANGPT2 mutations on the development of lymphedema. (genengnews.com)
Wong LL*, Lee NG*, Amarnani D, Choi CJ, Bielenberg DR, Freitag SK, D'Amore PA, Kim LA. (2016) Orbital angiogenesis and lymphangiogenesis in thyroid eye disease: an analysis of vascular growth factors with clinical correlation. (navbo.org)
A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development. (jeltsch.org)
For instance, while several semaphorins have been reported to reduce tumor growth and angiogenesis, others are found to promote tumor growth or metastasis [ 10 ]. (biomedcentral.com)

The blood and lymphatic vascular systems are essential for the efficient transport of oxygen, nutrients, signaling molecules, and leukocytes to and from peripheral tissues, the removal of waste products, and the preservation of fluid homeostasis. (nature.com)
Lymphedema can occur when tissue fluid cannot enter or leaks from the lymphatic system into surrounding tissues. (genengnews.com)
In 1889, Dr. Stephen Paget's "seed and soil" theory of metastasis stated that a tumor cell (or seed) will find a home in certain compatible tissues (soil) to continue growing in a suitable environment [ 1 ] . (encyclopedia.pub)

Lymphatic vascular development establishes embryonic and adult tissue fluid balance and is integral in disease. (shengsci.com)

In contrast, lymphatic vasculogenesis starts after the establishment of the blood circulatory system. (nature.com)
ICAM-)1, vascular cell adhesion molecule- (VCAM-)1, elargestcollectinglymphaticvessel,thethoracicduct,con- and E-selectin on activated blood vascular endothelial cells, nects the lymphatic system with the cardiovascular system. (sagepub.com)
The mutations result in loss of the normal function of the ANGPT2 protein that is known to play a role in lymphatic and blood vessel maturation. (genengnews.com)

LncSNHG5 was highly expressed in breast CAFs and played an essential role in premetastatic niche formation by promoting angiogenesis and vascular leakiness through regulation of ZNF281 in CAFs. (thno.org)
The lncSNHG5-ZNF281-CCL2/CCL5 signaling axis plays an essential role in inducing premetastatic niche formation to promote BC metastasis. (thno.org)
Our work demonstrates that lncSNHG5 and its downstream signaling ZNF281-CCL2/CCL5 in CAFs play a crucial role in premetastatic niche formation in breast cancer and may serve as potential targets for the diagnosis and treatment of BC metastasis. (thno.org)

Cancer-associated fibroblasts (CAFs) are a predominant stromal component in the tumor microenvironment and serve as a major contributor to tumor metastasis. (thno.org)

esides the increased in�amma- tory cell in�ltration into the in�amed tissue, it has become In vertebrates, there are two vascular systems: the cardio- clearintherecentyearsthatacuteandchronicin�ammatory vascular and the lymphatic system. (sagepub.com)
Therapy is limited to repeated manual lymphatic massage and use of compressive garments that are intended to decrease tissue swelling. (genengnews.com)

Absence of Functional Lymphatics within a Murine Sarcoma: A Molecular and Functional Evaluation," Cancer Research, Vol. 60, No. 16, 2000, pp. 4324-4327. (scirp.org)

The laboratory is especially interested in the role of neuropilins in cancer cells and examining the use of soluble neuropilin isoforms or inhibitory class 3 semaphorin ligands as inhibitors of tumor-associated angiogenesis and lymphangiogenesis. (navbo.org)
Jeltsch M . VEGFR-3 Ligands and Lymphangiogenesis [Internet]. (jeltsch.org)

I continue to work on a variety of infectious diseases and immune disorders (e.g., inflammatory bowel disease, AIDS, Kaposi sarcoma, tuberculosis, filariasis, congenital/hereditary lymphatic system syndromes, opportunistic infections/neoplasms) and direct an internationally recognized Lymphedema-Angiodysplasia clinic. (arizona.edu)

Anatomy14

Organisms8

Diseases33

Chemicals and Drugs20

Analytical, Diagnostic and Therapeutic Techniques and Equipment18

Phenomena and Processes8

Disciplines and Occupations1

Information Science1

Health Care4

Geographicals1

Vessels38

Breast Cancer Metastasis1

Tumors11

Induces lymphangiogenesis1

Vasculature1

Endothelium1

Dermal lymphatic1

Tumour7

Thoracic duct2

Drainage4

Invasion3

Endothelial cell growth1

Progression6

Extracellular matrix2

Cutaneous3

Prognostic4

Inflammation2

Poor prognosis2

Prognosis2

Organs1

Receptor4

Melanoma5

Lymphangiogenic2

NRP22

Capillaries2

Vessel density2

Distant2

Vascular system1

VEGF8

Growth7

Tissues3

Embryonic1

Blood3

Premetastatic niche3

Microenvironment1

Tissue2

Absence1

Ligands2

Congenital1