Promotes gata2 transcription factor. Medical search. Frequent questions

The erbA work led Martin Zenke to work on red blood cell differentiation, focussing on the just discovered GATA transcription factors. (wikipedia.org)
Notably, transfection with miR-409-3p mimics promoted the proliferation of cardiac fibroblasts and fibroblast-to-myofibroblast differentiation, accompanied by upregulated expression of Col1a1, Col3a1, and α -SMA. (hindawi.com)
For instance, miR-409-3p promotes epithelial to mesenchymal transition and tumor growth in prostate cancer and also accelerates osteoblastic differentiation through the Wnt/ β -catenin pathway [ 17 , 18 ], a crucial pathway in regulating cardiac fibrosis. (hindawi.com)
Dynamically and epigenetically coordinated gata/ets/sox transcription factor expression is indispensable for endothelial cell differentiation. (medicalxpress.com)
Furthermore, they found that a transcription factor group essential for blood vessel differentiation (ETS/GATA/SOX) has a previously unknown role. (medicalxpress.com)
Schematic representation of the genetic regulatory network linking four transcription factors and EC differentiation. (medicalxpress.com)
The protein GATA2, which binds to ETV2 and supports vascular endothelial differentiation, was induced immediately thereafter. (medicalxpress.com)
Transcription factors SOX and FLI1, both important for endothelial differentiation, were induced between 12 and 24 hours. (medicalxpress.com)
At 48 hours, after differentiation into vascular endothelium was determined, a system of transcription was established in which genes unique to vascular endothelial differentiation were induced. (medicalxpress.com)
Previously, in the region that controls the function of the transcription factor that promotes differentiation from ES cells to a specific cell type, bivalent modifications of histones such as the accelerator and brake histone marks for transcription were thought to have coexisted. (medicalxpress.com)
In development, lineage-restricted transcription factors simultaneously promote differentiation while repressing alternative fates. (prolekarniky.cz)
Here, we have analyzed cis element regulation of the critical hematopoietic factor Gata2 , which is expressed in early precursors and repressed as GATA-1 levels rise during terminal differentiation. (prolekarniky.cz)
Although Gata2 is normally repressed in late-stage erythroblasts, the −1.8 kb mutation unexpectedly resulted in reactivated Gata2 transcription, blocked differentiation, and an aberrant lineage-specific gene expression pattern. (prolekarniky.cz)
The transcription factor GATA2 regulates differentiation of brown adipocytes. (harvard.edu)
The histone methyltransferase Setd8 alters the chromatin landscape and regulates the expression of key transcription factors during erythroid differentiation. (rochester.edu)
Granulocyte-macrophage colony-stimulating factor (GM-CSF) promotes the proliferation and differentiation of hematopoietic progenitor cells and the generation of neutrophils, eosinophils, and macrophages. (stemcell.com)
At the proliferation stage, proliferation related pathways and basic cellular and metabolic processes were inhibited, while regulatory factors that initiate differentiation enter the ready-to-activate state, which provides a precondition for initiating adipose differentiation. (biomedcentral.com)
Moreover, we identified and classified more than 100 transcription factors that showed significant changes during differentiation, and found novel transcription factors that were not reported to be related to preadipoctye differentiation. (biomedcentral.com)

He found that GATA-1 promotes red blood cell development whereas GATA-2 blocks red blood cell development. (wikipedia.org)
Herein, by analyzing multi-omics data, GATA binding protein 2 (GATA2) and its antisense RNA 1 (GATA2-AS1) were identified to suppress MAS during NB progression. (bvsalud.org)
Furthermore, an examination of the histone code revealed that the regulatory genomic region of the transcription factors (ETS/GATA/SOX) was found to have gradually switched from a "brake histone mark," which suppresses transcription, to an "accelerator histone mark," which activates transcription, while in the process of differentiating into the vascular endothelium. (medicalxpress.com)
GATA factor cross-regulation represents an instructive model system for investigating the contribution of individual cis elements to the initiation and maintenance of transcriptional repression. (prolekarniky.cz)
The GATA family of transcription factors plays diverse roles in multiple developmental contexts [5] . (prolekarniky.cz)
GATA factors are often expressed in an overlapping but reciprocal pattern, such that expression of one GATA factor increases as expression of another decreases. (prolekarniky.cz)
For example, GATA-1 directly represses Gata2 transcription via displacing GATA-2 from chromatin sites at its own locus, a process termed a "GATA Switch" [6] , [7] . (prolekarniky.cz)
GATA factor function has been extensively studied in the context of hematopoiesis, where GATA-1, GATA-2, and GATA-3 are key regulators. (prolekarniky.cz)
GATA-2 has a broad role in hematopoietic development, as demonstrated by impaired hematopoiesis in Gata2 knock-out mice resulting in lethality during midgestation [8] , [9] . (prolekarniky.cz)
One such code defined by the homeodomain transcription factor Even-skipped (Eve) and by the GATA 2/3 homologue Grain (Grn) is specifically required for motor axon projection towards dorsal muscles in Drosophila . (biologists.com)

Haploinsufficiency of GATA2, also known as GATA2 deficiency, leads to a wide spectrum of clinical manifestations. (bvsalud.org)
We reviewed GATA2 deficiency patients with HLH and found that GATA2 variants causing loss of zinc finger domains were associated with HLH, and erythema nodosa might be an accompanying symptom. (bvsalud.org)
Germline mutation of the +9.5 enhancer (or coding mutations) cause GATA2-deficiency syndrome, which involves immunodeficiency, bone marrow failure and predisposition to develop myelodysplastic syndromes and acute myeloid leukemia. (wisc.edu)
The Clinical Spectrum, Diagnosis, and Management of GATA2 Deficiency. (cdc.gov)
HDAC inhibitor C001 is an inhibitor of HDACs with IC50 of 4 nM (HDAC1), 15 nM (HDAC2), 114 nM (HDAC3), and can increase Gata2 expression, which may be useful in treatment of Gata2-deficiency-associated diseases, including leukemia and other blood cell disorders. (csnpharm.cn)

They promote the proliferation of fibroblasts, fibroblast-to-myofibroblast transdifferentiation (FMT), and ECM accumulation [ 10 ]. (hindawi.com)
Proliferation was characterized by enrichment in genes involved in basic cellular and metabolic processes (transcription, ribosome biogenesis, translation and protein folding), cellular remodelling and autophagy. (biomedcentral.com)
A) The biological activity of Human Recombinant GM-CSF was tested by its ability to promote the proliferation of TF-1 cells. (stemcell.com)
2021. Gata2 haploinsufficiency promotes proliferation and functional decline of HSCs with myeloid bias during aging . (cardiff.ac.uk)
X-VIVO Serum-free Hematopoietic Cell Media provide nutritionally complete and balanced environments for a variety of cells including lymphokine activated killer (LAK) cells, peripheral blood lymphocytes (PBL), and tumor infiltrating lymphocytes (TIL).These media do not contain any exogenous growth factors, artificial stimulators of cellular proliferation, or undefined supplements. (lonza.com)

The cyclin-dependent kinase 7 (CDK7) subunit of TFIIH regulates RNA polymerase-II-based transcription and promotes tumor progression. (biomedcentral.com)

Moreover, GATA2 was identified as a cardiac fibrosis-associated upstream positive transcription factor of miR-409-3p. (hindawi.com)
As a long non-coding RNA destabilized by RNA binding motif protein 15-mediated N6-methyladenosine methylation, GATA2-AS1 bound with far upstream element binding protein 3 (FUBP3) to repress its liquid-liquid phase separation and interaction with suppressor of zest 12 (SUZ12), resulting in decrease of SUZ12 activity and epigenetic up-regulation of GATA2 and other tumor suppressors. (bvsalud.org)
Remarkably, homozygous mice harbouring the cyclin B1 mitosis degradation domain upstream Gata2 partially phenocopy knockout mice. (bvsalud.org)
We engineered mice lacking a single cis element −1.8 kb upstream of the Gata2 transcriptional start site. (prolekarniky.cz)

We discovered GATA2 enhancers that are essential for hematopoiesis and embryonic development, and their disruption causes human diseases. (wisc.edu)
We identified GATA2-instigated networks that control hematopoiesis and are deciphering the importance of components of these networks, including many genes/proteins representing potential targets to enhance the diagnosis, treatment and prevention of bone marrow failure, leukemia and clonal hematopoiesis of indeterminate potential (CH). CH afflicts large numbers of people, especially the elderly, and is associated with blood cancers and cardiovascular disease. (wisc.edu)

Interestingly, three soluble factors released from imMKCLs in the turbulent flow condition, macrophage migration inhibitory factor (MIF), insulin growth factor binding protein 2 (IGFBP2), and nardilysin (NRDC), enhanced platelet production. (biomedcentral.com)

Mechanistically, POM121 promoted PC progression by enhancing importin-dependent nuclear transport of key oncogenic (E2F1, MYC) and PC-specific (AR-GATA2) transcription factors, uncovering a pharmacologically targetable axis that, when inhibited, decreased tumor growth, restored standard therapy efficacy, and improved survival in patient-derived pre-clinical models. (elsevierpure.com)
Rescue experiments revealed that GATA2-AS1 inhibited MAS and NB progression via repressing interaction between FUBP3 and SUZ12. (bvsalud.org)
These findings suggest that GATA2-AS1 inhibits FUBP3 phase separation to repress MAS and NB progression via modulating SUZ12 activity. (bvsalud.org)
Histone H3.3 G34 mutations promote aberrant PRC2 activity to drive tumor progression. (wisc.edu)
RNA-Seq analyses demonstrated that neutrophil cytosolic factor 1 (NCF1), a key factor in controlling neutrophilic ROS production, was upregulated and correlated with hepatic inflammation and disease progression. (jci.org)

Here we described another 28-year-old man with a GATA2 variant who also suffered from hemophagocytic lymphohistiocytosis(HLH), who was finally diagnosed with HLH triggered by Mycobacterium avium bloodstream infection due to primary immunodeficiency. (bvsalud.org)
The Ets variant 2 (ETV2) transcription factor, which belongs to the E26 transformation-specific (ETS) family, has been reported to play a key role in neovascularization. (biomedcentral.com)
In particular, the ETS factor, Ets variant 2 (ETV2), is closely linked to development of the vascular lineage [ 19 ]. (biomedcentral.com)
In many of these cases, a single exon is involved, and its transcription yields a variant mRNA [ 5 ]. (ecancer.org)
We found that H3K9me3, the histone variant H3.3 and its deposition factor ATRX-DAXX, and the Human Silencing Hub (HuSH) complex function together to silence retrotransposable elements in mammals. (wisc.edu)

In mitosis, most transcription factors detach from chromatin, but some are retained and bookmark genomic sites. (bvsalud.org)
The GATA2 work guided genomic studies that identified a large enhancer cohort predicted to serve critical roles. (wisc.edu)
Covalent modifications to DNA and histone proteins allows chromatin to act as a dynamic information hub that integrates diverse biochemical stimuli to regulate genomic DNA access for transcription. (wisc.edu)
We seek to define the factors that impact PRC2 recruitment and activity by using a combination of biochemical and genomic approaches. (wisc.edu)
Our research seeks to define the pathways and factors involved in establishing heterochromatin at transposons and other highly repetitive genomic sequences. (wisc.edu)

CEBPADM) in acute myeloid leukemia (AML) with a combination of hypermorphic N-terminal mutations (CEBPANT), promoting expression of the leukemia-associated p30 isoform, and amorphic C-terminal mutations. (bvsalud.org)
Recombinant human GM-CSF (rhGM-CSF) promotes the production of myeloid cells of the granulocytic (neutrophils, eosinophils and basophils) and monocytic lineages in vivo. (stemcell.com)
2023. Nuclear factor I-C overexpression promotes monocytic development and cell survival in acute myeloid leukemia . (cardiff.ac.uk)

Nuclear pore complexes (NPCs) regulate nuclear-cytoplasmic transport, transcription, and genome integrity in eukaryotic cells. (elsevierpure.com)
However, how transcription codes regulate axon pathfinding remains poorly understood. (biologists.com)
In order to understand the development of adiposity, it is crucial to identify the factors and mechanisms that regulate the recruitment of mesenchymal stem cells (MSCs) of the vascular stromal fraction of the adipose tissue and its transformation into lipid-filled adipocytes. (biomedcentral.com)

Finally, we constructed the drug, transcription factors (TFs), and microRNA network of the diagnostic genes. (nature.com)
The most frequently co-mutated genes in CEBPADM AML are GATA2 and TET2, however the molecular mechanisms underlying this co-mutational spectrum are incomplete. (bvsalud.org)
Representative activated (red) or repressed (blue) genes by each transcription factor are shown in the box. (medicalxpress.com)
Insertions of TEs influence the transcriptional regulation of some genes as well as the termination of transcription. (ecancer.org)
To preserve cell identity, lineage-specific gene expression must be maintained, and failure to silence genes from other lineages has the potential to cause developmental defects or promote tumorigenesis. (wisc.edu)

1979-1986: SV40 Enhancer and SV40 Chromatin In the 1980s Martin Zenke's research focused on gene transcription and chromatin. (wikipedia.org)
This is textbook knowledge nowadays but in the 1980s enhancers were initially thought to boost transcription by a unique and particular strong enhancer sequence and factor. (wikipedia.org)
Elevated CEBPA levels, driven by CEBPANT, mediate recruitment of TET2 to the Gata2 distal hematopoietic enhancer thereby increasing Gata2 expression. (bvsalud.org)

Studies are testing whether dysregulation of these components in families with a history of hematologic disease, yet lack mutations in established hematopoietic regulators, corrupts GATA2 genetic networks as a pathogenic mechanism. (wisc.edu)

Our results demonstrated that ETV2 overexpression significantly upregulated the mRNA and protein expression levels of osteogenic markers, markedly enhanced ALP activity, and promoted matrix mineralization of hDPSCs. (biomedcentral.com)
2022. Protein kinase C epsilon overexpression is associated with poor patient outcomes in AML and promotes daunorubicin resistance through p-glycoprotein-mediated drug efflux . (cardiff.ac.uk)
Overexpression of Dlx3 (but not GATA2 ) in the neural plate is sufficient to induce different non-neural markers in a signaling-dependent manner, with epidermal markers being induced in the presence, and panplacodal markers in the absence, of BMP signaling. (xenbase.org)

POM121- and importin β-mediated nuclear import of a subset of oncogenic transcription factors promotes prostate cancer aggressiveness and reveals a pharmacologically targetable dependency. (elsevierpure.com)
GATA2 bookmarks a subset of its interphase targets that are co-enriched for RUNX1 and other regulators of definitive haematopoiesis. (bvsalud.org)

B) Histone marking on the regulatory region of EC master transcription factors was switched following the order, (1) release the brake mark and then (2) enter the acceleration mark. (medicalxpress.com)
The covalent modification of histones to yield specific histone marks promotes either the activation or repression of transcription [3] . (prolekarniky.cz)

We also highlight recent studies identifying the cis -regulatory elements such as enhancers at the global level and explain how their developmental activity is regulated by the cooperation of cell-type specific and ubiquitous transcription factors with extrinsic signals. (amegroups.org)

We show that GATA2 remains bound to chromatin throughout mitosis, in contrast to GFI1B and FOS, via C-terminal zinc finger-mediated DNA binding. (bvsalud.org)

This complex process is regulated by the interplay of transcription factors with a chromatin environment, both of which provide the epigenetic information maintaining cell-type specific gene expression patterns. (amegroups.org)
The whole adipogenic process was driven by a coordinated activation of transcription factors and epigenetic modulators. (biomedcentral.com)

We further show that Dlx3 and GATA2 are required cell-autonomously for panplacodal and epidermal marker expression in the non-neural ectoderm , while ectopic expression of Dlx3 or GATA2 in the neural plate suppresses neural plate , border and crest markers. (xenbase.org)

In synergy with other cytokines such as stem cell factor, IL-3, erythropoietin, and thrombopoietin, it also stimulates erythroid and megakaryocyte progenitor cells (Barreda et al. (stemcell.com)

Notably, low GATA2-AS1 or GATA2 expression and high FUBP3, SUZ12, GOT2 or MDH2 levels were linked with unfavorable outcome of NB patients. (bvsalud.org)

This endocardial Notch signaling can in turn non-cell autonomously initiate myocardial Erbb2 and BMP signaling to promote cardiomyocyte reprogramming and heart regeneration, whereas its inhibition through either using tissue-specific genetic-based strategies or altering blood flow impairs this reparative event. (elifesciences.org)

In vitro hematopoietic systems might be improved by identifying novel factors from human genetic studies. (biomedcentral.com)

Taken together, these findings demonstrate a non-neural versus neural origin of placodes and neural crest , respectively, strongly implicate Dlx3 in the regulation of non-neural competence, and show that GATA2 contributes to non-neural competence but is not sufficient to promote it ectopically. (xenbase.org)

We observe several master transcription regulators (e.g. (biomedcentral.com)

These studies reveal how an individual cis element establishes a normal developmental program via regulating specific steps in the mechanism by which a critical transcription factor is repressed. (prolekarniky.cz)

Each transcription factor can independently induce unc-5 expression but unc-5 expression is more robust when both factors are expressed together. (biologists.com)
Specifically, these altered forces are sensed by the endocardium through the mechanosensitive channel Trpv4 to control Klf2a transcription factor expression. (elifesciences.org)
Altonsy MO, Mostafa MM, Gerber AN , Newton R. Long-acting beta2-agonists promote glucocorticoid-mediated repression of NF-kappaB by enhancing expression of the feedback regulator TNFAIP3. (nationaljewish.org)
In this review, we highlight the main signals and transcription factors and how they are integrated at the level of chromatin programming and gene expression control. (amegroups.org)
Peak evaluation is complex, as gene expression regulation involves interactions between combinatorial transcription factor binding sites and chromatin states. (biomedcentral.com)
4)IH promoted the expression of miR-486( P ＜0.01) and inhibited Sirt1 expression in K562 cells( P ＜0.01). (magtechjournal.com)

Gpd1 siRNA abolished the antifibrotic effect of miR-409-3p inhibitor in neonatal rat cardiac fibroblasts, suggesting that miR-409-3p promotes cardiac fibrosis at least partially through Gpd1. (hindawi.com)

Concurrent loss of TET2 in CEBPADM AML induces a competitive advantage by increasing Gata2 promoter methylation, thereby rebalancing GATA2 levels. (bvsalud.org)
Corynebacterium tuberculostearicum, a human skin colonizer, induces the canonical nuclear factor-kappaB inflammatory signaling pathway in human skin cells. (nationaljewish.org)

Results Our findings indicate that the platelets in HD are dysfunctional with respect to the release of angiogenic factors and functions including thrombosis, angiogenesis and vascular haemostasis. (bmj.com)

We examine the impact that processes such as transcription and replication have on genome stability. (birmingham.ac.uk)
The archetype is the Ion Torrent Personal Genome Machine (PGM), but with similar form factors are the 454 Jr and MiSeq. (blogspot.com)
Transcription factors are specific proteins that bind to distinct sites on the genome. (biomedcentral.com)

Consequently, Klf2a then activates endocardial Notch signaling which results in the non-cell autonomous initiation of myocardial Erbb2 and BMP signaling to promote cardiomyocyte reprogramming and heart regeneration. (elifesciences.org)

This work led to the discovery of the Id2 transcription factor in DC development. (wikipedia.org)
Despite of the relevance of this issue, very little is known about the factors regulating the development of adipose tissue in fish, and the possible health alterations associated to an increased fat deposition. (biomedcentral.com)

The activity of these elements is controlled by transcription factors (TFs) which bind to DNA wrapped into chromatin, leading to the modification of the chromatin landscape, and the assembly of the transcription machinery. (amegroups.org)

While transcription factors bind and recruit chromatin-modifying and remodeling proteins, the relative contribution of individual cis elements residing within clusters of cis elements to the transcriptional control of endogenous loci is incompletely understood. (prolekarniky.cz)

Molecular dissection of this process has been challenging as transcription factor loci are regulated by many trans -acting factors functioning through dispersed cis elements. (prolekarniky.cz)

Th1 cytokines TNF-alpha and IFN-gamma promote corticosteroid resistance in developing human airway smooth muscle. (nationaljewish.org)
HEXIM1 is an Essential Transcription Regulator During Human Erythropoiesis. (rochester.edu)

Circadian rhythms refer to the 24-hour cycles of biological processes that promote daily functioning. (warf.org)

Here, we address mitotic retention of the hemogenic factors GATA2, GFI1B and FOS during haematopoietic specification. (bvsalud.org)
Transcription factor codes play an essential role in neuronal specification and axonal guidance in both vertebrate and invertebrate organisms. (biologists.com)

Mechanistic studies revealed that GATA2 inhibited the transcription of glutamic-oxaloacetic transaminase 2 (GOT2) and malate dehydrogenase 2 (MDH2). (bvsalud.org)

Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. (harvard.edu)

Of clinical relevance, demethylating treatment of Cebpa-Tet2 co-mutated AML restores Gata2 levels and prolongs disease latency. (bvsalud.org)

LncRNA IMFlnc1 increases caveolin-1 by sponging miR-199a-5p to promote porcine intramuscular adipocyte adipogenesis [ 9 ]. (animbiosci.org)

During the creation of new blood vessels, the vascular endothelial growth factor (VEGF) protein differentiates stem cells into vascular endothelial cells and stimulates them to create new blood vessels. (medicalxpress.com)

We found that miR-409-3p was consistently increased in three fibrotic models, including heart tissues of postmyocardial infarction (MI) mice and neonatal rat cardiac fibroblasts treated with angiotensin II (Ang II) or transforming growth factor- β (TGF- β ). (hindawi.com)

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GATA10

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Binding protein1

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Regulate3

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Enhancer3

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