MRNAUpstream open learniMRNAsStart codonTumorMiRNAsTranscriptHelicaseEukaryotic translation initiation factorSubunitRegulateProteinGenesCarcinomaGenomeVariantsVIVOAccumulationProgressionInvolvementConverselyPathwayInhibitProteinsIncidencePathwaysMiceResponseRegulationTranslationBiogenesisExpressionCellLongArticleCalciumCancerCellsDeathTherapyStudyPreviouslyInternal
MRNA19
- mechanism underlying c-Myc down-regulation in response to UV-mediated DNA damage, wherein L11 promotes miR-130a-loaded miRISC to target mRNA. (nuche.org)
- According to the current model, scanning ribosomes translate the 5′-most uORF (uORF1) and, under non-starvation conditions, reinitiate translation at downstream uORFs 2, 3, or 4 and subsequently dissociate from the mRNA, keeping GCN4 translation repressed. (nih.gov)
- We have also investigated the roles of various eIFs, tRNAi and the 40S subunit in scanning the mRNA 5′ untranslated region and in accurately identifying the AUG initiation codon. (nih.gov)
- For the translation of amino acids into proteins, 5' capping and later tailing at the 3' prime occurs in the mature mRNA. (biologyreader.com)
- The coding region also functions as a regulating sequence, exonic splicing enhancer and inhibitors in the precursor mRNA. (biologyreader.com)
- There are two untranslated regions in mature mRNA, one at 5' prime and the other at 3' prime . (biologyreader.com)
- Both 5' and 3' untranslated regions regulate mRNA stability due to varying affinity for ribonucleases and ancillary proteins that can promote or inhibit RNA degradation. (biologyreader.com)
- 3' or 5' UTR may influence the transitional efficiency by controlling the ribosome's ability to bind with the mRNA. (biologyreader.com)
- First, we completed our studies on the roles of the domains of the eukaryotic translation initiation factor eIF3 in promoting recruitment of mRNA and initiator tRNA to the ribosomal pre-translation initiation complex (PIC). (nih.gov)
- In our studies of the role of the RNA-activated ATPase eIF4A in promoting mRNA recruitment to the PIC, we showed that the PIC itself activates the ATPase function of the factor over and above the stimulation provided by RNA. (nih.gov)
- In addition, structures in the 5′-untranslated region (UTR) and body of the mRNA contribute in a non-additive manner to inhibiting recruitment of mRNAs to the PIC and in imposing a requirement for eIF4A. (nih.gov)
- These data are in contrast to prevailing models for mRNA recruitment, which suggest that eIF4A's sole role is to unwind secondary structures in the 5′-UTRs of mRNAs. (nih.gov)
- Trimmed mature miRNA is loaded and targets mRNA at the 3' or 5' untranslated region (UTR) by recognition of base-pairing in the miRNA-loaded RISC, where it is involved in gene silencing including translational repression and/or degradation along with deadenylation. (elsevierpure.com)
- MicroRNAs (miRNAs) negatively regulate gene expression post-transcriptionally by binding to the 3'-untranslated region (3'-UTR) of the target mRNA sequences and have been shown to be involved in various types of cancers. (biomedcentral.com)
- This study showed that miR-146a has a stimulatory role in HepG2 cells and promotes HepG2 cell migration and invasion by targeting FLAP mRNA. (biomedcentral.com)
- MicroRNAs (miRNAs), with the length of 18-22 nucleotides, have been shown to downregulate target mRNA expression post-transcriptionally by binding to the 3'-untranslated region (UTR) of the target mRNA sequences [ 9 ]. (biomedcentral.com)
- mRNA aim showed that RIDD craft can be slow down the stream out of newly synthesized peptides stepping into this new Emergency room, otherwise promote apoptosis. (dscompany-hp.com)
- Phosphorylation of eIF2α on Ser51 inhibits 5' cap-dependent mRNA translation, resulting in the global suppression of protein synthesis to facilitate adaptation to a variety of stresses linked to protein synthesis, including proteotoxic stress, viral replication, heme depletion and amino acid withdrawal [ 2 ]. (biomedcentral.com)
- Paradoxically, eIF2α phosphorylation also results in the increased translation of select mRNA bearing upstream open reading frames that favor 5' cap-independent translation [ 3 ]. (biomedcentral.com)
Upstream open learni1
- phosphorylation lets translation out-of a particular set of mRNAs one to hold a minumum of one upstream open learning frames inside their 5? (dscompany-hp.com)
MRNAs3
- By then targeting host translation initiation factors for degradation these viruses can promote their own translation to the detriment of the host (5 6 In contrast many DNA viruses produce mRNAs that resemble host mRNAs. (biongenex.com)
- MiRNAs bind the 3' untranslated region (3'UTR) of target mRNAs. (ukessays.com)
- MicroRNAs (miRNAs) are small noncoding RNAs (~22 nucleotides in length) that regulate gene expression post-transcriptionally by imperfect binding to the 3′ untranslated region of target mRNAs in a wide variety of cell types. (biomedcentral.com)
Start codon4
- ii) identifying a higher-order assembly of initiation factors 1, 2, 3, and 5-the multifactor complex (MFC)-and elucidating its roles in PIC assembly and accurate start codon selection. (nih.gov)
- The possible hypoxia response element (HRE) sequences in 5' non-coding Region before ATG start codon of Sema4D were screened, followed by point mutagenesis and luciferase assay analysis. (jcancer.org)
- The coding region begins with a " Start codon " (AUG) and ends with the " Termination codon " (UAA, UAG and UGA). (biologyreader.com)
- The 5' untranslated region is present in between the 5' cap and start codon. (biologyreader.com)
Tumor5
- CircHERC1 is a new circRNA that promotes tumor function in NSCLC and may serve as a potential prognostic biomarker and therapeutic target for NSCLC. (biomedcentral.com)
- Abnormal expression of 5-Lipoxygenase Activating Protein (FLAP) has been detected in many tumor cells. (biomedcentral.com)
- Here at Stanford, I am using different genome editing tools and mouse models to investigate the role of macrophages in promoting tumor progression and immune tolerance in liver cancer. (stanford.edu)
- The contribution of the microenvironment to promoting tumor growth has been recognized for decades [ 1 ]. (biomedcentral.com)
- Observed during CRC tumorigenesis is loss of post-transcriptional regulation of tumor-promoting genes such as COX-2, TNFα and VEGF. (oncotarget.com)
MiRNAs1
- miRNAs are exported by exportin-5 from the nucleus to the cytoplasm after cropping. (elsevierpure.com)
Transcript3
- There are four alternate promoters that promote different transcript variants. (wikipedia.org)
- This is regulated by 3' UTR that contain sequences, which allow the transcript to be localized to the region for translation. (biologyreader.com)
- These include the expression of specific transcript isoforms and 3' untranslated regions. (nih.gov)
Helicase1
- 5' RNA helicase. (colorado.edu)
Eukaryotic translation initiation factor1
- These viruses stimulate canonical cap-dependent initiation of translation by promoting eukaryotic translation initiation factor 4 subunit F (eIF4F) assembly while simultaneously stimulating the dephosphorylation of eIF2α to avoid suppression Timosaponin b-II of protein translation (7 8 Alternatively two DNA viruses that replicate in the cytosol poxviruses and asfarviruses have been suggested to promote viral translation by recruiting host translational factors to the sites of viral replication (9 -11). (biongenex.com)
Subunit1
- Three other factors, eIF1, eIF1A, and eIF3, also bind to the 40S subunit and promote the loading of the TC. (nih.gov)
Regulate2
- As a TF, USF1 has a bidirectional regulatory function, being able to regulate gene expression by activating or suppressing the promoter region of target genes ( 5 , 6 ). (spandidos-publications.com)
- In addition, circHERC1 can promote cell proliferation and inhibit apoptosis by sequestering FOXO1 in the cytoplasm to regulate AKT activity and BIM transcription. (biomedcentral.com)
Protein4
- The etiology of Parkinson's disease (PD) is linked with cellular inclusions in the substantia nigra pars compacta region of the brain that are enriched in the misfolded presynaptic protein α -synuclein ( α S) and death of the dopaminergic neurons. (hindawi.com)
- The major constituent of LBs is aggregated α -synuclein ( α S), an intrinsically unfolded protein predominantly localized in the presynaptic regions of dopaminergic neurons. (hindawi.com)
- The metabolic pathway of arachidonic acid (AA) has two main branches: 1) AA is converted by COX-1 and COX-2 into prostaglandins (PG) and thromboxane (TX), and 2) the actions of 5-lipoxygenase (5-LO) and 5-Lipoxygenase Activating Protein (FLAP) create leukotrienes (LT) in the other arm of the pathway [ 16 ]. (biomedcentral.com)
- Mechanistically, METTL3 mediates the N 6 -methyladenosine (m 6 A) modification of circIGF2BP3 and promotes its circularization in a manner dependent on the m 6 A reader protein YTHDC1. (biomedcentral.com)
Genes5
- It was also demonstrated that USF1 directly binds to the promoter region of 2,492 genes, which may be involved in the viral progression and cell proliferation pathways. (spandidos-publications.com)
- Promoter region motif analysis indicated that ETV5 has more binding motifs and genes than USF1 itself for USF1‑regulated DEGs, indicating that USF1 may indirectly modulate gene expression by regulating ETV5 expression in Huh7 cells. (spandidos-publications.com)
- In summary, the results demonstrated that USF1 binds to the promoter region of thousands of genes and affects a large part of DEGs indirectly. (spandidos-publications.com)
- circRNAs are generated by back-splicing from their host genes and are highly stable due to the absence of 5′ caps and 3′ tails [ 11 ]. (biomedcentral.com)
- These 12 genes are located at a region, which is frequently deleted in cancer. (ukessays.com)
Carcinoma3
- At present, 21 histological subtypes have been described, the most frequently occurring of which are ductal carcinoma (40-75% of cases) and lobular carcinoma (5-15% of cases) ( 5 ). (spandidos-publications.com)
- The mainstay of treatment for advanced hepatocellular carcinoma (HCC) was the tyrosine kinase inhibitor (TKI) sorafenib [ 5 ]. (biomedcentral.com)
- The authors evaluated the efficacy of photodynamic therapy (PDT) with or without topical 5-fluorouracil (F5U) pretreatment in patients with actinic keratoses, precancerous lesions that can progress to squamous cell carcinoma of the skin. (aacr.org)
Genome2
- For example positive-sense RNA viruses such as hepatitis C virus (HCV) have specialized RNA structures in the 5′ untranslated region of their genome which serve as internal ribosomal entry sites allowing translation to initiate without a 5′-methylguanosine cap (4). (biongenex.com)
- Furthermore, this resource has allowed the identification of cis -regulatory sites in previously unexplored regions of the genome and the cooperating transcription factors underlying estrogen signaling in breast cancer. (nature.com)
Variants2
- To date, nine missense variants and 5 microdeletions have been reported in CdLS patients (Kline et al. (springer.com)
- This analysis revealed previously unidentified alterations in untranslated regions, long noncoding RNAs, and introns that may guide the interpretation of noncoding variants in cancer genomes. (aacr.org)
VIVO1
- In vivo magnetic resonance imaging (MRI) has highlighted the accumulation of iron in the SNpc region of the PD brain, which disrupts iron circulation pathways to create an imbalance of the metal [ 11 , 12 ]. (hindawi.com)
Accumulation2
- Evidence for iron accumulation within the SNpc region of the PD brain along with abundant misfolded α S inclusions implies a direct relationship between iron and α S in the pathogenesis of PD [ 17 ]. (hindawi.com)
- The accumulation of FOXO1 in the cytosol and nuclear exclusion promoted cell proliferation and inhibited apoptosis. (biomedcentral.com)
Progression2
- Various genetic alterations have been identified that promote the initiation and progression of colon tumorigenesis. (oncotarget.com)
- H3K18 lactylation promotes the progression of arsenite-related idiopathic pulmonary fibrosis via YTHDF1/m6A/NREP. (cdc.gov)
Involvement1
- Figure 5: Involvement of cooperating transcription factors at estrogen receptor binding sites. (nature.com)
Conversely1
- Conversely, 3' untranslated region is present in between the stop codon and 3' tail. (biologyreader.com)
Pathway2
- However, we show that the JAK/STAT pathway plays an important role in patterning the eye disc:it promotes formation of the eye field through repression of the wg gene. (biologists.com)
- Furthermore, we show that the JAK/STAT pathway regulates a small enhancer in the wg 3′ cis genomic region. (biologists.com)
Inhibit1
- Targeted therapies exploit molecular vulnerabilities unique to cancer cells and typically alter cellular signaling pathways to inhibit tumorigenic growth and promote cell death. (biomedcentral.com)
Proteins3
- Several of the most common and most conserved transcription factor binding sites families that are predicted to be found in C9orf84's promoter region are ETS1 factors, Ccaat/Enhancer Binding Proteins, and Lymphoid enhancer-binding factor 1. (wikipedia.org)
- Moreover, defects in core proteins involved in miRNA biogenesis including Drosha, DGCR8, and Dicer promote tumorigenesis. (elsevierpure.com)
- The method enables a comprehensive evaluation of significantly mutated areas in both coding and noncoding regions of DNA that affect the sites for RNA-binding proteins. (aacr.org)
Incidence1
- The incidence of BC varies greatly with geographic region, but the death rates are less variable. (spandidos-publications.com)
Pathways1
- Further mechanistic research indicated that circHERC1 acted as a competing endogenous RNA of miR-142-3p to relieve the repressive effect of miR-142-3p on its target HMGB1, activating the MAPK/ERK and NF-κB pathways and promoting cell migration and invasion. (biomedcentral.com)
Mice1
- A peptide encoded within a 5' untranslated region promotes pain sensitization in mice. (wisc.edu)
Response1
- This response is predicted to promote the underlying inflammatory responses contributing to disease. (boisestate.edu)
Regulation1
- The 5' untranslated region is a major decisive factor for initiation and regulation of translation in the chloroplast. (igem.org)
Translation1
- c-Myc translation can be regulated at both the 5-untranslated region (UTR) and the 3-UTR [7, 8]. (nuche.org)
Biogenesis1
- These changes can promote mitochondrial biogenesis and membrane dynamics that in turn support mitochondrial respiration. (nature.com)
Expression2
- Most striking among these are ESRP1 and ESRP2, which accelerate and enhance the efficiency of somatic cell reprogramming by promoting isoform expression changes associated with mesenchymal-to-epithelial transition. (nih.gov)
- Specifically, miR-145 binds to the 3' untranslated region (UTR) of Camk1d and represses its expression. (biomedcentral.com)
Cell2
- Sequencing and alignment of this region in 11 cancer cell lines and 4 normal cell lines were also performed, followed by cloning, mutation and luciferase assay analysis. (jcancer.org)
- In PAE cells, soluble Sema4D promoted cell migration and developed a "tubulogenic" phenotype ( 4 ). (jcancer.org)
Long2
- The promoter for SHOC1 Isoform 1 in humans is 639 bp long and overlaps with the 5' untranslated region of the gene. (wikipedia.org)
- A common site of OS formation is usually near the growth plate of long bones such as the tibia, femur, and humerus [ 5 ]. (biomedcentral.com)
Article1
- In the version of this article initially published online, the estrogen receptor and RNA PolII binding data were aligned incorrectly in the top panel of Figure 3, which represents estrogen receptor binding at the ESR1 gene region. (nature.com)
Calcium1
- Ten glutamic acids on prothrombin are converted by vitamin K to gamma-carboxyglutamic acid (Gla) residues, the effect of which is to promote prothrombin binding to phospholipid bilayers when calcium is present. (medscape.com)
Cancer1
- The lifetime risk of developing colorectal (CRC) cancer is ~5% for both men and women in the USA [ 1 ]. (oncotarget.com)
Cells1
- MiR-146a has also been shown to promote the angiogenic activity of endothelial cells in HCC patients [ 11 ]. (biomedcentral.com)
Death1
- As of 5 death ( 6 ). (who.int)
Therapy1
- DAT1 5'-Un-Translated-Region Methylation Patterns as Bio-Markers of ADHD Psycho-Pathology: Contribution to Disease Prognosis and to Monitoring of a Successful Therapy. (cdc.gov)
Study1
- Our study describes the sequence characteristics of 5' non-coding region of Sema4D, enhances our understanding of the regulatory mechanism of Sema4D and benefits the development of a possible anti-angiogenesis therapeutic strategy for malignancies. (jcancer.org)
Previously1
- A polymorphism (TaqI) in the 3' untranslated region of the dopamine receptor gene (DRD2), later localized to the neighboring ANKK1 gene, has been previously linked to cigarette smoking. (who.int)
Internal1
- Internal base pairs maintain the coding region. (biologyreader.com)