Promoters that regulate the expression. Medical search. Frequent questions

Treatment with a DNA-demethylating agent restored BVES expression in CRC cell lines, indicating that methylation represses BVES expression. (jci.org)
Other mechanisms such as DNA methylation regulate gene expression via epigenetic phenomena. (bmj.com)
The epigenetic regulation through methylation at F7 promoter as well as the inter-relationship of genetic and epigenetic modifications at F7 promoter site were both previously unexplored. (bmj.com)
Reversible Regulation of Promoter and Enhancer Histone Landscape by DNA Methylation in Mouse Embryonic Stem Cells. (ca.gov)
DNA methylation promotes H3K27me3 deposition at bivalent promoters, while opposing H3K27me3 at silent promoters. (ca.gov)
DNA methylation also reversibly regulates H3K27ac and H3K27me3 at previously identified tissue-specific enhancers. (ca.gov)
Collectively, our data show that DNA methylation is essential and instructive for deposition of specific histone modifications across regulatory regions, which together influences gene expression patterns in mESCs. (ca.gov)
When located at gene promoters, DNA methylation is usually association with repression of gene expression. (nationaljewish.org)
To explore the effect of DNA methyltransferase, demethylase and methyl-CpG binding protein MeCP2 on the expressions and methylation of hMSH2 and proto-oncogene in human gastric cancer. (wjgnet.com)
Promoter methylation of p16 INK4A , c-myc and hMSH2 genes was assayed by methylation-specific PCR (MSP) and sequencing (mapping). (wjgnet.com)
Histone hyperacetylation and H3K4 methylation are associated with unmethylated DNA, euchromatin, and gene expression ( Fig. 2 ). (aacrjournals.org)
A cross-sectional study was designed to investigate the promoter methylation status of candidate genes in DI-exposed workers. (cdc.gov)
We studied four candidate genes (GSTM1, DUSP22, IFN-y, and IL-4) for which altered promoter methylation has been previously investigated for relationships with a variety of other environmental exposures. (cdc.gov)
In summary, this study shows that Hcy can activate autophagy by inhibiting DNMT3b-mediated DNA methylation and upregulating TFEB expression. (lu.se)
DNA methylation is a chemical process that regulates the function of the genes. (lu.se)
The level of methylation in the promoter can affect its effectiveness. (lu.se)
The ASXL1 protein may have an additional role in gene regulation by signaling to molecules to add a methyl group (a process called methylation) to an area near a gene called the promoter region, which controls gene activity. (medlineplus.gov)

Moreover, experiments with the luciferase activity analysis of truncated apoM promoters could demonstrate that a regulatory region (from-1580 to −1575 bp (−GGTCA-)) upstream of the transcriptional start. (lu.se)
Sp3, a member of this family, functions to repress transcriptional activation in two viral promoters, most likely by competing with Sp1 for GC box/Sp binding sites. (nih.gov)
In contrast, the single G/C boxes within the histone H4 or TK promoters, which confer transcriptional activation via Sp1 binding, are not responsive to repression by Sp3. (nih.gov)
Generally speaking, expression of a foreign gene requires restructuring the gene to include sequences that are required for producing an mRNA molecule that can be used by the host's translational apparatus (e.g. promoter, translational initiation signal, and transcriptional terminator). (wikipedia.org)
Similarly, the majority of CRC cell lines tested exhibited decreased BVES expression and promoter DNA hypermethylation, a modification associated with transcriptional silencing. (jci.org)
Previously, we have demonstrated that NPAS3 regulates VGF at the transcriptional level. (frontiersin.org)
Here, we hypothesized that multiple transcriptional regulators, including: (i) a primary Nrf2-Maf heterodimer, (ii) a proposed secondary, EpRE-specific, p160 family coactivator, ARE-binding protein-1, and (iii) a tertiary coactivator, CBP/p300, nucleate to form a complex at the EpRE that regulates transcription of the dependent gene. (nih.gov)
To identify the involvement of specific, primary and higher-order transcriptional regulators in the EpRE-mediated regulation of the GFP reporter gene, we microinjected antibodies directed against specific transcription factors into the HepG2/GFP cells and determined their effect upon tBHQ-induced expression of the GFP gene. (nih.gov)
Impossible Foods has filed a patent for materials and methods that involve overexpression of a transcriptional activator called retrograde regulation protein 1 (Rtg1) to increase the expression of one or more polypeptides. (just-drinks.com)
This transcriptional activator is operably linked to one of the promoter elements. (just-drinks.com)
Furthermore, the yeast cell can be modified to express multiple transcriptional activators, each linked to a different promoter element. (just-drinks.com)
The use of different promoter elements, transcriptional activators, and heme biosynthesis enzymes allows for precise control and optimization of protein expression in yeast cells. (just-drinks.com)
Recent advances in understanding the role that epigenetics plays in cancer pathogenesis and understanding the mechanisms through which these processes regulate gene expression have stimulated considerable interest in developing clinically viable antineoplastic agents that target enzymatic components of transcriptional regulatory complexes responsible for the establishment of pathologic epigenetic modifications that lead to deregulated gene expression in cancer. (aacrjournals.org)
To address the problem of sustained expression in vivo (a major limitation of many gene transfer methods as of now) we are investigating the use of different promoters, post-transcriptional regulating elements and vectors. (lu.se)

Proteins that can result from the expression of recombinant DNA within living cells are termed recombinant proteins. (wikipedia.org)
Expression of foreign proteins requires the use of specialized expression vectors and often necessitates significant restructuring by foreign coding sequences. (wikipedia.org)
Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. (nih.gov)
Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)
Proteins called repressors bind to these regions, preventing polymerase-promoter association, inhibiting transcription. (jove.com)
Inducible promoter elements, such as methanol-inducible promoter elements, can be used to regulate the expression of the proteins. (just-drinks.com)
Overall, this patent presents a novel approach to genetically modifying yeast cells for the expression of specific proteins. (just-drinks.com)
Gene expression generally produces proteins, but there are also non-coding genes that produce RNA molecules (rRNA, tRNA). (lu.se)
Using the novel CRISPR/Cas9-based enChIP technology in combination with SILAC-MS, we have isolated and identified potential regulatory proteins bound to the HIF2A promoter at normoxia and hypoxia. (lu.se)

This signaling cascade was shown to be recurrently inactivated in DLBCL, mainly by hypermethylation of five promoter regions surrounding the SMAD1 transcription start site, which finally generates a significant growth advantage for lymphoma cells. (haematologica.org)
There were down-regulation and hypermethylation of hMSH2 in cancer tissues, and the hypermethylation of hMSH2 coexisted with down-regulated transcription. (wjgnet.com)

For the last 30 years, mapping chromatin accessible sites has been the gold standard method to identify the location of active regulatory elements, including promoters, enhancers, silencers, and locus control regions. (duke.edu)
We find that genome-wide DNA demethylation alters occupancy of histone modifications at both promoters and enhancers. (ca.gov)
However, these intergenic regions carry important elements that regulate gene activity, for instance, the promoter where transcription starts, and enhancers and silencers that fine-tune gene expression. (jove.com)

Two scenarios could potentially explain the co-occurrence of H3K4me3 and H3K27me3 observed by ChIP-seq on bivalent promoters. (researchgate.net)
reports suggested that targeting of H2A.Z to bivalent promoters may depend on PRC1/2 complexes and vice versa ( Creyghton et al. (researchgate.net)
Bivalent promoters are defined by the presence of both activating (H3K4me3) and repressive (H3K27me3) chromatin marks. (researchgate.net)

Transient cotransfections of Drosophila cells with Sp1 and Sp3 expression vectors and with the histone H4, thymidine kinase (TK), or dihydrofolate reductase (DHFR) promoters show that only the DHFR promoter, containing multiple functional GC boxes, displays Sp3 repression of Sp1 activation. (nih.gov)
Here we describe how microRNA-regulated lentiviral vectors can be used to visualize specific cell populations by exploiting endogenous microRNA expression patterns. (lu.se)
Strategies for gene therapy and production of medicines via genetically-modified organisms (expression vectors and viral vectors). (lu.se)

Moreover, IL-6 (Interleukin 6) rather than IFNγ, is identified as the main candidate cytokine regulating such an immune/MER41/cognition pathway. (biorxiv.org)
We hypothesized that diisocyanate (DI) exposure could modify gene promoter regions regulating transcription of cytokine mediators and thereby influence expression of DA. (cdc.gov)

Conculsion: In summary, the present study indicates that 17β-estradiol induced up-regulation of apoM in HepG2 cells is through an ER-α-dependent pathway involving ER-α binding element in the promoter of the apoM gene. (lu.se)

Further, using gel mobility shift assays, we show that both Sp1 and Sp3 interact specifically with the histone H4 promoter. (nih.gov)
Histone modifications and chromatin-associated protein complexes are crucially involved in the control of gene expression, supervising cell fate decisions and differentiation. (researchgate.net)
Many promoters in embryonic stem (ES) cells harbor a distinctive histone modification signature that combines the activating histone H3 Lys 4 trimethylation (H3K4me3) mark an. (researchgate.net)
Central to the epigenetic control of gene expression is the histone code through which input signals can be translated into a heritable pattern of gene expression defining cellular output states ( Fig. 1 ). (aacrjournals.org)

Plant biologists subsequently discovered that many phytohormones regulate signaling through CID mechanisms. (nature.com)
However, the mechanisms regulating its expression have not been completely explored. (xenbase.org)
Molecular mechanisms for regulation of gene expression at different levels: remodeling of chromatin, initiation of transcription, nuclear transport and signalling, and RNA interference. (lu.se)
Mechanisms that regulate development from single cell to multicellular organisms. (lu.se)

The text reviews the synthesis of DNA and genome engineering and offers a discussion of the parts and devices that control protein expression and activity. (wiley-vch.de)
HMGCS2 protein expression is down-regulated preferentially in moderately and poorly differentiated carcinomas. (aacrjournals.org)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
Among them a promoter, exons, introns, and regulatory elements, which together help to determine protein expression in a cell. (jove.com)

This expression was dependent on activation of either NF-κB, JAK1/JAK2 or BTK pathways since these pathways were activated in tumor B-cells and ex vivo treatment with the inhibitory molecules PHA-408, ruxolitinib and ibrutinib led to decrease of its expression. (springer.com)
Treatment of LMP1/CD40-expressing lymphomatous mice with an anti-PD-L1 monoclonal antibody induced tumor regression with decreased spleen content, activation and proliferation rate of B-cells as well as a marked increase in T-cell activation, as assessed by CD62L and CD44 expression. (springer.com)
NF-κB, one of the most cited transcription factor in B-cell lymphomas, is able to increase tumor cell expression of PD-L1 either directly or indirectly [ 3 ]. (springer.com)
This led us to hypothesize that the absence of SMAD1 expression in HRS cells may mechanistically be linked to their resistance to the tumor-suppressive effects of TGF-β. (haematologica.org)
WNT5A act as both tumor promoter as well as tumor suppressor, depending on cell type. (lu.se)

Results: Our results demonstrated either free 17β-estradiol (E2) or membrane-impermeable bovine serum albumin-conjugated E2 (E2-BSA) could modulate human apoM gene expression via the estrogen receptor alpha (ER-α) pathway in the HepG2 cells. (lu.se)
Furthermore, ectopically expressed NPAS3 in PC12 cells produced parallel responses for nuclear factor kappa-light-chain-enhancer of activated B cells [NF-κB (P65)] expression, which specifies that NPAS3 regulates VGF through the NF-κB signaling pathway. (frontiersin.org)
dGLYAT was found to regulate Gadd45 -mediated JNK pathway activation and cell invasion. (sdbonline.org)
Of note, functionally-relevant differences between humans and chimpanzees are observed regarding the 3 main components of this pathway: i) the protein sequences of immunes TFs binding MER41 LTRs, ii) the insertion sites of MER41 LTRs in the promoter regions of ID-associated genes and iii) the protein sequences of the targeted ID-associated genes. (biorxiv.org)
In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal-regulated kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)
In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal–regulated kinase (MEK)/extracellular signal–regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)

The nucleic acids are controlled by promoter elements, which can be constitutive or inducible. (just-drinks.com)

its inducible expression is regulated by a synthetic TK promoter containing a linked EpRE. (nih.gov)
The study examined the expression of Neuroglobin (Ngb) and Hypoxia-inducible factor-1α (Hif-1α) in adult and young yak brain tissues, and provided researchers with meaningful insight into the anatomy, physiology, and biochemistry of this mammal. (scielo.br)

These data provide the first insight into the three- dimensional (3D) structure of the CFTR locus and confirm the contribution of intronic cis-acting elements to the regulation of CFTR gene expression. (duke.edu)
To further investigate the mechanism behind the estrogen induced up-regulation of apoM expression. (lu.se)
It also plays a role in gene expression regulation and RNA metabolism. (cnr.it)
An alternative, human SRC promoter and its regulation by hepatic nuclear factor-1alpha. (xenbase.org)
The epigenetic regulation of spatiotemporal gene expression is crucial for human development. (researchgate.net)
The up-regulation of proto-oncogene may be the consequence of epigenetic control of gene expression by demethylase, and mbd2 is involved in the regulation of hMSH2 expression in human gastric cancer. (wjgnet.com)
Principles for regulation of gene expression through intercellular signalling. (lu.se)

Iron (Fe), zinc (Zn), manganese (Mn), and copper (Cu) are essential micronutrient mineral elements for living organisms, as they regulate essential cellular processes, such as chlorophyll synthesis and photosynthesis (Fe, Cu, and Mn), respiration (Fe and Cu), and transcription (Zn). (frontiersin.org)
Even if the DNA sequence - the set of genes - is the same in all cells, only certain genes are expressed, i.e. only information from certain genes is copied (transcribed) and used to build protein structures or regulate processes. (lu.se)

Differential use of these promoters and their associated exons coupled with subsequent splicing to a common downstream exon results in c-Src transcripts with different 5' ends but identical coding regions. (xenbase.org)

In addition to regulating each other through feedback loops, these genes also regulate downstream target genes involved in the maintenance and differentiation of embryonic stem cells. (lu.se)
The switch stabilizes the expression levels of the three genes, and through their regulatory roles on the downstream target genes, leads to a binary decision: When OCT4, SOX2 and NANOG are expressed and the switch is ON, the self-renewal genes are ON and the differentiation genes are OFF. (lu.se)

In addition, expression of IGF-II and HIF-2α correlates in neuroblastoma cell lines, tumors and in sympathetic neuroblasts during embryonic week 6.5, but not later, suggesting that these IGF-II and HIF-2α expressing neuroblastomas originate from sympathetic pre-ganglia at developmental week 6.5 or earlier. (lu.se)

With a kinetic modeling approach we ascribe function to the observed OCT4-SOX2-NANOG network by making plausible assumptions about the interactions between the transcription factors at the gene promoter binding sites and RNA polymerase (RNAP), at each of the three genes as well as the target genes. (lu.se)
Transcription factors bind alongside the promoter and set off the gene expression. (lu.se)

Another, poorly characterized function is its ability to bind to negative calcium responsive elements (nCaRE) of some gene promoters. (cnr.it)
To understand this mechanism, we need to know which transcription factor (TFs) would bind to which promoter, thus regulate their target gene expression. (usda.gov)

Thus, regulating the uptake and cellular distribution of these minerals is extremely important for optimal cellular functioning and could lead to breeding crop plants with better adaptability to changing environments and may contribute to providing healthy food with improved mineral contents. (frontiersin.org)
NimR regulates the expression of a Ni 2+ uptake transporter (NikKLMQO). (rsc.org)

Glucose and GLP-1 also synergistically activated NFAT (nuclear factor of activated T-cells)-mediated transcription from a minimal promoter construct containing tandem NFAT consensus sequences. (diabetesjournals.org)

An element located within a DNase I-hypersensitive site (DHS) 10 kb into the first intron was previously shown to augment CFTR promoter activity in a tissue-specific manner. (duke.edu)
In the present study, we analyze the activity and binding of Sp3 on several eukaryotic promoters that contain G/C boxes and are known to be regulated during cellular proliferation and the cell cycle. (nih.gov)
c-Myc transrepression is mediated by blockade of the transactivating activity of Miz-1, which occurs mainly through a Sp1-binding site in the proximal promoter of the gene. (aacrjournals.org)
In this study, GLP-1 (100 nmol/l), in the presence of glucose (11 mmol/l), induced a ∼71-fold increase in insulin gene promoter activity in INS-1 pancreatic β-cells, an effect that was an order of magnitude larger than with either stimulant alone. (diabetesjournals.org)
Both glucose and GLP-1 stimulate insulin promoter activity, stabilize proinsulin mRNA, and increase proinsulin biosynthesis ( 14 ). (diabetesjournals.org)
Mutation of the HNF-1 site resulted in a dramatic reduction in SRC promoter activity. (xenbase.org)
NimR did not directly regulate the expression of urease genes but the activity of urease requires both nimR and nikQ . (rsc.org)
The activity of the promoter can therefore be regulated differently in different cells. (lu.se)
When DNA is tightly packed, gene activity (expression) is lower than when DNA is loosely packed. (medlineplus.gov)
When a promoter region is methylated, gene activity is repressed, and when a promoter region is not methylated, the gene is active. (medlineplus.gov)
In summary, we have identified, and at the molecular level characterized, signaling pathways and specific factors through which oncogenic HIF2A activity is regulated and may be targeted. (lu.se)

Here, we present evidence that the promoter regions of intellectual disability-associated genes are uniquely enriched in LTR sequences of the MER41 HERVs. (biorxiv.org)
Moreover, we have not found such a significant enrichment in the promoter regions of genes that associate with autism spectrum disorder (ASD) or schizophrenia. (biorxiv.org)

The transcription factor Sp1 plays a key role in the activation of many cellular and viral gene promoters, including those that are regulated during the cell cycle. (nih.gov)
κB site within VGF promoter was identified for VGF activation induced by NPAS3, apart from direct binding to E-box. (frontiersin.org)
Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)

Promoter analysis following transient transfections into HepG2 cells mapped the minimal 1alpha promoter to a region 145 bp upstream of the major transcription start site. (xenbase.org)

Moreover, using chromosome conformation capture (3C) analysis, we show that this element interacts with the CFTR promoter in CFTR-expressing cells. (duke.edu)
DNA expression requires the transfection of suitable host cells. (wikipedia.org)
In CaCo-2 colonic epithelial cells, the expression of this gene increases with cell differentiation. (aacrjournals.org)
In this study, VGF (non-acronymic) was found regulated by NPAS3 in neuronal stem cells. (frontiersin.org)
The rate of insulin gene transcription in pancreatic β-cells is regulated by a complex integration of signals derived from nutrients, hormones, and neurotransmitters ( 1 - 5 ). (diabetesjournals.org)
The yeast cells are cultured under conditions suitable for the expression of the exogenous nucleic acids. (just-drinks.com)
As ChIP-seq cannot establish physical co-occurrence of two marks on the same allele, admixture of cells that either express (green) or do not express (red) the gene in focus could explain the occurrence of both marks as well as the low expression level in the overall population. (researchgate.net)
In contrast, in the case of ''true'' bivalency, virtually all cells in the population carry both marks simultaneously at the promoter in question, leading to low, if any, expression for that gene in all cells. (researchgate.net)
Here we show that bivalent domains and chromosome architecture for bivalent genes are dynamically regulated during the cell cycle in human pluripotent cells. (researchgate.net)
Three types of epigenetic modification that regulate gene expression in mammalian cells. (nationaljewish.org)
When a microRNA is present in the cell, it binds to the target sites and downregulates GFP expression, while in cells that do not express the microRNA GFP, it is expressed. (lu.se)
In this study, we analyzed lncRNA expression in ovarian granulosa cells (GCs) collected from women with and without PCOS via high-throughput sequencing. (bvsalud.org)
The gene expression varies between different types of cell and when these epigenetic changes are inherited by daughter cells through cell division in the womb, different tissues and organs are built. (lu.se)

As a result, silencers help to regulate gene expression. (jove.com)

Promoters of genes associated with oxidative phosphorylation are preferentially remethylated at the 8-cell stage, suggesting that this mode of energy metabolism may not be favored. (nature.com)

A complex intronic enhancer regulates expression of the CFTR gene by direct interaction with the promoter. (duke.edu)
Transfection of promoter-reporter constructs demonstrated that the element displays classical tissue-specific enhancer properties and can independently recruit factors necessary for transcription initiation. (duke.edu)
Second, Mutated enhancer box (E-box) of VGF promoter showed a significant response to this basic helix-loop-helix (bHLH) transcription factor, which suggested an indirect regulatory mechanism for controlling VGF expression by NPAS3. (frontiersin.org)

With the applications of an electrophoresis mobility shift assay and a chromatin immunoprecipitation assay, we could successfully identify a specific ER-α binding element in the apoM promoter region. (lu.se)
Here, we used a chromatin immunoprecipitation assay to study the molecular mechanism responsible for this expression pattern. (aacrjournals.org)
Through its role in chromatin remodeling, the ASXL1 protein regulates the expression of many genes, including a group of genes known as HOX genes, which play important roles in development before birth. (medlineplus.gov)

However, the physiological role of Sp3 in the repression of endogenous cellular promoters has not been experimentally addressed. (nih.gov)
Therefore, we demonstrate that the endogenous cellular DHFR promoter is selectively responsive to Sp3 repression. (nih.gov)

Based on these findings, we propose that ketogenesis is an undesirable metabolic characteristic of the proliferating cell, which is down-regulated through c-Myc-mediated repression of the key metabolic gene HMGCS2 . (aacrjournals.org)
These modifications lead to either repression or enhancement of gene expression. (nationaljewish.org)

We demonstrate that APE1 is part of a multiprotein complex including hOGG1, Ku70, and RNA Pol II, which is recruited on SIRT1 promoter to regulate SIRT1 gene functions during early response to oxidative stress. (cnr.it)

NFAT binds to three distinct NFAT elements within the rat I insulin promoter and activates insulin gene transcription. (diabetesjournals.org)
Activates transcription from class II MHC promoters. (lu.se)

The data suggest that Sp3 may contribute to the control of proliferation- and/or cell-regulated promoters depending upon the context and/or number of functional Sp1 binding sites. (nih.gov)
The presence of many functional nCaRE sequences regulating gene transcription can be envisioned, given their conservation within ALU repeats. (cnr.it)
To look for functional nCaRE sequences within the human genome, we performed bioinformatic analyses and identified 57 genes potentially regulated by APE1. (cnr.it)

Background: We have previously demonstrated that estrogen could significantly enhance expression of apolipoprotein M (apoM), whereas the molecular basis of its mechanism is not fully elucidated yet. (lu.se)

Over-expression of NPAS3 also enhances the cell proliferation, which can be blocked by knockdown of VGF. (frontiersin.org)
Currently there is intense interest to define the mechanism of action of glucagon-like peptide-1 (GLP-1) in regulating β-cell function, including insulin gene transcription. (diabetesjournals.org)
The patent claim describes a yeast cell comprising exogenous nucleic acids encoding Rtg and a polypeptide, operably linked to promoter elements. (just-drinks.com)
Expression of cell-cycle regulator CDK2-associating protein 1 (p12CDK2AP1) in transgenic mice induces testicular and ovarian atrophy in vivo. (nih.gov)
Gene expression is the process of several steps through which the information in a gene's DNA sequence is transferred to the structures and functions of a cell. (lu.se)
Our laboratory focusses on how WNT5A expression is regulated in these cancers and deciphering the WNT5A signaling pathways governing cancer cell migration and invasion. (lu.se)
May regulate other genes in the cell. (lu.se)

Genes can maintain spatiotemporal expression patterns by long-range interactions between cis-acting elements. (duke.edu)
The human SIRT1 promoter presents two nCaRE elements stably bound by APE1 through its N-terminus. (cnr.it)
The promoters for nimR and the nik operon are divergent and overlapping and NimR binds at a site between the promoter elements for nikKLMQO . (rsc.org)

Key to the organization of an individual gene is its promoter, to which machinery, especially RNA polymerase, can attach. (jove.com)

The results demonstrate that microinjected antibodies directed against Nrf2, MafK, CBP and p300 could each, individually, significantly inhibit tBHQ-induced GFP expression. (nih.gov)
0.05) expressed in the cerebellar cortex, piriform lobe, medulla, and corpus callosum of the adult yak while in the young yak brain tissues, the protein expressions were significantly found in the white matter of the cerebellum, pineal gland, corpus callosum, and cerebellar cortex. (scielo.br)
promoter was significantly increased in DA+ in comparison with both comparator groups (DA- and AW), and it exhibited good sensitivity (77.5%) and specificity (80%) for identifying DA workers in a multivariate predictive model after adjusting for type of DI exposure, smoking status, methacholine PC20, and gender. (cdc.gov)

Starting with the Escherichia coli lac operon in the 1970s, many synthetic ligand-regulated circuits have been built by rewiring natural systems for new functions 1 . (nature.com)

We previously developed multiple agrochemical-regulated CID modules, including PYR1 MANDI , designed to enable agrochemical control of plant ABA signaling 25 . (nature.com)
Here we describe the isolation of a new distal SRC promoter and associated exon, designated 1alpha, which we mapped to a position 1.0 kilobase upstream of the previously described SRC1A housekeeping promoter. (xenbase.org)

Our finding suggests that exposure to occupational chemicals could play a heretofore undefined mechanistic role via epigenetic modification of specific genes in the promoter region. (cdc.gov)

The storage and distribution of these minerals in various cellular organelles is strictly regulated to ensure optimal metabolic rates. (frontiersin.org)
Different subcellular compartments are suggested to be linked through complex retrograde signaling networks to regulate cellular metal homeostasis. (frontiersin.org)
Various genes regulating cellular and subcellular metal distribution have been identified and characterized. (frontiersin.org)
Here, we review progress in the understanding of different subcellular metal transport components in plants and discuss the prospects of regulating cellular metabolism and strategies to develop biofortified crop plants. (frontiersin.org)

We demonstrate that this resource and the eY1H assay enable rapid, efficient and systematic mapping of plant TF-promoter interactions using thirteen stele-expressed TF promoters. (usda.gov)

Accordingly, the expression of human HMGCS2 is down-regulated in 90% of Myc-dependent colon and rectum tumors. (aacrjournals.org)
Aberrant GLYAT expression is associated with human cancers, yet its role in cancer remains unknown. (sdbonline.org)
2000), An alternative, human SRC promoter and its regu. (xenbase.org)
In addition, the SRC gene is differentially expressed, developmentally regulated, and frequently overexpressed in human neoplasia. (xenbase.org)

Expression of this operon requires NimR and depends on Ni 2+ . (rsc.org)

Anatomy15

Organisms16

Diseases2

Chemicals and Drugs107

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes94

Information Science3

Methylation17

Transcriptional14

Proteins9

Hypermethylation2

Enhancers3

Bivalent promoters3

Vectors3

Cytokine2

Element in the promoter1

Histone4

Mechanisms4

Protein expression4

Tumor5

Pathway6

Constitutive1

Inducible2

Regulation7

Processes2

Exons1

Downstream2

Developmental1

Transcription factors2

Bind2

Uptake2

Consensus sequences1

Activity11

Regions2

Activation3

Transient1

Cells13

Silencers1

Preferentially1

Enhancer3

Chromatin3

Endogenous2

Repression2

Oxidative1

Activates2

Functional3

Molecular1

Cell7

Elements3

Polymerase1

Significantly3

Synthetic1

Previously2

Modification1

Cellular4

Interactions1

Human4

Operon1