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Transcription Factor Brn-3ATranscription Factor Brn-3BCOUP Transcription Factor IMiosisCOUP Transcription Factor IITranscription Factor Brn-3COUP Transcription FactorsTranscription FactorsPromoter Regions, GeneticTranscription, GeneticReceptors, SteroidDNA-Binding ProteinsBase SequenceHepatocyte Nuclear Factor 4Molecular Sequence DataChickensGene Expression RegulationBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsBinding SitesNuclear ProteinsRetinoid X ReceptorsTransfectionReceptors, Cytoplasmic and NuclearCell LineReceptors, Retinoic AcidTranscriptional ActivationSp1 Transcription FactorProtein BindingRepressor ProteinsGenes, ReporterRegulatory Sequences, Nucleic AcidTrans-ActivatorsRNA, MessengerHeLa CellsChloramphenicol O-AcetyltransferaseBasic Helix-Loop-Helix Transcription FactorsHomeodomain ProteinsTranscription Factor AP-1DNAAmino Acid SequenceGene Expression Regulation, DevelopmentalMutationTranscription Factor Brn-3CSignal TransductionForkhead Transcription FactorsChromatin ImmunoprecipitationCell NucleusCell DifferentiationBasic-Leucine Zipper Transcription FactorsTranscription Factor AP-2POU Domain FactorsTranscription Initiation SitePlasmidsElectrophoretic Mobility Shift AssayEnhancer Elements, GeneticCells, CulturedCloning, MolecularKruppel-Like Transcription FactorsTranscription Factors, TFIILuciferasesYY1 Transcription FactorReverse Transcriptase Polymerase Chain ReactionSp3 Transcription FactorTranscription Factor TFIIDRecombinant Fusion ProteinsGene ExpressionNF-kappa BGATA4 Transcription FactorSTAT3 Transcription FactorTATA BoxPaired Box Transcription FactorsZinc FingersOvalbuminRNA Polymerase IINFATC Transcription FactorsActivating Transcription Factor 3Gene Expression ProfilingCell Line, TumorTranscription Factor TFIIBGene Expression Regulation, BacterialActivating Transcription Factor 2Gene Expression Regulation, FungalE2F1 Transcription FactorChromatinDNA FootprintingDNA-Directed RNA PolymerasesTumor Cells, Cultured
SubfamilyGeneSequence-specificProteinsRegionsSequencesChromosomeMembersExpressionTargetDomain
Subfamily3
Gene4
  • POU domain, class 4, transcription factor 1 (POU4F1) also known as brain-specific homeobox/POU domain protein 3A (BRN3A), homeobox/POU domain protein RDC-1 or Oct-T1 is a protein that in humans is encoded by the POU4F1 gene. (wikipedia.org)
  • We show that the promoter of the gene encoding the presynaptic nerve terminal protein SNAP-25 resembles previously characterised target genes in being activated by Brn-3a and Brn-3c, but being repressed by Brn-3b. (ox.ac.uk)
  • In contrast to the SNAP-25 gene, the gene encoding the synaptic vesicle protein synapsin 1 is activated by all the Brn-3 factors, the first gene for which this activation pattern has been reported Interestingly, however, similar activation by all three Brn-3 factors can be observed if the SNAP-25 promoter is truncated by removal of sequences from -2200 to -288 relative to the transcriptional start site. (ox.ac.uk)
  • This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. (cancerindex.org)
Sequence-specific1
Proteins3
  • Differences in promoter structure may thus result in differences in the response to different Brn-3 factors, thus allowing these factors to produce diverse activation patterns of neuronally expressed genes, such as those encoding different synaptic proteins. (ox.ac.uk)
  • POU proteins are eukaryotic transcription factors containing a bipartite DNA binding domain referred to as the POU domain. (embl.de)
  • The acronym POU (pronounced 'pow') is derived from the names of three mammalian transcription factors, the pituitary-specific Pit-1, the octamer-binding proteins Oct-1 and Oct-2, and the neural Unc-86 from Caenorhabditis elegans. (embl.de)
Regions1
  • BRN3A (POU4F1) is a class IV POU domain-containing transcription factor highly expressed in the developing peripheral sensory nervous system (dorsal root ganglia, trigeminal ganglion, and hindbrain sensory ganglia), certain regions of the central nervous system, retinal neurons called ganglion cells, and in cells of the B- and T-lymphocytic lineages. (wikipedia.org)
Sequences1
  • Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. (cancerindex.org)
Chromosome1
  • however, mRNAs encoding a subset of factors important for error-free replication and chromosome segregation, including TIPIN, PLK2 and PLK3, remain at low abundance. (babraham.ac.uk)
Members1
  • The combination of homozygote lethality and dosage compensation in heterozygotes may explain why POU4F1 mutations have not been identified in any human disease, whereas diseases are associated with several other members of the POU domain transcription factor class. (wikipedia.org)
Expression1
  • Among 4,180 transcripts that changed significantly during development, approximately 2/3 of the genes were expressed at high levels up until PN5 and then declined whereas the other 1/3 of the genes increased expression from PN5 and remained at the higher levels until at least PN21. (biomedcentral.com)
Target2
  • Brn3a is a transcription factor which acts in development by regulating downstream "target" genes. (wikipedia.org)
  • Unlike other target genes, however, the SNAP-25 promoter can be activated by either the N- or C-terminal activation domains of Brn-3a. (ox.ac.uk)
Domain2
  • In the sensory neurons Brn3a is co-expressed with the LIM domain transcription factor ISL1 or Islet1, and has many downstream targets in common with Isl1. (wikipedia.org)
  • POU-domain transcription factors: pou-er-ful developmental regulators. (embl.de)