Promoter of cyclin a1. Medical search. Frequent questions

The overexpression of miRNA‑375 significantly increased caspase‑3 and caspase‑9 activities, induced B‑cell lymphoma 2 (Bcl‑2)/Bcl‑2‑associated X protein, tumor protein 53 and cyclin‑dependent kinase inhibitor 1 protein expression and suppressed cyclin D1 and survivin protein expression in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
In addition, numerous important cellular proteins, such as B-cell lymphoma-2 homologous antagonist/killer, Myc proto-oncogene protein, cyclin-dependent kinase inhibitor 1B, DNA replication licensing factor MCM-7, retinoblastoma 1 and Annexin A1, are degenerated through the UBE3A-mediated ubiquitin proteasome pathway ( 7 ). (spandidos-publications.com)

Cyclin-A1 is a protein that in humans is encoded by the CCNA1 gene. (wikipedia.org)
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell division cycle. (wikipedia.org)
The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. (cancerindex.org)
The BIC gene is activated by promoter insertion at a retroviral integration site on chromosome 21q21 in B cell lymphomas induced by avian leukosis virus. (biomedcentral.com)
An additional examine indicated that novel genetic variant 4 from the SMAD4 gene promoter impacts its action. (microrna1.com)
Obtained preliminary results indicate that SMAD4 gene promoter haplotype 462 four represents a probably pertinent genetic marker for pancreatic and colorectal cancer. (microrna1.com)
We identify an important role for DDX5 in G 1 -S-phase progression where it directly regulates DNA replication factor expression by promoting the recruitment of RNA polymerase II to E2F-regulated gene promoters. (aacrjournals.org)

This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F1, and the Kip/Cip family of CDK-inhibitor proteins. (wikipedia.org)
CDKs are cyclin-dependent serine-/threonine-specific proteins kinases, the experience of which depends upon cyclin binding. (niepokorny.org)

Cyclins function as activating subunits of enzymatic complex together with cyclin-dependent kinases (CDKs). (wikipedia.org)
Here, we show that Mcl-1 down-regulation by the cyclin-dependent kinase (CDK) inhibitor roscovitine or Mcl-1-shRNA dramatically increases ABT-737 lethality in human leukemia cells. (aacrjournals.org)
Cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) interacts with CDK2AP2, modulates the actions of transforming growth factor-B1, cyclin-dependent kinase 2 and retinoblastoma protein, and closely interacts with micro-RNA21 and micro-RNA25. (cancerindex.org)
cyclin dependent kinase 7 [Source:HGNC Sy. (gsea-msigdb.org)
Current scientific trials are looking into cyclin-dependent kinase (CDK) inhibitors, such as for example roscovitine, an inhibitor of CDK1, -2, -5, -7, and -9, that lowers viral DNA synthesis, creation of late protein and infectious pathogen particles [4]. (niepokorny.org)

In addition with their main function in the legislation of cell routine progression, particular types of CDKs and cyclins get excited about transcription also, splicing, epigenetic legislation, neuronal features, stem cell regeneration, spermatogenesis, and differentiation [10]. (niepokorny.org)

Cyclin A1 (CCNA1) and CREB binding protein (CREBBP) are downstream targets for RNF6 transcription regulation in GC. (bvsalud.org)
RNF6 binds to the promoter region of CCNA1/CREBBP and is actively regulating their expression in GC cells. (bvsalud.org)

Binding from the A1 isoform from the Tumor Necrosis Element relative Ectodysplasin to its receptor EDAR induces nuclear translocation from the transcription element NF-B, and NF-B pathway activation in developing locks follicle placodes (Kumar et al. (bio-cavagnou.info)
As a promoter of cellular growth and a key regulator of several tumor suppressors, REGγ-proteasome as a potential target of new cancer-drug development. (amegroups.org)

This cyclin binds both Cdk1 and Cdk2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. (wikipedia.org)

In the PyVmT model, the transgene encodes a powerful oncogene (PyVmT) and is controlled by the MMTV promoter, whereby the oncogene is primarily expressed in mammary epithelium (12). (campaignfornonviolentschools.org)

In HCMV-infected cells, particular subsets of CDK-cyclin complexes are downregulated/suppressed (CDK4-cyclin D, CDK6-cyclin D, CDK2-cyclin A) or upregulated/turned on (CDK1-cyclin B, CDK2-cyclin E), leading to an early on S stage arrest termed pseudomitosis [11] eventually. (niepokorny.org)

In contrast, cyclin A binding to E2F-1 impedes PRMT1 methylation and augments PRMT5 methylation, thus ensuring that E2F-1 is locked into its cell-cycle progression mode. (embl.de)

Homo sapiens shugoshin-like 1 (S. pombe) (SGOL1), transcript variant A1, mRNA. (dbcls.jp)

transcription elongation factor A1 [Sourc. (gsea-msigdb.org)

It functions as a repressor by binding to INSULATOR ELEMENTS and preventing interaction between promoters and nearby enhancers and silencers. (nih.gov)

In yet another older study, Orlowski et al reported an ORR of 41 along with a median TTP of six.5 months of single agent bortezomib in RR myeloma.22 Time to response The time to response to remedy with carfilzomib in relapsed refractory sufferers was evaluated in patients enrolled inside the PX 171 003 A1 and PX 171 004 trials. (srcsignaling.com)

Cyclin A1 was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of meiosis. (wikipedia.org)

Different cyclins exhibit distinct expression and degradation patterns that contribute to the temporal coordination of cell cycle events. (wikipedia.org)

The main goal of the work was to analyze the characteristics of Tat protein in HIV-1 A6 variant, that is, to identify substitutions characteristic for A6 and A1 variants, as well as to compare the frequency of mutations in functionally significant domains in sub-subtype A6 and subtype B. (crie.ru)

translocated promoter region, nuclear bas. (gsea-msigdb.org)
Among them, the most studied and validated genetic risk factor is represented by the single nucleotide polymorphism in the promoter region of the mucin 5B (MUC5B) responsible for sporadic and familial IPF [ 12 ] . (encyclopedia.pub)

A1 cells readily up regu lated the expression of three integrin in response to TGF, a molecule we established as one particular on the most delicate and robust markers of TGF signaling. (microrna1.com)

A stage-related loss of estrogen receptors (ER) as well as ErbB2/Neu and cyclin D1 overexpression seen in human breast cancer are reproduced in this model (20). (campaignfornonviolentschools.org)

Transient transfection and infection with viral vectors expressing cyclin A1 and short hairpin RNA (shRNA) targeting cyclin A1 were used to study the effects of altered cyclin A1 expression in PC3 prostate cancer cells. (medscape.com)

Aberrant promoter hypermethylation of tumor suppressor genes is proposed to be a common feature of primary cancer cells. (nih.gov)
Association of altered DNA methylation patterns of the promoter CpG islands with the expression profile of cancer-related genes, has been found in many human tumors. (nih.gov)
We used the methylation specific PCR in conjunction with sequencing verification to establish the methylation profile of the promoter CpG island of thirty four genes in astrocytoma tissues from fifty three patients (The WHO grading: I: 14, II: 15, III: 12 and IV: 12 cases, respectively). (nih.gov)
One of the genes regulated through this mechanism en-codes the B-Myb transcription factor, which has been shown to be critically required for early embryonal de-velopment in the mouse. (123dok.net)
C2 The Cyclin E and A genes (but not the Cyclin D gene) are strongly activated by E2F1 (DeGregori et al. (nih.gov)
Cell survival and apoptotic regulatory proteins such as the Bcl-2 family of genes, PCNA, p16, p21, p27, and cyclin D1 are of vital importance to malignant neoplasms in prolonging cell survival. (biomedcentral.com)
[3] Active cyclin D-CDK4/6 complex induces release of E2F transcription factor, which in turn initiates expression of S-phase genes. (wikipedia.org)
[6] NPAT is activated by phosphorylation and recruits the Tip60 chromatin remodeling complex to the promoters of histone genes. (wikipedia.org)
Regenerative DMRs inversely affected by aging during 8-to-16 m/o were found in the promoter/gene regions of 12 genes. (biomedcentral.com)
Hallazgos recientes justifican un renovado interés en este proceso, el cual se estima que afecta más del 95% de los genes humanos. (uba.ar)
Encontramos que el cloroplasto responde a la luz generando una señal retrógrada que actúa en el núcleo en la regulación del splicing alternativo de determinados genes. (uba.ar)
We generated the Jdp2 -promoter-Cre mice and Jdp2 -KO mice to examine the levels of Slc7a11, ROS levels and the expressions of antioxidation related genes were examined in the mouse cerebellum using the immunohistochemistry. (biomedcentral.com)
Gli3 repressor proteins translocates towards the nucleus where it binds towards the promoters of Hedgehog focus on genes to shut down transcription. (cell-metabolism.com)

Immunohistochemistry and cDNA microarray analyses were used to assess protein and mRNA expression of cyclin A1 and proteins with roles in metastasis, including vascular endothelial growth factor (VEGF), metalloproteinase 2 (MMP2), and MMP9, in human prostate cancer. (medscape.com)
Cyclin A1 protein and mRNA expression were statistically significantly higher in prostate cancers than in adjacent benign tissues. (medscape.com)
Cyclin A1 mRNA expression in EOC and healthy tissues was quantified by microarray analysis and quantitative real-time PCR (qRT-PCR). (biomedcentral.com)

In previous study, we demonstrated that TLS binds to long noncoding RNA, promoter-associated ncRNA-D (pncRNA-D), transcribed from the 5′ upstream region of cyclin D1 (CCND1), and inhibits the expression of CCND1. (biomedcentral.com)

Cyclin A1 is a cell cycle regulator that has been implicated in the progression of prostate cancer. (medscape.com)
Cyclin A1, a cell cycle regulatory factor, has been demonstrated to be required for the G2/M phase transition in meiotic division of male germ cells by gene targeting, [ 14 ] and it contributes to the G1/S cell cycle progression in leukemic cell lines. (medscape.com)
The colocalization of SMYD3 and H2A.Z.1K101me2 at the promoter of cyclin A1 activated its expression and G 1 -S progression. (aacrjournals.org)
Moreover, a large number of reports indicate that TGF-β can turn into a promoter of progression at later tumour stages [ 15 ]. (springer.com)

Moreover, we discovered that cyclin A1 methylation was inversely related to p53 mutational status in primary tumors (P = 0.015), and forced expression of cyclin A1 resulted in robust induction of wild-type p53 in HNSCC cell lines. (nih.gov)

The role of cyclin A1 and androgen receptor (AR) in transcription of VEGF and MMP2 was assessed by promoter mutation and chromatin immunoprecipitation. (medscape.com)
001). Cyclin A1, in concert with AR, bound to and increased expression from the VEGF and MMP2 promoters. (medscape.com)
Cyclin A1 contributes to prostate cancer invasion by modulating the expression of MMPs and VEGF and by interacting with AR. (medscape.com)

Cyclin-A1 is a protein that in humans is encoded by the CCNA1 gene. (wikipedia.org)
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell division cycle. (wikipedia.org)
After vascular complex pathway is caused on a Electrical snRNP, MAML( other) radicals direct in brain with cyclin C, including protein of followed high-affinity ligands in TAD and PEST cilia of NICD1 by CDK8. (evakoch.com)

In previous study, we demonstrated that long noncoding RNAs (lncRNAs) transcribed from the 5′ upstream region of cyclin D1 ( CCND1 ), and these lncRNA are expected to bind to TLS and inhibits the histone acetyltransferase activity of CBP/p300 at the CCND1 promoter. (biomedcentral.com)

1996). Further details about cyclin E promoter regulation have recently been reported (Le Cam et al. (nih.gov)

Inverse correlation between cyclin A1 hypermethylation and p53 mutation in head and neck cancer identified by reversal of epigenetic silencing. (nih.gov)
We analyzed Cyclin A1 expression in EOC and its correlation with clinical features to evaluate Cyclin A1 as a T-cell target in EOC. (biomedcentral.com)

001). PC3 cells that overexpressed cyclin A1 showed increased invasiveness, and inhibition of cyclin A1 expression via shRNA expression reduced invasiveness of these cells. (medscape.com)
The transcription of shRNA gene is driven by a U6 or H1 promoter. (biomedcentral.com)

In addition to a constitutively occupied E2F1-Sp1 site immediately upstream of the cyclin E transcription start region, there is downstream a cell cycle-regulated site (termed CERM) that may function as a cyclin E-repressor module. (nih.gov)

Cyclin A1 expression has been reported in several epithelial malignancies, including testicular, endometrial, and epithelial ovarian cancer (EOC). (biomedcentral.com)

Our findings suggest that SMYD3-mediated H2A.Z.1K101 dimethylation activates cyclin A1 expression and contributes to driving the proliferation of breast cancer cells. (aacrjournals.org)

During this mechanism, binding between the lncRNA, promoter-associated noncoding RNA (pncRNA), and TLS changes the structure of TLS and allows it to interact with CBP/p300. (biomedcentral.com)
The complexing of C/EBPα with Brm or HDAC1 is regulated by phosphorylation on C/EBPα-S193, which is increased by age via a cyclin D3 and GSK3β-mediated mechanism [ 27 ]. (biomedcentral.com)

C1 The Cyclin D1 promoter is activated by E2F4, but it is repressed by E2F1 via pRb (Watanabe et al. (nih.gov)
1998) . In pRb-deficient cells, E2F1 stimulates this promoter. (nih.gov)

Cyclin A1 is highly expressed in most EOCs. (biomedcentral.com)

According to the origins of transcription sites, lncRNAs can be summarized into different types, including enhancer-associated lncRNA, promoter-associated lncRNA, exonic and intronic lncRNA, long intergenic lncRNA, and antisense lncRNA. (biomedcentral.com)

Cyclin A1 was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of meiosis. (wikipedia.org)
In this study we performed a systematic immunolocalization screen to identify Arabidopsis thaliana A- and B-type cyclins expressed in meiosis. (prolekarniky.cz)
We found six A-type cyclins and a single B-type cyclin (CYCB3;1) to be expressed in male meiosis. (prolekarniky.cz)
Mutant analysis revealed that these cyclins contribute to distinct meiosis-related processes. (prolekarniky.cz)
We further show that cyclin SDS does not contain a D-box and is constitutively expressed throughout meiosis. (prolekarniky.cz)

[3] Mitogenic signals received throughout G1-phase cause gradual accumulation of cyclin D, which complexes with CDK4/6. (wikipedia.org)

Furthermore because both plasmids are in order from the constitutive promoter no induction is essential and optimum creation requires five times of IKK-2 inhibitor VIII fermentation at 30 °C. The overall system once was optimized and we showed that addition of repressors or inducers serve to diminish yields.25 Thus after five times without induction internal controls 1 and 3 are created and perhaps new derivatives encoded on ptruE. (immune-source.com)

Identification of Meiotic Cyclins Reveals Fun. (prolekarniky.cz)

Jdp2 -promoter-Cre transgenic mouse displayed a positive signal in the cerebellum, especially within granule cells. (biomedcentral.com)

A1 ATM is present in a complex that includes c-Abl and Rad51 (Yuan et al. (nih.gov)

Estamos llevando a cabo un estudio sistemático para identificar en el genoma humano sitios blanco de AGO1 con un rol en el control del splicing alternativo por siRNAs. (uba.ar)
En otros palabras, descubrimos que en en las plantas, la elongación de la transcripción es más rápida de día que de noche, lo cual explica el mecanismo nuclear del control del splicing alternativo por la luz. (uba.ar)

Analysis of plants carrying cyclin SDS with an introduced D-box motif determined that, in addition to its function in recombination, SDS acts together with CYCB3;1 in suppressing unscheduled cell wall synthesis. (prolekarniky.cz)

cyclin L2 [Source:HGNC Symbol;Acc:H. (gsea-msigdb.org)

Cyclin A1 is essential for male gametopoiesis. (biomedcentral.com)

While A2 cyclins are important for chromosome segregation, CYCB3;1 prevents ectopic cell wall formation. (prolekarniky.cz)

The cyclin gene family has undergone a massive expansion in angiosperm plants, but only a few cyclins were thoroughly characterized. (prolekarniky.cz)

Cyclin-D1 was focally expressed only in the carcinomatous elements. (biomedcentral.com)

Anatomy14

Organisms10

Diseases2

Chemicals and Drugs116

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes86

Disciplines and Occupations1

Information Science3

Kinase inhibitor2

Gene7

Proteins2

Dependent5

CDKs1

CCNA12

Tumor2

Kinases1

Oncogene1

Cdk21

Progression1

Transcript1

Transcription1

Interaction1

Trials1

Primarily1

Cell1

Variant1

Region2

Expression1

Human1

Altered cyclin A1 expression1

Genes13

MRNA expression3

Binds1

Progression4

Methylation1

VEGF3

Protein3

Histone1

19961

Correlation2

ShRNA2

Upstream1

Ovarian cancer1

Contributes1

Mechanism2

E2F12

Highly expressed1

LncRNA1

Meiosis5

Complexes1

Induction1

Identification1

Cells1

Complex1

Control2

Function1

Source1

Essential1

Important1

Family1

Elements1