• Within this conserved region is a consensus site for myocyte enhancer factor 2 (MEF2) proteins that we show is bound efficiently by MEF2 and is required for transgene expression in all three muscle lineages in vivo. (ox.ac.uk)
  • The Arabidopsis genome contains an estimated 340,000 potential MADS binding sites ( de Folter and Angenent, 2006 ), leading to the intriguing question: What is the biological significance of the large number of potential MADS binding sites, and how many target genes do MADS proteins really regulate? (frontiersin.org)
  • Based on these studies, it appears that MADS proteins may directly regulate thousands of target genes (Figure 1 A), and may serve to integrate different biological processes. (frontiersin.org)
  • (A) Network representation (Cytoscape) of the reported target genes (represented by blue lines) of the four MADS proteins (yellow circles). (frontiersin.org)
  • The four MADS proteins share 70 target genes. (frontiersin.org)
  • We hypothesize that both the tissue-specific and the hormonal and/or metabolic regulation of the GLUT4 gene are carried out through these two regulatory domains and their cognate binding proteins. (ouhsc.edu)
  • To achieve these goals, we propose the following specific aims: 1) To understand the basis of cooperation between GEF and MEF2 proteins for DNA binding;2) To understand the mechanisms by which GEF and MEF2 proteins regulate the GLUT4 promoter;3) ) To determine the nature of the metabolic signal(s) that regulates GLUT4 gene transcription in vivo. (ouhsc.edu)
  • MSY3 (MSY4, YB-2, CSDA, dbpA, ZONAB) is a member of the cold shock domain (CSD) family of proteins also known as Y-box proteins, which are evolutionarily conserved proteins that function as transcription factors and regulators of RNA metabolism and protein synthesis. (biomedcentral.com)
  • these multidomain guanine nucleotide exchange factors (GEFs) contain additional domains known to interact with phosphatidylinositides as well as with a number of different proteins. (biomedcentral.com)
  • Tamir, Y., and Bengal E . (2000) Phosphoinositide 3-kinase induces the transcriptional activity of MEF2 proteins during muscle differentiation . (technion.ac.il)
  • Regulatory proteins, namely the Transcription Factors (TFs), bind in a sequence-specific manner to TFBSs to activate or suppress gene transcription (gene expression). (biomedcentral.com)
  • The download Hanging Sam: A Military Biography of General of Insulin like Growth Factor Binding Proteins( IGFBPs) phase 50 response pathway good research with reviewed N cell and C formation enzymes binding for conjugating Insulin like Growth Factors I and II( IGF I and IGF II). (evakoch.com)
  • Chemically induced gene expression changes were characterized by qRT-PCR, global run-on sequencing (GRO-seq) and immunoblotting, and the network of cooperative proteins of GATA4 and NKX2-5 were further explored by the examination of the GATA4 and NKX2-5 interactome by BioID. (biomedcentral.com)
  • This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS. (lookformedical.com)
  • Structural genes encode proteins that are not involved in gene regulation. (p450inhibitors.com)
  • In order to understand the development of adiposity, it is crucial to identify the factors and mechanisms that regulate the recruitment of mesenchymal stem cells (MSCs) of the vascular stromal fraction of the adipose tissue and its transformation into lipid-filled adipocytes. (biomedcentral.com)
  • Drosophila endocytic neoplastic tumor suppressor genes regulate Sav/Wts/Hpo signaling and the c-Jun N-terminal kinase pathway. (uiowa.edu)
  • Consistent with the latter observation, we show that IRF4 can regulate the IL-10 promoter in B cells. (prelekara.sk)
  • Published results indicate that protein kinase C (PKC) activity in conjunction with innervation-induced activation of cell signaling mediated by the muscarinic acetylcholine receptor, Gaq, and the 1,4,5 inositol triphosphate receptor 1 (IP3R1) differentially regulate fast versus slow muscle fiber type gene expression in innervated muscle fibers. (rosalindfranklin.edu)
  • The mechanisms that regulate myoblast cell proliferation versus differentiation involve extracellular signaling via growth factors, their cognate receptors, intracellular signal transduction cascades, and transcriptional regulation of genes associated with cell proliferation. (rosalindfranklin.edu)
  • Our results suggest that previous estimates of the number of human miRNA genes were low, and that miRNAs regulate at least 20% of human genes. (gsea-msigdb.org)
  • These factors then induce myostatin-specific gene regulation. (wikipedia.org)
  • Mutation of the MEF2 elements indicate that they might play redundant roles in XMLC2 regulation. (ucl.ac.uk)
  • This Sbp sequence does not conform to any known transcription factor binding site involved in contractile isoform regulation, therefore, might represent a novel control element required for cardiac muscle-specific activation of the cardiac α-actin gene. (ucl.ac.uk)
  • the presence of HDAC7 blocked the induction of key genes for macrophage function, such as immune, inflammatory, and defense response, cellular response to infections, positive regulation of cytokines production, and phagocytosis. (eur.nl)
  • We find that during normal lifespan of CMs gene regulation is mainly orchestrated by dynamic mCpG and canonical histone marks at distal regulatory and genic regions. (nature.com)
  • Thus, these studies identify the HRC enhancer as the first MEF2-dependent, CArG-independent transcriptional target in smooth muscle and represent the first analysis of the transcriptional regulation of an SR gene in vivo. (ox.ac.uk)
  • The study suggested that TCAP gene might be a prospective candidate gene affecting muscle mass and meat quality traits in the pig and would lay the groundwork for the further investigations on the regulation and physiological function of porcine TCAP gene. (medwelljournals.com)
  • To reach this goal, we must first understand the molecular basis for transcriptional regulation of the GLUT4 gene. (ouhsc.edu)
  • The primary goal of this proposal is to understand the molecular mechanisms of the tissue-specific and hormonal/metabolic regulation of GLUT4 gene transcription. (ouhsc.edu)
  • We have previously shown that MSY3/Csda binds a highly conserved cis-acting element located upstream of the myogenin promoter (myogHCE) and regulates the postnatal down-regulation of myogenin [ 16 ]. (biomedcentral.com)
  • Kolpakova A*, Katz S*, Keren A, Rojtblat A, Bengal E . (2013) Transcriptional Regulation of Mesoderm Genes by MEF2D during Early Xenopus Development . (technion.ac.il)
  • Identification of transcription factor binding sites (TFBSs) is a central problem in Bioinformatics on gene regulation. (biomedcentral.com)
  • Therefore, TFBSs are a critical component in gene regulation, and identification of TFBSs is a central problem for understanding gene regulation in molecular biology. (biomedcentral.com)
  • Motif discovery provides significant insights into the understanding of the mechanisms of gene regulation. (biomedcentral.com)
  • This indicated the involvement of epigenetic modulators in the regulation of GATA-dependent transcription. (biomedcentral.com)
  • This signaling culminates in regulation of transcription factors governing expression of the slow myosin heavy chain 2 gene - indicative of the slow muscle fiber phenotype. (rosalindfranklin.edu)
  • We are interested in the transcriptional regulation of the FGFR1 gene because its expression is tightly linked to continued myoblast proliferation. (rosalindfranklin.edu)
  • The overall results provide a systematic view of gene regulation in the human, which will be refined as additional mammalian genomes become available. (gsea-msigdb.org)
  • Myostatin (also known as growth differentiation factor 8, abbreviated GDF8) is a protein that in humans is encoded by the MSTN gene. (wikipedia.org)
  • Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family. (wikipedia.org)
  • Human myostatin consists of two identical subunits, each consisting of 109 (NCBI database claims human myostatin is 375 residues long) amino acid residues [note the full length gene encodes a 375AA prepro-protein which is proteolytically processed to its shorter active form]. (wikipedia.org)
  • The Xenopus cardiac myosin light chain 2 gene (XMLC2) encodes a contractile protein localised exclusively to the heart of the embryo. (ucl.ac.uk)
  • Gel shift experiments reveal that the four consensus MEF2 sites in the 5' flanking region of the XMLC2 gene bind Xenopus MEF2D protein. (ucl.ac.uk)
  • The cardiac α-actin gene is a contractile protein expressed concomitantly in the somitic and cardiac muscle during Xenopus embryogenesis. (ucl.ac.uk)
  • The HRC gene encodes the histidine-rich calcium-binding protein, which is found in the lumen of the junctional sarcoplasmic reticulum (SR) of cardiac and skeletal muscle and within calciosomes of arterial smooth muscle. (ox.ac.uk)
  • Proliferation was characterized by enrichment in genes involved in basic cellular and metabolic processes (transcription, ribosome biogenesis, translation and protein folding), cellular remodelling and autophagy. (biomedcentral.com)
  • 2550146 . RA Hahn S., Buratowski S., Sharp P. A., Guarente L. RT Isolation of the gene encoding the yeast TATA binding protein TFIID: A gene identical to the SPT15 suppressor of Ty element insertions RL Cell 58:1173-1181 (1989). (genexplain.com)
  • MEF2 isoforms and GEF form a protein complex in vivo;however, the function of this complex in regulating gene transcription is not known. (ouhsc.edu)
  • The Y-box protein MSY3/Csda represses myogenin transcription in skeletal muscle by binding a highly conserved cis-acting DNA element located just upstream of the myogenin minimal promoter (myogHCE). (biomedcentral.com)
  • In most single gene autisms (Rett, Fragile-X, Pitt Hopkins etc) the underlying problem is that a faulty gene does not do its job of producing the expected protein. (epiphanyasd.com)
  • For example, in Timothy Syndrome the mutation in the gene produces too much of the protein, in this case the L-type calcium channel Cav1.2. (epiphanyasd.com)
  • Alter J, Bengal E. (2011) Stress-Induced C/EBP Homology Protein (CHOP) Represses MyoD Transcription to Delay Myoblast Differentiation . (technion.ac.il)
  • Zetser, A., Gredinger, E., and Bengal, E. (1999) p38 mitogen-activated protein kinase promotes skeletal muscle differentiation: participation of the MEF2C transcription factor . (technion.ac.il)
  • Tamir, Y., and Bengal, E. (1998) p53 protein is activated during muscle differentiation and participates with MyoD in the transcription of muscle creatine kinase gene . (technion.ac.il)
  • A retinoblastoma-binding protein that is involved in CHROMATIN REMODELING, histone deacetylation, and repression of GENETIC TRANSCRIPTION. (lookformedical.com)
  • Although initially discovered as a retinoblastoma binding protein it has an affinity for core HISTONES and is a subunit of chromatin assembly factor-1 and polycomb repressive complex 2. (lookformedical.com)
  • These mice express tamoxifen-induced Cre recombinase (Mer-cre-Mer) that enzymatically removes a stop codon flanked by lox sequences (floxed) on a reporter gene such as green fluorescent protein or yellow fluorescent protein, thus resulting in traceable fluorescence on the cells of interest. (musculoskeletalkey.com)
  • During vertebrate myogenesis, myoblast cell populations proliferate and fuse to form multinucleated muscle fibers that express a battery of contractile protein genes. (rosalindfranklin.edu)
  • Neural retina-specific leucine zipper protein is a protein that in humans is encoded by the NRL gene . (en-academic.com)
  • FASLG, the protein encoded by this gene would be the ligand for FAS. (microrna21.com)
  • Bioinformatic analysis of the 5' regulatory region has revealed that in addition to several ubiquitous transcription factors binding sites (SP1, AP1 and C/EBP) were found, several putative muscle-specific transcription factor binding sites (MyoD, MyoG and MEF2) were present in this region. (medwelljournals.com)
  • The MyoD gene was duplicated during the teleost whole genome duplication and, while a second MyoD gene ( MyoD2 ) was subsequently lost from the genomes of some lineages (including zebrafish), many fish lineages (including Alcolapia species) have retained both MyoD paralogues. (mdpi.com)
  • Here we reveal the expression patterns of the two MyoD genes in Oreochromis ( Alcolapia) alcalica using in situ hybridisation. (mdpi.com)
  • To identify the regulatory sequences responsible for cardiac muscle-specific expression of XMLC2,1 investigated the sequences immediately upstream of the gene. (ucl.ac.uk)
  • Of particular importance has been the identification of two families of transcription factors: the myogenic regulatory factors (MRFs) and the myocyte enhancer factors (MEFs). (biologists.com)
  • This region contains two major regulatory domains, referred to as Domain I and the MEF2 domain. (ouhsc.edu)
  • Basic helix-loop-helix (bHLH) myogenic regulatory factors coordinate the correct function and organization of many skeletal muscle functions. (biomedcentral.com)
  • Transcription Factor Binding Sites (TFBSs) are small nucleotide fragments (usually ≤ 30 bp) in the cis-regulatory/intergenic regions in DNA sequences. (biomedcentral.com)
  • Here, employing an inducible B cell expression system, we have determined that M2 activates the NFAT pathway in a Src kinase-dependent manner - leading to induction of the plasma cell-associated transcription factor, Interferon Regulatory Factor-4 (IRF4). (prelekara.sk)
  • Pharmacological modulation of cell fate decisions and developmental gene regulatory networks holds promise for the treatment of heart failure. (biomedcentral.com)
  • Collectively, these results indicate the potential for therapeutic alteration of cell fate decisions and pathological gene regulatory networks by GATA4-targeted compounds modulating chamber-specific transcriptional programs in multipotent cardiac progenitor cells and cardiomyocytes. (biomedcentral.com)
  • Our on-going research is focused on the regulatory mechanisms that link innervation, PKC activity, IP3R1 activity, transcriptional regulators, and expression of slow muscle fiber type specific genes. (rosalindfranklin.edu)
  • The goal of our on-going research is to define and characterize the transcriptional complexes resident on the FGFR1 regulatory regions as well as those interactions off the promoter that govern its expression in both proliferating myoblasts and differentiated muscle fibers. (rosalindfranklin.edu)
  • Lately research connected to mechanisms of leukemia cell resistance to Fas FasL mediated apoptosis selleck chemical such as Fas and FasL mutation and expression abnormality, Fas signaling transduction pathway abnormality, and regulatory have an impact on of apoptotic regulatory genes on Fas FasL process, as well as tactics replying to antiapoptosis of leukemia cells including NF kappa B, XIAP, membrane receptor CD28 and matrix metalloproteinase 7 obtained some pro gresses. (microrna21.com)
  • Here, we present a comparative analysis of the human, mouse, rat and dog genomes to create a systematic catalogue of common regulatory motifs in promoters and 3' untranslated regions (3' UTRs). (gsea-msigdb.org)
  • In this study, researchers cloned the 5' upstream region of porcine TCAP gene. (medwelljournals.com)
  • Most peaks, clearly enriched for CArG-box sequences, are present in upstream promoter regions close to the transcriptional start site, though some are also found in introns and 3′-UTR regions. (frontiersin.org)
  • Despite the expression of multiple Rho GDP/GTP exchange factors (GEFs) in the nervous system, the Kalrn gene, which encodes multiple isoforms of Kalirin, plays an essential, non-redundant role. (biomedcentral.com)
  • This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. (en-academic.com)
  • 1992). "A conserved retina-specific gene encodes a basic motif/leucine zipper domain" . (en-academic.com)
  • Transgenic frog technology indicates that the 3kb 5' proximal promoter fragment can direct cardiac muscle-specific reporter expression during Xenopus embryogenesis, reproducing the normal expression pattern of the endogenous gene. (ucl.ac.uk)
  • Using transgenic frog technology, I demonstrate that a 580bp cardiac α-actin promoter fragment drives high level expression of a GFP reporter in the heart and skeletal muscle of Xenopus embryos. (ucl.ac.uk)
  • In this study, we identified a transcriptional enhancer from the HRC gene that is sufficient to direct the expression of lacZ in the expression pattern of endogenous HRC in transgenic mice. (ox.ac.uk)
  • Using transgenic mice, we have shown that cis-elements regulating the human Glut4 promoter are located within 895 bp immediately 5'of the transcription initiation site. (ouhsc.edu)
  • Proliferation cluster comprised 1028 genes up-regulated from days 3 to 8 of culture meanwhile the differentiation cluster was characterized by 2140 induced genes from days 15 to 21. (biomedcentral.com)
  • Overall, our study demonstrates the coordinated expression of functionally related genes during proliferation and differentiation of rainbow trout adipocyte cells. (biomedcentral.com)
  • Notch and Mef2 synergize to promote proliferation and metastasis through JNK signal activation in Drosophila. (uiowa.edu)
  • BTG anti-proliferation factor 4. (gsea-msigdb.org)
  • An SRF binding site (CArG box 1) in the 580bp cardiac α-actin promoter is necessary but not sufficient for high level muscle-specific expression. (ucl.ac.uk)
  • In contrast, deletion of the E-box elements from the 580bp cardiac α-actin promoter had no effect on transcription of the transgene. (ucl.ac.uk)
  • Epigenetic mechanisms and transcription factor networks essential for differentiation of cardiac myocytes have been uncovered. (nature.com)
  • HRC is a direct transcriptional target of MEF2 during cardiac, skeletal, and arterial smooth muscle development in vivo. (ox.ac.uk)
  • In the present study bioinformatics analysis demonstrated cardiac hypertrophy signaling may be the most important pathway for upregulating genes in sesamin-treated groups. (spandidos-publications.com)
  • 2011. Gene Coexpression Network Topology of Cardiac Development, Hypertrophy, and FailureClinical Perspective . (umd.edu)
  • Transcription factor GATA4-targeted compounds that have previously shown in vivo efficacy in cardiac injury models were tested for stage-specific activation of atrial and ventricular reporter genes in differentiating pluripotent stem cells using a dual reporter assay. (biomedcentral.com)
  • In this line, reporter gene assays with combinatorial treatment of 3i-1000 and the BET bromodomain inhibitor (+)-JQ1 demonstrated the cooperative role of GATA4 and BRD4 in the modulation of chamber-specific cardiac gene expression. (biomedcentral.com)
  • The MEF2 domain binds isoforms of the Myocyte Enhancer Factor 2 (MEF2) family of transcription factors, while Domain I binds GEF (GLUT4 Enhancer Factor), a transcriptional activator identified and cloned in our laboratory. (ouhsc.edu)
  • To date, the central role of specific transcription factors in positively regulating these distinct differentiation processes to acquire a B cell-specific genetic program is well established. (eur.nl)
  • To understand the development of adiposity, it is crucial to identify the genes which expression is associated with adipogenic differentiation. (biomedcentral.com)
  • On the other hand, the terminal differentiation phase was enriched with genes involved in energy production, lipid and carbohydrate metabolism. (biomedcentral.com)
  • Alter, J., Rozentzweig, D., and Bengal, E. (2008) Inhibition of myoblast differentiation by tumor necrosis factor alpha is mediated by c-Jun N-terminal kinase 1 and leukemia inhibitory factor . (technion.ac.il)
  • Among these genes is the fibroblast growth factor receptor 1 (FGFR1) gene which is expressed in proliferating myoblasts and down-regulated during differentiation. (rosalindfranklin.edu)
  • Furthermore, the entire HRC enhancer sequence lacks any discernible CArG motifs, the binding site for serum response factor (SRF), and we show that the enhancer is not activated by SRF. (ox.ac.uk)
  • Furthermore, the information generated will allow future investigations of specific genes involved in particular stages of fish adipogenesis. (biomedcentral.com)
  • Deletion mapping of the 3kb XMLC2 promoter by Xenopus transgenesis defines the most proximal 708bp as the minimal promoter fragment sufficient to confer high level reporter expression in the embryonic heart. (ucl.ac.uk)
  • The whole adipogenic process was driven by a coordinated activation of transcription factors and epigenetic modulators. (biomedcentral.com)
  • GATA4-targeted compounds 3i-1000 and 3i-1103 were identified as differential modulators of atrial and ventricular gene expression. (biomedcentral.com)
  • The thorough expression of every Inhibitors,Modulators,Libraries up regulated gene in pediatric AML was presented in Figure two along with the expression of down regulated genes was presented in Figure three. (microrna21.com)
  • Chronic cocaine treatment increases usage of the promoter encoding the Δ-Kalirin isoforms but does not alter full-length Kalirin promoter usage. (biomedcentral.com)
  • 2009. Gene Profiling of Human Adipose Tissue During Evoked Inflammation In Vivo . (umd.edu)
  • Further 5' or 3' truncations attenuate the transcriptional activity of the XMLC2 promoter, whilst sequences contained between -217bp and -86bp are critical for myocardial-specific activity. (ucl.ac.uk)
  • While the two most distal full-length Kalrn promoters are used equally in the prefrontal cortex, the more proximal of these promoters accounts for most of the transcripts expressed in the nucleus accumbens. (biomedcentral.com)
  • Expression of a 3kb XMLC2 promoter-CAT reporter gene introduced into the oocyte germinal vesicle is only detected in oocytes previously injected with MEF2D RNA, but not MEF2A. (ucl.ac.uk)
  • In contrast, pathological gene expression in terminal heart failure is accompanied by changes in active histone marks without major alterations in CpG methylation and repressive chromatin marks. (nature.com)
  • Many of these transitions involve changes of gene expression. (nature.com)
  • In contrast to previous findings in heart tissue, expression of the pathological gene program in heart failure was not accompanied by changes in the CM DNA methylome but by active histone marks. (nature.com)
  • Tissue expression analysis showed that the porcine TCAP gene was expressed abundantly in skeletal muscle. (medwelljournals.com)
  • A straightforward approach to enhance GLUT4 expression is to increase the transcription rate of the gene. (ouhsc.edu)
  • GLUT4 gene expression is transcriptionally regulated in physiologic states such as insulin-deficiency and exercise, and it is likely that a pharmacological intervention can be developed to enhance Glut4 gene transcription. (ouhsc.edu)
  • In the nucleus accumbens, cocaine-mediated alterations in promoter usage and 3'-terminal exon usage favor expression of Kalirin 7 and Δ-Kalirin 7. (biomedcentral.com)
  • PTH regulates myleoid ELF-1-like factor (MEF)-induced MAB-21-like-1 (MAB21L1) expression through the JNK1 pathway. (univ-paris5.fr)
  • Reporter gene assays were conducted to examine combinatorial effects of GATA-targeted compounds and bromodomain and extraterminal domain (BET) inhibition on chamber-specific gene expression. (biomedcentral.com)
  • Additionally, innervation modulates muscle fiber type and associated fiber type specific gene expression. (rosalindfranklin.edu)
  • A high frequency of BCL2 mRNA over expression plus a reasonably minimal frequency of BAX mRNA above expression detected in each analyzed leukemia within this research, indicate that altered transcription of those genes may very well be involved in leukemogenesis. (microrna21.com)
  • Ectopic expression of PML recruits HDAC7 to PML NBs and leads to activation of MEF2 reporter activity. (microrna21.com)
  • Evaluated the mRNA gene expression profile of 12 HDAC genes by quantitative serious time polymerase chain reaction in 94 consecutive childhood acute lymphoblastic leukaemia samples and its association with clinical biological functions and survival. (microrna21.com)
  • Proteoglycan 4, a novel immunomodulatory factor, regulates parathyroid hormone actions on hematopoietic cells. (univ-paris5.fr)
  • Using genetic mouse models, we found that mutations of two different molecular clock genes, Clock and Bmal1, dramatically disrupt skeletal muscle structure and function. (ufl.edu)
  • Here we addressed the molecular mechanism behind repression of non-lymphoid genes in B cells. (eur.nl)
  • A download Hanging Sam: A Military Biography of General Samuel T. Williams: From Pancho Villa to of residues are experienced regulated for the high 3-phosphate by which SP1 assemblies present to connected formation phagosome by UCP1 in transmembrane C1q-mediated fusion momenta, and preferentially by the intracellular genes as Once. (evakoch.com)
  • The gene encoding myostatin was discovered in 1997 by geneticists Se-Jin Lee and Alexandra McPherron who produced a knockout strain of mice that lack the gene, and have approximately twice as much muscle as normal mice. (wikipedia.org)
  • Unlike mice with a damaged myostatin gene, in these cattle breeds, muscle cells multiply rather than enlarge. (wikipedia.org)
  • Genes having at least one occurrence of the highly conserved motif M53 RYTGCNNRGNAAC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb]. (gsea-msigdb.org)
  • We found that HDAC7 specifically interacted with the transcription factor MEF2C in pre-B cells and was recruited to MEF2 binding sites located at the promoters of genes critical for macrophage function. (eur.nl)
  • Characterisation of a 3kb XMLC2 promoter fragment reveals the presence of four MEF2 and four GATA transcription factor binding sites. (ucl.ac.uk)
  • This suggests that XMLC2 is a direct target for activation by MEF2D and indicates that functional differences exist between MEF2 family members to activate the XMLC2 gene. (ucl.ac.uk)
  • Depending on the organism and availability, mt-tRNA Val or mt-tRNA Phe are incorporated, most likely due to their genomic proximity to mt-rRNA genes and consequent near stoichiometric presence of their transcripts 4 , 8 . (nature.com)
  • The promoter analysis yields 174 candidate motifs, including most previously known transcription-factor binding sites and 105 new motifs. (gsea-msigdb.org)
  • After the discovery of the gene encoding myostatin 1997, several laboratories cloned and established the nucleotide sequence of a myostatin gene in two breeds of cattle, Belgian Blue and Piedmontese. (wikipedia.org)
  • Furthermore, individuals who have mutations in both copies of the myostatin gene (popularly, but inaccurately called the "Hercules gene") have significantly more muscle mass and are stronger than normal. (wikipedia.org)
  • They found mutations in the myostatin gene (various mutations in each breed) which in one way or another lead to absence of functional myostatin. (wikipedia.org)
  • Mutations in this gene have been associated with retinitis pigmentosa and retinal degenerative diseases. (en-academic.com)
  • showed the Wilms tumor gene is in excess of expressed in sufferers with most varieties of acute leukemia. (microrna21.com)
  • Nearly one-half are associated with microRNAs (miRNAs), leading to the discovery of many new miRNA genes and their likely target genes. (gsea-msigdb.org)
  • Compounds that target tissue-specific transcription factors could overcome non-specific effects of small molecules and lead to the regeneration of heart muscle following myocardial infarction. (biomedcentral.com)
  • e.g. they bind selectively to DNA, stimulate transcription resulting in tissue-specific RNA synthesis and undergo specific changes in response to various hormones or phytomitogens. (lookformedical.com)
  • Our findings uncover a novel role for HDAC7 in maintaining the identity of a particular cell type by silencing lineage-inappropriate genes. (eur.nl)
  • Our published findings demonstrate that the FGFR1 gene is positively regulated by the Sp1 transcriptional regulator and negatively regulated by the transcription factor E2F4. (rosalindfranklin.edu)
  • ChIP-seq was performed using antibodies against SEP3 in wild type and agamous ( ag-1 ) inflorescence tissues, resulting in 4282 and 2828 peaks (binding events) respectively, corresponding to 3475 and 2424 putative target genes. (frontiersin.org)
  • The putative targets are enriched for transcription factors of different families and, interestingly, for hormonal signaling pathways (auxin, brassinosteroids, and gibberellins). (frontiersin.org)
  • This coreceptor then initiates a cell signaling cascade in the muscle that includes the activation of transcription factors in the SMAD family-SMAD2 and SMAD3. (wikipedia.org)
  • Moreover, during this phase an enrichment in genes involved in the formation of the lipid droplets was evidenced as well as the activation of the thyroid-receptor/retinoic X receptor (TR/RXR) and the peroxisome proliferator activated receptors (PPARs) signalling pathways. (biomedcentral.com)
  • Due to cellular heterogeneity in the heart, the activation of gene programs representing specific atrial and ventricular cardiomyocyte subtypes would be highly desirable. (biomedcentral.com)
  • Thus, in B cells HDAC7 is a transcriptional repressor of undesirable genes. (eur.nl)
  • Parathyroid hormone activates the orphan nuclear receptor Nurr1 to induce FGF23 transcription. (univ-paris5.fr)
  • (B) Venn diagram depicting the numbers of shared target genes. (frontiersin.org)
  • In this study the authors were also interested in identifying target genes associated with perianth development. (frontiersin.org)
  • Preliminary evidence suggests that changes in lipid metabolism and/or cAMP signaling target GLUT4 promoter function. (ouhsc.edu)