Promoter in transgenic mice. Medical search. Frequent questions

To determine whether seizures affect GABA(A)-receptor gene transcription in vivo, a transgenic mouse line carrying a lacZ-fusion gene driven by GABA(A)-receptor δ-subunit promoter and upstream sequences was subjected to pentylenetetrazol (PTZ)-induced seizures. (psu.edu)
In vivo vMSOT brain imaging of P301L mice showed higher retention of PBB5 in the tau-laden cortex and hippocampus compared to wild-type mice, as confirmed by ex vivo vMSOT, epi-fluorescence, multiphoton microscopy, and immunofluorescence staining. (springer.com)
Here, we used in vivo two-photon Ca 2+ imaging to probe the organization of the mouse primary auditory cortex and show that the spatial organization of neural response properties (frequency tuning) within the thalamorecipient layer (L3b/4) is more homogeneous than in supragranular layers (L2/3). (jneurosci.org)
The enhanced efficacy and exquisite specificity of SELECTIV has broad utility in development of new mouse model systems and expands the use of AAV for gene delivery in vivo. (nature.com)
A complementary approach uses mice with targeted gene disruption to elucidate the physiological roles of ion exchangers and associated proteins under in vivo conditions. (yale.edu)
A 3-component transgenic mouse model to track and manipulate senescent cells in vivo . (jax.org)
Using these p16-3MR mice and in vivo bioluminescent imaging, the researchers observed a robust, but transient, increase in senescent cells at the site of cutaneous injury. (jax.org)
In vivo studies demonstrated that cadmium could also induce transactivation of AP-1 in AP-1-luciferase report transgenic mice. (cdc.gov)
Anti-Siglec-8 antibody administration in vivo to humanized and transgenic mice selectively expressing Siglec-8 on mouse eosinophils and mast cells confirmed the in vitro findings, and identified additional anti-inflammatory effects. (mdpi.com)
2003). The therapeutic effects of different genes delivered by ment of the hGFAP promoter used here has been extensively studied and lentiviral vectors have been documented in a number of animal found to be up-regulated after several different stimuli both in vitro and models, both in rodents and primates, and examples include delivery in vivo in transgenic mice (Brenner et al. (lu.se)
For instance, mice are able to reconstitute most lymphomas in monkeys and humans woodchuck hepatitis virus induces major components of the human provides strong support for a direct hepatocellular carcinoma (HCC) haematolymphoid system including oncogenic role of EBV in vivo. (who.int)
To model the effect in vivo, the authors used a transgenic mouse which over-expressed UMOD leading to salt-sensitive hypertension and interstitial nephritis . (medscape.com)

GnRH mRNA levels were reduced in Jak2 G −/− mice when compared with controls, while the number of GnRH neurons was equivalent, indicating a reduction in GnRH gene expression. (jneurosci.org)
ETS-1 and ETS-2 mRNA and protein levels were much higher in the ocular tissues of Tyrp-1-TAg mice than in control ocular tissues from wild-type mice. (molvis.org)
Unexpectedly, for all stably-transmitting lines examined, MATR3 transgenic mRNA expression was more robust in muscle, with minimal expression in spinal cord. (biomedcentral.com)
The levels of transgenic mRNA in muscle did not differ between mice from our lead MATR3 F115C line and lead MATR3 WT line, but mice from the lead MATR3 F115C line had significantly higher levels of MATR3 protein in muscle over the lead MATR3 WT line. (biomedcentral.com)
Other recent studies verified the presence of PAPP-A mRNA in granulosa cells of humans, monkeys, cattle, mice, and pigs. (bioone.org)

These findings demonstrate that expression of a proexendin-4 transgene may be associated with activation of humoral and cellular immune responses in mice. (diabetesjournals.org)
In contrast, mice kindled by repeated administration of initially subconvulsive doses of PTZ did not show a change in transgene expression, even shortly after the last PTZ-induced seizure. (psu.edu)
We have generated four lines of transgenic mice carrying a transgene in which 1.34 kb of the 5′-flanking sequence of the mouse MBP gene was fused upstream of the coding region of the Escherichia coli lac Z gene in order to investigate developmental and tissue-specific expression of the MBP gene. (elsevierpure.com)
Expression of both the lacZ transgene and the endogenous MBP gene followed a common developmental pattern in mouse brain. (elsevierpure.com)
Three independently established transgenic lines demonstrated a good correlation between the sensitivity of hepatocytes to DT and the expression level of the DT receptors. (nih.gov)
Using semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blots experiments, we compared changes in ETS-1 and ETS-2 expression, their protein levels, and the regulation of some of their target gene expressions at different stages of the ocular tumoral progression in the transgenic mouse model, Tyrp-1-TAg, with those in normal eyes from control mice of the same age. (molvis.org)
The directed expression of SV40 T antigen has led to the development of several important transgenic models with spontaneous epithelial tumor formation. (molvis.org)
Transgene expression using viral vectors provides an alternative, which allows for temporal expression of genes in mice with reduced cost and effort. (nature.com)
Notably, this was also the only group in which tibial adiponectin expression was lower than in WT mice, suggesting a close association between MAT adiponectin production and circulating adiponectin. (frontiersin.org)
In this model, the senescence-sensitive promoter from the cyclin-dependent kinase inhibitor 2A ( Cdkn2a ) gene, also known as p16 INK4a , drives expression of 3MR, a fusion protein that is composed of luciferase and red fluorescent protein (RFP) reporters and herpes simplex virus-1 thymidine kinase, which converts ganciclovir (GCV) into an apoptosis inducer. (jax.org)
Systemic expression of HIV-1 tat gene in transgenic mice induces endothelial proliferation and tumors of different histotypes. (microbiologyresearch.org)
Expression directed from HIV long terminal repeats in the central nervous system of transgenic mice. (microbiologyresearch.org)
The inventors found that GLP-1R agonists inhibited IL-33 expression and release from the lungs of mice in response to an airway challenge the allergen extract of the aeroallergen Alternaria alternata , an aeroallergen which has protease activity and which is associated with severe asthma exacerbations. (justia.com)
We generated transgenic mice for tamoxifen-inducible, cardiomyocyte-specific expression of NL-RSK1 by inserting the transgene in the ROSA26 locus, separated from the promoter by a LoxP-flanked stop cassette. (bmj.com)
In both the rd and the rhodopsin mutant mice, expression of either bcl-2 or bcl-XL transgenes did not prevent or measurably delay photoreceptor degeneration. (arvojournals.org)
Apoptosis-related nuclear DNA fragmentation, as assessed by in situ labeling with terminal deoxynucleotidyl transferase, was present in 13-day-old rd/rd mouse retinas with or without transgene expression. (arvojournals.org)
CamKII-tTA transgenic mice are viable and fertile, with expression of the tetracycline-controlled transactivator protein (tTA) directed to forebrain neurons by the forebrain-specific calcium-calmodulin-dependent kinase II (Camk2a) promoter. (mmrrc.org)
These mice are a "Tet-Off" tool that allow the inducible expression of genes in forebrain neurons. (mmrrc.org)
RePub, Erasmus University Repository: Tissue specific and position independent expression of the complete gene domain for chicken lysozyme in transgenic mice. (eur.nl)
There are a number of hypothesized that regulating the transgene with a GFAP promoter in a different vectors that transduce cells in the brain in a slightly different viral vector would give rise to a high transgenic expression in the manner (for a review see, e.g. (lu.se)
Jakobsson expression under a human GFAP (hGFAP) promoter. (lu.se)
Materials and methods approach to regulate transgenic expression. (lu.se)
The KKU-055-CSC exhibits CSC characteristics, including: (1) the ability to grow stably and withstand continuous passage for a long period of culture in the stem cell medium, (2) high expression of stem cell markers, (3) low responsiveness to standard chemotherapy drugs, (4) multilineage differentiation, and (5) faster and constant expansive tumor formation in xenograft mouse models. (bvsalud.org)
UMOD risk variants identified in the above-mentioned GWAS are located in the promoter region of the gene, leading to a theory that they altered UMOD expression. (medscape.com)
1994. Ah receptor in embryonic mouse palate and effects of TCDD on receptor expression. (cdc.gov)

To directly compare the specificity and efficacy of different Cre lines in mediating adipocyte specific recombination, transgenic Cre lines driven by the adipocyte protein 2 (aP2) and adiponectin (Adipoq) gene promoters, as well as a tamoxifen-inducible Cre driven by the aP2 gene promoter (iaP2), were bred to the Rosa26R (R26R) reporter. (diabetesjournals.org)

Male and female WT or Ocn -Wnt10b mice (C57BL/6J) were treated with or without rosiglitazone for 2, 4, or 8 weeks, up to 30 weeks of age. (frontiersin.org)
The p16-3MR mouse model was created and backcrossed to C57BL/6J ( 000664 ) using a "speed congenic" approach. (jax.org)
These mice were subsequently bred onto a C57BL/6 genetic background and obtained by Dr. Ulrich Mueller (The Scripps Research Institute). (mmrrc.org)
There, mice were backcrossed to C57BL/6J inbred mice for more than ten generations prior to sending to the MMRRC. (mmrrc.org)
When maintained as a live colony,hemizygous mice may be bred with wildtype (noncarrier) mice from the colony or with C57BL/6J inbred mice (Jax Stock No. 000664 ). (mmrrc.org)

We observed that the majority of non-photoreceptor genes had promoters in a repressive chromatin state, but these promoters were in unmethylated or low-methylated regions. (nih.gov)
Meanwhile, the majority of promoters for photoreceptor genes were found in a permissive chromatin state, but were highly-methylated. (nih.gov)
However, promoters of these genes were demethylated and activated during retinal development. (nih.gov)
2) highly-methylated promoters of photoreceptor-related genes. (nih.gov)
The development of transgenic mouse models that express genes of interest in specific cell types has transformed our understanding of basic biology and disease. (nature.com)
HIV-associated nephropathy in transgenic mice expressing HIV-1 genes. (microbiologyresearch.org)
Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)
We used the CRISPR/Cas9 method to generate BKdelK1 and BKdelK2 mutant mice, targeting the BK portion of mouse kininogen1 and kininogen2 genes, respectively. (bvsalud.org)

Induction of tyrosine hydroxylase in the locus coeruleus of transgenic mice in response to stress or nicotine treatment: lack of activation of tyrosine hydroxylase promoter activity. (rochester.edu)
A 21.5 kb DNA fragment carrying the entire chicken lysozyme gene locus was introduced into the germ line of mice. (eur.nl)

To study whether nontransferable lipoprotein lipase has physiological actions, we placed an α-myosin heavy-chain promoter upstream of a human lipoprotein lipase minigene construct with a glycosylphosphatidylinositol anchoring sequence on the carboxyl terminal region. (jci.org)
The CamKII-tTA transgene was designed by Dr. Mark Mayford (Columbia University, New York) with 8.5 kb of the mouse CaMKIIalpha promoter placed upstream of the tetracycline-regulated transactivator (tTA or "Tet-Off") gene (flanked by an artificial intron and splice sites at the 5' end and by a polyadenylation signal from SV40 at the 3' end). (mmrrc.org)

Unexpectedly, the atypical scrapie agent appeared to undergo a strain phenotype shift upon transmission to porcine-PrP transgenic mice and acquired new strain properties, suggesting that atypical scrapie agent may exhibit different phenotypes depending on the host cellular PrP or other genetic factors. (cdc.gov)
20 months were not overtly distinguishable from non-transgenic (NT) littermates based on basic motor phenotype. (biomedcentral.com)
For example, work with mice lacking anion exchanger Slc26a6, which can function as an oxalate transporter, revealed a phenotype of calcium oxalate kidney stones. (yale.edu)
Also the rate of differentiation into a dopaminergic phenotype of the newly born neurons in the periglomerular zone of the OB was not significantly changed with 93 % in the orexin/ataxin-3 mice compared to 91 % in the WT mice. (uni-marburg.de)

Unlike cancer arising in the human population, tumors in genetically engineered mouse models arise in mice with well defined genetic backgrounds where genetic variability can be minimized. (molvis.org)
A novel approach to define genetic elements associated with diabetes in the BB rat is described, and the role of MHC class II molecules in development of IDDM in mice, rats and humans is reviewed. (powells.com)
If you have a mutation that you would like to transfer to a different genetic background, JAX offers both a comprehensive Speed Congenic Service as well as a Genome Scanning Service to assist you with backcrossing your mice at your facility. (jax.org)
Hematopoiesis, in particular the genetic control of hematopoietic cell proliferation and differentiation is also studied in human cell cultures and transgenic mouse model systems. (lu.se)

To begin to understand how mutations in MATR3 may cause disease, here we provide initial characterization of transgenic (Tg) mice expressing human wild-type (WT) MATR3 (MATR3 WT ) and ALS-mutant F115C MATR3 (MATR3 F115C ) proteins under the control of the mouse prion promoter (MoPrP). (biomedcentral.com)

For each construct, we established multiple independent lines of mice that stably transmitted the transgene. (biomedcentral.com)

We have developed a simple and sensitive method for conditional cell ablation in transgenic mice, called "toxin receptor-mediated cell knockout. (nih.gov)
We found that "knockout" mice lacking one of these transport proteins have a high incidence of calcium oxalate urinary stones, the same type that is most common in human patients with kidney stones. (yale.edu)
Likewise, p16/p21 double knockout mice, which have very few senescent cells, showed similar delays in wound closure. (jax.org)

NL-RSK1 mice were crossed with mice with tamoxifen (Tam) inducible CRE under control of the α myosin heavy chain promoter, producing double heterozygotes and wild-type (WT) littermates for experiments (n=9 per group). (bmj.com)

Hearts of transgenic mice were dilated, and left ventricular systolic function was impaired. (jci.org)
Tam-treatment (7 d) significantly increased diastolic (d) or systolic (s) left ventricular (LV) posterior wall (PW) thickness (16%) in transgenic, not wild-type (WT) mice indicating that enhanced NL-RSK1 alone promotes hypertrophy. (bmj.com)

To study the consequences of sustained exposure to Ex-4, we generated metallothionein promoter-exendin-4 (MT-Exendin) mice that continuously express a proexendin-4 transgene in multiple murine tissues. (diabetesjournals.org)
This system is useful for generating mouse models of disease and for studying the recovery or regeneration of tissues from cell damage or loss. (nih.gov)
As DT is a potent inhibitor of protein synthesis in both growing and non-growing cells, the method is applicable to a wide range of cells and tissues in mice or in other DT-insensitive animals. (nih.gov)
In combination with transgenic organisms, such enzyme-actuated antisense tools will enable gene silencing in specific cell types, including tissues that are not amenable to optical targeting. (cdc.gov)

After injection of a single convulsive dose of PTZ, the activity of the δ-subunit promoter, as monitored by β-galactosidase immunohistochemistry, was increased selectively in neurons of layers II-IV of neocortex. (psu.edu)

However, the experimental inoculation of pigs and transgenic mice overexpressing porcine PrP has indicated that swine are susceptible to BSE infection by the parenteral route, although with a considerable transmission barrier ( 8 , 9 ). (cdc.gov)

We show, through transmission experiments in transgenic mice expressing porcine prion protein (PrP), that the susceptibility of this mouse model to bovine spongiform encephalopathy (BSE) can be enhanced after its passage in ARQ sheep, indicating that the pathogenicity of the BSE agent is modified after passage in sheep. (cdc.gov)

The limited responsiveness of the GABA(A)-receptor δ-subunit promoter after repeated stimulation may reflect an inappropriate adaptation of cellular responses to recurrent excitation, thereby contributing to the development of seizure. (psu.edu)
We expressed the diphtheria toxin (DT) receptor in transgenic mice using a hepatocyte-specific promoter and found that injection of DT caused fulminant hepatitis. (nih.gov)
1999. Adverse reproductive outcomes in the transgenic Ah receptor-deficient mouse. (cdc.gov)
1991. Effects of polychlorinated biphenyls with Ah receptor affinity on lymphoid development in the thymus and the bursa of Fabricius on chick embryos in ovo and in mouse thymus anlagen in vitro . (cdc.gov)

Mice, which are susceptible to SARS-CoV, are resistant to infection with SARS-CoV-2 because of incompatibilities between mouse ACE2 and the viral spike protein. (nature.com)
The antitumor efficacy was studied in mouse mammary carcinoma models (Her2/neu transgenic and 4T1-luc mammary cancers) treated with systemic recombinant protein with/without the depletion of myeloid-derived suppressor cells or intra-tumoral gene electrotransfer (GET). (frontiersin.org)
For this purpose, a transgenic mouse line expressing a green fluorecescent protein (GFP) under the control of the GAD65 (GAD: glutamate decarboxilase enzyme involved in the synthesis of GABA) promoter will be used. (europa.eu)
Hearts of transgenic mice expressed the altered lipoprotein lipase, and the protein localized to the surface of cardiomyocytes. (jci.org)
Aim: We aimed to study the possible role of the protein orexin in the regulation of adult neurogenesis in the orexin/ataxin-3 mouse. (uni-marburg.de)
Mice are refractory to SARS-CoV-2 infection owing to low-affinity binding to the murine angiotensin-converting enzyme 2 (ACE2) protein. (jci.org)
Here we describe a different method of transgene regulation by the use of the human glial ®brillary acidic protein (GFAP) promoter. (lu.se)

Results: We found a significantly higher proliferation of stem/precursor cells in the orexin/ataxin-3 mice in both neurogenic regions, the SGZ and the SVZ. (uni-marburg.de)

K18-hACE2 mice express hACE2 driven by the cytokeratin 18 ( KRT18 ) promoter, predominantly in epithelial cells 8 . (nature.com)

To understand how senescent cells promote repair, the Campisi team surveyed wound sites in GCV-treated p16-3MR mice and found fewer endothelial cells and fibroblasts, including myofibroblasts, which are contractile cells responsible for wound closure. (jax.org)

These results demonstrate an essential role for Jak2 signaling in GnRH neurons for normal reproductive development and fertility in female mice. (jneurosci.org)
This activity-induced gene enabled targeting of neurons that are activated when a mouse hears a pure 15 kHz tone. (stanford.edu)
By targeting a genetically-encoded hybrid voltage sensor (hVOS) to identify neurons activated during the presentation of sound, the properties and function of these neurons become accessible to study in slices of mouse ventral cochlear nucleus. (stanford.edu)
The postulated pathophysiology of human narcolepsy is mimicked very closely in a transgenic mouse model called orexin/ataxin-3 mouse, in which orexin-containing neurons are ablated progressively by specific overexpression of a truncated cytotoxic ataxin-3 gene product under the orexin-promoter. (uni-marburg.de)

We have studied the transgenic mouse strain, Tyrp-1-TAg, to try to gain insight into possible molecular mechanisms common to pigmented ocular neoplasms occurring spontaneously in the eyes of these mice and human choroidal melanoma. (molvis.org)

Transgenic models of tumour development. (microbiologyresearch.org)
One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)

This is the first study describing the production and distribution of ETS-1 and ETS-2 mRNAs and proteins using in situ hybridization and immunohistochemistry in murine ocular tissue sections of normal control eyes and tumoral eyes from mice of the same age. (molvis.org)

For instance, GLP-1R agonist administration decreased TNFα and IL-6 production by peripheral blood mononuclear cells (PBMC) of obese patients with T2D and diabetic mouse adipose tissue. (justia.com)

Thus, K18-hACE2 mice provide a useful model for studying the pathological basis of both mild and lethal COVID-19 and for assessing therapeutic interventions. (nature.com)
This platform provides a new tool to study tau spreading and clearance in a tauopathy mouse model, foreseeable in monitoring tau targeting putative therapeutics. (springer.com)
The MPTP-treated mouse has been the most widely used model for assessing neuroprotective agents for Parkinson's disease. (researchgate.net)
In their study, the Campisi team developed a transgenic mouse model to label and eliminate cells undergoing cellular senescence. (jax.org)
that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)
In an ATLL xenografted mouse model, SHK treatment suppressed tumor growth without significant adverse effects. (bvsalud.org)

METHODS: Transgenic mice were generated in which the bcl-2 or bcl-XL transgenes were expressed in photoreceptor cells under the transcriptional control of a rhodopsin gene promoter. (arvojournals.org)
Photoreceptor cell death in mice expressing one of the bcl transgenes and carrying either the rd mutation homozygously or the rhodopsin mutation heterozygously was examined by histologic and electroretinographic measurements. (arvojournals.org)
Bcl-2 and bcl-XL transgenic mice also were tested for possible resistance to light-induced photoreceptor damage under two different experimental conditions. (arvojournals.org)
RESULTS: Bcl-2 or bcl-XL transgenes were expressed in photoreceptor cells of all lines of transgenic mice. (arvojournals.org)
Twelve days after exposure to 2 hours of high-intensity light, bcl-2 transgenic mice retained approximately four rows of photoreceptor cells in the central retina as compared to none in littermate controls, whereas bcl-XL transgenic mice showed no increased resistance to light damage. (arvojournals.org)

i ) control mice used in IGF1 signaling experiments performed in different labs (see references to Figure 5 ), ( ii ) female mice bread at Jackson Laboratories, and ( iii ) several samples of female 129/Sv mice bread at authors' laboratory [ 20 ]. (aging-us.com)
To assess the susceptibility of K18-hACE2 mice to SARS-CoV-2, we intranasally challenged male and female mice using inocula of 10 3 , 10 4 and 10 5 plaque-forming units (PFU). (nature.com)
There was variable mortality when mice were inoculated with 10 4 PFU (2 out of 3 female mice and 3 out of 7 male mice survived). (nature.com)
and report here a role for the Jak2 signaling molecule in the regulation of reproductive development and function in female mice. (jneurosci.org)
Here, we evaluated the pathogenesis of SARS-CoV-2 in male and female mice expressing the human ACE2 gene under the control of the keratin 18 promoter (K18). (jci.org)
Male mice that succumbed to disease had higher levels of inflammatory transcripts compared with female mice. (jci.org)

Secretion of GnRH is also reduced as basal serum luteinizing hormone (LH) levels were significantly lower in female Jak2 G −/− mice while the pituitary responded normally to exogenous GnRH. (jneurosci.org)
Female Jak2 G −/− mice exhibited significantly delayed puberty and first estrus, abnormal estrous cyclicity, and impaired fertility. (jneurosci.org)
however, in females receiving rosiglitazone for 4 weeks, hyperadiponectinemia was significantly blunted in Ocn- Wnt10b compared to WT mice. (frontiersin.org)
PE (40 mg/kg/d, 3 d) increased LVPW~99% in WT or transgenic mice with corresponding decreases in LV internal diameters, but the degree of hypertrophy was significantly reduced (~45%) in transgenic mice pretreated (4 d) with Tam. (bmj.com)
Conclusion: In the absence of orexin in the adult mouse brain, the proliferation of adult neural stem/precursor cells was increased, the survival rate was significantly increased in the granular zone of the OB and a consistent not significant trend was seen in the HC. (uni-marburg.de)
Both BKdelK1 and BKdelK2 mice had significantly elevated systolic blood pressure compared to WT mice. (bvsalud.org)

In this study we used a lentiviral vector that drives transgenic populations (BloÈmer et al. (lu.se)

In mouse models, though, the existence of precise tonotopic gradients appears somewhat unresolved. (jneurosci.org)
Relevant mouse models of human uveal melanoma still remain to be developed. (molvis.org)
Three experimental animal models are particularly important for the study of IDDM: the low dose streptozotocin induced diabetes in mice, the BB-rat and the NOD-mouse. (powells.com)
A final chapter discusses the inferences that can be drawn from transgenic animal models on MHC molecules and the cells. (powells.com)
It is worth noting that while addressing the hypothesis of the role of class II major histocompatibility glycoproteins in autoimmune diabetes (insulin-dependent diabetes, IDDM) a number of investigators established animal models in which class II molecules were expressed under the control of the rat insulin promoter. (powells.com)
Transgenic mouse models pro- fection. (who.int)

This offers significant advantages for studying tumor pathogenesis and molecular mechanisms of oncogenesis caused by a single initiating oncogenic event introduced through the mouse germ line. (molvis.org)
The BKdelK1 and BKdelK2 mutant mice had about 50% reductions in plasma low molecular weight kininogen and trypsin-released BK, compared to wild mice. (bvsalud.org)

1991. Promotion of mouse lung tumors by bioaccumulated polychlorinated aromatic hydrocarbons. (cdc.gov)

Myc, E 2 f 1 , and a combination of the two was driven by the albumin promoter. (wikigenes.org)

TZD-induced hyperadiponectinemia is closely associated with increased adiponectin production in MAT but is not prevented by the partial loss of MAT that occurs in Ocn- Wnt10b mice. (frontiersin.org)

To understand the cause(s) of this morbidity and mortality better, we assessed the tissue distribution of infectious virus and viral genomic RNA at 2, 4 and 6 days post infection (dpi) in mice receiving 10 5 PFU of SARS-CoV-2. (nature.com)

In the present study, we found that exposure of cells to cadmium induced significant activation of AP-1 and all three members of the MAP kinase family in mouse epidermal JB6 cells. (cdc.gov)

To test the hypothesis that MAT expansion contributes to TZD-associated hyperadiponectinemia, we investigated the effects of rosiglitazone, a prototypical TZD, in wild-type (WT) or Ocn -Wnt10b mice. (frontiersin.org)
For the evaluation of the stem cell proliferation in SVZ and SGZ and migration in the RMS, orexin/ataxin-3 mice (n = 8) and wild type (WT) mice (n = 8) received a single intraperitoneal injection of 100 mg BrdU (bromodeoxyuridine)/kg body weight 2 hour prior to sacrifice. (uni-marburg.de)
In contrast to wild-type mice, the transgenic UMOD mice had marked improvement in blood pressure with furosemide (an inhibitor of NKCC2). (medscape.com)

Hearts, but not postheparin plasma, of these mice contained human lipoprotein lipase activity. (jci.org)
In this combined immunodeficiency (SCID) cancer is low in these species (as it chapter, some aspects of this issue mice, in which the human target is in humans), which renders cancer are discussed. (who.int)

We now report that MT-Exendin mice develop extensive tissue lymphocytic infiltration with increased numbers of CD4 + and CD8a + cells in the liver and/or kidney and increased numbers of B220 + cells present in the pancreas and liver. (diabetesjournals.org)

We also demonstrated upregulation of ETS-1 and ETS-2 target expressions in Tyrp-1-TAg mice when comparing with the same target expressions in control mice. (molvis.org)
Scar tissue (stained for collagen, in orange) is evident in healed wounds from transgenic p16-3MR mice lacking senescent cells (bottom panel, GCV-treated) compared to control mice (top panel, PBS-treated). (jax.org)
2.1-kb hGFAP promoter or a 1.5-kb rat neuron-speci®c enolase (rNSE) promoter (control vector) has been described elsewhere (Jakobsson et al. (lu.se)

In contrast to nontransgenic mice, intranasal exposure of K18-hACE2 animals to 2 different doses of SARS-CoV-2 resulted in acute disease, including weight loss, lung injury, brain infection, and lethality. (jci.org)

The system allows for the generation of mice with specific overexpression of AAVR through breeding with available Cre mouse lines, as well as the option to detarget AAV from other tissue when paired with Aavr -KO mice. (nature.com)
16 , 17 In particular, transgenic zebrafish lines that express nfsB in β cells, cardiomyocytes, or other cell types have been established, and their exposure to the metronidazole leads to the targeted loss of these cells. (cdc.gov)

We demonstrate that transgenic AAVR overexpression greatly increases the efficiency of transduction of many diverse cell types, including muscle stem cells, which are normally refractory to AAV transduction. (nature.com)

There was no significant difference between transgenic mice and WT litter mates up to 10 weeks of age in any of the variables studied. (bmj.com)

To determine its biological function in reproduction, we used Cre (cAMP response element)/LoxP technology to generate GnRH neuron-specific Jak2 conditional knock-out (Jak2 G −/− ) mice. (jneurosci.org)

A promoter mutation in the erythroid-specific 5-aminolevulinate synthase (ALAS2) gene causes X-linked sideroblastic anemia. (medlineplus.gov)

CD4 cell surface downregulation in HIV-1 Nef transgenic mice is a consequence of intracellular sequestration. (microbiologyresearch.org)

Anatomy35

Organisms21

Diseases14

Chemicals and Drugs72

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Psychiatry and Psychology3

Phenomena and Processes81

Disciplines and Occupations1

Information Science3

Vivo12

MRNA5

Expression25

Tamoxifen-inducible1

C57BL5

Genes8

Locus2

Upstream2

Phenotype4

Genetic4

Characterization1

Transmitted the transgene1

Knockout3

Inducible1

Left ventricular2

Tissues4

Selectively1

Inoculation1

Prion1

Receptor4

Protein7

Regions1

Epithelial1

Endothelial1

Neurons4

Strain1

Tumour2

Proteins1

Adipose Tissue1

Model6

Photoreceptor5

Female mice6

Significantly6

Populations1

Models6

Molecular2

Tumors1

Driven1

Adiponectin1

Viral1

Epidermal1

Wild-type3

Human2

Liver1

Control3

Contrast1

Lines2

Increases1

Litter1

Conditional1

Mutation1

Cell Surface1