Promoter contains transcription factor binding. Medical search. Frequent questions

This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. (nih.gov)
Most genes are associated with factors that establish and release paused Pol II and therefore appear to progress through this step, although only a subset of genes appears to be directly regulated by pausing. (nature.com)
Although pausing has been connected to extremely rapid and synchronous activation of genes, pausing is also highly associated with constitutively expressed genes that encode signalling and transcription factors. (nature.com)
Distinct signals that act through diverse targeted transcription factors can regulate different steps in the transcription pathway and provide a highly modulated transcriptional response at individual genes. (nature.com)
We mapped all estrogen receptor and RNA polymerase II binding sites on a genome-wide scale, identifying the authentic cis binding sites and target genes, in breast cancer cells. (nature.com)
The regulatory genes primarily the transcription factors that exert their activity by binding to certain cis DNA elements and consequently either up regulated or down regulate to target expression. (scielo.br)
For example, steroid and thyroid hormones directly bind to nuclear receptors, which induce expression of specific genes. (intechopen.com)
Our in silico findings report that there is cross-regulation between both pathways at the level of gene transcription regulation, mediated by the presence of binding sites for both factors in promoters of genes essential for these pathways. (biomedcentral.com)
In this paper we examine evidence for a direct crosstalk of the NF-κB and IRF3 signaling pathways at the lowest level, between main transcription factors and genes coding for these transcription factors. (biomedcentral.com)
We analyzed respective gene promoters' sequences using in silico methods for identification of transcription binding sites, mainly in the NF-κB- and IRF-coding genes. (biomedcentral.com)
Conserved transcription factor-binding sites within promoter regions of human RON genes were then searched. (spandidos-publications.com)
Forkhead box protein M1 (FOXM1) is a key transcription factor (TF) that regulates a common set of genes related to the cell cycle in various cell types. (mdpi.com)
With a kinetic modeling approach we ascribe function to the observed OCT4-SOX2-NANOG network by making plausible assumptions about the interactions between the transcription factors at the gene promoter binding sites and RNA polymerase (RNAP), at each of the three genes as well as the target genes. (lu.se)
[ 4 ] The 6 genes involved in WS are PAX3 (encoding the paired box 3 transcription factor), MITF (microphthalmia-associated transcription factor), EDN3 (endothelin 3), EDNRB (endothelin receptor type B), SOX10 (encoding the Sry bOX10 transcription factor), and SNAI2 (snail homolog 2), with different frequencies. (medscape.com)
These dCas9-activator fusions targeted to the promoter region of endogenous genes can then modulate gene expression 7 - 11 . (cdc.gov)

TcMYC2a was also found to bind with TcJAZ3 in yeast, which was a homolog of Arabidopsis JASMONATE ZIM-domain JAZ proteins, indicating that TcMYC2a had a similar function to AtMYC2 of JA signal transduction. (frontiersin.org)
Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. (nih.gov)
This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. (nih.gov)
Two Ets proteins, PU.1 and elf-1, that have previously been shown to bind to an adjacent DNA element were shown to physically interact with CArG- box binding factor.A. An antiserum raised against the protein recognized two different forms indicating either that different splice-forms of. (lu.se)
The others are the site-specific TFs or the DNA sequence-specific binding proteins. (intechopen.com)
GS-002 also induced endoplasmic reticular (ER) stress as evidenced by increases in ER stress-responsive proteins including glucose-regulated protein 78 (GRP78), growth arrest- and DNA damage-inducible gene 153 (GADD153), phosphorylated eukaryotic initiation factor 2 α (eIF2 α ), phosphorylated protein endoplasmic-reticular-resident kinase (PERK), and ATF-3. (hindawi.com)
This increases the transcription of proteins such as CpxP, DegP and CpxR. (igem.org)
Transcription factors are a group of proteins that are needed for a gene to start being copied to RNA, i.e. for transcription to start. (lu.se)
The protein structure that surrounds the DNA, chromatin, largely comprises histone proteins and can be open or closed and thus allow or prevent factors binding to the DNA. (lu.se)
Modulation of Basic Helix-Loop-Helix Transcription Complex Formation by Id Proteins during Neuronal Differentiation. (lu.se)
It is assumed that the Id helix-loop-helix (HLH) proteins act by associating with ubiquitously expressed basic HLH (bHLH) transcription factors, such as E47 and E2-2, which prevents these factors from forming functional hetero- or homodimeric DNA binding complexes. (lu.se)
However, the Id proteins did complex with HES-1, and increased levels of Id2 reduced the DNA binding activity of HES-1. (lu.se)
Programmable DNA binding proteins have emerged as an exciting platform for engineering synthetic transcription factors for modulating endogenous gene expression 5 - 11 . (cdc.gov)
Among the established custom DNA binding domains, Cas9 is most easily scaled to facilitate genome-scale perturbations 3 , 4 due to its simplicity of programming relative to zinc finger proteins and transcription activator-like effectors (TALEs). (cdc.gov)
Using the novel CRISPR/Cas9-based enChIP technology in combination with SILAC-MS, we have isolated and identified potential regulatory proteins bound to the HIF2A promoter at normoxia and hypoxia. (lu.se)

Shahmuradov IA, Solovyev VV (2003) PromH: promoters identification using orthologous genomic sequences. (wikipedia.org)
Little or no protein interaction at promoter sequences was detected early (5 hr) after infection but strong interactions at the major late transcription factor (MLTF/USF) binding site and at the TATA box were evident late (12 hr) after infection. (princeton.edu)
Classification tasks included the prediction of enhancer and promoter sequences and transcription factor binding sites. (nvidia.com)
The crystal structures of the conserved ETS domain of SAP-1 bound to DNA sequences from the E74 and c-fos promoters reveal that a set of conserved residues contact a GGA core DNA sequence. (rcsb.org)
The extracellular sequences of RON contain several domains including an N-terminal semaphorin (sema) domain, followed by the plexin, semaphorin, integrin (PSI) domain, and four immunoglobulin, plexin, transcription factor (IPT) domains. (spandidos-publications.com)

This transcription-dependent TAF complex promotes subsequent activator-independent transcription, and promoter response to TAF mutations in vivo correlates with the level of downstream, rather than overall, Taf1 crosslinking. (biorxiv.org)
We propose a new model in which TAFs function as reinitiation factors, accounting for the differential responses of promoters to various transcription factor mutations. (biorxiv.org)
If sequencing does not detect a Btk mutation in a patient with absent Btk protein deletion/duplication analysis should be performed to detect mutations occurring outside the coding regions such as mutations in the promoter region. (medscape.com)

Sequence alignment kernel for recognition of promoter regions. (wikipedia.org)
Furthermore, this resource has allowed the identification of cis -regulatory sites in previously unexplored regions of the genome and the cooperating transcription factors underlying estrogen signaling in breast cancer. (nature.com)
Regulatory regions include promoters (proximal and distal) and enhancers. (yeastgenome.org)
The phosphorylated CpxR then binds to promoter regions that code for proteases such as DegP, ppiD etc. (igem.org)

This is the basic 'amplifier' system that consists of an input sensitive promoter system,a protein activator and sensitive promoter. (igem.org)
Activator is made by transcription from pBAD, the mRNA is then translated (the potential time delays will be taken into account). (igem.org)
an activator placed downstream of its own promoter (as well as the reporter/ pigment) will, in theory, keep pigment production going. (igem.org)
The rate of activator production from its own promoter is given in equation 3 above, which is dependent on activator concentration itself. (igem.org)
The data collection separates the promoter and activator by use of both RFP and GFP reporters. (igem.org)
Stimulation of TLRs (Toll-Like Receptors) by a pathogen induces activation of signal transduction cascades, which leads to translocation of nuclear factor-κB (NF-κB) to the nucleus [ 1 ], activation of interferon regulatory factors 3/7 (IRF3/7) and/or activator protein-1 (AP-1), which cooperate to induce transcription of various cytokines such as alpha/beta interferon (IFN-α/β) to counteract infection [ 2 - 4 ]. (biomedcentral.com)
This TF induction was dependent on signal transducer and activator of transcription-6 signaling and poly ADP ribose polymerase activity. (haematologica.org)

Among all JA downstream transcription factors, MYC2 is considered as the fatal point of the entire JA signaling pathway ( Kazan and Manners, 2013 ). (frontiersin.org)
Although the TATA-Binding Protein (TBP) subunit of TFIID is necessary and sufficient for in vitro transcription, the TBP-Associated Factor (TAF) subunits recognize downstream promoter elements, act as co-activators, and interact with nucleosomes. (biorxiv.org)
Here we show that transcription induces stable TAF binding to downstream promoter DNA, independent of upstream contacts, TBP, or other basal transcription factors. (biorxiv.org)
NF-κB also controls expression of the downstream IFN auto-amplification loop through STAT1, IRF-1, −5, and −7 transcription factors. (biomedcentral.com)
In the presence of misfolded protein in the envelope, CpxP binds to the misfolded protein which allows CpxA to phosphorylate CpxR which acts as a TF for downstream proteases such as DegP. (igem.org)

Further, using gel mobility shift assays, we show that both Sp1 and Sp3 interact specifically with the histone H4 promoter. (nih.gov)
Transient cotransfections of Drosophila cells with Sp1 and Sp3 expression vectors and with the histone H4, thymidine kinase (TK), or dihydrofolate reductase (DHFR) promoters show that only the DHFR promoter, containing multiple functional GC boxes, displays Sp3 repression of Sp1 activation. (nih.gov)
In contrast, the single G/C boxes within the histone H4 or TK promoters, which confer transcriptional activation via Sp1 binding, are not responsive to repression by Sp3. (nih.gov)
Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. (cancerindex.org)
It has histone deacetylase activity and represses transcription when tethered to a promoter. (cancerindex.org)
As aKG is a co-factor for histone de-methylase, we looked at histone methylation and found that histone H3K4me3 at the Tnfrsf12a promoter is increased under glutamine-deprived conditions and rescued via DM-aKG supplementation. (bvsalud.org)

A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. (yeastgenome.org)
Aberrant DNA methylation changes the genomic transcription, representing promising molecular targets for better cancer diagnostics and therapeutics. (selectbiosciences.com)

To gain insight into the regulation of this promoter, we analyzed protein-DNA interactions by in vivo DMS and DNasel footprinting during the course of adenovirus infection. (princeton.edu)
Chromatin interactions can connect distal transcription factor binding sites with target gene promoters. (selectbiosciences.com)
In this talk, I will introduce Chromatin Interaction Analysis with Paired-End Tag sequencing (ChIA-PET), a next-generation sequencing-based method for identifying chromatin interactions between transcription factor binding sites on a genome-wide scale which was part of the ENCODE consortium. (selectbiosciences.com)
Our results suggest that chromatin interactions may be a major mechanism by which transcription regulation occurs in human cells. (selectbiosciences.com)

Recent years have witnessed a sea change in our understanding of transcription regulation: whereas traditional models focused solely on the events that brought RNA polymerase II (Pol II) to a gene promoter to initiate RNA synthesis, emerging evidence points to the pausing of Pol II during early elongation as a widespread regulatory mechanism in higher eukaryotes. (nature.com)
Their regulation may be carried out either through direct binding to DNA as peroxisome proliferator-activated receptors or via modulation in an indirect manner of signaling pathway molecules (e.g., protein kinase C) and other transcription factors (nuclear factor kappa B and sterol regulatory element binding protein). (springer.com)
Recent ChIP experiments of human and mouse embryonic stem cells have elucidated the architecture of the transcriptional regulatory circuitry responsible for cell determination, which involves the transcription factors OCT4, SOX2 and NANOG. (lu.se)
Fn14 promotes myoblast fusion without affecting the levels of myogenic regulatory factors in the regenerating muscle. (bvsalud.org)
RFXANKbase: Mutation registry for Ankyrin repeat containing regulatory factor X-associated protein deficiency. (lu.se)

Constitutively active RON variants may be generated by alternative splicing (RONΔ165, RONΔ160, and RONΔ155) or by methylation-dependent promoter usage [short form RON (sfRON)] ( 10 , 11 ). (spandidos-publications.com)
The inability of proinflammatory activated macrophages to respond to lipopolysaccharide and interferon-γ with an increase in TF production seems to be due to an increase in TF promoter methylation and was reversible when treating these macrophages with a demethylation agent. (haematologica.org)
Among the epigenetic entities, DNA methylation is the best characterized and contributes to the transmission of the long-lasting transcription memory through cell division and therefore the phenotype. (selectbiosciences.com)
The level of methylation in the promoter can affect its effectiveness. (lu.se)

Multiple lines of evidence support the idea that Pol II and nucleosomes compete for promoter binding and suggest that a crucial role of paused Pol II involves maintenance of accessible promoter chromatin architecture. (nature.com)

It acts as a transcription regulator that binds target promoter DNA and bends the DNA. (thermofisher.com)
We establish that IGF-II-induced HIF2A/EPAS1 expression during hypoxia is due to de novo transcription and further present the estrogen-related receptor alpha (ERRα) transcription factor as a positive regulator of HIF2A. (lu.se)

Molecular mechanisms of the initiation of transcription from TATA box have been well known as the most essential nuclear events in mammalian cells. (intechopen.com)
Despite being a relatively common disease, the precise molecular mechanisms for the onset of ischemic stroke (IS) are still incompletely understood, with both environmental and genetic factors being implicated in this disease in a complex manner. (hindawi.com)
In summary, we have identified, and at the molecular level characterized, signaling pathways and specific factors through which oncogenic HIF2A activity is regulated and may be targeted. (lu.se)

Association of single nucleotide polymorphisms in the nuclear respiratory factor-2 beta subunit-encoding the GABPB1 gene within the occupational environment. (nih.gov)
Has cohesin ATPase activity, double-stranded DNA binding, topological DNA entrapment activity, role in mitotic cohesin loading and condensed nuclear chromosome, centromeric region, nuclear mitotic cohesin complex localization. (cdc.gov)
Nuclear extracts prepared from uninfected cells as well as cells harvested at 5 and 12 hr after infection contained similar levels of MLTF/USF footprint activity, therefore the lack of a detectable interaction early after infection is not due to reduced levels of the factor early in the viral growth cycle. (princeton.edu)
It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. (nih.gov)
The objective of the current study was to analyze the effects of fiber length on the ability of macrophages to phagocytize these fibers and to determine the potency of fibers of various lengths to activate nuclear transcription and cytokine production and to elicit cytotoxicity. (cdc.gov)
Bioactivity was measured as the ability of glass fiber fractions to activate the DNA binding of the transcription factor, nuclear factor kappa B(NFkappaB), to activate the gene promoter for tumor necrosis factor alpha(TNFalpha), and to increase the TNF alpha production by macrophages in vitro. (cdc.gov)

The promoters of choice include CpxP, CpxR and DegP promoters. (igem.org)

AFUA_2G16480 domain(s) with predicted zinc ion binding activity. (cdc.gov)
The activity of the adenovirus major late promoter is substantially Increased as the infection proceeds from the early to late phase. (princeton.edu)
In the present study, we analyze the activity and binding of Sp3 on several eukaryotic promoters that contain G/C boxes and are known to be regulated during cellular proliferation and the cell cycle. (nih.gov)
Changes in dietary fatty acids, specifically the polyunsaturated fatty acids of the ω-3 and ω-6 families and some derived eicosanoids from lipoxygenases, cyclooxygenases, and cytochrome P-450, seem to control the activity of transcription factor families involved in cancer cell proliferation or cell death. (springer.com)
discovered that the rs145204276 indel polymorphism in the GAS5 promoter area alters GAS5 transcript activity, thereby increasing hepatocellular carcinoma (HCC) risk [ 12 ]. (hindawi.com)
The activity of the promoter can therefore be regulated differently in different cells. (lu.se)
The binding of STAT3 to the hTERT promoter region and telomerase activity showed reduction with withaferin A treatments. (bvsalud.org)

Core, L. J., Waterfall, J. J. & Lis, J. T. Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters. (nature.com)
All organisms-bacteria, archaea, and eukaryotes-have a transcription initiation factor that contains a structural module that binds within the RNA polymerase (RNAP) active-center cleft and interacts with template-strand single-stranded DNA (ssDNA) in the immediate vicinity of the RNAP active center. (osti.gov)
This transcription initiation-factor structural module preorganizes template-strand ssDNA to engage the RNAP active center, thereby facilitating binding of initiating nucleotides and enabling transcription initiation from initiating mononucleotides. (osti.gov)
However, this transcription initiation-factor structural module occupies the path of nascent RNA and thus presumably must be displaced before or during initial transcription. (osti.gov)
In this paper, we report four sets of crystal structures of bacterial initially transcribing complexes that demonstrate and define details of stepwise, RNA-extension-driven displacement of the "σ-finger" of the bacterial transcription initiation factor σ. (osti.gov)
First, the general TFs (GTFs), including preinitiation complex components TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and THIIH, are the primary protein factors that are required for the initiation of transcription from the TATA box (or TATA element), then elongation is executed by RNA polymerase II (RNA pol II) [ 1 ]. (intechopen.com)

The transcription factor Sp1 plays a key role in the activation of many cellular and viral gene promoters, including those that are regulated during the cell cycle. (nih.gov)
Sp3, a member of this family, functions to repress transcriptional activation in two viral promoters, most likely by competing with Sp1 for GC box/Sp binding sites. (nih.gov)
Cas9 nuclease can be converted into an RNA-guided DNA binding protein (dCas9) via inactivation of its two catalytic domains 12 , 13 and then fused to transcription activation domains. (cdc.gov)
Tiling a given promoter region with several sgRNAs can produce more robust transcriptional activation 9 - 11 , but this requirement presents enormous challenges for scalability, and in particular for establishing pooled, genome-wide GOF screens. (cdc.gov)

Many distal transcription factor binding sites have been observed. (selectbiosciences.com)

Pausing is now recognized to be a pervasive feature of promoters in mammals and Drosophila melanogaster , and the evidence supporting this from genome-wide studies is presented. (nature.com)
To investigate this further, we developed and trained spatial models of binding site positioning and applied them to the genome of the yeast Saccharomyces cerevisiae. (nih.gov)
For each of the datatypes , Pathway Tools provides querying capabilities, visualization tools (such as for drawing pathways and genome maps), and interactive editing tools to allow users to update data (such as modifying a metabolic pathway or defining a new DNA binding site for a transcription factor). (sri.com)
have several native sigma factors in the genome that are upregulated during envelope stress. (igem.org)

Classical polarization is usually associated with a proinflammatory response, including the increased production of tumor necrosis factor (TNF)-α, IL-1, and IL-6. (haematologica.org)

The data suggest that Sp3 may contribute to the control of proliferation- and/or cell-regulated promoters depending upon the context and/or number of functional Sp1 binding sites. (nih.gov)
Figure 1: Summary of estrogen receptor and RNA PolII binding sites and correlation with nucleotide and gene number. (nature.com)
Figure 4: Identification of enriched motifs within the estrogen receptor binding sites and validation of transcription factor binding. (nature.com)
Figure 5: Involvement of cooperating transcription factors at estrogen receptor binding sites. (nature.com)
The short length and high degeneracy of sites recognized by DNA-binding transcription factors limit the amount of information they can carry, and individual sites are rarely sufficient to mediate the regulation of specific targets. (nih.gov)
We found evidence of non-random organization of sites within promoters, differences in binding site density, or both for thirty-eight transcription factors. (nih.gov)
We illustrate how spatial information dictating the positioning and density of binding sites can in principle increase the information available to the organism for differentiating a transcription factor's true targets, and we indicate how this information could potentially be leveraged for the same purpose in bioinformatic analyses. (nih.gov)
the binding sites with a similar sequence. (ugent.be)

Comparison of in vivo and in vitro footprints revealed that the in vivo interaction late after infection results from binding of the cellular transcription factor MLTF/USF. (princeton.edu)
However, the physiological role of Sp3 in the repression of endogenous cellular promoters has not been experimentally addressed. (nih.gov)
Therefore, we demonstrate that the endogenous cellular DHFR promoter is selectively responsive to Sp3 repression. (nih.gov)

This gene encodes the GA-binding protein transcription factor, beta subunit. (nih.gov)

CpxR is a transcription factor that is generally dephoshorylated (inactive form). (igem.org)
cpxR promoter. (igem.org)

Although the current generation of dCas9-based transcription activators is able to achieve up-regulation of some endogenous loci, the magnitude of transcriptional up-regulation achieved by individual single-guide RNAs (sgRNAs) 12 typically ranges from low to ineffective 8 - 11 . (cdc.gov)

associated Gene Ontology annotation of this binding site. (ugent.be)

In front of every gene is a DNA sequence called a promoter. (lu.se)

For this purpose, WIN 55,212-2 was injected in pregnant wistar rats from gestation day 5 to 20 and a detailed analysis of the levels of the neurotrophin brain-derived neurotrophic factor (BDNF) as well as of the signaling molecules extracellular signal-regulated kinase (ERK)1/2 and alpha-calcium/calmodulin-dependent protein kinase II (alpha-CaMKII) was carried out in adult offspring. (researchgate.net)

We show that these signatures allow transcription factors with substantial differences in binding site specificity to share similar promoter specificities. (nih.gov)

The major risk factors include chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, environmental carcinogens such as aflatoxin B1 (AFB1), alcoholic cirrhosis, and inherited genetic disorder such as hemochromatosis, Wilson's disease, and tyrosinemia. (hindawi.com)

These transcription factors are known as masters regulators because its single transcript regulate more than one gene, in this context the regulon word is fascinating more in compass of transcription factors. (scielo.br)

However, recent evidence indicates that Sp1 belongs to a larger family of factors which bind G/C box elements in order to either activate or repress transcription. (nih.gov)
SAP-1 is a member of the Ets transcription factors and cooperates with SRF protein to activate transcription of the c-fos protooncogene. (rcsb.org)

It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. (cancerindex.org)

In differentiating neuroblastoma cells, HASH-1 is down-regulated, and there is coincident up-regulation of the transcriptional repressor HES-1, which is known to bind the HASH-1 promoter. (lu.se)

TFIID binds promoter DNA to recruit RNA polymerase II and other basal factors for transcription. (biorxiv.org)

Using antibodies specific for Sp1 and Sp3, we observe that both of these factors localize to the cell nucleus and have a similar, dispersed subnuclear distribution. (nih.gov)

Periplasmic stress, also known as envelope stress, is triggered by several factors that influence the ability of the bacteria to communicate with other cells through quorum sensing, pathological pathway, pili formation, outer membrane protein formation which plays a role in adhesion of the cells allowing them to form proper colonies and survive. (igem.org)
These images illustrate the promoters of choice by team Calgary for detection of periplasmic stress. (igem.org)

Fibroblast growth factor-inducible 14 (Fn14) is a bona fide receptor for the TWEAK cytokine. (bvsalud.org)

To model this situation, araC is first assumed to take the role of a repressor that reversibly binds and unbinds a site on the DNA. (igem.org)
This gives the rate of transcription as a function of X* which represents the concentration of active repressor, unbound to arabinose. (igem.org)
n is the number of arabinose molecules binding to each molecule of the repressor, and K is a binding constant. (igem.org)

A protein interacting with an A-T-rich region that is a positive control element within the SP6 κ promoter was purified and identified as CArG-box binding factor-A. The purified protein was shown to interact specifically with the coding strand of single-stranded DNA and, with lower affinity, with double-stranded DNA. (lu.se)
Park et al analyzed TNF-alpha haplotypes in the promoter response element that affect the binding affinity of certain transcription factors. (medscape.com)
IL-6 and TNF-α stimulation further enhanced STAT3 binding affinity. (bvsalud.org)

Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. (nature.com)
Computational analysis of microbial genomes has suggested that many factors function optimally when in a particular orientation and position with respect to their target promoters. (nih.gov)

Figure 1: Defining the terms used to describe promoter-associated Pol II complexes. (nature.com)
RFX forms cooperative DNA binding complexes with x2bp and cbf/nf-y. (lu.se)

Their roles in intracellular signalling pathways suggest factors such as STAT3 might be involved in ageing and/or age-related disease [ 266 ]. (senescence.info)
Combined treatment of IL-6 and TNF-α phosphorylated transcription factors STAT3 in a synergistic manner. (bvsalud.org)
STAT3 was bound to the promoter region of human telomerase reverse transcriptase (hTERT). (bvsalud.org)

These two factors act upon and induce different proteases and chaperones which act to correct the misfolding agent. (igem.org)

These models demonstrate state-of-the-art performance across many prediction tasks, such as promoter and enhancer site predictions. (nvidia.com)

A mutation that inhibited binding of the protein to the A-T-rich region also aborted the transcriptional stimulatory effect of the region. (lu.se)
Such a mutation has been described which resulted in defective binding of the transcription factor PU.1, leading to defective transcription of Btk. (medscape.com)

when unbound to arabinose a dimer restricts access of polymersase to reduce basal levels of transcription, upon binding arabinose the conformation changes and the dimer permits binding of polymerase. (igem.org)
Increasing the binding strength of NANOG to OCT4 and SOX2, or increasing its basal transcriptional rate, leads to an irreversible bistable switch: The switch remains ON even when the activating signal is removed. (lu.se)

Figure 2: Estrogen-mediated transcript changes and correlation with estrogen receptor binding. (nature.com)

Knowledge of the mechanisms by which fatty acids control specific gene expression may identify important risk factors for cancer and provide insight into the development of new therapeutic strategies for a better management of whole body lipid metabolism. (springer.com)

showed that the GAS5 rs55829688 promoter polymorphism alters the ability of the Yin-Yang 1 (YY1) transcription factor to bind to this region, thereby increasing GAS5 expression and elevated colorectal cancer risk [ 13 ]. (hindawi.com)

Note: In August, 2008, the nomenclature of the GA binding protein transcription factors was clarified. (nih.gov)
The nomenclature of different promoter-associated RNA polymerase II (Pol II) species is explicitly defined in an effort to provide consistency in future literature. (nature.com)

Viral DNA replication was required for MLTF/USF binding at the major late promoter. (princeton.edu)

Anatomy14

Organisms9

Chemicals and Drugs115

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes89

Disciplines and Occupations2

Information Science10

Health Care2

Genes15

Proteins15

Sequences5

Mutations3

Regions4

Activator7

Downstream5

Histone6

Genomic2

Interactions4

Regulatory5

Methylation4

Chromatin1

REGULATOR2

Molecular3

Nuclear6

CpxP1

Activity7

Initiation6

Activation4

Distal1

Genome4

Tumor1

Sites8

Cellular3

Subunit1

CpxR2

Endogenous1

Gene Ontology Annotation1

Sequence1

Signaling molecules1

Specificity1

Genetic1

Regulate1

Activate2

Regulation of transcription1

Transcriptional repressor1

TFIID1

Nucleus1

Periplasmic2

Cytokine1

Repressor3

Affinity3

Target2

Complexes2

STAT33

Induce1

Prediction1

Mutation2

Basal2

Transcript1

Metabolism1

Alters1

Nomenclature2

Viral1