Proline directed protein kinases. Medical search. Frequent questions

This study is to investigate the role of p38 mitogen-activated protein kinase (p38MAPK) in tert -butyl hydroperoxide ( t BHP)-induced apoptosis of human trabecular meshwork (iHTM) cells. (molvis.org)
Mitogen-Activated Protein Kinase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
This graph shows the total number of publications written about "Mitogen-Activated Protein Kinase 1" by people in UAMS Profiles by year, and whether "Mitogen-Activated Protein Kinase 1" was a major or minor topic of these publications. (uams.edu)
Below are the most recent publications written about "Mitogen-Activated Protein Kinase 1" by people in Profiles over the past ten years. (uams.edu)
Extracellular signal-regulated kinase (ERK) is a part of the mitogen-activated protein kinase (MAPK) signaling pathway which allows the transduction of various cellular signals to final effectors and regulation of elementary cellular processes. (mdpi.com)

Unlike other cyclin-dependent kinases, it is expressed predominantly in post-mitotic neurons, its activity modulated by association with nervous system-specific propeins. (pathologyresjournal.com)
A relatively well understood example is the network that controls progression of the cell cycle, where cyclin-dependent kinases (CDKs) couple with various cyclins over the cell cycle to regulate critical processes [ 2 - 4 ]. (biomedcentral.com)

Tyrosine kinases Fyn and FAK interact with NCAM and undergo phosphorylation and this transiently activates the MAPK, ERK 1 and 2, cAMP response element binding protein (CREB) and transcription factors ELK and NFkB. (uni-freiburg.de)
Targeted inhibition of individual kinases of the MAPK signaling pathway using synthetic compounds represents a promising way to effective anti-cancer therapy. (mdpi.com)
Cross-talk of the MAPK signaling pathway with other proteins and signaling pathways have a crucial impact on clinical outcomes of targeted therapies and plays important role during development of drug resistance in cancers. (mdpi.com)
The upstream activator of MAPK7 is the MAPK kinase MAP2K5. (abcam.com)

STP, serine/threonine protein phosphatase. (rupress.org)
The normal physiological processes within neurons are controlled by signal transduction mechanisms that regulate the balance between protein kinase and protein phosphatase activities. (pathologyresjournal.com)
PTPH1 is a protein tyrosine phosphatase expressed in T cells but its effect on immune response is still controversial. (biomedcentral.com)

The Cdc14 family of dual-specificity protein phosphatases (DSPs) is conserved within eukaryotes and functions to down-regulate mitotic Cdk activities, promoting cytokinesis and mitotic exit. (rcsb.org)
Homeodomain-interacting protein kinases (HIPKs) belong to the CMGC kinase family and are closely related to dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs). (nature.com)
HIPKs belong to the CMGC group of serine/threonine kinases and are part of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. (nature.com)

A subclass of protein serine-threonine kinases that phosphorylate proteins on a SERINE or THREONINE residue that is immediately preceding a PROLINE residue. (jefferson.edu)
The reversible phosphorylation of proteins on serine, threonine, and tyrosine residues represents a fundamental strategy used by eukaryotic organisms to regulate a host of biological functions, including DNA replication, cell cycle progression, energy metabolism, and cell growth and differentiation. (rupress.org)
A proline-directed serine/threonine protein kinase which mediates signal transduction from the cell surface to the nucleus. (uams.edu)
C-terminally adjacent to the HID follows a proline, glutamate, serine, and threonine (PEST)-rich domain, mediating proteasomal degradation of these kinases. (nature.com)
Catalytic domain of the Protein Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase. (umbc.edu)
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. (umbc.edu)
A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors. (uchicago.edu)
Below are the most recent publications written about "Protein-Serine-Threonine Kinases" by people in Profiles. (uchicago.edu)
The mammalian target of rapamycin ( mTOR ) is a serine/threonine kinase, which forms the core component of mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2) (Bhat et al. (bio-rad-antibodies.com)

The N-proximal portion is devoid of positively charged residues as well as the amino acids glycine and proline. (silverchair.com)

Additionally, we detected increased levels of active glycogen synthase kinase 3 β, a physiological kinase of TAU, in neurons derived from AD iPSCs, as well as significant upregulation of amyloid precursor protein (APP) synthesis and APP carboxy-terminal fragment cleavage. (biomedcentral.com)
Distinct roles of glycogen synthase kinase (GSK)-3alpha and GSK-3beta in mediating cardiomyocyte differentiation in murine bone marrow-derived mesenchymal stem cells. (connsante.com)
Overexpression of glycogen synthase kinase-3 in ovarian carcinoma cells with acquired paclitaxel resistance. (connsante.com)
Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses. (connsante.com)
Differential effects of apolipoprotein E isoforms on phosphorylation at specific sites on tau by glycogen synthase kinase-3 beta identified by nano-electrospray mass spectrometry. (ox.ac.uk)
We have, therefore, investigated the effects of apoE on tau phosphorylation in vitro by the proline-directed kinase, glycogen synthase kinase (GSK)-3 beta. (ox.ac.uk)

Dedication of IC50 of AKR1B10 inhibitors The em IC /em 50-value of the inhibitors were identified using the assay combination comprising 0.1 M sodium phosphate buffer (pH 7.5), 7.5 mM DL-glyceraldehyde, 0.2 mM NADPH, 0.3 M AKR1B10 wild-type protein and varying concentrations of inhibitors depending on their inhibition potency. (tam-receptor.com)
Inhibition kinetics of daunorubicin reduction by AKR1B10 The inhibition kinetics of daunorubicin reduction by histagged AKR1B10 wild-type protein was monitored spectrophotometrically, by measuring decrease in the absorbance of the cofactor NADPH at 340 nm (Balendiran and Rajkumar, 2005, Martin et al. (tam-receptor.com)
Mechanistically, we see that this un(der)phosphorylated Ascl1 is resistant to inhibition by both cyclin-dependent kinase activity and Notch signaling, both of which normally limit its neurogenic potential. (genengnews.com)

Along with S65, S95 is proposed to constitute a casein kinase 1 interaction site while S119 might be modified by cyclin-dependent kinase 5 (Talbot et al. (springer.com)

Two well-defined pathological hallmarks of AD have been described: the formation of extracellular amyloid plaques and the development of intracellular neurofibrillary tangles (NFTs) formed by aggregated hyperphosphorylated TAU protein [ 4 ]. (biomedcentral.com)
NCAM based signaling complexes can initiate downstream intracellular signals by at least two mechanisms: (1) activation of FGFR and (2) formation of intracellular signaling complexes by direct interaction with cytoplasmic interaction partners such as Fyn and FAK. (uni-freiburg.de)
Intracellular signaling protein kinases that play a signaling role in the regulation of cellular energy metabolism. (rush.edu)

OSR1 and SPAK contain a conserved C-terminal (CCT) domain, which recognizes a unique motif ([RK]FX[VI]) present in their activating kinases (WNK1/WNK4) and their substrates. (umbc.edu)
Although all the substrates, kinases, phosphatases and their regulators are synthesized in neuronal cell bodies, little or no cytoskeletal protein phosphorylation has been detected in the cell body compartment. (pathologyresjournal.com)
Protein kinases are critical to cellular signalling and post-translational gene regulation, but their biological substrates are difficult to identify. (biomedcentral.com)
AMP-activated protein kinases modify enzymes involved in LIPID METABOLISM, which in turn provide substrates needed to convert AMP into ATP. (rush.edu)
Proteins associated with the Wnt/β-catenin pathway have been identified as SUMOylated substrates, and evidences suggested that the initiation and progression of cancers depended on the function of the SUMOylation ( 23 ). (frontiersin.org)

Protein phosphorylation can regulate enzyme function, mediate protein-protein interactions, alter subcellular localization, and control protein stability. (rupress.org)
OSR1 and SPAK regulate the activity of cation-chloride cotransporters through direct interaction and phosphorylation. (umbc.edu)
Post-translational modifications (PTMs) of proteins, including phosphorylation, acetylation, ubiquitination, and SUMOylation, can regulate the function of proteins, determine the active state and subcellular location of proteins, and dynamically interact with other proteins related to carcinogenesis and progression ( 17 - 20 ). (frontiersin.org)

SH3 domains bind to proline-rich peptides that form a left-handed polyproline type II helix (PPII) in one of two opposite orientations. (eu.org)

The other project is to study the expression, regulation and role of neuronal Cdk5 in nerve cell function.Cdk5 is a unique multifunctional kinase. (pathologyresjournal.com)
Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1. (eu.org)
A multifunctional CDC2 kinase-related kinase that plays roles in transcriptional elongation, CELL DIFFERENTIATION , and APOPTOSIS . (nih.gov)

A pyruvate dehydrogenase kinase isozyme located in the mitochondria which converts PYRUVATE to ACETYL CoA in the CITRIC ACID CYCLE, phosphorylates SERINE residues on pyruvate dehydrogenase using ATP, and plays a key role in the regulation of GLUCOSE and fatty acid metabolism. (bvsalud.org)
Putative target residues can be predicted by searching for matches to the consensus for a particular kinase. (biomedcentral.com)
SH3 (Src Homolgy 3) domains are small protein modules of about 50-60 residues. (eu.org)
c-Src tyrosine kinase plays an important role in signal transduction pathways, where its activity is regulated by phosphorylation of the two tyrosine residues. (intechopen.com)
To investigate the conformational change of c-Src tyrosine kinase, we applied network analysis to time series of correlation among residues. (intechopen.com)
With centrality measures such as betweenness centrality, degree centrality, and closeness centrality, we observed a few important residues that significantly contribute to the conformational change of c-Src tyrosine kinase for the different time steps. (intechopen.com)

Explore our solutions for multiple applications - vaccines, monoclonal antibodies, recombinant proteins, cell or gene therapy. (vwr.com)

The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. (wikipedia.org)
Identification of two SH3-binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase. (eu.org)
The precursor forms of prominent chloroplast proteins like the small subunit of stromal Rubisco (SSU), the thylakoid a/b binding protein (LHCP), or the thylakoid lumen localized subunits of the oxygen evolving complex of 23 kD and 33 kD (OE23, OE33) contain a phosphorylation site within the chloroplast targeting signal ( Waegemann and Soll 1996 ). (silverchair.com)

It is inhibited by Cyclin-dependent kinase inhibitors (CKI). (biomedcentral.com)

Although specific mechanisms by which HCV disease progresses remains unknown, direct interaction of specific viral proteins with host cell system has shown to be accounted for some of its pathophysiological profile of HCV patients [ 4 ]. (biomedcentral.com)
This motif is involved in protein-protein interaction mediated by SH3 domains. (eu.org)
The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains. (eu.org)

Homeodomain-interacting protein kinases (HIPKs) are an evolutionarily conserved kinase family comprising the members HIPK1, HIPK2, and HIPK3 in vertebrates, and, additionally, HIPK4 in mammals. (nature.com)
The dysbindin (dystrobrevin-binding protein) protein family is a group of evolutionarily related proteins of moderate size (Mw 13-45 kDa) in higher Eukaryotes. (springer.com)
Proteins with high sequence identity to human DBNDD1 can also be found in evolutionarily more distant species (e.g. (springer.com)

Neutrophil cytosol factor 1, also known as p47phox, is a protein that in humans is encoded by the NCF1 gene. (wikipedia.org)
A variety of approaches, including biochemical purification, gene isolation by homology, and genetic screens, have been successfully used for the identification of putative protein kinases and phosphatases. (rupress.org)
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. (affbiotech.com)
Hepatitis C virus (HCV) Core protein is thought to trigger activation of multiple signaling pathways and play a significant role in the alteration of cellular gene expression responsible for HCV pathogenesis leading to hepatocellular carcinoma (HCC). (biomedcentral.com)
Over expression of Core gene of HCV 3a genotype showed stronger effect in regulating RNA and protein levels of Cox-2, iNOS, VEGF, p-Akt as compared to HCV-1a Core in hepatocellular carcinoma cell line Huh-7 accompanied by enhanced PGE2 release and cell proliferation. (biomedcentral.com)
Besides nucleocaspid formation, HCV Core protein, in particular, also modulates gene transcription, cell proliferation, cell death and interferes with metabolism leading to oxidative stress, liver steatosis and eventually HCC. (biomedcentral.com)
c-Src (cellular Src), encoded by Src gene, is a non-receptor tyrosine kinase first isolated as the normal cellular homolog to the potent avian sarcoma viral transforming oncogene v-Src [ 4 ]. (intechopen.com)
Human dysbindin domain-containing protein 1 (DBNDD1) is encoded by the gene DBNDD1 at chromosome locus 16q24.3. (springer.com)

Through extensive biochemical and genetic analysis, we now know that pathways are not simply switched on with kinases and off with phosphatases. (rupress.org)
In particular, the amino acid leucine is indicated as being primarily responsible for the branched chain amino-acid induced activation of mTOR signaling pathways, and therefore mTOR's effect on protein turnover and synthesis (1 6). (fitmag.ru)
It is found in proteins involved in several biological processes as diverse as signal transduction pathways, cytoskeleton organization, membrane traffic or organelle assembly. (eu.org)

Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks. (ukrbiochemjournal.org)
2012). The mTORC1 complex consists of mTOR , DEP domain-containing mTOR-interacting protein (DEPTOR), mammalian lethal with SEC13 protein 8 ( mLST8 ), proline-rich AKT1 substrate 1 ( PRAS40 ), and regulatory-associated protein of mTOR ( RAPTOR ) (Figure 2). (bio-rad-antibodies.com)

The human trabecular meshwork cells were treated with t BHP for 1 or 2 h with or without pretreatment of SB203580, an inhibitor of MAP kinase homologs. (molvis.org)
Most MutL homologs direct strand-specific DNA mismatch repair by cleaving the error-containing daughter DNA strand. (bvsalud.org)

We show that it is possible to predict proteins that are likely to be targets of CDKs in S. cerevisiae by searching for proteins that contain clustered matches to the CDK consensus. (biomedcentral.com)
We also show that human CDK targets are enriched for proteins that contain clustered consensus matches and, by searching human cell cycle genes, we predict several putative CDK targets, including the human orthologs of Schizosaccharomyces pombe CDC5 (CDC5L) and S. cerevisiae Cdc20p (CDC20). (biomedcentral.com)
Protein Kinases Promising Targets for Anticancer Drug Researc. (intechopen.com)

The evolutionary history of MyoD1 and MyoD2 is compared to the presence of this polyserine region using phylogenetics, and its functional relevance is tested using overexpression in a heterologous system to investigate subcellular localisation, stability, and activity of MyoD proteins that include and do not include the polyserine region. (mdpi.com)

With his lab, he has shown that the most abundant and extensively phosphorylated motifs in the c-terminal domains (lys-ser-pro-, or KSP) are primarily phosphorylated by proline directed kinases, cdk5 and MAP kinases. (pathologyresjournal.com)
We show that cyclin-dependent kinase (CDK) consensus motifs are frequently clustered in CDK substrate proteins. (biomedcentral.com)
Our data suggest that regulatory modules may exist in protein sequence as clusters of short sequence motifs. (biomedcentral.com)

Here, using different experimental approaches, especially designer receptor exclusively activated by designer drug (DREADD) chemogenetic technology, we found that sustained activation of G q -protein signaling impairs the functionality of striatal neurons and we unveil the precise molecular mechanism underlying this process: a phospholipase C/Ca 2+ /proline-rich tyrosine kinase 2/cJun N -terminal kinase pathway. (jneurosci.org)

During these studies I discovered a neuronal cell cycle like kinase now known as Cdk5 and small twenty four amino acid peptide, (TFP5), from the activator of neuronal cell cycle like kinase (Cdk5), p35, drastically reduced the pathological symptoms of neurodegenerative diseases like Alzheimer's, Parkinson's diseases and ALS without toxicity. (pathologyresjournal.com)
Cyclin-dependent kinase 5 (CDK5) affects the tumor microenvironment, which may influence the efficacy of TKI+IO. (e-crt.org)

To fully understand this complex and essential regulatory process, the kinases and phosphatases mediating the changes in cellular phosphorylation must be identified and characterized. (rupress.org)
c-Src tyrosine kinase consists of the N-terminal unique region, the Src homology 3 (SH3), SH2, linker, kinase domain, and the regulatory C-terminal tail. (intechopen.com)

Western Blotting was used to determine the level of expression of CDC2 protein as measure to quantify down regulation of CDC2 expression along with use of flow cytometry to investigate effect of shRNAs on cell cycles and detection of apoptosis. (biomedcentral.com)

MutL family proteins contain an N-terminal ATPase domain (NTD), an unstructured interdomain linker, and a C-terminal domain (CTD), which mediates constitutive dimerization between subunits and often contains an endonuclease active site. (bvsalud.org)
Unlike other dysbindin family proteins, DBNDD1 isoforms are probably non-classical secretory proteins (Talbot et al. (springer.com)

Levels of cellular protein phosphorylation are modulated both by protein kinases and phosphatases. (rupress.org)
Overexpression of cellular activity and protein level of protein kinase FA/GSK-3α correlates with human thyroid tumor cell dedifferentiation. (connsante.com)
Thus, although NOX orthologs have been identified in organisms as diverse as plants, fruit flies, rodents, and humans, ROS functions have developed and diversified to affect a multitude of cellular properties, i.e., far beyond direct antimicrobial activity. (frontiersin.org)
We examined the in vitro effects of HCV Core protein of HCV genotype 3a and 1a on the cellular genes involved in oxidative stress and angiogenesis. (biomedcentral.com)
HCV virion is enveloped and has a positive strand genome comprising 9.6 kb RNA which is processed by cellular and viral proteases into 10 viral proteins, Core, E1, E2, p7 (structural proteins), NS2, NS3, NS4a, NS4b, NS5a and NS5b (nonstructural proteins). (biomedcentral.com)
Protein kinases are ubiquitous components of cellular signalling networks [ 1 ]. (biomedcentral.com)
SUMOylation of proteins is an important mechanism in cellular responses to environmental stress ( 21 , 22 ). (frontiersin.org)

J Protein Chem 17: 329-335 (1998). (connsante.com)

Ricchiuti N, Chenoweth K, Gao X, Bare DJ, Yan J, Ai X. Long-Term Alcohol-Activated c-Jun N-terminal Kinase Isoform 2 Preserves Cardiac Function but Drives Ca2+-Triggered Arrhythmias. (rush.edu)

Our structural and kinetic data support a role for Cdc14 in the preferential dephosphorylation of proteins modified by proline-directed kinases. (rcsb.org)

I became independent investigator in 1995 and senior principal investigator of Cytoskeletal Protein Regulation Laboratory of Neurochemistry, National Institute of Neurological Disorder and Stroke, NIH, Bethesda, Maryland 20892 in 2000. (pathologyresjournal.com)
When preSSU or preOE33 are synthesized in a wheat germ lysate, they form an oligomeric guidance complex with other proteins, two of which are hsp70 and 14-3-3 ( May and Soll 2000 ). (silverchair.com)

Neurons from patients with fAD and patients with sAD showed increased phosphorylation of TAU protein at all investigated phosphorylation sites. (biomedcentral.com)
To our knowledge, this is the first study in which the hyperphosphorylation of TAU protein has been compared in fAD and sAD iPSC-derived neurons. (biomedcentral.com)
Whereas the G s /G i -protein-dependent tuning of striatal neurons is fairly well known, the precise impact and underlying mechanism of G q -protein-dependent signals remain poorly understood. (jneurosci.org)
To analyze this effect anatomically, we manipulated G q -protein-dependent signaling selectively in neurons belonging to the direct or indirect striatal pathway. (jneurosci.org)
Acute G q -protein activation in direct-pathway or indirect-pathway neurons produced an enhancement or a decrease, respectively, of activity-dependent parameters. (jneurosci.org)
In contrast, sustained G q -protein activation impaired the functionality of direct-pathway and indirect-pathway neurons and disrupted the behavioral performance and electroencephalography-related activity tasks controlled by either anatomical framework. (jneurosci.org)

Recombinant HIPKs and DYRK1A are auto-activated and phosphorylate the negative elongation factor SPT5, the transcription factor c-Myc, and the C-terminal domain of RNA polymerase II, suggesting a direct function in transcriptional regulation. (nature.com)
Functions and regulation of the 70kDa ribosomal S6 kinases. (ukrbiochemjournal.org)
The major focus of his research has been to study the mechanisms of topographic regulation of neuronal cytoskeletal proteins regulation by phosphorylation and neurodegeneration. (pathologyresjournal.com)
In more recent years, the lab focused on the other part of this regulation, the protein phosphatases. (pathologyresjournal.com)
Genetic and Molecular Regulation of Seed Storage Proteins (SSPs) to Improve Protein Nutritional Value of Oilseed Rape (Brassica napus L.) Seeds. (uni-bielefeld.de)

In a normal physiological state, cytoskeletal proteins are phosphorylated extensively in the axonal compartment of a mature neuron. (pathologyresjournal.com)

We propose that Toc64 functions early in preprotein translocation, maybe as a docking protein for cytosolic cofactors of the protein import into chloroplasts. (silverchair.com)
Their amino acid sequences suggest that they are mainly cytosolic or nuclear proteins partly associating with membranes (Talbot et al. (springer.com)

Within the HIPK family, HIPK1 and HIPK2 are the most closely related members, sharing about 93% sequence identity in their kinase domains, while HIPK3 is slightly less conserved with 87% identity. (nature.com)
2009 ). The designated dysbindin paralogs show very limited sequence homology which raised the question whether DBNDD1 and DBNDD2 are dysbindin-like proteins or proteins that share a less conserved domain with DTNBP1 in the context of otherwise unrelated sequences (Ghiani and Dell'Angelica 2011 ). (springer.com)

A phosphorylated precursor protein can still bind to the chloroplast import machinery, but must become dephosphorylated before translocating through the membranes. (silverchair.com)

Adding further complexity to this picture is the fact that both kinases and phosphatases can function in signaling networks where multiple kinases and phosphatases contribute to the outcome of a pathway. (rupress.org)
SUMOylation is a post-translational modification of proteins that has been found to play a major role in the Wnt/β-catenin signaling pathway. (frontiersin.org)

Our findings provide a eukaryote-specific mechanism of co-translational protein folding and a previously unknown mechanism of action to target protein misfolding diseases. (bvsalud.org)
Tyrosine phosphorylation is a central mechanism in the control of key signaling proteins involved in innate immunity. (biomedcentral.com)

Most cases of early-onset AD are linked to autosomal dominant inherited mutations in the genes encoding amyloid precursor protein ( APP ), presenilin 1 ( PSEN1 ), and presenilin 2 ( PSEN2 ). (biomedcentral.com)
This domain occurred 432 times on human genes ( 1002 proteins). (umbc.edu)

The main result reported by the authors was as follows: "The use of phosphomutant Ascl1 in place of the wild-type protein significantly promotes neuronal maturity after human fibroblast reprogramming in vitro. (genengnews.com)

instead of attempting to predict individual phosphorylation sites, we search for proteins that contain high densities of strong and weak consensus matches that are closely spaced in the primary amino acid sequence. (biomedcentral.com)

Overexpression of protein kinase FA/GSK-3α (a proline-directed protein kinase) correlates with human hepatoma dedifferentiation/progression. (connsante.com)
Association of protein kinase FA/GSK-3alpha (a proline-directed kinase and a regulator of protooncogenes) with human cervical carcinoma dedifferentiation/progression. (connsante.com)
Proline-directed protein kinase FA is a powerful and independent prognostic predictor for progression and patient survival of hepatocellular carcinoma. (connsante.com)

Immunotherapy (IO) plus tyrosine kinase inhibitor (TKI) has become the first-line treatment for advanced renal cell carcinoma, despite the lack of prognostic biomarkers. (e-crt.org)

2021 ), https://pfam.xfam.org/ ] predicts human DBNDD1 mainly as an intrinsically disordered protein (IDP) and also the recently released AlphaFold database (Jumper et al. (springer.com)

Role of mitogen-activated protein kinases and Mcl-1 in apoptosis induction by withaferin A in human breast cancer cells. (rush.edu)

Because of the low specificity of the CDK consensus, however, databases of protein sequences are expected to contain large numbers of matches by chance. (biomedcentral.com)
Therefore, many of the matches in protein sequences are likely to be false-positive predictions. (biomedcentral.com)
We report our analysis of MyoD1 and MyoD2 protein sequences from 54 teleost species, and show that O. alcalica , along with some other teleosts, include a polyserine repeat between the amino terminal transactivation domains (TAD) and the cysteine-histidine rich region (H/C) in MyoD1. (mdpi.com)
We performed a Basic Local Alignment Search Tool (BLAST) analysis to identify regions of local similarity between the human DBNDD1 and protein sequences from other species (Fig. 1 ). (springer.com)
2019 ) was used, https://www.ebi.ac.uk/Tools/msa/clustalo/ ] of human DBNDD1 and similar protein sequences found by a BLAST search in other selected species. (springer.com)

As an outcome human DBNDD1 revealed a high sequence identity to dysbindin domain-containing proteins from other Hominidae (e.g. (springer.com)

Additionally, it is a proline-rich (10% prolines) cytoplasmatic protein with expression in nearly all organs and e.g., neuronal cells. (springer.com)

mTORC1 regulates cell growth and proliferation by controlling protein synthesis, lipid synthesis, autophagy, and metabolic programs (Bhat et al. (bio-rad-antibodies.com)

Phosphorylation Regulates CAP1 (Cyclase-Associated Protein 1) Functions in the Motility and Invasion of Pancreatic Cancer Cells. (uams.edu)

Most chloroplastic proteins are nuclear encoded, synthesized in the cytosol, and posttranslationally imported into the organelle. (silverchair.com)
Mitochondrial and chloroplast proteins are therefore synthesized in the cytosol as preproteins with an NH 2 -terminal targeting sequence, which is both necessary and sufficient for directing the preproteins to the correct organelle. (silverchair.com)
The protein kinase is found in the cytosol of pea mesophyll cells or in wheat germ extract. (silverchair.com)

Anatomy11

Organisms7

Chemicals and Drugs145

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Phenomena and Processes35

Information Science3

Mitogen-activa5

Cyclin-depende2

MAPK4

Phosphatase3

Dual-specificity3

THREONINE9

Amino Acids1

Glycogen6

Inhibition3

Casein1

Intracellular3

Substrates5

Regulate3

Peptides1

Multifunctional3

Residues6

Recombinant proteins1

Subunit3

Inhibitors1

Interaction3

Evolutionarily3

Gene8

Pathways3

MTOR2

Homologs2

Targets3

Subcellular1

Motifs3

Phospholipase1

Cdk52

Regulatory2

CDC21

Family proteins2

Cellular7

Chem1

Isoform1

Dephosphorylation1

20002

Neurons6

Regulation5

Physiological1

Cytosolic2

Less conserved2

Membranes1

Pathway2

Mechanism2

Genes2

Vitro1

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Progression3

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20211

Apoptosis1

Sequences5

Outcome1

Neuronal1

Metabolic1

Regulates1

Cytosol3