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  • amino acid
  • Proline is the only proteinogenic amino acid with a secondary amine, in that the alpha-amino group is attached directly to the side chain, making the ╬▒ carbon a direct substituent of the side chain. (wikipedia.org)
  • Proline was first isolated in 1900 by Richard Willst├Ątter who obtained the amino acid while studying N-methylproline. (wikipedia.org)
  • Proline is biosynthetically derived from the amino acid L-glutamate. (wikipedia.org)
  • collagen
  • Multiple prolines and/or hydroxyprolines in a row can create a polyproline helix, the predominant secondary structure in collagen. (wikipedia.org)
  • physiological
  • In plants, proline accumulation is a common physiological response to various stresses but is also part of the developmental program in generative tissues (e.g. pollen). (wikipedia.org)
  • commonly
  • however, proline is commonly found as the first residue of an alpha helix and also in the edge strands of beta sheets. (wikipedia.org)
  • Proline is also commonly found in turns (another kind of secondary structure), and aids in the formation of beta turns. (wikipedia.org)