• It also affects the rate of peptide bond formation between proline and other amino acids. (wikipedia.org)
  • When proline is bound as an amide in a peptide bond, its nitrogen is not bound to any hydrogen, meaning it cannot act as a hydrogen bond donor, but can be a hydrogen bond acceptor. (wikipedia.org)
  • Peptide bonds to proline, and to other N-substituted amino acids (such as sarcosine), are able to populate both the cis and trans isomers. (wikipedia.org)
  • The exceptional conformational rigidity of proline affects the secondary structure of proteins near a proline residue and may account for proline's higher prevalence in the proteins of thermophilic organisms. (wikipedia.org)
  • however, proline is commonly found as the first residue of an alpha helix and also in the edge strands of beta sheets. (wikipedia.org)
  • Notably, mice infected with fungal cells unable to catabolize proline, e.g., cells lacking the Put2 enzyme (1-pyrroline-5-carboxylate (P5C) dehydrogenase) , showed milder illness or no symptoms at all. (sciencedaily.com)
  • The distinctive cyclic structure of proline's side chain gives proline an exceptional conformational rigidity compared to other amino acids. (wikipedia.org)
  • Proline, one of the 20 naturally occurring amino acids in the body, is enriched in extracellular matrix proteins, e.g., collagen, and as such is readily available when connective tissue is broken down at sites of infection, or when a host becomes vulnerable as a result of cancerous growth or upon the onset of sarcopenia. (sciencedaily.com)
  • Compressed disc did not incorporate proline, demonstrating marked interference with protein metabolism. (cdc.gov)
  • The hydroxylation of proline by prolyl hydroxylase (or other additions of electron-withdrawing substituents such as fluorine) increases the conformational stability of collagen significantly. (wikipedia.org)
  • The results consistently showed that strains unable to metabolize proline exhibit significantly reduced virulence properties and a clearly diminished capacity to undergo morphological transitions. (sciencedaily.com)
  • ProLine Powder, 1 lb. (ritdye.com)
  • mg / dose Vitamin C (ascorbic acid) 225 Calcium ascorbate 630 Ext Rosa Canina (70% vit.C) 45 L-Lysine 900 L-Proline 900 Citrus Bioflavonoids 60% 180 1575 Pineapple powder Scent of Lemons. (farmacia-internacional.net)
  • A powdered formulation, our ProLine formula is non-toxic and safe for septic and sewer systems. (ritdye.com)
  • The next year, Emil Fischer isolated proline from casein and the decomposition products of γ-phthalimido-propylmalonic ester, and published the synthesis of proline from phthalimide propylmalonic ester. (wikipedia.org)
  • Proline (symbol Pro or P) is an organic acid classed as a proteinogenic amino acid (used in the biosynthesis of proteins), although it does not contain the amino group -NH 2 but is rather a secondary amine. (wikipedia.org)
  • Proline is the only proteinogenic secondary amino acid which is a secondary amine, as the nitrogen atom is attached both to the α-carbon and to a chain of three carbons that together form a five-membered ring. (wikipedia.org)
  • Proline is also commonly found in turns (another kind of secondary structure), and aids in the formation of beta turns. (wikipedia.org)
  • Multiple prolines and/or hydroxyprolines in a row can create a polyproline helix, the predominant secondary structure in collagen. (wikipedia.org)
  • Thanks to boatdesign.net, I'm now down to needing designers who use MultiSurf and ProLines, please. (boatdesign.net)
  • L-Proline has been found to act as a weak agonist of the glycine receptor and of both NMDA and non-NMDA (AMPA/kainate) ionotropic glutamate receptors. (wikipedia.org)
  • To obtain answers, the team initially applied a mouse model of infection, which remains invaluable for this kind of work, and found that C. albicans cells lacking the capacity to utilize proline were less invasive and virulent. (sciencedaily.com)
  • Prolines are rarely found in helices, becuase they force them to break their hydrogen bonding pattern and bend sharply. (shapeways.com)
  • This may account for the curious fact that proline is usually solvent-exposed, despite having a completely aliphatic side chain. (wikipedia.org)
  • ProLine Waterfall Boxes are designed to accommodate additional Mechanical or Biological Filter Media for super clean water. (lilypons.com)
  • The investigating team now report that proline is an important source of energy in other pathogenic Candida species, including the multidrug resistant C. auris , an emerging health threat and also a WHO critical priority fungal pathogen. (sciencedaily.com)
  • The team used proline as a reducing agent, potassium acetate as a base, and dimethylsulfoxide (DMSO) as the solvent. (chemistryviews.org)
  • Although proline has long been known to trigger hyphal growth, we have recently discovered that C. albicans can use proline as a main source of energy. (sciencedaily.com)
  • ProLine PRO3000 features an extra long weir for stacking stones in front of the Waterfall. (lilypons.com)
  • Physiology and production of sugar-apple under water stress and application of proline. (bvsalud.org)
  • The study reveals that the opportunistic human fungal pathogen Candida albicans requires the ability to metabolize proline, an amino acid obtained from the host, to mount virulent infections. (sciencedaily.com)
  • We provide the chemical tools to investigate proline isomerization and its ability to selectively enhance signaling in transcription and other biological contexts. (rcsb.org)
  • f Increased para-amino-isobutyric acid, leucine, and proline levels in the urine. (medscape.com)
  • In plants, proline accumulation is a common physiological response to various stresses but is also part of the developmental program in generative tissues (e.g. pollen). (wikipedia.org)
  • A randomized block design was laid out in a 4 × 2 factorial scheme, with treatments resulting from the combination of four irrigation intervals (1, 4, 8 and 12 days) and two concentrations of proline (0 and 10 mM), with four replicates, and the plot consisted of four usable plants . (bvsalud.org)
  • Exogenous application of proline at concentration of 10 mM increased contents of chlorophyll a , chlorophyll b, total chlorophyll and carotenoids and fruit fresh mass in plants grown under 12-day irrigation intervals. (bvsalud.org)
  • The lead author of this study Dr. Fitz Gerald S. Silao explains: "In fungal cells possessing mitochondria equipped with a full complement of energy conserving respiratory complexes, the catabolism of proline generates almost as much chemical energy (ATP) as does the catabolism of the energy-rich sugar glucose. (sciencedaily.com)
  • Strikingly, genetic dissection of the Proline UTilization (PUT) pathway and of the control mechanisms governing proline use led to the discovery that proline is toxic to cells unable to catabolize it. (sciencedaily.com)
  • A cartoon version of an alpha-helix that includes the amino acid proline. (shapeways.com)
  • The objective of this study was to evaluate the physiology and production of sugar - apple as a function of irrigation intervals and foliar application of proline under the conditions of Paraíba's semi-arid region. (bvsalud.org)
  • Rit ProLine contains an advanced mix of direct, acid and disperse dyes, enabling you to dye a wide range of fabrics and materials at scale. (ritdye.com)
  • Therefore, this work aimed to evaluate the viability of ADMSCs cryopreserved with the combination of L-proline and trehalose over up to 90 days. (bvsalud.org)
  • The association of L-proline and trehalose kept ADMSC viable for 30 and 90 days of freezing, and could be an alternative as a cellular cryopreservative without toxicity and enabling the use of serial fat grafting. (bvsalud.org)