• The reduction in tumor volume as well as pro-apoptotic and anti-proliferative effects in HT-29 nude mice xenograft are comparable to those produced by 5-FU. (spandidos-publications.com)
  • Inhibiting LDH activity has an anti-proliferative effect on cancer cells (2). (rndsystems.com)
  • Coral K, Angayarkanni N, Gomathy N, Bharathselvi M, Pukhraj R, Rupak R. Homocysteine levels in the vitreous of proliferative diabetic retinopathy and rhegmatogenous retinal detachment: its modulating role on lysyl oxidase. (medscape.com)
  • Vitreous and serum levels of platelet-derived growth factor and their correlation in patients with proliferative diabetic retinopathy. (medscape.com)
  • Diabetic retinopathy can progress to this more severe type, known as proliferative diabetic retinopathy when damaged blood vessels get blocked and new, abnormal blood vessels grow in the retina. (dragarwal.com)
  • Widespread blood vessel growth in the retina, which occurs in proliferative diabetic retinopathy, can be treated by creating a pattern of scattered laser burns across the retina. (dragarwal.com)
  • The most severe form of the condition is proliferative diabetic retinopathy, in which abnormal vessels grow on the retina. (medlineplus.gov)
  • Proliferative fasciitis and proliferative myositis (PF/PM) are rare benign soft tissue lesions (i.e. a damaged or unspecified abnormal change in a tissue) that increase in size over several weeks and often regress over the ensuing 1-3 months. (wikipedia.org)
  • In 2020, the World Health Organization agreed with this view and defined these lesions as virtually identical disorders termed proliferative fasciitis/proliferative myositis or proliferative fasciitis and proliferative myositis. (wikipedia.org)
  • Nonproliferative and Proliferative Lesions of the Rat and Mouse Skeletal Tissues (Bones, Joints, and Teeth). (nih.gov)
  • International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate ( M. fascicularis ). (nih.gov)
  • Rheumatic fever is characterized pathologically by exudative and proliferative inflammatory lesions of the connective tissue in the heart, joints, blood vessels, and subcutaneous tissue. (medscape.com)
  • microRNA (miRNA) expression level alterations between endometrial tissue and endometriotic lesions indicate their involvement in endometriosis pathogenesis. (mdpi.com)
  • During the late proliferative phase, the stripe may appear to be layered, with a darker line that runs through the middle. (healthline.com)
  • The normal wound healing process includes four stages: hemostasis (clotting), inflammatory (localized swelling), proliferative (rebuilding), and maturation (remodeling). (thehorse.com)
  • Senescent cells in aging tissues are characterized by increased inflammatory cytokine and growth factor secretion. (jax.org)
  • Treatments include anti-inflammatory drugs, drugs to suppress ovarian function and endometrial tissue growth, surgical ablation and excision of endometriotic implants, and, if disease is severe and no childbearing is planned, hysterectomy alone or hysterectomy plus bilateral salpingo-oophorectomy. (msdmanuals.com)
  • Pigmented villonodular synovitis is a proliferative synovial-based inflammatory process that can lead to joint destruction and debilitating pain. (medscape.com)
  • the adnexa refers to the ovaries, fallopian tubes, and surrounding connective tissues. (msdmanuals.com)
  • The purpose of this study was to investigate the levels of p53 expression and proliferative activity in non-malignant glandular epithelium of the breast after BCT. (maastrichtuniversity.nl)
  • Proliferative vitreoretinopathy can occur from glial or retinal pigment epithelium (RPE) proliferation. (medscape.com)
  • First, the fin margin is covered by a wound epithelium, and next a proliferative blastema arises by dedifferentiation of stump tissues near the amputation. (unifr.ch)
  • Proliferative myositis is an intramuscular reactive process. (tumorsurgery.org)
  • Historically, many studies had grouped the two descriptive forms of PF/PM as similar disorders with the exception that proliferative fasciitis occurs in subcutaneous tissues while proliferative myositis occurs in muscle tissues. (wikipedia.org)
  • It is identical in appearance to proliferative fasciitis, except its locations is within skeletal muscle. (tumorsurgery.org)
  • Gestational trophoblastic disease is a group of proliferative disorders originating from trophoblastic tissue in the uterus. (msdmanuals.com)
  • White adipose tissue (WAT) has key metabolic and endocrine functions and plays a role in regulating energy homeostasis and insulin sensitivity. (springer.com)
  • Conversely, brown adipose tissue (BAT) and browning of WAT represent potential therapeutic approaches, since dysfunctional white adipocyte-induced lipid overspill can be halted by BAT/browning-mediated oxidative anti-lipotoxic effects. (springer.com)
  • Here, we summarise the mechanisms contributing to adipose tissue (AT) plasticity and function including characteristics and cellular complexity of the various adipose depots and we discuss recent insights into AT origins, identification of adipose precursors, pathophysiological regulation of adipogenesis and its relation to WAT/BAT expandability in obesity and its associated comorbidities. (springer.com)
  • White adipose tissue (WAT) plays a key homeostatic role, not only by ensuring efficient energy storage but also by its quick mobilisation (lipids) to ensure peripheral demands. (springer.com)
  • The 'adipose tissue expandability model' identifies the limited capacity and dysfunctionality of WAT, preventing its expansion and accommodation of surplus of energy, as key determinants for the onset and progression of obesity-associated metabolopathologies as a result of ectopic deposition of toxic lipid species in metabolic organs (i.e. muscle or liver [also known as lipotoxic insult]) [ 7 ]. (springer.com)
  • There is also evidence that the deleterious effects mediated by dysfunctional white adipocyte-induced lipid overspill can be halted by the pro-oxidative anti-lipotoxic effects mediated by brown adipose tissue (BAT) activation. (springer.com)
  • Fat cells, or adipose tissue, produce excess amounts of the hormone estrogen . (healthline.com)
  • Endometrial cells can appear in other parts of your body as a symptom of endometriosis , but an "endometrial stripe" specifically refers to endometrial tissue in your uterus. (healthline.com)
  • Your endometrial tissue will begin to thicken later in your cycle. (healthline.com)
  • Unless you're experiencing unusual symptoms, thick endometrial tissue generally isn't a cause for concern. (healthline.com)
  • Interestingly, similar secretory responses occur during tissue injury. (jax.org)
  • We show here that, like SRC-2, SRC-3 is expressed in the epithelial and stromal cellular compartments of the human endometrium during the proliferative and secretory phase of the menstrual cycle as well as in cultured HESCs. (frontiersin.org)
  • This predisposition occurs due to the high tissue tension and mobility in these areas. (thehorse.com)
  • Endometrial hyperplasia occurs when your endometrial glands cause the tissue to grow more quickly. (healthline.com)
  • The compelling conclusion that proliferative exhausted T cells are associated with response in HPV+ head and neck cancer is supported by the cohort of 14 patients with paired tumor and adjacent normal tissue and rigorous bioinformatic analysis of nearly 50,000 single CD3+ T cell transcriptomes. (elifesciences.org)
  • Here we have investigated nc886 in gastric cancer where its expression is suppressed due to CpG DNA hypermethylation at its promoter region in a cohort of paired tumor/normal tissues from 88 gastric cancer patients. (oncotarget.com)
  • The tumor size and the number of proliferating cells were reduced in the tumor tissues obtained from the formononetin-treated group. (spandidos-publications.com)
  • To this end, we utilized RNA sequencing data from the TCGA and GEO databases, as well as tumor tissue specimens obtained from our clinical centre. (bvsalud.org)
  • During Central Nervous System ontogenesis, myelinating oligodendrocytes (OLs) arise from highly ramified and proliferative precursors called oligodendrocyte progenitor cells (OPCs). (nature.com)
  • If several operations are required to repair proliferative vitreoretinopathy, poor vision may result even with a successfully attached retina. (medscape.com)
  • The abnormal blood vessels can form scar tissue which can pull on the retina and cause retinal detachment . (dragarwal.com)
  • with caseation necrosis, foreign body-type giant cells, and The patient was referred to a consultant and hospital- proliferative endarteritis with vascular occlusions. (cdc.gov)
  • They are the same in that most of the reproductive organs of both sexes develop from similar embryonic tissue, meaning they are homologous. (wikibooks.org)
  • Our experiments revealed that the myocardium adjacent to the injury undergoes dedifferentiation, during which embryonic cardiac programs become reactivated to give rise to new tissue. (unifr.ch)
  • Thymus tissue is obtained from donors less than or equal to 9 months of age undergoing cardiac surgery. (rxlist.com)
  • Vitrectomy involves removing scar tissue and blood from the vitreous fluid of the eye. (dragarwal.com)
  • Given the limited soft tissues surrounding the ankle in conjunction with the ability of arthroscopy to easily access the entire joint, arthroscopic management of ankle pigmented villonodular synovitis allows for successful treatment while minimizing the surgical complications of an open approach. (medscape.com)
  • Arthroscopically assisted synovectomy in patients with pigmented villonodular synovitis of the ankle and hindfoot is an effective treatment option, providing adequate visualization for complete excision while minimizing soft-tissue complications related to larger surgical exposures. (medscape.com)
  • [ 10 , 13 ] With the limited soft tissues surrounding the ankle as compared to the knee and the ability of arthroscopy to easily access the entire joint, arthroscopic management of ankle PVNS allows for successful treatment while minimizing surgical complications. (medscape.com)
  • This new tissue is called granulation tissue and special growth factors to stimulate skin formation (epithelialization). (huffpost.com)
  • Those on distal (lower-below the knee/carpus or hock/tarsus) limbs are especially difficult to manage, which often leads to the production of proud flesh, or exuberant granulation tissue, resulting in a chronic wound. (thehorse.com)
  • Typically, granulation tissue is pink and appears rough or bumpy. (thehorse.com)
  • A new technique has been presented that results in an acceleration of delayed primary healing with full thickness skin and subcutaneous tissue coverage. (who.int)
  • Cell type and tissue specific alterations in fine GAG structure, which are strictly predetermined [ 8 - 10 ], allow these molecules to modulate with high specificity different cellular processes [ 7 ]. (hindawi.com)
  • Objective An epidemiological survey of oral soft tissue proliferative processes diagnosed at the center of Pathological Anatomy of Oral ASCES Faculty. (bvsalud.org)
  • Conclusion Non neoplastic proliferative processes processes are found in the general population, more common in females, affecting wide age-range, predominantly in individuals in the fifth and sixth decades of life, and fibrous hyperplasia was the most frequently found lesion. (bvsalud.org)
  • Proliferative vitreoretinopathy is a reparative process, similar to a keloid, initiated by full- or partial-thickness retinal breaks, retinopexy, and other types of retinal damage. (medscape.com)
  • 5. Buccal soft tissue thickness: measured using a pre-fabricated stent and its clinical reference points with the addition of an endodontic spreader with rubber stops, recorded before extraction and 4 months after the alveolar ridge preservation. (who.int)
  • rather, the body has to rebuild and repair tissue on the cellular level. (huffpost.com)
  • Cellular metabolism, tissue repair and immune support. (huffpost.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Cellular senescence, that is the loss of proliferative capacity, has a complex role in homeostasis. (jax.org)
  • In the histopathologic exam, it was observed the presence of exuberant production of mesenchymal tissue, showing multiples cellular bundles randomly. (vin.com)
  • Increased proliferative activity and p53 expression in normal glandular breast tissue after radiation therapy. (maastrichtuniversity.nl)
  • In normal glandular breast tissue, p53 expression is very low, as is proliferative activity. (maastrichtuniversity.nl)
  • In contrast, in the patients with contralateral breast cancer, the levels of p53 and Ki-67 immunoreactivity in the normal glandular breast tissue were comparable to the ipsilateral side (P = 0.7 and P = 0.1, respectively). (maastrichtuniversity.nl)
  • In conclusion, increased expression of p53 and Ki-67 is present in normal glandular breast tissue, even 2-5 years after radiation therapy. (maastrichtuniversity.nl)
  • Glial remodeling and neural plasticity in human retinal detachment with proliferative vitreoretinopathy. (medscape.com)
  • Regeneration in zebrafish predominantly relies on the intrinsic plasticity of mature tissues. (unifr.ch)
  • Tissue regeneration involves the restoration of tissue components by regrowth of damaged tissues. (bartleby.com)
  • In contrast, tissue repair involves patching of injured tissue rather than restoring it. (bartleby.com)
  • This property involves activation of the remaining tissue at the site of injury to promote cell division, cell migration and replacement of the missing structures. (unifr.ch)
  • An essential trace mineral used in enzymatic reactions involved in tissue and wound healing, regeneration and repair. (huffpost.com)
  • The focus of her studies includes the coordination of wound repair and functional regeneration of tissues in fish. (unifr.ch)
  • This tissue is highly vascularized but does not contain nerve endings, which means it contains many blood vessels that help supply oxygen to the area but does not have any sensation. (thehorse.com)
  • In contrast to T cells, which did not exhibit a significant difference, B cells from PPARĪ³ +/- showed an enhanced proliferative response to stimulation by either lipopolysaccharide or cross-linking of antigen receptors. (jci.org)
  • The manufacturing process preserves the thymic epithelial cells and tissue structure and depletes most of the donor thymocytes from the tissue. (rxlist.com)
  • The body starts building tissue with specialized collagen-forming cells called fibroblasts. (huffpost.com)
  • Together, these results suggest that senescent cells accelerate and improve tissue repair. (jax.org)
  • Scar tissue (stained for collagen, in orange) is evident in healed wounds from transgenic p16-3MR mice lacking senescent cells (bottom panel, GCV-treated) compared to control mice (top panel, PBS-treated). (jax.org)
  • The tissue was composed of cells containing elongated nucleus, with discrete pleomorphism and rare stroma. (vin.com)
  • rbf1 , the Drosophila homolog of Rb , also displays a pro- apoptotic activity in proliferative cells. (sdbonline.org)
  • After mitosis, daughter cells can either remain proliferative and re-enter the cell cycle or become terminally postmitotic and migrate out of the VZ ( McConnell, 1995 ). (jneurosci.org)
  • Both intrinsic and extrinsic signals are likely to influence the proliferative potential and eventual fates of precursor cells within the VZ. (jneurosci.org)
  • Then, CDKN2A expression in glioma tissues/cells or paracancer tissues/astrocytes was measured by quantitative reverse transcription polymerase chain reaction (qRT-PCR) or Western blot. (bvsalud.org)
  • RESULTS: CDKN2A was low-expressed in glioma tissue/cells as compared to paracancer tissue/astrocytes, and was strongly associated to the poor prognosis of glioma. (bvsalud.org)
  • Little is known about the effect of the commonly used doses of radiation therapy on normal breast tissue. (maastrichtuniversity.nl)
  • Only 3 benign breast tumour tissues (12.5%) and none of the healthy breast tissue specimens were HPV-DNA-positive. (who.int)
  • It is a moisturizing cream with a light texture and a pleasant silky touch, enriched with herbal extracts specifically selected for the breast tissue. (bayho.com)
  • The body transforms and replaces the collagen that was placed during the proliferative phase into a stronger collagen to support structure and function over the long term. (huffpost.com)
  • This study in Iraq used in situ hybridization to detect the frequency and genotyping of HPV in tissue specimens from 129 patients diagnosed with malignant breast cancer, 24 with benign breast tumours and 20 healthy controls. (who.int)
  • Proliferative vitreoretinopathy (PVR) is the most common cause of failure in retinal detachment surgery. (medscape.com)
  • Epimacular membranes occurring after retinal detachment surgery can be thought of as limited proliferative vitreoretinopathy. (medscape.com)
  • Of all retinal detachment surgery cases, 5-10% develop proliferative vitreoretinopathy. (medscape.com)
  • No known racial predilection exists for proliferative retinal detachment. (medscape.com)
  • Interaction between surgical procedure for repairing retinal detachment and clinical risk factors for proliferative vitreoretinopathy. (medscape.com)
  • Our laboratory identified signalling pathways that orchestrate proliferation, migration and patterning of different tissues in the regenerating fin. (unifr.ch)
  • Intraneural connective tissue proliferation of the median nerve in the carpal tunnel. (cdc.gov)
  • A proliferation of the intraneural connective tissue in the flattened sections of most nerves was noted and was mainly due to the proliferation of the epineural layers. (cdc.gov)
  • A proliferative exhausted CD8 + T cell cluster (P-Tex) which was beneficial to survival outcomes of patients with HPV-positive HNSCC was identified. (elifesciences.org)
  • In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)
  • This term doesn't refer to a health condition or diagnosis, but to a normal part of your body's tissue. (healthline.com)
  • Our Rethymic (allogeneic processed thymus tissue-agdc) for Surgical Implantation Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • RETHYMIC consists of yellow to brown slices of allogeneic processed thymus tissue for administration by surgical implantation. (rxlist.com)
  • Tissue samples were collected from primary pterygia, recurrent pterygia, and normal conjunctiva to perform the following experiments: immunohistochemical measurement of IPO13 and K17. (molvis.org)
  • Proud flesh develops when the normal proliferative phase of the wound healing process proceeds unrestricted. (thehorse.com)
  • Samples of altered and normal tissues were collected and kept in a 10% formalin solution for histopathologic and exams. (vin.com)
  • The authors conclude that the proliferative increase of the intraneural connective tissue is a localized characteristic of the median nerve in the carpal tunnel and is a normal occurrence in males and females. (cdc.gov)
  • Rethymic ( allogeneic processed thymus tissue-agdc) is processed thymus tissue indicated for immune reconstitution in pediatric patients with congenital athymia. (rxlist.com)
  • Your veterinarian should examine any wound closely and remove foreign material, bone fragments, or dead tissue that can cause inflammation and infection. (thehorse.com)
  • Results from this study define an unanticipated role for senescence in tissue repair and suggest that topical application of PDGF-AA may accelerate and improve cutaneous wound healing. (jax.org)
  • Although proliferative vitreoretinopathy can occur at all ages, some observers believe that proliferative tissue may develop more rapidly in children. (medscape.com)
  • This technique is specific and uses native tissues for functional studies of epithelia. (jove.com)
  • In short, this is a known list of sex organs that evolve from the same tissues in a human life. (wikibooks.org)
  • OBJECTIVE: Human chorionic gonadotropin (hCG) has proliferative effects on uterine smooth muscle and leiomyoma tissue in vitro. (rti.org)
  • To begin, place the desired segments of intestinal tissue collected from claudin-15 knockout mice into ice cold bubbled Ringer's solution and trim away the fat and connective tissue. (jove.com)
  • The days during your period and immediately after it are called the menstrual, or early proliferative, phase. (healthline.com)
  • Histological examination of tissues collected at necropsy revealed proliferative abomasitis and nematodes consistent with Ostertagia spp. (usda.gov)
  • The paraspinal abscess and the diseased in-tervertebral space tissue were taken for pathological examination during the operation. (scirp.org)
  • In addition, this technique measures the real-time physiological properties of a tissue, which is very useful. (jove.com)
  • This tissue will naturally change as you age and move through different reproductive stages. (healthline.com)
  • Relating in vitro to in vivo exposures with physiologically-based tissue dosimetry and tissue response models. (cdc.gov)
  • Soft-tissue swelling and early erosions in the proximal interphalangeal joints in a patient with rheumatoid arthritis of the hands. (medscape.com)
  • After sulcular incisions without flap reflection, teeth will be extracted atraumatically utilizing periotomes with care to preserve the buccal bone plate and the surrounding soft tissues. (who.int)