• Proliferative vitreoretinopathy (PVR) is the most common cause of failure in retinal detachment surgery. (medscape.com)
  • Epimacular membranes occurring after retinal detachment surgery can be thought of as limited proliferative vitreoretinopathy. (medscape.com)
  • Proliferative vitreoretinopathy can occur from glial or retinal pigment epithelium (RPE) proliferation. (medscape.com)
  • Penetrating or blunt trauma may also result in proliferative vitreoretinopathy. (medscape.com)
  • Proliferative vitreoretinopathy is a reparative process, similar to a keloid, initiated by full- or partial-thickness retinal breaks, retinopexy, and other types of retinal damage. (medscape.com)
  • Of all retinal detachment surgery cases, 5-10% develop proliferative vitreoretinopathy. (medscape.com)
  • Proliferative vitreoretinopathy has no associated mortality. (medscape.com)
  • If several operations are required to repair proliferative vitreoretinopathy, poor vision may result even with a successfully attached retina. (medscape.com)
  • Although proliferative vitreoretinopathy can occur at all ages, some observers believe that proliferative tissue may develop more rapidly in children. (medscape.com)
  • Glial remodeling and neural plasticity in human retinal detachment with proliferative vitreoretinopathy. (medscape.com)
  • Interaction between surgical procedure for repairing retinal detachment and clinical risk factors for proliferative vitreoretinopathy. (medscape.com)
  • Retinotomy and silicone oil for detachments complicated by anterior inferior proliferative vitreoretinopathy. (medscape.com)
  • To evaluate the effect of extrascleral cryocoagulation for the treatment of proliferative vitreoretinopathy (PVR) during retinal detachment repair. (kssg.ch)
  • Proliferative vitreoretinopathy has been observed in cases of retinal detachment. (wikipedia.org)
  • University Medical tive retinal detachment, and proliferative vitreoretinopathy. (cdc.gov)
  • Complicated retinal detachments with severe posterior and anterior proliferative vitreoretinopathy (PVR) were included in this study. (springer.com)
  • Abrams GW, Azen SP, McCuen BW II, Flynn HW Jr, Lai MY, Ryan SJ (1997) Vitrectomy with silicone oil or long-acting gas in eyes with severe proliferative vitreoretinopathy: results of additional and long-term follow-up. (springer.com)
  • Cox MS, Trese MT, Murphy PL (1986) Silicone oil for advanced proliferative vitreoretinopathy. (springer.com)
  • Machemer R, Aaberg TM, Freeman HM, Irvine AR, Lean JS, Michels RM (1991) An updated classification of retinal detachment with proliferative vitreoretinopathy. (springer.com)
  • Figure 10-9 Preretinal membrane (area between arrows) on the surface of the retina, secondary to proliferative vitreoretinopathy. (aao.org)
  • Garweg JG, Tappeiner C, Halberstadt M. Pathophysiology of proliferative vitreoretinopathy in retinal detachment. (aao.org)
  • RRD patients with or without proliferative vitreoretinopathy (PVR) were included. (dovepress.com)
  • Rhegmatogenous retinal detachment (RRD) is the most common form of retinal detachment (RD). Proliferative vitreoretinopathy (PVR) is primarily a result of failure to correct RRD after initial retinal reattachment surgery, occurs in 5%-10% of patients, and may lead to recurrent RD. 1 Further surgery is the only proven therapy for recurrent RD with PVR. (dovepress.com)
  • The development of proliferative vitreoretinopathy with retinal detachment in 4 patients was the main complication observed after pars plana vitrectomy. (thieme-connect.de)
  • Seventy-six consecutive patients with total rhegmatogenous retinal detachments and severe proliferative vitreoretinopathy underwent combined pars plana vitrectomy, lensectomy, panretinal photocoagulation, perfluoropropane gas (C3F8)/fluid exchange, and scleral buckling. (nih.gov)
  • Silicone oil (SO) is used mainly when managing complex retinal detachments, commonly with proliferative vitreoretinopathy, and as a hemostatic agent in proliferative diabetic retinopathy [1] . (researchsquare.com)
  • Combined retinal detachments with features of ERD and TRD may be associated with proliferative diabetic retinopathy or proliferative vitreoretinopathy and trauma. (institut-vision.org)
  • however, recurrence rates for retinal detachment could be as high as 10% to 20%, 1 and even higher in the presence of proliferative vitreoretinopathy (PVR). (bmj.com)
  • 2. Charteris DG, Downie J, Aylward GW, Sethi C, Luthert P. Intraretinal and periretinal pathology in anterior proliferative vitreoretinopathy. (medline.ru)
  • Classifications for Proliferative Vitreoretinopathy (PVR): An Analysis of Their Use in Publications over the Last 15 Years. (medline.ru)
  • 4. Pastor JC, de la Rúa ER, Martín F. Proliferative vitreoretinopathy: risk factors and pathobiology. (medline.ru)
  • Anterior proliferative vitreoretinopathy in the silicone study. (medline.ru)
  • 11. Hocaoglu M, Karacorlu M, Giray Ersoz M, Sayman Muslubas I, Arf S. Retinotomy and retinectomy for anterior inferior proliferative vitreoretinopathy: Can visual outcome be improved? (medline.ru)
  • Outcomes of vitrectomy with inferior retinectomy in patients with recurrent rhegmatogenous retinal detachments and proliferative vitreoretinopathy. (medline.ru)
  • Tolerability and Efficacy of Multiple Series of Intravitreal Methotrexate Injections for Complex Retinal Detachment Associated with Proliferative Vitreoretinopathy. (ucsf.edu)
  • Specific platelet-derived growth element (PDGF) isoforms are connected with proliferative vitreoretinopathy (PVR), a sight-threatening complication that develops inside a subset of individuals dealing with retinal reattachment surgery. (woofahs.com)
  • Intro Proliferative vitreoretinopathy (PVR) can be a blinding disease occurring in up to 10% of individuals dealing with retinal reattachment medical procedures (16, 23, 52). (woofahs.com)
  • Missed retinal breaks, new retinal break formation, opening of old retinal breaks and proliferative vitreoretinopathy have been identified as major causes of retinal re-detachment [ 4 , 8 ]. (biomedcentral.com)
  • Mysore Y, Del Amo EM, Loukovaara S, Hagström M, Urtti A, Kauppinen A. Statins for the prevention of proliferative vitreoretinopathy: cellular responses in cultured cells and clinical statin concentrations in the vitreous . (helsinki.fi)
  • It reduces the risk of developing posttraumatic complications of proliferative vitreoretinopathy (PVR). (balimedicaljournal.org)
  • Outcome measures were total retinal reattachment and the occurrence of proliferative vitreoretinopathy (PVR). (eyehospital.nl)
  • Outcome measures were total retinal reattachment and the occurrence of proliferative vitreoretinopathy (PVR).RESULTS: A total of 123 patients (124 eyes) were included in this study. (eyehospital.nl)
  • and structural and functional macular changes in a large series of non-primary retinectomies performed for rhegmatogenous retinal detachments (RRD) complicated by proliferative vitreoretinopathy (PVR) grade C. This was a retrospective single-centre cohort study lead by myself and Mr Anand Chawla FRCOphth MD. The cases were collected from a large dataset from the Royal Hallamshire Hospital in Sheffield, a busy supraregional tertiary referral centre in the UK. (soevision.org)
  • SSK Ankara Hastanesi 2.Göz Kliniği To determine the role of vitreoretinal surgery, by releasing anterior traction in eyes with chronic hypotony we operated on 12 eyes of 12 consecutive patients with previous vitreoretinal surgeries for retinal detachment and severe proliferative vitreoretinopathy. (retinavitreus.com)
  • These eyes had developed chronic hypotony and anterior proliferative vitreoretinopathy. (retinavitreus.com)
  • Proliferative vitreoretinopathy (PVR) is the most serious fibrous complication that causes vision loss after intraocular surgery, and there is currently no effective treatment in clinical. (ijbs.com)
  • Comparison of Peroperative Methotrexate Infusion With Postoperative Intra Silicon Oil Methotrexate Injections for Prevention of Proliferative Vitreoretinopathy Development After Vitrectomy for Rhegmatogenous Retinal Detachment Repair. (who.int)
  • Presence of proliferative vitreoretinopathy grade C, previous retinal detachment surgery in the same eye, penetrating ocular trauma, Presence of intraocular foreign bodies, previous glaucoma filtration surgery, allergy to methotrexate, and pregnant and lactating women. (who.int)
  • As the understanding of the pathophysiological mechanisms developed, so did the treatment options, from the first realization that thermal cautery around a retinal break will prevent retinal detachment, through the use of scleral buckles, to the cutting-edge technologies that enable small gauge vitrectomy and manipulation of the retina. (hindawi.com)
  • Rhegmatogenous retinal detachments can occur following the development of holes in areas of healed retinitis (retina may be atrophic). (wikipedia.org)
  • Localized scatter photocoagulation is effective in treating early proliferative changes, especially neovascular lesions that lie flat against the retina. (medscape.com)
  • Circumferential scatter photocoagulation places laser burns over a retinal zone of one of the following: at least 3 disc diameter areas of the nonperfused retina, as outlined by fluorescein angiography, or the entire avascular retina, as determined by fluorescein angiography or estimated by the distribution of the occluded vessel. (medscape.com)
  • Posterior vitreous detachment (PVD) occurs when a dehiscence in the vitreous cortex allows fluid from a syneretic cavity to enter the potential subhyaloid space, causing the remaining hyaloid face to be stripped from the internal limiting membrane (ILM) of the retina (Fig 10-7). (aao.org)
  • Occasionally, traction may occur on the peripheral retina, perifoveal macula, or retinal blood vessels as a PVD occurs. (aao.org)
  • Retinal tears (breaks) are often the result of vitreous traction on the retina during or after a PVD or secondary to ocular trauma. (aao.org)
  • Histologic examination of retinal tears reveals that the vitreous adheres to the retina along the flap of the tear. (aao.org)
  • In the area of retina separated from the underlying retinal pigment epithelium (RPE), there is loss of photoreceptors. (aao.org)
  • Detachment of the posterior hyaloid from the pericentral retina exerts anterior traction on the foveola and localizes the dynamic vitreous traction associated with ocular rotations into the perifoveolar region. (aao.org)
  • The majority of eyes with retinal breaks do not develop retinal detachment because normal physiological forces keep the retina in place. (aao.org)
  • However, the combination of retinal breaks, vitreous liquefaction and detachment, traction on the retina (vitreoretinal traction), and intraocular fluid currents associated with movement of liquid vitreous and subretinal fluid can overwhelm these "attachment factors," causing retinal detachment. (aao.org)
  • Proliferative" means there is abnormal blood vessel growth ( neovascularization ) in the retina , while "nonproliferative" indicates the opposite. (allaboutvision.com)
  • In the remaining 22 cases with successful reattachment of the retina posterior to the equator, partial peripheral retinal detachments were observed. (nih.gov)
  • The abnormal blood vessels can form scar tissue which can pull on the retina and cause retinal detachment . (dragarwal.com)
  • The entity retinal detachment (RD) was recognized early in 18th century by Saint-Yves who described the gross pathologic examination of detached retina. (institut-vision.org)
  • Retinal detachment (RD) occurs when the neurosensory retina separates from the underlying retinal pigment epithelium (RPE) and fluid accumulates within this potential space. (institut-vision.org)
  • Rhegmatogenous retinal detachment (RRD) is caused by a break in the retina (including round holes and tears), through which vitreous fluid passes from the vitreous cavity into the subretinal space, thus separating the sensory retina from the RPE. (institut-vision.org)
  • Tractional retinal detachment (TRD) occurs when vitreoretinal adhesions or membranes mechanically pull the retina away from the RPE, without a retinal break (Fig. 1). (institut-vision.org)
  • The term "recurrent RD" is used to describe repeated occurrence of the primary detachment, occurrence of new or missed retinal breaks, or overgrowth of the retina by membranes and scar tissue. (institut-vision.org)
  • Written by a group of retina specialists, this book is an excellent resource for knowledge about retinal disorders. (benthambooks.com)
  • Rhegmatogenous retinal detachment (RRD) is a vision-threatening condition caused by tractional forces of the vitreous onto the retina leading to full-thickness retinal tears and accumulation of fluid in the subretinal space [ 1 ]. (biomedcentral.com)
  • As a consequence of the neurosensory retina separating from the retinal pigment epithelium (RPE), the outer retina loses its choroidal blood supply and becomes ischaemic [ 1 ]. (biomedcentral.com)
  • Indications for pars plana vitrectomy include removal of vitreous opacities, relieving vitreoretinal traction, restoring the normal anatomical relationship of the retina and retinal pigment epithelium (RPE), and accessing the subretinal space. (eyewiki.org)
  • This area comprises two-thirds of the volume of the eye and is called vitreous cavity, which along with the retina, the retinal pigment epithelium, choroid, and sclera, make up the posterior segment. (retinafoundation.com)
  • This condition can lead to seriously impaired vision as blood vessels grow in the retina and the threat is bleeding from these vessels which can lead to retinal damage, and even to retinal detachment at the back of the eye. (moorfields.ae)
  • Damaged retinal blood vessels leak blood and fluid into the retina. (msdmanuals.com)
  • Detachment of the Retina Detachment of the retina is separation of the retina (the transparent, light-sensitive structure at the back of the eye) from the underlying layer to which it is attached. (msdmanuals.com)
  • Proliferative retinopathy is characterized by abnormal new vessel formation (neovascularization), which occurs on the inner (vitreous) surface of the retina and may extend into the vitreous cavity and cause vitreous hemorrhage. (msdmanuals.com)
  • Retinal detachment -- Scarring that may cause part of the retina to pull away from the back of your eyeball. (medlineplus.gov)
  • Advanced stage (proliferative): In this stage, the retina begins to grow new blood vessels. (cdc.gov)
  • Scleral buckling is an ophthalmic surgical technique that has been successfully employed as a primary or adjuvant procedure to repair rhegmatogenous retinal detachments for over 60 years. (aao.org)
  • Retinal detachments can develop by several mechanisms (rhegmatogenous, tractional, exudative, or a combination of those) and have a multitude of presentations. (hindawi.com)
  • Diabetic tractional retinal detachments are challenging to address in surgery. (crstoday.com)
  • The subsequent analysis of all retinal layers of the macular OCT allowed us to identify the location of cystoid macular oedema and to distinguish between exudative intraretinal cystoid spaces (exudative maculopathy) and tractional intraretinal cystoid spaces (tractional maculopathy), as described in previous literature. (soevision.org)
  • Relaxing retinectomies and the use a silicone oil intraocular tamponade are useful for complex retinal detachments with PVR when other procedures including membrane peeling and scleral buckling are insufficient. (soevision.org)
  • The most widely used therapeutic modalities include laser retinal photocoagulation, retinal cryotherapy, and vitrectomy/membranectomy. (medscape.com)
  • Early pars plana vitrectomy for proliferative diabetic retin. (lww.com)
  • Lucke KH, Foerster MH, Laqua H (1987) Long-term results of vitrectomy and silicone oil in 500 cases of complicated retinal detachments. (springer.com)
  • Subjects with inconceivable objective refraction, with a cataract due to capsular touch during vitrectomy, or with macular detachment in the ophthalmic examination and/or optical coherence tomography during assessment of refraction were excluded. (researchsquare.com)
  • Outcome of scleral buckling with or without gas tamponade for recurrent retinal detachment in post-vitrectomy eyes. (medline.ru)
  • 15. Tatsumi T, Baba T, Iwase T, Nizawa T, Miura G, Yokouchi H, Yamamoto S. Outcomes of Vitrectomy Combined with Scleral Buckling for Eyes with Early Recurrence of Simple Rhegmatogenous Retinal Detachment Previously Treated by Pars Plana Vitrectomy. (medline.ru)
  • To determine patient and surgical factors associated with the use of 360-degree laser retinopexy during primary pars plana vitrectomy (PPV) ± scleral buckle (SB) for rhegmatogenous retinal detachment (RRD) and its impact on surgical outcomes. (biomedcentral.com)
  • Mura M, Barca F, Dell'Omo R, Nasini F, Peiretti E. Iatrogenic retinal breaks in ultrahigh-speed 25-gauge vitrectomy: a prospective study of elective cases. (medscape.com)
  • Liu H, Zuo S, Ding C, Dai X, Zhu X. Comparison of the Effectiveness of Pars Plana Vitrectomy with and without Internal Limiting Membrane Peeling for Idiopathic Retinal Membrane Removal: A Meta-Analysis. (medscape.com)
  • Vitrectomy has been implemented and developed continuously and has become the standard for successful treatment of RRD, especially in cases of complex retinal detachment [ 2 ]. (ijbs.com)
  • PVR odds ratio, visual acuity, retinal reattachment rate, and complications were evaluated in three trials. (dovepress.com)
  • Anti-VEGF therapy can also reduce vision-threatening complications associated with proliferative DR (PDR). (crstoday.com)
  • Although many hemoglobinopathies exist, those resulting in proliferative retinopathy are limited to sickle cell disease. (medscape.com)
  • The widely accepted pathogenesis for sickle cell retinopathy is vasoocclusion that leads to retinal hypoxia, ischemia, infarction, neovascularization, and fibrovascularization. (medscape.com)
  • Different techniques have been advocated in treating proliferative sickle retinopathy, including scatter photocoagulation and feeder vessel photocoagulation. (medscape.com)
  • This technique has been shown to manage proliferative sickle retinopathy effectively, especially in cases where neovascularization has persisted after extensive scatter photocoagulation treatment. (medscape.com)
  • An interruption in blood supply to the eye can produce a vascular retinopathy, which is a noninflammatory retinal disorder. (doctor-clinic.org)
  • Hypertensive retinopathy results from prolonged hypertension, which produces retinal vasospasm and consequent damage to and narrowing of the arteriolar lumen. (doctor-clinic.org)
  • Trained non-physician evaluators who studied retinal images transmitted to computer screens at a remote central reading center successfully identified newborn infants likely to require a specialized medical evaluation for retinopathy of prematurity (ROP), a leading cause of treatable blindness. (news-medical.net)
  • Vision loss with proliferative retinopathy may be severe. (msdmanuals.com)
  • Proliferative retinopathy, unlike nonproliferative retinopathy, causes formation of fine preretinal vessel neovascularization visible on the optic nerve or retinal surface. (msdmanuals.com)
  • In eyes with proliferative retinopathy and center-involving macular edema, an intraocular VEGF inhibitor injection should be considered at the time of PRP to improve the near-term vision result. (medscape.com)
  • 8 , 9 Daunomycin inhibits formation of PVR in pigmented rabbits 10 and proliferation of human retinal cells. (dovepress.com)
  • Longitudinal fundus imaging and its genome-wide association analysis provide evidence for a human retinal aging clock. (ucsf.edu)
  • Participants: In vitro primary culture human retinal endothelial cell (HREC) culture. (bvsalud.org)
  • Jonas JB, Budde WM, Knorr HL (1999) Timing of retinal redetachment after removal of intraocular silicone oil tamponade. (springer.com)
  • This is due to a combination of retinal breaks, vitreous changes inducing a retinal break and vitreoretinal traction, and intraocular fluid currents. (aao.org)
  • Disadvantages include the risk of new retinal breaks, cataract formation and elevation of intraocular pressure [ 6 ]. (biomedcentral.com)
  • The purpose of this special issue is to serve as a platform for sharing current data and new innovations in the management of all types of retinal detachments. (hindawi.com)
  • Although considerable debate persists regarding the optimal form of treatment for many types of retinal detachments, scleral buckling is declining in popularity, particularly in regard to pseudophakic cases. (aao.org)
  • To assess the efficacy and safety of a heavy silicone oil (Densiron 68®), a mixture of perfluorohexyloctane (F 6 H 8 ) with silicone oil as temporary internal tamponade in selected retinal detachments treated with large inferior retinectomy. (springer.com)
  • Homozygous sickle cell disease (SS disease), sickle cell C disease (SC disease), and sickle cell-thalassemia disease (S-Thal disease) are common hemoglobinopathies that can present with mild-to-severe proliferative retinal findings. (medscape.com)
  • It allows early diagnosis of macular holes and severe retinal detachments, which require acute surgical therapy to prevent legal blindness. (cns.org)
  • Laser retinal photocoagulation is the more commonly practiced therapeutic modality. (medscape.com)
  • However, in cases where scatter photocoagulation alone does not achieve the desired result (ie, regression of proliferative changes), feeder vessel photocoagulation may be used as an adjunct to induce infarction to the remaining sea fans. (medscape.com)
  • Obliterating feeder vessels by retinal photocoagulation has been used to cause infarction of peripheral neovascular beds. (medscape.com)
  • In 16 of the 22 cases, the detachments occurred entirely anterior to the boundary of the previously placed photocoagulation lesions. (nih.gov)
  • One method proposed to reduce re-detachment rates in patients undergoing PPV is 360-degree prophylactic endolaser photocoagulation. (biomedcentral.com)
  • PURPOSE: To evaluate postoperative laser photocoagulation as retinopexy mode in patients with rhegmatogenous retinal detachment treated with scleral buckling surgery. (eyehospital.nl)
  • abstract = "PURPOSE: To evaluate postoperative laser photocoagulation as retinopexy mode in patients with rhegmatogenous retinal detachment treated with scleral buckling surgery.METHODS: The authors conducted a prospective feasibility study of consecutive patients with rhegmatogenous retinal detachment treated with scleral buckling surgery and postoperative laser during an 18-month period with a minimal follow-up of 6 months. (eyehospital.nl)
  • The next level of complexity for the surgeon would include beginning to perform endoscopic retinal laser photocoagulation treatment and endoscopic cyclophotocoagulation treatment. (entokey.com)
  • Utilizing the endoscopic laser for both retinal photocoagulation and cyclophotocoagulation treatment further increases the comfort level with the endoscopic system. (entokey.com)
  • Fabrikantov O. L., Shmykov A. V. Role of vitreoretinal interface in the pathogenesis of retinal detachment (literature review). (pmarchive.ru)
  • Since the importance of retinal tears and detachment in the pathogenesis of rhegmatogenous retinal detachment (RRD) was clarified in 1930 [ 1 ], therapeutic interventions of RRD are rapidly developing. (ijbs.com)
  • B, The photomicrograph demonstrates condensed vitreous (arrow) attached to the anterior flap of the retinal tear. (aao.org)
  • Theoretically, application of 360-degree laser creates a chorioretinal scar that may wall off subretinal fluid conduits from anterior to posterior retinal areas and cover any missed breaks [ 4 , 9 ]. (biomedcentral.com)
  • Signs can include the presence of conjunctival and episcleral scarring, low endothelial cell count, a deep anterior chamber with or without the presence of emulsified silicone oil bubbles, iridophacodonesis indicating compromised zonules, poor pupillary status and integrity of the macula, and presence of open retinal breaks. (crstodayeurope.com)
  • Retinal detachment occurs in up to 29% of affected eyes, repair being most effective with endolaser and silicone oil endotamponade. (wikipedia.org)
  • Vitreous detachment generally occurs rapidly over the course of a few hours to days. (aao.org)
  • Rhegmatogenous retinal detachment (RRD) occurs when vitreous traction and fluid currents resulting from eye movements combine to overcome the forces maintaining retinal adhesion to the RPE. (aao.org)
  • As noted above, retinal detachment occurs when the combination of factors that promote retinal detachment overwhelms the normal attachment forces. (aao.org)
  • Posterior vitreous detachment (PVD) usually occurs as an acute event after liquefaction of the vitreous gel reaches a critical degree. (aao.org)
  • Exudative retinal detachment (ERD), also known as serous RD, occurs when subretinal fluid accumulates without a retinal break. (institut-vision.org)
  • Central retinal artery occlusion occurs unilaterally and affects elderly patients. (doctor-clinic.org)
  • After several years, some retinal change occurs in almost all people with diabetes, regardless of whether they use insulin therapy. (msdmanuals.com)
  • Dr. Nguyen is known for his innovative work in early proof-of-concept, first-in-human clinical trials to evaluate potential pharmacotherapeutic agents for retinal vascular and uveitic diseases. (stanford.edu)
  • This 3 volume set offers a comprehensive compilation which presents detailed information about ophthalmic (retinal, vitreous and macular) diseases. (benthambooks.com)
  • The second volume of this set covers several choroid and retinal disorders including, commotio retinae, choroidal rupture and macular trauma, retinal breaks and detachment, and a variety of congenital / genetic eye diseases such as Best's disease and Stargardt disease. (benthambooks.com)
  • Central retinal vein occlusion, most prevalent in elderly patients, causes vision loss more slowly than central retinal artery occlusion. (doctor-clinic.org)
  • Therapy for central retinal vein occlusion may include aspirin, which acts as a mild anticoagulant. (doctor-clinic.org)
  • 3 , 4 Several recent studies have indicated that postoperative treatment with oral 13- cis -retinoic acid decreases the risk of PVR and improves the operative rate of RD and visual acuity (VA). 5 , 6 Curcumin effectively causes human fetal retinal pigment epithelium cell accumulation at the G2/M phase in vitro 7 and also inhibits proliferation by causing cell death. (dovepress.com)
  • Karacorlu M, Ozdemir H, Senturk F, Karacorlu SA, Uysal O. Correlation of retinal sensitivity with visual acuity and macular thickness in eyes with idiopathic epimacular membrane. (medscape.com)
  • Of these 62 patients, 40 (65%) had complete retinal attachment, with no evidence of regrowth of periretinal membranes or redetachments following the initial procedure. (nih.gov)
  • Over the past century, the treatment of retinal detachment has been revolutionized, and it has evolved from an incurable untreatable condition leading to irreversible vision loss to a repairable occurrence after which visual recovery is possible. (hindawi.com)
  • Successful surgical management of RRD requires effective treatment of retinal breaks and relief of vitreoretinal traction [ 4 , 5 ]. (biomedcentral.com)
  • At the 4-week follow-up visit, only one retinectomy was reopened by a recurrent inferior retinal detachment with PVR CP3. (springer.com)
  • Visual outcome after silicone oil removal and recurrent retinal detachment repair. (medline.ru)
  • Single surgery anatomical success (SSAS) is a key outcome in primary RRD repair as the risk of recurrent detachment and poor functional outcome increases with subsequent procedures [ 7 ]. (biomedcentral.com)
  • Wang M, Li H, Wang F. Roles of Transepithelial Electrical Resistance in Mechanisms of Retinal Pigment Epithelial Barrier and Retinal Disorders. (medscape.com)
  • The rigid sickled erythrocytes lead to vascular occlusion, which results in retinal hypoxia, ischemia, and neovascularization. (medscape.com)
  • The usual pathological sequence that results in retinal detachment is vitreous liquefaction followed by a posterior vitreous detachment (PVD), which in turn causes retinal tears at the sites of significant vitreoretinal adhesions (Figure 1). (aao.org)
  • Cammacho H, Bajaire B, Mejia LF (1992) Silicone oil in the management of giant retinal tears. (springer.com)
  • Cibis A, Becker B, Okun E, Canaan S (1962) The use of liquid silicone oil in retinal detachment surgery. (springer.com)
  • Gonvers M (1983) Temporary use of silicone oil in the treatment of special cases of retinal detachment. (springer.com)
  • Herbrig E, Sandner D, Engelmann K (2007) Anatomical results of endotemponade with heavy silicone oil - Densiron 68 - in complicated retinal detachment. (springer.com)
  • Retinal holes are full-thickness retinal defects that are typically not associated with persistent vitreoretinal traction in their vicinity. (aao.org)
  • Retinal detachments are frequently encountered by ophthalmologists of all subspecialties and are managed by all vitreoretinal surgeons. (hindawi.com)
  • Often individuals with CMV retinitis will need surgery for either retinal detachment or intravitreal instillation of ganciclovir. (wikipedia.org)
  • Follow-up care is usually within 1 week after laser surgery to rule out retinal detachment from contracture of the neovascular membrane after laser treatment. (medscape.com)
  • This meta-analysis was performed to determine the effectiveness of steroids as an adjunct following rhegmatogenous retinal detachment (RRD) surgery. (dovepress.com)
  • Bimanual retinal surgery can help to address these challenges. (crstoday.com)
  • METHODS: The authors conducted a prospective feasibility study of consecutive patients with rhegmatogenous retinal detachment treated with scleral buckling surgery and postoperative laser during an 18-month period with a minimal follow-up of 6 months. (eyehospital.nl)
  • Figure 10-8 Peripheral retinal tears. (aao.org)
  • However, an attempt is made to release the occlusive plaque or emboli into the peripheral retinal circulation. (doctor-clinic.org)
  • The essential requirements for a rhegmatogenous retinal detachment include a retinal break (rhegma = rent or rupture) and vitreous liquefaction sufficient to allow fluid in the vitreous cavity to pass through the break(s) into the subretinal space. (aao.org)
  • One of the revelations of the abnormal posterior detachment of the VB is vitreoschisis, when the cortical layers of the VB are split. (pmarchive.ru)
  • Major risk factors have in common an increased incidence of retinal break(s), vitreous liquification and detachment, and abnormal vitreoretinal adhesions. (aao.org)
  • All ocular conditions that are associated with an increased prevalence of vitreous liquefaction and PVD or with an increased number or extent of vitreoretinal adhesions are associated with a higher incidence of retinal detachment, including trauma. (aao.org)
  • A, The gross photograph shows several retinal tears at the vitreous base. (aao.org)
  • Retinal breaks are traditionally classified as holes, tears, or dialyses. (aao.org)
  • Retinal tears are usually produced by an acute PVD due to excess vitreoretinal traction at sites of significant vitreoretinal adhesions. (aao.org)
  • Dialyses are circumferential retinal breaks that occur at the ora serrata. (aao.org)
  • Posterior vitreous detachments occur earlier in life in highly myopic eyes. (institut-vision.org)
  • By constructing an EMT model of retinal pigment epithelial (RPE) cells in vitro, we found that autophagy was activated in the EMT process of RPE cells. (ijbs.com)
  • In this pathological process, retinal pigment epithelial (RPE) loses epithelial characteristics through an epithelial-mesenchymal transition (EMT), transforms into mesenchymal phenotype, increasing cells migration ability, invasiveness, resistance to apoptosis, and production of extracellular matrix, turning RPE into fibroblast-like cells [ 7 ]. (ijbs.com)
  • Patients with a rhegmatogenous retinal detachment associated with peripheral PVR Grade C star-folds were included in this study and analysed retrospectively. (kssg.ch)
  • A total of six patients with a rhegmatogenous retinal detachment associated with at least one peripheral PVR star-fold were included in this study. (kssg.ch)
  • The article presents morphological analysis of the changes in vitreoretinal interface (VRI) structures in patients with rhegmatogenous retinal detachment. (pmarchive.ru)
  • In our research we found that in 10 cases of patients with retinal detachment, the posterior macular surface had a fixed dense thin structure of collagen character (c VB layer). (pmarchive.ru)
  • Patients typically have vitritis, papillitis, and gray-white retinal lesions ( 1,2 ). (cdc.gov)
  • Sixty-two (82%) of the patients had successful, sustained (greater than 12 months) posterior retinal reattachments at last examination. (nih.gov)
  • Reoperation was required in the other six patients to achieve sustained posterior retinal reattachment. (nih.gov)
  • OCT identified 7 patients (22.6% incidence of TS in our aSAH sample: 7 in the acute phase, a large retinal detachment was initially missed by fundoscopy and diagnosed by OCT in follow up clinic). (cns.org)
  • Densiron 68® appeared to be an efficient endotamponade agent in selected retinal detachments treated with large inferior retinectomy. (springer.com)