• MicroRNAs are likely to play roles in most cellular processes, including proliferation, development, differentiation and apoptosis. (wikipedia.org)
  • demonstrated that miR-203 expression in keratinocytes is dependent on regulation of p53 levels by E6, which may explain how expression of HPV16 E6 can disrupt the balance between proliferation and differentiation, as well as the response to DNA damage, in keratinocytes. (wikipedia.org)
  • The PI3K/Akt/mTOR signal pathway is involved in multiple cellular functions including proliferation, differentiation, tumorigenesis, and apoptosis. (biomedcentral.com)
  • Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B. JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction.JunB is an important regulator of erythroid Differentiation. (avivasysbio.com)
  • JUN-regulated genes are involved in a wide range of biological processes, including cell proliferation, differentiation, apoptosis, and inflammation. (cusabio.com)
  • Regulation of the proliferation and differentiation of immune cells nuclear retinoid acid receptor.B group vitamins1. (eyesoftheelephants.com)
  • Regulation of nuclear factorthe nuclear retinoid acid receptor (68, 69) and regulates the proliferation and differentiation of immune cells 10-Deacetylbaccatin III and modulates the expression of proinflammatory cytokines including TNF and IL 6 (70, 71). (eyesoftheelephants.com)
  • Enhancer of zeste homolog 2 (EZH2) belongs to poly-sulfur protein family and can mediate cell proliferation and differentiation via the modulation of various genes expressions. (medscimonit.com)
  • Epigenetic modifications alter cellular plasticity, differentiation, and reprogramming without changing the primary DNA sequence or the genetic code of organisms [ 3 ]. (ijbs.com)
  • Long non-coding (lnc)RNAs play important roles in the development, differentiation, proliferation and apoptosis of cells ( 6 , 7 ). (spandidos-publications.com)
  • The Notch signaling pathway plays a key role in the proliferation and differentiation of many tissues. (molvis.org)
  • Developmentally regulated EZH2 levels are one of the factors that can determine the higher order chromatin structure and expression pattern of the INK4b-ARF-INK4a locus, coupling human progenitor cell differentiation to proliferation control. (biomedcentral.com)
  • Development and homeostasis require the coordinate regulation of cell proliferation and differentiation. (biomedcentral.com)
  • MYC encodes a transcriptional regulator that modulates expression of genes controlling cell growth, proliferation, metabolism, differentiation, and death. (cshlpress.com)
  • BTK is necessary for the proliferation and the differentiation of B lymphocytes. (medscape.com)
  • PI3K activates a number of signaling molecules, among which the Akt/mTOR pathway is of particular interest because of its role in inhibiting apoptosis and promoting cell proliferation [ 3 ]. (biomedcentral.com)
  • Inhibition of viral-induced cell apoptosis.3. (eyesoftheelephants.com)
  • Cell proliferation ability and apoptosis were detected using Cell Counting Kit-8 (CCK-8), 5-ethynyl-2'-deoxyuridine (EDU), and flow cytometry assays. (iasp-pain.org)
  • Moreover, circ_0037658 silencing promoted proliferation and impaired inflammation, apoptosis, and ECM degradation in IL-1β-treated CHON-001 cells. (iasp-pain.org)
  • Cell Counting Kit‑8 assay and flow cytometry were undertaken to measure proliferation and apoptosis. (spandidos-publications.com)
  • shlncRNA XIST attenuated cell proliferation, invasion and migration, while increasing the apoptosis of hepatic carcinoma cells. (spandidos-publications.com)
  • The miR‑320a mimic and PIK3CA inhibitor could recover the effect of oe‑lncRNA in terms of the proliferation, invasion, migration and apoptosis of hepatic carcinoma cells. (spandidos-publications.com)
  • Pathway analysis of these 42 human proteins shows that they are involved in key host cellular processes related to cell cycle regulation, proliferation, protein degradation, apoptosis, and immune responses. (springernature.com)
  • The proliferation was decreased after a downregulation of FASN, which was consistent with an increased apoptosis rate. (biomedcentral.com)
  • Activating transcription factor-(ATF-) 3, a stress-inducible transcription factor, is rapidly upregulated under various stress conditions and plays an important role in inducing cancer cell apoptosis. (hindawi.com)
  • First, we found that GS-002 significantly inhibited cell proliferation and induced cell apoptosis in dose-dependent manners. (hindawi.com)
  • Furthermore, we found that GS-002 induced more cell apoptosis in ATF-3-overexpressing cells. (hindawi.com)
  • These results suggest that the induction of apoptosis by the propolis derivative, GS-002, is partially mediated through ER stress and ATF-3-dependent pathways, and GS-002 has the potential for development as an antitumor drug. (hindawi.com)
  • After 3 days of stimulation, HTF displayed increased alpha-SMA protein levels, enhanced contractility, and assembly of actin stress fibers. (nih.gov)
  • Pharmacologic inhibition of p38 abrogates TGF-beta-induced myofibroblast transdifferentiation, reduces extracellular matrix protein expression and HTF proliferation, and may therefore serve to inhibit scarring after glaucoma surgery. (nih.gov)
  • ELAV like RNA binding protein 4 [S. (gsea-msigdb.org)
  • 2017). Eukaryotic RNAPIII transcribes transfer RNAs (tRNAs), ribosomal 5S rRNA, and other small non-coding RNAs required for protein synthesis to control cell division and proliferation events essential for organ/tissue development (Li et al. (plantae.org)
  • The authors mapped the smk7 mutation to a gene encoding the second-largest subunit of RNAPIII, NRPC2 (Nuclear RNA Polymerase C2) using map-based sequencing and confirmed that the mutation leads to a defective NRPC2 protein in smk7 . (plantae.org)
  • In animal models of corona virus infection, the levels of plasma retinol and retinol-binding protein is significantly reduced and mortality from respiratory infections decreases in those with adequate vitamin A 10-Deacetylbaccatin III within their diets (74, 75). (eyesoftheelephants.com)
  • Western blot assay was used to measure the protein levels of Bcl-2-related X protein (Bax), cleaved-caspase-3, MMP13, Aggrecan, and ADAMTS5. (iasp-pain.org)
  • The non-structural protein 5 (NS5) of dengue virus may be involved in host-pathogen interactions in addition to its core, essential functions - replicating and capping the viral RNA. (springernature.com)
  • The first protein to have this activity, tyrosyl DNA phosphodiesterase I (Tdp1), has robust activity against 3′ phosphotyrosyl linkages generated by type 1B topoisomerases [7] . (prolekarniky.cz)
  • They demonstrated that TTRAP had tyrosyl DNA phosphodiesterase activity for both 3′ phosphotyrosyl- and 5′ phosphotyrosyl-linked oligonucleotides, and therefore termed the protein Tdp2. (prolekarniky.cz)
  • Physique 1 Structural representations of the kinase inhibitors Hyericin Rottlerin and SP600125 The p53 tumor suppressor protein promotes longevity by reducing somatic mutations or the survival and proliferation of mutant cells [4]. (opioid-receptors.com)
  • In this context, during any sort of stress condition the alternative reading frame protein p14ARF subtracts MDM2, an E3 ubiquitin ligase, from the interaction with p53 in manner to free and stabilise p53 level in the nucleolus of the cell where it inhibits RNA polymerase I activity [ 3 ]. (biomedcentral.com)
  • GS-002 also induced endoplasmic reticular (ER) stress as evidenced by increases in ER stress-responsive proteins including glucose-regulated protein 78 (GRP78), growth arrest- and DNA damage-inducible gene 153 (GADD153), phosphorylated eukaryotic initiation factor 2 α (eIF2 α ), phosphorylated protein endoplasmic-reticular-resident kinase (PERK), and ATF-3. (hindawi.com)
  • The induction of ATF-3 expression was mediated by mitogen-activated protein kinase (MAPK) signaling pathways in GS-002-treated cells. (hindawi.com)
  • This gene codes a fusion protein with high tyrosine kinase activity, resulting in growth factor-independent proliferation. (medscape.com)
  • The definitive determinant of XLA is the complete absence of BTK ribonucleic acid (RNA) or protein. (medscape.com)
  • nc886 inhibits cell proliferation when ectopically expressed in gastric cancer cells. (oncotarget.com)
  • In conclusion, the present study demonstrated that TMZ inhibits GBM cell proliferation by inhibiting the expression of miR‑223, which leads to increased expression of tumor suppressor PAX6. (spandidos-publications.com)
  • It inhibits adione-stimulated proliferation of 17β-HSD3-expressing androgen receptor-positive LNCaP(HSD3) prostate cancer cells in vitro. (ox.ac.uk)
  • Zinc inhibits SARS-CoV RNA polymerase, and thus its replication capacity. (frontiersin.org)
  • These proteins are involved in the production of a molecule called ribosomal RNA (rRNA), a chemical cousin of DNA. (medlineplus.gov)
  • In the eukaryotic cells the production of ribosomes takes place in the nucleolus, a specialized subnuclear compartment where the RNA Polymerase I (RNA Pol I) catalyses the ribosomal RNA synthesis (rRNA). (biomedcentral.com)
  • Ribosomal RNA is synthesised as precursor 47S pre-rRNA which is subjected to specific and highly regulated processing steps that allow to mature 18S, 5.6S and 28S RNAs. (biomedcentral.com)
  • During ribosomal RNA processing, ribosomal proteins are incorporated into the pre-ribosomal subunits to form the mature 40S and 60S subunits. (biomedcentral.com)
  • Ribosomal RNA analyses demonstrated presence of additional bacterial and fungal species not identified with culture. (cdc.gov)
  • Antiviral and antibacterial immunity, inhibition of viral RNA polymerase and ACE2 activity.2. (eyesoftheelephants.com)
  • The results demonstrated that overexpression of miR-223 in GBM cells markedly decreased TMZ-induced inhibition of cell proliferation and increased TMZ IC50, which could be abolished by overexpression of PAX6. (spandidos-publications.com)
  • Inhibition of RNA polymerase II being a cause for the p53 response. (opioid-receptors.com)
  • p15 INK4b and p16 INK4a are closely related proteins and both act on the Rb-pathway through the inhibition of the proliferation-promoting cyclin-dependent kinases CDK4 and CDK6. (biomedcentral.com)
  • The expression of circ_0037658, microRNA-665 (miR-665), and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) 5 was detected using real-time quantitative polymerase chain reaction (RT-qPCR). (iasp-pain.org)
  • The top 8% of upregulated genes shown in RNA sequencing included ADAMTS14 , ARHGAP22 , and EPDR1 , which was also reflected in real-time quantitative polymerase chain reaction (qPCR) results. (ajmc.com)
  • Cell proliferation was measured with an MTT assay. (nih.gov)
  • Clonal formation assay analyzed the change of cell proliferation potency. (medscimonit.com)
  • Dual-luciferase reporter assay and RNA Immunoprecipitation (RIP) assay were manipulated to analyze the relationships of circ_0037658, miR-665, and ADAMTS5. (iasp-pain.org)
  • Aberrant changes in epigenetic mechanisms regulating DNA methylation, histone methylation and acetylation, expression of noncoding RNAs, and mRNA methylation are associated with the initiation, growth, and progression of digestive system tumors [ 2 , 4 ]. (ijbs.com)
  • miRNAs normally cleave mRNA by base-pairing to the 3′-untranslated region (UTR) of the target genes ( 9 ). (spandidos-publications.com)
  • While their cytoplasmic features are less realized Pkp-catenins get excited about regulating mRNA manifestation the trafficking of desmosomal cadherins and insulin-induced cell proliferation [20]-[23]. (healthyconnectionsinc.com)
  • regulation by RNA polymerase II (RNA Pol II) is a highly regulated process involving the action of multiple transcription factors that collectively regulate synthesis of messenger RNA (mRNA). (opioid-receptors.com)
  • Similarly both non-tumor and tumor cells of main ESCC predominantly indicated mRNA and the mRNA manifestation levels in tumors were higher than in ANGPT1 those in combined non-tumor cells in 3/6 (50%) of ESCC instances whose RNA was available (Supplementary Number S3B). (mdm-inhibitors.com)
  • RNA polymerases read the codes from specific areas of the DNA and transcribe the information into a mRNA copy of the DNA. (cdc.gov)
  • The present study showed the remarkable overexpression of the 3 genes in comparison to healthy control at the time of diagnosis," study authors concluded, "which urges further investigation of their implications in disease initiation and perhaps potential use as biomarkers. (ajmc.com)
  • The synthesis of a DNA molecule can be divided into three stages: initiation, elongation, and termination. (online-sciences.com)
  • MicroRNAs function to regulate the expression levels of other genes by several mechanisms, such as translational repression and Argonaute-catalyzed messenger RNA cleavage. (wikipedia.org)
  • Gene transcription of proteins involved in T-cell proliferation, phagocytosis 10-Deacetylbaccatin III and cytotoxicity, regulate the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS), and modulate signal transduction.MineralsZinc1. (eyesoftheelephants.com)
  • In particular, they regulate the function of natural killer cells and cytotoxic CD8+ lymphocytes and thereby contribute to effective viral clearance 10-Deacetylbaccatin III (78). (eyesoftheelephants.com)
  • Recent studies have shown that microRNAs regulate several cancer-related biological processes, including enhanced proliferation, tumor angiogenesis and metastasis. (thegomap.org)
  • Tumor suppressors such as retinoblastoma (pRB) and p53 negatively regulate RNA polymerase I and interfere with the assembly of transcriptional machinery on the rDNA promoter. (biomedcentral.com)
  • The RNA polymerase II primary promoter - the gateway to transcription. (opioid-receptors.com)
  • Here, we identified a second peak of PcG binding that is located ~3 kb upstream of the INK4b promoter. (biomedcentral.com)
  • The activity of this enzyme is under the control of two main factors, UBF and SL1 both components of the complex that stabilizes RNA Pol I on rDNA promoter [ 1 , 2 ]. (biomedcentral.com)
  • This study investigated the effect of EZH2 expression on proliferation and tumorigenesis of brain glioma cells. (medscimonit.com)
  • Our data demonstrated that in brain glioma cells, the decrease of EZH2 level could suppress cell proliferation and tumorigenesis potency, and meanwhile inhibit the expressions of oncogenes including c-myc and Akt. (medscimonit.com)
  • Misregulation of the cell cycle may result in malignant cell proliferation, tumorigenesis or cell death. (intechopen.com)
  • A total 3 short hairpin RNA (sh)‑lncRNA XIST sequences, overexpression vector (oe)‑lncRNA XIST, microRNA (miR)‑320a mimic, miR‑320a inhibitor, PIK3CA inhibitor, and their corresponding controls were transfected in hepatic carcinoma cells. (spandidos-publications.com)
  • Interestingly, ZNFX1 antisense RNA 1 (ZFAS1) could abolish its tumor suppressor effect by binding microRNA (miR)-150, while miR-150 could inhibit the invasion of hepatic carcinoma cells by inhibiting zinc finger E-box binding homeobox 1 (ZEB1) and matrix metalloproteinases (MMP)14 and MMP16 ( 10 ). (spandidos-publications.com)
  • nc886 is a 101 nucleotide long non-coding RNA that has been designated as a precursor microRNA or a vault RNA based upon it sequence. (oncotarget.com)
  • All these activities of nc886 are undoubtedly independent of mature microRNA or vault RNA. (oncotarget.com)
  • RNA polymerase II transcribes microRNA genes, generating long primary transcripts. (thegomap.org)
  • Fibroblast contractility was assessed in three-dimensional collagen gel contraction assays, stress fiber assembly with rhodamine-phalloidin stains, and confocal microscopy. (nih.gov)
  • Luciferase reporter assays confirmed that miR‑223 directly targets PAX6 through binding to its 3'‑untranslated region. (spandidos-publications.com)
  • analyzed the impact of multiple kinase inhibitors on RNA transcriptional activity along three p53 target gene core regulatory elements using transcription and electrophoretic mobility shift (EMSA) assays. (opioid-receptors.com)
  • The MTT and colony formation assays were used to assess the proliferation potential. (biomedcentral.com)
  • C: Proliferation of AGS and HGC-27 cells assessed by EdU assays. (wjgnet.com)
  • The cDNA synthesized by RNA reverse transcription is then used as a template for PCR amplification of the JUN antibody gene. (cusabio.com)
  • Comparing HESC controls with HESCs deficient in SRC-3, gene enrichment analysis of the differentially expressed gene set revealed an overrepresentation of genes involved in chromatin remodeling, cell proliferation/motility, and programmed cell death. (frontiersin.org)
  • MicroRNAs (miRNAs) are small non-coding RNA molecules (containing ~22 nucleotides) that function in RNA silencing and post-transcriptional regulation of gene expression. (spandidos-publications.com)
  • and interaction of RMRP and hTERT leads to an RNA-dependent RNA polymerase activity leading to siRNA altering gene expression. (medscape.com)
  • MicroRNAs are an abundant class of small non-coding RNAs that play key roles in gene regulation. (thegomap.org)
  • Targeting AML cells is difficult despite advances in the understanding of its genetic alterations, so a recent study aimed to add potential novel therapeutic targets and gene variants based on RNA sequencing. (ajmc.com)
  • ATF-3 induces DNA synthesis and expression of cyclin D1 in hepatocytes [ 21 ] and is involved in serum-induced cell proliferation as a target gene of c-myc [ 10 ]. (hindawi.com)
  • Tumor suppressors, oncogenes and alternatively deregulated upstream signalling pathways can directly influence the RNA polymerase I activity inducing hyper activation of rRNA transcription in cancer cells. (biomedcentral.com)
  • Glioma tumor tissues were collected from 3 patients who received surgery, and the glioma stem cells were then separated, cultured, and identified by flow cytometry. (medscimonit.com)
  • The RNA-primed synthesis of DNA demonstrating the template function of the complementary strand parental DNA . (online-sciences.com)
  • These data point to the existence of an ErbB3-mediated non canonical pathway that glioblastoma cells use to control ribosomes synthesis and cell proliferation. (biomedcentral.com)
  • Nucleolar activity is also influenced by the interaction between pathways activated from extracellular signals in order to coordinate ribosome synthesis and cell proliferation [ 6 ]. (biomedcentral.com)
  • Reverse transcription is the synthesis of a complementary DNA sequence from an RNA template using reverse transcriptase, which is an RNA-dependent DNA polymerase. (medscape.com)
  • Further, Zamani et al ( 9 ) investigated the epigenetic effects of solute carrier family 25 member 19 in hepatic carcinoma and confirmed that DNA methylation in the functional region of maternally expressed 3 (MEG3) was associated with its loss of expression in hepatic carcinoma. (spandidos-publications.com)
  • We highlight the role of SE-driven genes, enhancer RNAs (eRNAs), lncRNAs, and miRNAs in the digestive system tumor growth and progression. (ijbs.com)
  • Although TMZ has been identified to improve the survival rates of patients with GBM, a majority experience disease progression within one year ( 3 ). (spandidos-publications.com)
  • Instead ErbB3 silencing or nucleolar stress reduce cell proliferation and affect cell cycle progression. (biomedcentral.com)
  • Several main apoptotic indicators were found in GS-002-treated cells, such as the cleaved forms of caspase-3, caspase-9, and poly(ADP-ribose) polymerase (PARP). (hindawi.com)
  • Interestingly, multiple recent studies have shown that these p53 mutations not only result in loss of tumor suppressive functions, but also gain of oncogenic functions that lead to enhanced proliferation and metastasis. (thegomap.org)
  • No single mutation accounts for more than 3% of mutations in patients. (medscape.com)
  • Number 2 Subcellular distribution of the TIA1 isoforms Involvement of TIA1 in ESCC cell proliferation To gain insight into the potential function Lidocaine (Alphacaine) of TIA1 whose overexpression could be associated with esophageal carcinogenesis we 1st tested the effects of small interfering RNA (siRNA) focusing on TIA1 on cell proliferation. (mdm-inhibitors.com)
  • MicroRNAs are short (20-22nt), non-coding RNA molecules involved in the regulation of messenger RNAs (mRNAs) by pairing with their 3' UTR and affecting their stability or directing their silencing or degradation. (wikipedia.org)
  • Subsequently, the pri-microRNAs are processed to mature microRNAs in a two step process involving RNase-III enzymes (Drosha and Dicer). (thegomap.org)
  • In molecular biology miR-203 is a short non-coding RNA molecule. (wikipedia.org)
  • It functions both as an RNA-dependent RNA polymerase and an RNA-methyltransferase and is therefore essential for the replication of viral RNA. (springernature.com)
  • DENV belongs to the family Flaviviridae that comprises arthropod-borne, enveloped, single-stranded RNA viruses such as Zika, Japanese encephalitis and yellow fever among others. (springernature.com)
  • Further Pkp-catenin actions in the nuclear area have grown to be of increased curiosity using the recognition of relationships between Pkp2-catenin and RNA Pol III and Pkp1 with single-stranded DNA. (healthyconnectionsinc.com)
  • DNA polymerases require the presence of a primer (i.e. oligonucleotide of RNA with free 3´ hydroxyl group), a template (i.e single-stranded DNA), and deoxyribonucleotides (d ATP , d CTP, d GTP, and d TTP) in order to function. (online-sciences.com)
  • Initially, DNA is taken from the clinical specimen, as well as certain sequence-specific oligonucleotide primers, thermostable DNA polymerase, nucleotides, and buffer. (medscape.com)
  • Finally, nucleotides complementary to the target DNA are added extending each primer by the thermostable DNA polymerase. (medscape.com)
  • this study identified an essential Jun/miR-22/HuR regulatory axis in CRC (the working model is summarised in Fig. 8) and highlighted the vital role of HuR and miR-22 in CRC proliferation and migration. (cusabio.com)
  • Our results also suggest that regulation of let-7 by mutant p53 plays an important role in driving cellular proliferation and increasing cell migration and invasion. (thegomap.org)
  • And the influence of FASN on proliferation and migration of colorectal cancer cells was also explored. (biomedcentral.com)
  • We further discover that Pkp3-catenin affiliates with ETV5 which can be closely linked to ETV1 and is one of the same three-member Polyomavirus enhancer activator 3 (PEA3)-subgroup of Ets-family people. (healthyconnectionsinc.com)
  • West Nile viral RNA in the brain of the wolf and the (9,12). (cdc.gov)
  • Proliferation and activation of viral specific immune cells its receptor.3. (eyesoftheelephants.com)
  • The diagnosis of many infectious diseases, both viral and bacterial, may include the use of reverse transcriptase-polymerase chain reaction (RT-PCR). (medscape.com)
  • 17β-HSD type 3 (17β-HSD3) catalyses the reduction of the weakly androgenic androstenedione (adione) to testosterone, suggesting that specific inhibitors of 17β-HSD3 may have a role in the treatment of hormone-dependent prostate cancer and benign prostate hyperplasia. (ox.ac.uk)
  • Tumor stroma promotes tumor proliferation, invasion, and metastasis, but how stromal lipids influence these processes remain to be defined. (aacrjournals.org)
  • Reverse transcription‑quantitative polymerase chain reaction was conducted to detect lncRNA‑XIST, miR‑320a and PIK3CA expression. (spandidos-publications.com)
  • The expression of Notch pathway genes in the limbal and central human corneal epithelium was compared by reverse transcription polymerase chain reaction (RT-PCR). (molvis.org)
  • Next-generation sequencing analyses revealed the expression of TRPV1 in several native breast cancer tissues, which was subsequently validated via reverse transcriptase-polymerase chain reaction. (dovepress.com)
  • Reverse transcriptase (RT) PCR is PCR performed on RNA targets. (medscape.com)
  • Specific molecular analysis is made by single-strand confirmation polymorphism (SSCP), direct DNA analysis, denaturing gradient gel electrophoresis, or reverse transcriptase-polymerase chain reaction to search for the BTK mutation. (medscape.com)
  • Since the EGFR signalling promotes proliferation in tumor the EGFR receptors often represent a marker of resistance with poor prognosis. (biomedcentral.com)
  • For example, the active form of vitamin B6, pyridoxal phosphate, is a cofactor for 10-Deacetylbaccatin III many metabolic processes particularly transamination or breakdown of amino acids and the metabolism of important immunomodulatory mediators (76, 77). (eyesoftheelephants.com)
  • DNA polymerase ε removes the primers of Okazaki fragments on the lagging strand. (online-sciences.com)
  • RNA, lipids, and proteins. (who.int)
  • These molecular findings are supported at the cellular level by the inability of HESCs to morphologically transform from a stromal fibroblastoid cell to an epithelioid decidual cell when endogenous SRC-3 levels are markedly reduced. (frontiersin.org)
  • Since perturbation of normal homeostatic levels of SRC-3 is linked with common gynecological disorders diagnosed in reproductive age women, this endometrial coregulator-along with its new molecular targets described here-may open novel clinical avenues in the diagnosis and/or treatment of a non-receptive endometrium, particularly in patients presenting non-aneuploid early pregnancy loss. (frontiersin.org)
  • The aim of the present study was to reveal the new molecular mechanism of long non‑coding (lnc)RNA XIST in the development of hepatic carcinoma. (spandidos-publications.com)
  • EPDR1 is the final suggested novel target in this study, and it is another candidate that has shown relevance in the proliferation of other cancer types, including colorectal cancer and hepatocellular carcinoma. (ajmc.com)
  • Development of such strategies will require an understanding of the therapeutic concepts that have evolved over the past three decades. (bmj.com)
  • To identify genes, signaling pathways and networks that are controlled by SRC-3 and potentially important for hormone-dependent decidualization, we performed RNA-sequencing on HESCs in which SRC-3 levels were significantly reduced at the time of administering the deciduogenic stimulus. (frontiersin.org)
  • [ 16 ] The 3' end of RMRP is essential for RNA dependent RNA polymerase acitivity of the RMRP-hTERT complex. (medscape.com)
  • The dengue virus (DENV) possesses an RNA-dependent RNA polymerase (NS5) that replicates its RNA genome besides capping the nascent RNA to enhance stability. (springernature.com)
  • STX2171, a 17β-hydroxysteroid dehydrogenase type 3 inhibitor, is efficacious in vivo in a novel hormone-dependent prostate cancer model. (ox.ac.uk)
  • Other proposed targets are suppressor of cytokine signaling 3 (SOCS3) and ABL1. (wikipedia.org)
  • We show here that, like SRC-2, SRC-3 is expressed in the epithelial and stromal cellular compartments of the human endometrium during the proliferative and secretory phase of the menstrual cycle as well as in cultured HESCs. (frontiersin.org)
  • 7518 /organism="Norwalk-like virus" /mol_type="genomic RNA" /strain="Hu/Norovirus/hiroshima/1999/JP(9912-02F)" /db_xref="taxon:95340" 5'UTR 1. (cdc.gov)
  • By silencing endogenous TIA1 using three different siRNAs cell proliferation was significantly suppressed in KYSE140 KYSE180 and TE4 cells. (mdm-inhibitors.com)
  • Number 3 Effects of TIA1 knockdown on cell proliferation We next launched a TIA1[v1]- or TIA1[v2]-expressing retrovirus into KYSE190 and KYSE2270 cells expressing relatively lower levels of endogenous TIA1 to determine the effects of exogenously indicated TIA1 isoforms. (mdm-inhibitors.com)
  • alkaline ceramidase 3 [Source:HGNC. (gsea-msigdb.org)
  • For example, important zinc metalloenzymes include alkaline phosphatase, RNA polymerases, and alcohol dehydrogenase ( 3 ). (frontiersin.org)