Proliferation receptor mediating interactions receptors laminin. Medical search. Frequent questions

Given the multi-domain architecture of Ln5, it seems conceivable that other receptors in addition to integrins interact with one of its many potential ligand sites to mediate its diverse cellular functions, including activation of EGFR signaling. (spandidos-publications.com)
Integrins are heterodimeric, transmembrane receptors that function as mechanosensors, adhesion molecules and signal transduction platforms in a multitude of biological processes. (thno.org)
Integrins are heterodimeric cell surface receptors found in nearly all metazoan cell types, composed of non-covalently linked α and β subunits. (thno.org)
Integrins are not constitutively active but rather exist in multiple activation states wherein ligand binding stability is related to the activation status of the receptor. (thno.org)
Cell lines and transfected cell systems augment this study with particular emphasis on perturbations in the biology of selectins, integrins, matrix adhesion, and chemokine receptors. (stjude.org)
Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. (embl.de)
Rap-1 is an essential protein involved in signaling mediated by integrins. (medscape.com)
To begin to build such an interaction map, we have initially focused on integrins, the major receptors for extracellular matrix proteins. (uiowa.edu)
Integrins mediate cell adhesion and migration during development, in homeostasis, and in a variety of pathological settings, including tumor cell metastasis. (uiowa.edu)
Thus at present there is no satisfactory explanation for how different integrins that share a common β subunit are able to mediate different cellular responses. (uiowa.edu)
For example, tumor cell motility mediated by α3β1 integrin on its ligand, laminin-332 (laminin-5), can be 3-4 fold faster than motility mediated by other β1 integrins, such as the collagen receptor, α2β1, or the fibronectin receptor, α5β1. (uiowa.edu)
We hypothesize that the diversity in the functions of different β1 integrins may derive in part from their differing patterns of lateral cell surface interactions. (uiowa.edu)
Another form of integrin functional diversity is the ability of individual integrins to mediate different responses in different cell types. (uiowa.edu)

Currently, a major focus in the lab is determining (i) the extent to which assembly into tetraspanin complexes can help to explain α3β1 integrin's ability to mediate unusually rapid tumor cell migration, and (ii) the implications of tetraspanin association for the role of α3β1 in metastatic tumor cell spread. (uiowa.edu)
A tumor microenvironment that is altered (such as by frontline treatment) can mediate tumor cell entrance into, maintenance, and exit from dormancy through interaction with cells at niches, such as endothelial cells, stroma, or immune cells. (biomedcentral.com)

The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. (wikipedia.org)

Laminin 5 (Ln5) is an extracellular matrix protein that plays an important role in cell migration and tumor invasion. (spandidos-publications.com)
Loss of GPR56 does not affect cell proliferation, migration, or neurite outgrowth. (jneurosci.org)
Consistent with this hypothesis, developing granule cells from the rostral region of Gpr56 −/− cerebella at birth exhibit a specific defect in cell adhesion to extracellular matrix (ECM) molecules of the pial basement membrane (BM) but no defects in migration, proliferation, or process outgrowth. (jneurosci.org)
Integrin-mediated interactions with the extracellular matrix (ECM) are required for the attachment, cytoskeletal organization, mechanosensing, migration, proliferation, differentiation and survival of cells in the context of a multitude of biological processes including fertilization, implantation and embryonic development, immune response, bone resorption and platelet aggregation. (thno.org)
Hamilton: B. C. Decker Inc.). A number of anti-angiogenic activities have been reported for this protein, such as inhibition of endothelial cell proliferation, migration, and tube formation. (justia.com)
Thus, a more sophisticated understanding of cell migration will require a "cell surface interaction map" describing the physical and functional connections between receptors and their cell surface partners. (uiowa.edu)
Ectopic expression of HBP1 increased proliferation and migration of normal and cancerous pancreatic cells, indicating that HBP1 may confer the cell dissemination capacity in early PDAC progression. (bvsalud.org)

Important biological events associated with plasma membranes, such as signal transduction, cell adhesion, and protein trafficking, are mediated through the membrane microdomains. (mdpi.com)
CD11a/CD18 (LFA-1) expressed on lymphocytes is known to play an important role in lymphocyte trafficking (adhesion to vascular endothelium), as well as interactions to antigen presenting cells (APC). (medscape.com)
Interference RNA-mediated knockdown of GPR56 recapitulates the loss of adhesion seen in knock-outs, and reexpression of GPR56 rescues the adhesion defect in knock-out granule cells. (jneurosci.org)
Integrin mediated cellular adhesion is dynamic process that is both indicative of and influenced by cell status. (thno.org)
These cell adhesion molecules (CAM) will mediate the contact between two cells or between cells and the extracellular matrix, an essential process to the success of the implant. (bvsalud.org)
These properties will act mediating the action of cell adhesion proteins, regulating cell behavior and causing tissue regeneration. (bvsalud.org)
Notwithstanding, to achieve the effectiveness and integration of the grafted tissue to the receptor site, it is necessary a strong cell adhesion, so that it demands many molecules interaction to induce cell differentiation and the bone matrix mineralization formed onto the graft. (bvsalud.org)
Some of these molecules are glycoproteins expressed on the cell surface, socalled cell adhesion molecules (CAM), which mediate either the contact between two cells or the contact among cells and the extracellular matrix, being therefore of fundamental importance for adhesion 3 . (bvsalud.org)
To occur the adhesion of CAMs to the biomaterial, it is necessary their interaction with some components of extracellular matrix, such as proteoglycans, collagen and proteins 23 . (bvsalud.org)

Yap/Taz Cyclothiazide activation results in their retention within the nucleus where they regulate gene manifestation that promotes proliferation or differentiation with regards to the cell type 8. (holyexperiment.org)
Signals emanating from focal adhesions have been shown to promote survival, differentiation and proliferation [ 5 ]. (thno.org)
This process is mediated by 2 mutually exclusive programs of gene expression: 1) an undifferentiated program supporting proliferation by stem cells within the basal layer and 2) a differentiation program instructing growth arrest and differentiation-associated programmed cell death in suprabasal layers. (stanford.edu)
We are currently pursuing studies of the dominant signaling and gene regulatory networks that control this process, including the Ras/MAPK cascade, which is required for stem cell-mediated self-renewal and the p53 transcription factor family member, p63, which is required for epidermal differentiation. (stanford.edu)

BMs are specialized structures that underlie epithelia and surround organs and mainly comprise collagen IV, laminins, and heparan sulfate proteoglycans (HSPG). (nature.com)
Deposition of collagen and proliferation of smooth muscle cells are the response to chronic inflammation and injury of the submucosa leading to fibrosis and thickening of the submucosa and the smooth muscle layers of the bowel wall. (bmj.com)
2004) T cell receptors recognizing type II collagen in HLA-DR-transgenic mice characterized by highly restricted V beta usage. (scirp.org)

In patients with prolonged clinical dormancy, the presence of dormant cells is often identified by their lack of the cellular proliferation marker Ki-67 as well as the lack of apoptotic markers [ 12 - 14 ]. (biomedcentral.com)

Cytokines bind to their receptors, activating signal transduction pathways such as adenylate cyclase/cAMP, phospholipase C/inositol trisphosphate, and Ca 2+ and tyrosine kinases. (biomedcentral.com)

The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. (wikipedia.org)
While both subunits contribute to ligand-binding specificity, the β subunit cytoplasmic tail mediates most of the established integrin signaling and cytoskeletal interactions that have been identified. (uiowa.edu)

Finally, interaction with the basal lamina during radial sorting is mediated by laminin receptors 7, but what controls their expression is also not known. (holyexperiment.org)
After seven days in the presence of ascorbic acid, which causes proliferation, basal lamina deposition and myelination, Yap and Taz were found in the nuclei of many Schwann cells. (holyexperiment.org)
Mammalian epithelia are critically dependent on interactions with components in the underlying basal lamina for proper morphogenesis and function. (embl.de)
In contrast, in the submucosa, laminin was exclusively found in the basal lamina of blood vessels where many adherent mast cells were seen. (bmj.com)

EGFR is a key mediator of oncogenesis in NSCLCs, with its activation inducing tumor proliferation and growth, angiogenesis, invasion and metastasis, and inhibiting apoptosis ( 10 ). (spandidos-publications.com)
Dormancy can be induced by more than one mechanism: cellular dormancy (quiescence), angiogenic dormancy (tumor mass size limit), and immunologic dormancy (immunosurveillance, balance between proliferation and apoptosis). (biomedcentral.com)

Interaction of hepatocyte growth factor with heparan sulfate. (wikipedia.org)

GAGs and PGs perform multiple functions in specific stages of the metastatic cascade due to their defined structure and ability to interact with both ligands and receptors regulating cancer pathogenesis. (hindawi.com)
Free glycosaminoglycans (GAGs) and proteoglycan- (PG-) containing GAGs, key effectors of cell surface, pericellular and extracellular microenvironments, perform multiple functions in cancer by virtue of their coded structure and their ability to interact with both ligands and receptors that regulate cancer growth [ 1 - 4 ]. (hindawi.com)

The TGF-β family forms an important group of growth factors, consisting of three isoforms in man, and is important for matrix deposition because it modulates fibroblast recruitment and proliferation. (biomedcentral.com)

We show that the absence of Yap and Taz causes a severe peripheral neuropathy due to a developmental impairment in axonal sorting, and that Yap/Taz-Tead1 are required for the transcriptional regulation of laminin receptors in Schwann cell. (holyexperiment.org)

The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. (assaygenie.com)

These 2 members mediate leukocyte adhesions to endothelial cells but they also serve as receptors for iC3b (inactivated C3b). (medscape.com)

The cell surface receptors that interpret these cues engage cytoplasmic partners to transduce signals, but recent work reveals that many receptors also interact laterally with cell surface proteins that can be critical for proper receptor function. (uiowa.edu)

Oligomeric endostatin (NC1 and dimer) have been shown to be primarily associated with laminin in the basement membrane (Javaherian et al. (justia.com)

Differentiated neurons are resistant to oncogenic transformation and tumors of neural origin unusual during the N See this once more from the cell cycle, mitosis neurons, which then forward the death us that show t proliferation. (alksignaling.com)
In SB 202190 price fact, he interned in a variety of techniques, flies and people Lich has become proven that, when new neurons within the cell cycle, the end result of t degeneration is convinced that the proliferation and cell activation is neuronal ectopic cycle rather alien on the degeneration sen. (alksignaling.com)

In addition to providing biomechanical support to the islets, ECM components are required for β-cell development, proliferation, survival, and proper insulin secretion. (nature.com)

The present study results indicated that compared with the same number of 2D-cultured cells, microtissue could secrete more nerve regeneration related cytokines to promote SCs proliferation and axons growth. (biomedcentral.com)

In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. (assaygenie.com)

Activation of Akt (murine thymoma viral oncogene homolog) is one of the mechanisms that mediate the effects of EGFR ( 11 ). (spandidos-publications.com)
The biodirectional nature of integrin mediated signaling allows both extra- and intracellular cues to regulate activation [ 4 ] (Fig. 1 ). (thno.org)
There is also evidence that the deleterious effects mediated by dysfunctional white adipocyte-induced lipid overspill can be halted by the pro-oxidative anti-lipotoxic effects mediated by brown adipose tissue (BAT) activation. (springer.com)
The sympathetic nervous system regulates this function through β-adrenergic stimulation of brown mature adipocytes' dissipation of energy in the form of heat mediated by mitochondrial uncoupling protein-1 (UCP-1) activation. (springer.com)
Upon cellular activation, the bacteria then adhere to chemokine receptors, particularly the platelet-activating factor receptor. (stjude.org)

Conversely, brown adipose tissue (BAT) and browning of WAT represent potential therapeutic approaches, since dysfunctional white adipocyte-induced lipid overspill can be halted by BAT/browning-mediated oxidative anti-lipotoxic effects. (springer.com)
It will be endothelial dysfunction and monocyte involve oxidized LDL foam cells from macrophages, collectively macroscopically obvious that fatty streaks cell proliferation across borders Ren Vaskul followed smooth muscle and extracellular Re secretion of matrix-associated Ren fiber factors turned out to be w W During the accumulation of lipids and cell debris from necrotic lipid core plaque inflammatory atheromat sen mature. (alksignaling.com)

Combined with simple proliferative responses, the identified nucleotides are also shown to have functional consequences by inducing T cell proliferation for CD4/V β 20-1 + T cells, while failing to induce proliferation in other T cell isolates. (scirp.org)

Integrin α3β1 strongly interacts with one particular tetraspanin, CD151, which in turn links α3β1 into larger cell surface complexes that may contain other tetraspanins, Ig superfamily (IgSF) proteins, growth factor receptors, membrane-bound growth factors, and novel proteins (Figure 1). (uiowa.edu)
The most commonly used method for measuring immune cell‑mediated killing is the release assay, where effector cell‑mediated disruption of the target cell membrane results in leakage of its cytoplasmic contents into the culture medium. (technologynetworks.com)

1994) T cell receptor V alpha repertoire of infiltrating T cells in labial salivary glands from patients with Sjogren's syndrome. (scirp.org)

Compared to ECs, pancreatic pericytes produce significantly higher levels of α2 and α4 laminin chains, which constitute the peri-islet and vascular BM. (nature.com)
WAT is characterised by its capacity to adapt and expand in response to surplus energy through processes of adipocyte hypertrophy and/or recruitment and proliferation of precursor cells in combination with vascular and extracellular matrix remodelling. (springer.com)

Tyrosine kinase inhibitors (TKIs) targeting epidermal growth factor receptor (EGFR), including gefitinib and erlotinib, have become the standard first-line therapy for patients with advanced non-small cell lung cancers (NSCLCs) harboring activating EGFR mutations ( 4 , 5 ). (spandidos-publications.com)
Komatsu, T., Moriya, N. and Shiohara, T. (1996) T cell receptor (TCR) repertoire and function of human epidermal T cells: Restricted TCR V alpha-V beta genes are utilized by T cells residing in the lesional epidermis in fixed drug eruption. (scirp.org)

Noncoding RNA sequences can regulate gene expression via interactions with epigenetic and other control mechanisms. (stanford.edu)

An improved understanding of PSC biology and of the interactions of PSCs with other pancreatic cells provides a strong platform for the development of novel therapeutic approaches for notoriously hard to treat diseases of the pancreas such as chronic pancreatitis and pancreatic cancer. (pancreapedia.org)

Three molecular mechanisms involved in tumor dormancy have been identified: cellular dormancy (quiescence or mitotic arrest), angiogenic dormancy (limited tumor size), and immunologic dormancy (immunosurveillance, balance between clearance and proliferation) (Figure 1 ). (biomedcentral.com)

We further found that the pericytic laminin isoforms differentially regulate mouse β-cells. (nature.com)
However, while many studies demonstrated the importance of the ECM, its interactions with β-cells are still not fully understood. (nature.com)
The interactions with the various BM components differentially affect β-cells, although the underlying mechanism is largely unknown. (nature.com)
This interaction allows bacterial entry into cells and results in transmigration. (stjude.org)
All mast cells in the muscularis propria were colocalised with patches of laminin. (bmj.com)
The colocalisation with laminin indicates a mechanism of interaction between smooth muscle cells and mast cells that may be important in the role of mast cells in the process of fibrosis. (bmj.com)
The consecutive stages of cancer growth and dissemination are obligatorily perpetrated through specific interactions of the tumor cells with their microenvironment. (hindawi.com)
The consecutive steps of tumor growth, local invasion, intravasation, extravasation, and invasion of anatomically distant sites are obligatorily perpetrated through specific interactions of the tumor cells with their microenvironment. (hindawi.com)
Engler, O.B., Strasser, I., Naisbitt, D.J., Cerny, A. and Pichler, W.J. (2004) A chemically inert drug can stimulate T cells in vitro by their T cell receptor in non-sensitised individuals. (scirp.org)
1992) T cell receptor repertoire of infiltrating T cells in lips of Sjogren's syndrome patients. (scirp.org)
Wucherpfennig, K.W. and Hafler, D.A. (1995) A review of T-cell receptors in multiple sclerosis: Clonal expansion and persistence of human T-cells specific for an immunodominant myelin basic protein peptide. (scirp.org)
1998) Comparative sequence analysis of the human T cell receptor beta chain in juvenile rheumatoid arthritis and juvenile spondylarthropathies: Evidence for antigenic selection of T cells in the synovium. (scirp.org)

To determine the factors mediating these phenotypes, interestingly, three binding proteins of ZNF804A, galectin 1 (LGALS1), fasciculation and elongation protein zeta 1 (FEZ1) and ribosomal protein SA (RPSA), show different effects on reversing the deficits. (biomedcentral.com)

In contrast, culturing on Laminin-421 induced the expression of β-cell genes, including Ins1 , MafA , and Glut2 , and significantly improved glucose-stimulated insulin secretion. (nature.com)

To this end, molecular and cellular interactions may influence the tissue reactions to biomaterials. (bvsalud.org)
Likely other tissues, many events occur when a given biomaterial is in contact with the biological bone environment, with molecular and cellular interactions influencing on the tissue features surrounding the biomaterial. (bvsalud.org)

Whereas α2 laminins promoted islet cell clustering, they did not affect gene expression. (nature.com)

The heparin binding property of endostatin is mediated by noncontiguous arginines clustered over the three dimensional globular surface of the molecule (Sasaki et al. (justia.com)
On the other hand, the heparin binding properties of endostatin manifest themselves in its interaction with the cell surface. (justia.com)

2012) Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor. (scirp.org)

It is likely that endostatin has a number of biological functions mediated by different regions of the protein. (justia.com)

Ductal contractility during lactation is a well-known function delivered by the MECs however this is not the only assignment mediated by these cellular populations. (biomedcentral.com)

Interactions between Ln5 and PTEN, phospho-EGFR (p-EGFR) and phospho-Akt (p-Akt) in patients with NSCLC are not well understood at the clinical level. (spandidos-publications.com)

In the absence of integrin ligation, these processes are abrogated therefore pharmacological inhibition of integrin ligation is of great interest for the therapy of numerous diseases resulting from abberant integrin mediated signaling. (thno.org)

Anatomy42

Organisms13

Diseases13

Chemicals and Drugs101

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Phenomena and Processes52

Disciplines and Occupations1

Information Science3

Integrins13

Tumor cell2

Extracellular matrix p1

Migration7

Adhesion9

Differentiation4

Collagen3

Cellular proliferation1

Signal transduction1

Cytoskeletal2

Basal4

Apoptosis2

Heparan sulfate1

Ligands2

Deposition1

Schwann1

Vitronectin1

Endothelial cells1

Interact1

Basement membrane1

Neurons2

Survival1

Cytokines1

Angiogenesis1

Activation5

Lipid2

Induce1

Membrane2

19941

Vascular2

Epidermal2

Regulate gene1

Pancreatic cells1

Mechanisms1

Cells12

Proteins1

Contrast1

Molecular2

Gene expression1

Heparin2

Insight1

Biological1

Function1

Understood1

Processes1