Multiple MyelomaProliferating Cell Nuclear AntigenCell ProliferationCell CycleBoronic AcidsPyrazinesCell Line, TumorApoptosisCell DivisionMyeloma ProteinsTumor Cells, CulturedPlasma CellsCell Cycle ProteinsThalidomideSignal TransductionCell SurvivalMelphalanCells, CulturedSyndecan-1Antineoplastic AgentsDexamethasoneInterleukin-6Gene Expression Regulation, NeoplasticFlow CytometryMice, SCIDPhosphorylationRNA, MessengerCell DifferentiationBone MarrowBlotting, WesternLeukemia, Plasma CellParaproteinemiasG1 PhasePlasmacytomaProteasome InhibitorsDown-RegulationBone Marrow CellsCell LineDrug SynergismCell Cycle CheckpointsCell Growth ProcessesRNA, Small InterferingReverse Transcriptase Polymerase Chain ReactionSTAT3 Transcription FactorCyclin D1Drug Resistance, NeoplasmCell MovementNeoplasm ProteinsStromal CellsDose-Response Relationship, DrugTime FactorsImmunohistochemistryBromodeoxyuridineReceptors, Interleukin-6Xenograft Model Antitumor AssaysTransfectionSyndecansProto-Oncogene Proteins c-aktDNA-Binding ProteinsProto-Oncogene Proteins c-bcl-2Molecular Sequence DataEnzyme InhibitorsEnzyme ActivationMitosisProtein-Serine-Threonine KinasesMonoclonal Gammopathy of Undetermined SignificanceUp-RegulationCyclin-Dependent Kinase Inhibitor p27CyclinsTranscription FactorsAntibodies, MonoclonalS PhaseDrug Screening Assays, AntitumorProto-Oncogene ProteinsGene Expression ProfilingRNA InterferenceBase SequenceCyclin-Dependent Kinase Inhibitor p21Cell AdhesionCoculture TechniquesMice, Inbred C57BLGene ExpressionLymphocyte ActivationGene Expression RegulationInsulin-Like Growth Factor ITumor Suppressor ProteinsCaspasesNF-kappa BB-LymphocytesDNATransplantation, AutologousKi-67 AntigenMutationProtease InhibitorsTranscription, GeneticMice, NudeRetinoblastoma ProteinTumor Suppressor Protein p53Recombinant ProteinsTransplantation, Heterologous