AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation Science
Cell ProliferationCells, CulturedSignal TransductionCell DivisionApoptosisCell DifferentiationCell Line, TumorCell CycleLymphocyte ActivationBromodeoxyuridineCell MovementCell SurvivalRNA, MessengerImmunohistochemistryMice, Inbred C57BLCell LineKi-67 AntigenBlotting, WesternProliferating Cell Nuclear AntigenPhosphorylationT-LymphocytesReverse Transcriptase Polymerase Chain ReactionStem CellsFlow CytometryTumor Cells, CulturedMice, KnockoutGene Expression RegulationRNA, Small InterferingMice, TransgenicGene Expression Regulation, NeoplasticDown-RegulationDose-Response Relationship, DrugEpithelial CellsCell Growth ProcessesFibroblastsTime FactorsTransfectionGene ExpressionMuscle, Smooth, VascularCyclin D1ThymidineUp-RegulationCell CountMice, Inbred BALB CTranscription FactorsProto-Oncogene Proteins c-aktMice, NudeCyclin-Dependent Kinase Inhibitor p27RNA InterferenceMyocytes, Smooth MuscleHyperplasiaMolecular Sequence DataMitogensCell Transformation, NeoplasticInterleukin-2Enzyme ActivationExtracellular Signal-Regulated MAP KinasesDNAProto-Oncogene ProteinsEnzyme InhibitorsDNA-Binding ProteinsRats, Sprague-DawleyPhenotypeCell Cycle ProteinsGrowth InhibitorsProto-Oncogene Proteins c-mycDisease Models, AnimalGene Expression Regulation, DevelopmentalCell AdhesionBase SequenceB-LymphocytesCyclin-Dependent Kinase Inhibitor p21Growth SubstancesAntineoplastic AgentsRecombinant ProteinsMAP Kinase Signaling SystemPlatelet-Derived Growth FactorModels, BiologicalGene Knockdown TechniquesProtein-Serine-Threonine KinasesFibroblast Growth Factor 2MutationTransforming Growth Factor betaMitogen-Activated Protein Kinase 3Breast NeoplasmsPhosphatidylinositol 3-KinasesAntigens, CDG1 PhaseCytokinesMitogen-Activated Protein Kinase 1Gene Expression ProfilingMitogen-Activated Protein KinasesCell Culture TechniquesNuclear ProteinsEndothelial CellsCD4-Positive T-LymphocytesTrans-ActivatorsNeovascularization, PathologicWound HealingTumor Suppressor Protein p53
ApoptosisMigrationDifferentiationVitroInhibitionSuppressesInvasionInhibitCellsSignaling pathwayAssaysOxidative stressAtypicalTumorPromotes2018SurvivalClonalDownregulationMalignantLesionsViabilitySpecialtiesEndocrine2016ExtractAssessDepartment of NeurosurgeryRegulationCancerMiceStudyFormationHospitalExposureEfficaciousPotentiallySurgical TherapyRESULTSGeneVascular2023
Apoptosis8
  • It also suppresses the receptor of the epidermal growth factor called EGFR/HER2 and its signalling pathways, which could be an attractive target in cancer therapies because of their important role in the processes of cell survival and proliferation, as well as in those of apoptosis and metastasis. (agenciasinc.es)
  • In vitro exposure of human lymphocytes to 900 MHz CW and GSM modulated radiofrequency: studies of proliferation, apoptosis and mitochondrial membrane potential med. (emf-portal.org)
  • The role of hPOT1 in the cell proliferation, apoptosis and invasion of gastric cancer 7901 cells was determined by means of the RNA interference (RNAi) of hPOT1 mRNA. (bmj.com)
  • Transfection of hPOT1 siRNA into SGC-7901 cells led to a decrease in cell proliferation, colony formation and invasion, and also an increase of apoptosis. (bmj.com)
  • hPOT1 RNAi inhibits proliferation and invasion, and induces apoptosis of gastric cancer cells. (bmj.com)
  • In-depth study of small non-coding RNA molecules confirmed that microRNA (miR) has an important regulatory role in cell proliferation, differentiation, metabolism, apoptosis and development processes ( 3 ). (spandidos-publications.com)
  • Some lncRNAs affect the growth and development of breast cancer by regulating cell proliferation and apoptosis, and others are involved in invasion and metastasis and drug resistance of breast cancer [ 6 ]. (jcancer.org)
  • This experiment intends to activate the oxidative stress response by H2O2, regulate the autophagy level of human bone mesenchymal stem cells (hBMSCs), and observe the effect of autophagy on the proliferation and apoptosis of hMSCs under oxidative stress. (researchsquare.com)
Migration18
  • This study aimed to investigate the relationship between miR-506 and proliferation and migration of breast cancer cells. (medscimonit.com)
  • Cell proliferation, cell counting, colony formation assay, and Transwell assay were applied to evaluate the proliferation and migration of breast cancer cells. (medscimonit.com)
  • However, the effect of albuterol on the proliferation and migration has never been tested. (scirp.org)
  • Since (R)-, but not (S)-albuterol enhances bronchodilation, we expect the two racemic isomers would also affect proliferation and migration of tracheal cells differentially. (scirp.org)
  • By monitoring migratory properties of airway smooth muscle cells in the presence of albuterol isomers, the different effect of albuterol on proliferation and migration of airway smooth muscle cells is probed. (scirp.org)
  • However, the different effects of R- and S-albuterol on smooth muscle cells proliferation and migration have never been tested. (scirp.org)
  • As a kind of well mature pharmaceutical for asthma treatment, it would be very important to distinguish the effect of two different isomers of albuterol on proliferation and migration activities of airway smooth muscle cells. (scirp.org)
  • Yu M, Yu S, Gong W, Chen D, Guan J, Liu Y. Knockdown of linc01023 restrains glioma proliferation, migration and invasion by regulating IGF-1R/AKT pathway. (jcancer.org)
  • Moreover, loss-of-function studies reveal that restoration of linc01023 restrains glioma cell proliferation, migration and invasion by regulating IGF1R/AKT pathway in vitro and in vivo. (jcancer.org)
  • Moreover, linc01023 depletion inhibited glioma cell proliferation, migration and invasion by regulating IGF1R/AKT pathway in vitro and in vivo. (jcancer.org)
  • The EPCs plays critical role in postnatal vasculogenesis through pivotal bioactivities of mobilization, homing, migration, differentiation, and proliferation in angiovasculogenic tissues [ 6 ]. (hindawi.com)
  • In contrast, silencing of UASR1 suppressed cell proliferation and migration. (jcancer.org)
  • MTT, clone formation, wound healing and Transwell assays were performed to assess the viability, proliferation, migration, and invasion of MG‑63 and U2OS cells. (spandidos-publications.com)
  • HGK inhibited cell proliferation, migration, invasion, but promoted the expression of miR‑320a in MG‑63 and U2OS cells. (spandidos-publications.com)
  • Downregulation of miR‑320a reversed the effects of HGK on proliferation, migration and invasion of MG‑63 and U2OS cells, while upregulation of miR‑320a had the opposite effect. (spandidos-publications.com)
  • Inhibition of p62-Keap1-Nrf2 Pathway Activation by Realgar Promotes the Inhibition of Esophageal Cancer Cell Proliferation, Migration, and Ferroptosis. (bvsalud.org)
  • In this study, the role of the p62- Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in the regulation of EC cell proliferation , migration, and ferroptosis in response to realgar was assessed. (bvsalud.org)
  • In response to realgar, low p62 expression inhibited the proliferation, migration, and invasion of Eca109 and KYSE150 cells , as well as ferroptosis induction. (bvsalud.org)
Differentiation2
  • Enhancer of zeste homolog 2 (EZH2) belongs to poly-sulfur protein family and can mediate cell proliferation and differentiation via the modulation of various genes expressions. (medscimonit.com)
  • In recent years, due to its high proliferation ability and high differentiation ability, it has attracted widespread attention in stem cell research. (researchsquare.com)
Vitro7
  • The aim of the current study is to observe the effect of CSE on biological behavior of EPCs and, further, to search for potential candidate agent in protection of proliferation of EPCs against the damage caused by CSE exposure in vitro . (hindawi.com)
  • The 5-AZA-CdR partly protected the proliferation of EPCs against the damage caused by CSE exposure in vitro , suggesting that DNA methylation may be involved in the dysfunction of EPCs induced by CSE. (hindawi.com)
  • In this study, in attempt to provide fresh information about the impact of CS on proliferation of EPCs to elucidate the pathophysiological mechanisms of the diseases related to CS in cellular level, we assessed the proliferation of EPCs after interfering the cells with a series of concentrations of CSE for various times of exposure in vitro . (hindawi.com)
  • Cases of human anthrax have become rare in Europe ( 3,4 ), clonal proliferation when stimulated in vitro by a foreign but they can sometimes result from contact with imported antigen. (cdc.gov)
  • Under in vitro conditions, changes in the proliferation and invasion ability were detected in myeloma cells. (spandidos-publications.com)
  • Treatment of OMM2.5 MUM cells with ACY-1215 resulted in a significant ( p = 0.0001), dose-dependent reduction in cell survival and proliferation in vitro , and in vivo regression of primary OMM2.5 xenografts in zebrafish larvae. (biorxiv.org)
  • When treated with WIN55,212-2 (non-selective), ACEA (CBr1-selective) or AM1241 (CBr2-selective) agonists in vitro, oral cancer cell proliferation was significantly attenuated in a dose-dependent manner. (420magazine.com)
Inhibition2
  • Central-type and peripheral-type benzodiazepine receptor antagonists did not abrogate proliferation inhibition by midazolam, while the specific TRPM7 agonist bradykinin reversed this effect. (elsevierpure.com)
  • Inhibition of chondrocyte proliferation. (caringmedical.com)
Suppresses1
Invasion3
  • Glioma, the vast majority of intracranial malignant tumors, is characterized by rapid proliferation and aggressive invasion [ 1 ]. (jcancer.org)
  • Aims To explore the role of hPOT1 in the proliferation and invasion of gastric cancer cells. (bmj.com)
  • At 10 weeks, nFe2O3- and MWCNT-exposed cells displayed a neoplastic-like transformation phenotype with significant increased proliferation, invasion, and soft agar colony formation ability compared to controls. (cdc.gov)
Inhibit2
  • Our data demonstrated that in brain glioma cells, the decrease of EZH2 level could suppress cell proliferation and tumorigenesis potency, and meanwhile inhibit the expressions of oncogenes including c-myc and Akt. (medscimonit.com)
  • The present study used midazolam, a benzodiazepine class anesthesic, to pharmacologically intervene in the expression of TRPM7 and to inhibit cancer cell proliferation. (elsevierpure.com)
Cells16
  • This study investigated the effect of EZH2 expression on proliferation and tumorigenesis of brain glioma cells. (medscimonit.com)
  • Spanish and Italian researchers have proven that when honey from strawberry trees, a product typical of Mediterranean areas, is added to colon cancer cells grown in the laboratory, cell proliferation is stopped. (agenciasinc.es)
  • The results, published in the Journal of Functional Foods, show that strawberry tree honey is capable of inhibiting the proliferation of tumour cells cultivated in laboratory plates - more specifically, those of a line of human colon adenocarcinoma (HCT-116) and another with metastatic characteristics (LoVo), widely used to investigate this type of tumour. (agenciasinc.es)
  • Strawberry tree honey is capable of inhibiting the proliferation of tumour cells on a line of human colon adenocarcinoma (HCT-116) and another with metastatic characteristics (LoVo). (agenciasinc.es)
  • Exogenous DUSP22 expression in LNCaP, PC3, and C4-2B PCa cells inhibited cellular proliferation and colony formation, supporting a growth inhibitory role for DUSP22 in PCa cells. (tmu.edu.tw)
  • Transient receptor potential melastatin 7 (TRPM7), a Ca 2+ -permeable channel, has been demonstrated to be present in cancer cells and involved in their growth and proliferation. (elsevierpure.com)
  • Midazolam significantly inhibited the growth and proliferation of FaDu human hypopharyngeal squamous cell carcinoma cells, concurring with the induction of G 0 /G 1 cell cycle arrest and blockage of Rb activation. (elsevierpure.com)
  • Midazolam significantly inhibited the growth and proliferation of FaDu human hypopharyngeal squamous cell carcinoma cells, concurring with the induction of G0/G1 cell cycle arrest and blockage of Rb activation. (elsevierpure.com)
  • Ectopic expression of UASR1 promoted proliferation and clonogenic growth of breast cancer cells MCF7 and MDA-MB-231. (jcancer.org)
  • 1% proliferation index in tumor cells. (thieme-connect.com)
  • To observe the proliferation and adhesion of umbilical cord endothelial cells (HUVEC) on the titanium (Ti) surface with large particles blasted-etched (SLA) treatments and further clarify the mechanism of action of each other between the Ti implant surface and the body. (atlantis-press.com)
  • The proliferation of endothelial cells is detected by MTT method and adhesion of endothelial cells observed by PI fluorescence staining and western-bolt detection of protein of VE-cadherin. (atlantis-press.com)
  • Results: The proliferation of endothelial cells on the titanium surface is better than the culture plate surfaces, the adhesion cells on titanium surface are more numbers, cell morphology is more extended, titanium surface expression of VE-cadherin protein higher than the culture plate surface. (atlantis-press.com)
  • breast cancer cells by competitively binding to and blocking and the NIH Medical Scientist Training Program (L.H. Saal). (lu.se)
  • The histology was atypical with pronounced proliferation of endocrine cells comprising >70% of the pancreatic tissue and a small pancreatoblastoma. (lu.se)
  • Distinction between atypical lymphoid proliferations rich in Reed-Sternberg-like cells (reactive immunoblasts) and classic Hodgkin lymphomas. (medscape.com)
Signaling pathway2
  • Therefore, this study proves that Rh4 inhibits cancer cell proliferation by activating the ROS/p53 signaling pathway and activating autophagy to induce ferroptosis, which provides necessary scientific evidence of the great anticancer potential of Rh4. (hindawi.com)
  • Further studies showed that UASR1 activated AKT and AKT-mediated mTOR signaling pathway to stimulate cell proliferation and growth. (jcancer.org)
Assays1
  • Occupational Medicine were positive in proliferation assays. (cdc.gov)
Oxidative stress1
  • Suppression of proliferation and oxidative stress by extracts of Ganoderma lucidum in the ovarian cancer cell line OVCAR-3. (greenmedinfo.com)
Atypical2
  • Therefore, in addition to these two extremes, there also exist a third group of lymphoid proliferations - the atypical lymphoid proliferations (AtLP). (medscape.com)
  • Distinction between atypical lymphoid proliferations with follicular pattern and follicular lymphoma. (medscape.com)
Tumor1
  • Although medical and surgical developments have extended the overall survival of patients, CRC still has a poor long-term prognosis, high recurrence rate, low five-year postoperative survival, and high tumor metastasis rate, which reduce therapeutic efficacy [ 3 ]. (hindawi.com)
Promotes1
  • Previous studies have demonstrated that IGF-1R activates the phosphoinositide 3- kinase (PI3K)/AKT signaling pathways and promotes glioblastoma cell proliferation and survival by ligand binding [ 10 ]. (jcancer.org)
20181
  • A total of 427 patients who underwent elective cardiac surgery under ECC in affiliated hospital of north Sichuan medical college from January 1, 2018 to July 31, 2021 were divided into three groups according to ECC time. (nature.com)
Survival1
  • DS life expectancy increased from a median age of 4 in the 1950s to 58 in 2010 and presents an important public health challenge, since the survival of children born with this condition depends on special medical care to dis- eases, which appear in later life, social and educational treatment and this care is required for life (GLIVETIC et al . (bvsalud.org)
Clonal1
Downregulation1
  • Their use is associated with estrogen-receptor downregulation and reduced proliferation. (medscape.com)
Malignant3
  • Lymphoid proliferations are traditionally thought to be either benign conditions (reactive hyperplasia and lymphadenitis) or malignant lymphomas. (medscape.com)
  • They have some likelihood for subsequent transformation into lymphomas, and therefore AtLP occupy a middle ground between benign and malignant lymphoid proliferations. (medscape.com)
  • In the author's opinion, the use of this descriptive term AtLP may obviate the need to force some lymphoid proliferations (equivocal lesions or mimickers of lymphomas) into either the benign or malignant categories. (medscape.com)
Lesions1
  • Medical treatment is the first-line approach to treating potentially destructive lesions and is discussed in detail below. (medscape.com)
Viability3
  • This research was done to study the influence of Acalypha indica Linn root extract towards relative cell viability and proliferation as parameters of neurogenesis in post-hypoxic hippocampal tissue culture. (ui.ac.id)
  • After 90 hours of incubation, relative cell viability was measured by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) examination, and cell proliferation was measured by using 5-bromo2-deoxy-uridine (BrdU) for cell proliferation. (ui.ac.id)
  • Acalypha indica Linn root extract with doses of 10, 15, and 20 mg/mL can increase relative cell viability and proliferation in post-hypoxic hippocampal tissue culture. (ui.ac.id)
Specialties2
  • Choose from more than 140 specialties and sub-specialties for advanced medical training at MCW. (mcw.edu)
  • These days, we are seeing a proliferation of specialties within analytics based on certain methodologies, industries, and/or types of problems. (iianalytics.com)
Endocrine1
  • Mrs. Berta Kamprad Foundation, John and practice as a marker associated with prognosis and response to Augusta Persson Foundation for Medical Science, and University Hospital of Lund endocrine therapies such as tamoxifen (4). (lu.se)
20162
  • In 2016 he decided to move his lab to the Medical College of Wisconsin where he joined the faculty of the Biochemistry Department. (mcw.edu)
  • ENDORSES Document AFR/RC66/13 entitled Regional strategy on regulation of medical products in the African Region, 2016-2025. (who.int)
Extract1
  • Cell proliferation of rat hippocampal tissue culture treated with Acalypha indica Linn root extract with dose of 10, 15, and 20 mg/mL was significantly higher than control (0.132, 0.117, 0.114 vs 0.096). (ui.ac.id)
Assess1
Department of Neurosurgery1
  • Corresponding author: Yunhui Liu, Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang 110004, People's Republic of China. (jcancer.org)
Regulation1
  • TetOp16 transgenic mice offer a way to selectively manipulate cell proliferation by allowing for temporal and spatial regulation of p16INK4a expression. (foxchase.org)
Cancer5
  • Lingzhi (LZ) is a medical mushroom also known as Ganoderma lucidum, which has been used in traditional Chinese medicine for more than 4,000 years and moreover, due to its presumed health benefits and apparent absence of side-effects it has also been widely consumed as a dietary supplement by cancer patients and by individuals diagnosed with various chronic diseases. (greenmedinfo.com)
  • The inhibitory activity on cancer cell growth and proliferation, combined with the TRPM-dependent mechanism, reveals the anticancer potential of midazolam as a TRPM7 inhibitor and supports the suggestion that TRPM7 is a valuable target for pharmaceutical intervention. (elsevierpure.com)
  • The pharmaceutical industry currently uses cyclin-dependent kinase (CDK) inhibitors to target cell proliferation for cancer chemotherapy. (foxchase.org)
  • Thus, this mouse model is a very useful tool in research studies of cancer, development, tissue renewal, aging, and a variety of chronic diseases that involve cell proliferation. (foxchase.org)
  • Our findings suggest a direct role for cannabinoid mechanisms in oral cancer pain and proliferation. (420magazine.com)
Mice3
  • The proliferations of EPCs isolated from bone marrow of C57BL/6J mice were assessed by MTT after incubating the EPCs with a series of concentrations of CSE (1.0%, 2.5%, 5.0%, and 10.0%) for different times (3, 6, and 24 hours) as well as with 1.0% CSE in presence of 5-AZA-CdR for 24 hours. (hindawi.com)
  • The CSE showed dual effects on proliferation of EPCs isolated from mice. (hindawi.com)
  • Dr. Greg Enders developed TetOp16 transgenic mice which would allow for cell, tissue or organ-specific expression of p16INK4a, thereby allowing a broad control of cell proliferation in mice. (foxchase.org)
Study2
  • In the current study, we investigated the inhibitory effect of resveratrol on the proliferation of primary human myoma cell cultures. (tmu.edu.tw)
  • The secondary goal is to begin to explore why we medical sociologists and those we study often view these questions so differently. (springer.com)
Formation1
  • To develop more effective medical treatments for vascular tumors, studies are needed to clarify the pathogenic mechanism behind the formation of sporadic hemangiomas. (medscape.com)
Hospital4
  • Adverse effect (medicine) Adverse event Evidence-based medicine Hospital accreditation Iatrogenesis Iatrogenic disorder International healthcare accreditation Latent human error Medical error Nursing care Patient safety organization Peter Pronovost Root cause analysis Serious adverse event Swiss Cheese model of accident causation in human systems Palmieri, P. A., DeLucia, P. R., Ott, T. E., Peterson, L. T., & Green, A. (2008). (wikipedia.org)
  • Ethics approval This was granted by the Ethics Committee of the Medical Faculty of Southwest Hospital. (bmj.com)
  • gov ChiCTR2100053748, November 28, 2021), approved by Medical Ethics Committee of Affiliated Hospital of North Sichuan Medical College (NO. 2021ER148-1). (nature.com)
  • Those working in public health track the number of flu-related hospital and doctor visits, but many people suffer symptoms and don't seek medical treatment. (cdc.gov)
Exposure2
  • The proliferations of EPCs were significantly enhanced after 3 hours of exposure to concentrations of 1.0% and 2.5% CSE but depressed when exposed to concentrations of 5.0% and 10.0% CSE. (hindawi.com)
  • Furthermore, the 5-AZA-CdR in concentrations of 2.0 μ mol/L and 5.0 μ mol/L partly protected against the depression of proliferation of EPCs caused by CSE exposure. (hindawi.com)
Efficacious1
  • [ 50 ] A better understanding of the pathogenesis behind lymphangioma is needed to develop newer and more efficacious medical treatments. (medscape.com)
Potentially1
  • The net effect is reduced endometriosis proliferation and potentially improved symptoms. (medscape.com)
Surgical Therapy1
  • Colorectal Endometriosis: Medical or Surgical Therapy? (medscape.com)
RESULTS1
  • In addition, new medical treatments are being developed, with encouraging results. (medscape.com)
Gene1
  • Although GARP is physiologically expressed on a cell subset characterized by stringent control of proliferation, amplification of the GARP gene has been found in many tumors characterized by uncontrolled proliferation. (gla.ac.uk)
Vascular1
  • Medical and surgical treatments of vascular tumors are discussed below, and the way in which the involutional phase fits into the treatment plan is explained. (medscape.com)
20231
  • This August 2023, medical journal editors the world over continue this tradition of joint massive publication to preserve our planet and its inhabitants. (medscape.com)