Proliferation molecular activation analysis. Medical search. Frequent questions

In-depth study of small non-coding RNA molecules confirmed that microRNA (miR) has an important regulatory role in cell proliferation, differentiation, metabolism, apoptosis and development processes ( 3 ). (spandidos-publications.com)
Here, we demonstrated that chaetocin dramatically inhibited the proliferation in ESCC cells by causing cycle arrest in the M phase and activating the caspase-dependent apoptosis signaling pathway in vitro , and we also found that chaetocin induced the accumulation cellular reactive oxygen species (ROS). (aging-us.com)
Moreover, the MST1/2 inhibitor XMU-MP-1 not only partially rescued the inhibitory effect chaetocin-induced proliferation, but also rescued the chaetocin-induced apoptosis in ESCC cells. (aging-us.com)
The inhibitory effect of MicroRNA-16-5p on the proliferation, invasion, cell cycle and apoptosis of glioma cells was evaluated by the cell proliferation, invasion and flow cytometry. (ijpsonline.com)
Moreover, Plk1 depletion in cancer cells over an extended time induced apoptosis (cell death), as supported by the appearance of sub-genomic DNA, the activation of caspase 3, and the formation of fragmented nuclei. (harvard.edu)
Because inhibition of cell proliferation and activation of apoptosis are fundamental approaches to cancer therapy, it was of interest to test the effect of Plk1 depletion in normal human cells. (harvard.edu)
Tumours in mice treated with anti-miR-135b showed reduced proliferation and increased apoptosis. (gla.ac.uk)
CircHERC1 was significantly upregulated in lung cancer tissues and cells, ectopic expression of circHERC1 strikingly facilitated the proliferation, invasion and metastasis, and inhibited the apoptosis of lung cancer cells in vitro and in vivo. (biomedcentral.com)
The accumulation of FOXO1 in the cytosol and nuclear exclusion promoted cell proliferation and inhibited apoptosis. (biomedcentral.com)
In addition, circHERC1 can promote cell proliferation and inhibit apoptosis by sequestering FOXO1 in the cytoplasm to regulate AKT activity and BIM transcription. (biomedcentral.com)
These therapeutic molecules serve as important sources for new drugs that interfere with cellular proliferation, apoptosis, metastasis, and angiogenesis by regulating signaling pathways. (biomedcentral.com)
A hypoxic cell model prepared with CoCl 2 was developed to detect the effect of hypoxia on the proliferation and apoptosis of renal stem cells. (bjbms.org)
The effect and molecular mechanism of hypoxia-inducible factor 1-alpha (HIF-1α) on the proliferation and apoptosis of renal stem cells were also explored. (bjbms.org)
Both hypoxia and HIF-1α significantly promoted the proliferation of renal stem cells and inhibited cell apoptosis. (bjbms.org)
Liu H, Liu C, Qu Y. The effect and molecular mechanism of hypoxia on proliferation and apoptosis of CD133+ renal stem cells. (bjbms.org)
Furthermore, overexpression of Mahj in lgl-/- mutant cells suppresses JNK activation and blocks apoptosis of lgl-/- mutant cells in the wild-type wing-disc epithelium. (fsu.edu)

On a molecular level these signals mediate cell division, growth and differentiation. (wikipedia.org)
On a molecular level, mutations that affect FGFR2IIIc are associated with marked changes in osteoblast proliferation and differentiation. (wikipedia.org)
MYC encodes a transcriptional regulator that modulates expression of genes controlling cell growth, proliferation, metabolism, differentiation, and death. (cshlpress.com)
Among these, the neoplastic tumor-suppressor genes (nTSGs) have been shown to fulfill two significant functions requisite for organ size control: first, establishing apicobasal cell polarity as a principle of epithelial tissue organization and appropriate timing of terminal differentiation and, second, exerting cell-proliferation control as a primary factor in tissue growth. (fsu.edu)
In summary, the three major areas of research in my lab are independent yet connected-proper differentiation of follicle cells is key to the establishment of oocyte polarity, and cell competition involves intercellular communication and regulation of cell proliferation. (fsu.edu)
Through the study of temporal and spatial regulation of important genes and pathways in our model systems, we will develop a more comprehensive picture of the molecular mechanisms orchestrating egg development and gain a deeper understanding of how basic cellular functions such as proliferation, differentiation, and growth are regulated in development. (fsu.edu)
These molecular defects interfere with lymphocyte development and function, blocking the differentiation and proliferation of T cells and, in some types, of B cells and NK cells. (medscape.com)

To elucidate the mechanisms by which curcumin affects systemic amyloidosis, we investigated amyloid deposition and molecular changes in a mouse model of amyloid apolipoprotein A-II (AApoAII) amyloidosis, in which mice were fed a curcumin-supplemented diet. (elifesciences.org)
However, the molecular mechanisms of action of HNK in BCSCs, as well as its effects on the cell cycle, remain unclear. (hindawi.com)
This study aimed to explore the potential targets and molecular mechanisms of HNK on metastatic BCSC (mBCSC)-cell cycle arrest and the impact of the TME. (hindawi.com)
Better understanding of the cellular and molecular pathophysiological mechanisms regulating adipocyte size, number and depot-dependent expansion has become a focus of interest over recent decades. (springer.com)
My laboratory is focused on understanding mechanisms of resistance to molecular targeting agents directed against receptor tyrosine kinases. (wisc.edu)
The overall goal of this research is to identify these mechanisms of resistance and to target specific pathways to increase the efficacy of molecular targeting agents. (wisc.edu)
These findings provide new molecular basis for further understanding the mechanisms involved in ATP functions, as a signal transducer and activator of MAP kinase cascades, in Caco-2 cells derived from human colon adenocarcinoma. (conicet.gov.ar)
However, the mechanisms of cell proliferation induced by LPLI are poorly understood. (biomedcentral.com)
Therefore, we believe that the investigation of the molecular events induced by LPLI could eventually reveal the mechanisms of LPLI. (biomedcentral.com)
then we review the studies on the molecular mechanisms of LPLI-induced proliferation since January 1999, which will serve as a reference for the researchers in this field. (biomedcentral.com)
My areas of research interest include severe allergies, molecular and genetic mechanisms, eosinophilic gastrointestinal diseases (EGIDs) and precision medicine. (cincinnatichildrens.org)
These mechanisms are becoming finely tuned where many levels of organization converge from molecular to cellular to organismic and are critically examined revealing a depth never before known. (hindawi.com)
In certain respects, VEGFs share regulatory mechanisms with other well-characterized RTKs, such as the platelet-derived growth-factor receptors (PDGFRs) and the epidermal growth-factor receptors (EGFRs).These mechanisms include receptor dimerization and activation of the tyrosine kinase, as well as creation of docking sites for signal transducers. (molecular-view.com)
However, the exact roles and molecular mechanisms of linc01023 in glioma remain blurred. (jcancer.org)
By retrieving TCGA database, we discovered that expression of linc01023 was up-regulated in glioma, however, the molecular mechanisms of linc01023 in glioma remain unclear. (jcancer.org)
These data demonstrate that MAP3K4-dependent signalling events are required for normal expression of Sry during testis development, and create a novel entry point into the molecular and cellular mechanisms underlying sex determination in mice and disorders of sexual development in humans. (plos.org)

Previous studies had confirmed that Lasp1 was significantly overexpressed in multiple malignant tumors including non-small-cell lung cancer (NSCLC) and enhanced tumor proliferation, invasion and metastasis [ 7 - 13 ]. (oncotarget.com)

These receptors are responsible for activating key pathways in cancer cells that lead to their proliferation and survival. (wisc.edu)
In 2008 our lab was the first to report that tumor cells that acquired resistance to cetuximab exhibited dramatic up regulation of the EGFR, secondary to loss of ubiquitination, which led to enhanced signals to other EGFR family members (HER and HER3) that promoted proliferation and survival. (wisc.edu)
Analysis of patients with head and neck squamous cell carcinomas, oropharyngeal carcinomas, ovarian and endometrial carcinomas, and esophageal and gastric cancer has revealed a close correlation between lower survival rates and higher Plk1 expression levels. (harvard.edu)
Moreover, the VEGFRs induce cellular processes that are common to many growth-factor receptors, including cell migration, survival and proliferation. (molecular-view.com)
VEGFR2 (vascular epithelial growth factor receptor 2, or KDR) is the receptor of VEGF (and its isoforms) which mediates normal endothelial cell survival, migration, and proliferation of blood vessels. (molecular-view.com)
Previous studies have demonstrated that IGF-1R activates the phosphoinositide 3- kinase (PI3K)/AKT signaling pathways and promotes glioblastoma cell proliferation and survival by ligand binding [ 10 ]. (jcancer.org)
These data suggest a key role for HSP70 in proliferation and survival of the erythroid lineage in PV, and may represent a potential therapeutic target in MPN, especially in PV. (biomedcentral.com)

RNA-sequence analysis revealed that curcumin intake affected hepatic lipid metabolism via the peroxisome proliferator-activated receptor (PPAR) pathway, especially PPARα activation, resulting in increased Apoa2 mRNA expression. (elifesciences.org)
Li L , Jiang H , Li Y , Xiang X , Chu Y , Tang J , Liu K , Huo D , Zhang X , . Chaetocin exhibits anticancer effects in esophageal squamous cell carcinoma via activation of Hippo pathway. (aging-us.com)
The RNA-seq analysis indicated that the Hippo pathway is one of the most enriched pathways after chaetocin treatment. (aging-us.com)
We further revealed that chaetocin triggered the activation of Hippo pathway in ESCC cells, which is characterized by elevated phosphorylation levels of almost all core proteins in Hippo pathway, such as MST1 (Thr183), MST2 (Thr180), MOB1 (Thr35), LAST1 (Thr1079 and Ser909) and YAP (Ser127), ultimately leading to decreased nuclear translocation of YAP. (aging-us.com)
Taken together, our study demonstrates that chaetocin exhibits anticancer effects in ESCC via activation of Hippo pathway. (aging-us.com)
The intersection between the differentially expressed genes (DEGs) and the HNK-targets was determined using a Venn diagram, and the results were analyzed using a protein-protein interaction network, hub gene selection, gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses, genetic alteration analysis, survival rate, and immune cell infiltration levels. (hindawi.com)
The pathway analysis tool GoSeq identified KEGG pathways enriched by significantly differentially expressed genes at both time points. (biomedcentral.com)
Taken together, our data suggest that Mahjong and Lgl belong to a molecular pathway that plays an evolutionarily conserved role in regulating cellular competitiveness. (fsu.edu)
Yu M, Yu S, Gong W, Chen D, Guan J, Liu Y. Knockdown of linc01023 restrains glioma proliferation, migration and invasion by regulating IGF-1R/AKT pathway. (jcancer.org)
Moreover, loss-of-function studies reveal that restoration of linc01023 restrains glioma cell proliferation, migration and invasion by regulating IGF1R/AKT pathway in vitro and in vivo. (jcancer.org)
Collectively, the study indicates that linc01023 plays an oncogenic role in glioma through activation of IGF1R/AKT signal pathway, and it could be a candidate therapeutic target. (jcancer.org)
Moreover, linc01023 depletion inhibited glioma cell proliferation, migration and invasion by regulating IGF1R/AKT pathway in vitro and in vivo. (jcancer.org)
Candidate target genes were identified through Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis. (scirp.org)

Fluoride can cause abnormalities in osteoblast proliferation and activation, leading to skeletal fluorosis. (fluoridealert.org)

In vitro assays confirmed that the two compounds, to varying extents, inhibited RA-FLS proliferation, migration, invasion, and NF-κB signaling. (frontiersin.org)
This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. (antikoerper-online.de)
Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase that regulates cell signaling, proliferation, migration, and development. (rcsb.org)
The proliferation and migration of circHERC1 in vivo were verified by subcutaneous and tail vein injection in nude mice. (biomedcentral.com)
Analysis of XY byg/byg gonads at 11.5 d post coitum reveals a growth deficit and a failure to support mesonephric cell migration, both early cellular processes normally associated with testis development. (plos.org)

Molecular Diagnostic and Prognostication Assays for the Subtyping of Urinary Bladder Cancer Are on the Way to Illuminating Our Vision. (who.int)

Downregulation of miR-4755-5p promotes fluoride-induced osteoblast activation via tageting Cyclin D1. (fluoridealert.org)
Low power laser irradiation (LPLI) promotes proliferation of multiple cells, which (especially red and near infrared light) is mainly through the activation of mitochondrial respiratory chain and the initiation of cellular signaling. (biomedcentral.com)
Lasp1 (LIM and SH3 domain protein 1) promotes tumor proliferation and invasion in multiple cancer entities including non-small cell lung cancer (NSCLC). (oncotarget.com)

Epidemiology data is changing ever since we have a better understanding of molecular and genetic behaviors of these tumors and especially after the new World Health Organization (WHO) classification from 2016. (medscape.com)
Recently, genetic analyses in Drosophila have revealed various genes that regulate the competitive behavior of cells. (fsu.edu)
Proteomic screening methods to find new physiopathogenic candidate proteins have not been widely employed in cancer, although a large number of molecular genetic tests have been performed with variable results. (biomedcentral.com)
Over the past few decades, the diverse molecular genetic causes of SCID have been identified with progress from studies of the immune system. (medscape.com)

The Texas Biomedical Research Institute (Texas Biomed) Molecular Services Core (MSC) provides centralized access to high throughput genomics and molecular technology and bioinformatics support for the advancement of research conducted by Texas Biomed, the Southwest National Primate Research Center (SNPRC), and external investigators. (txbiomed.org)
Here, we used time-resolved high-throughput proteomic analyses to identify and quantify the phosphorylation events and protein-protein interactions encoding T cell ligand discrimination in antigen-experienced T cells. (nature.com)
In attempting to understanding ways to gauge therapeutic response to treatment, a 3D coculture model was established for quick, high throughput analysis of treatment on CAF functionality and subsequent effect on invasion capability. (lu.se)

In particular, it is unclear whether ligand affinity uniformly affects the different signaling pathways involved in T cell activation. (nature.com)
Our analysis indicated that ligand affinity differentially affected signaling pathways associated with specific kinases and biological processes. (nature.com)
In addition, western blot analysis revealed that ATP-induced phosphorylation of MAPKs in Caco-2 cells was dependent on calcium influx and intracellular calcium release, Src-family tyrosine kinases, and partially dependent on the cAMP/PKA and PKC pathways. (conicet.gov.ar)
Other two pathways, ΔΨm/ATP/cAMP/JNK/AP-1 and ROS/Src, are also involved in LPLI-induced proliferation. (biomedcentral.com)
Molecular studies in mouse embryo fibroblast and human colorectal cancer cell lines defined APC/β-catenin and SRC-PI3K as key pathways in miR-135b activation. (gla.ac.uk)
Molecular chaperones are essential for stabilizing the fragile structures of many receptors, protein kinases, and transcription factors that participate in the pathways of normal cellular growth. (biomedcentral.com)
Over-expression of COMP leads to activation of Notch which affects both Wnt/β-catenin and AKT pathways, already affected by COMP. (lu.se)

However, its detailed molecular mechanism remains unclear. (fluoridealert.org)
However, the molecular mechanism of the activation remains poorly understood. (rcsb.org)
We identified a network of mainly charged residue-residue interactions spanning from the PIP₂ binding site to the distant interface between the kinase and FERM domains, comprising candidate residues for mutagenesis to validate the predicted mechanism of FAK activation. (rcsb.org)
The effect of routine clinical treatment of glioma was not ideal, and the molecular mechanism of the occurrence and development of the disease was still unclear. (ijpsonline.com)
However, the molecular mechanism is uncertain to date. (oncotarget.com)
More generally, bioinformatics analyses have shown that ~15% of all phosphorylated residues are buried in the non-phosphorylated state, suggesting that transient exposure might be a general mechanism involved in protein regulation. (lu.se)

Analysis of the effect of THOR-707 in syngeneic mouse tumor models showed that THOR-707 induced infiltration of CD8+ T effector cells into tumors and elicited anti-tumor effects alone and in combination with a PD-1 immune checkpoint inhibitor. (biospace.com)
The authors also provide a detailed analysis of the role of MYC in tumor initiation and progression. (cshlpress.com)
Hepatocyte growth factor receptor (c-Met), a member of tyrosine protein kinase receptors (TPKR), is phosphorylated during LPLI-induced proliferation, but tumor necrosis factor alpha (TNF-alpha) receptor has not been affected. (biomedcentral.com)
In conclusion, Lasp1 facilitated tumor proliferation and invasion of NSCLC through directly binding to FAK and enhancing the phosphorylation of FAK (Tyr397) and AKT (Ser473). (oncotarget.com)
Inactivation of tumor suppressor genes, whose products normally provide negative control of cell proliferation, contributes to malignant transformation in various cell types. (medscape.com)

We demonstrate, by confocal microscopy, that stimulation of Caco-2 cells with ATP results in the translocation of active MAPKs to the nucleous where they induce the expression of c-Fos and Jun family proteins, the phosphorylation of ATF-1, ATF-2 and JunD transcription factors and stimulate Caco-2 cell proliferation. (conicet.gov.ar)
Recently, the signaling proteins involved in LPLI-induced proliferation merit special attention, some of which are regulated by mitochondrial signaling. (biomedcentral.com)
LPLI-induced cell cycle progression can be regulated by the activation or elevated expressions of cell cycle-specific proteins. (biomedcentral.com)
Recently, a large number of signaling proteins reported play an important key role in the process of LPLI-induced cell proliferation, probably due to the fact that the molecular events they are involved in are the basic response of the cells to extracellular stimuli. (biomedcentral.com)

Molecular metabolism 2023 9 101798. (cdc.gov)

Analysis of early gene expression revealed that signaling through class II molecules led to an increase in anti-μ-induced expression of c-myc, a proto-oncogene, and of ornithine decarboxylase, a key enzyme in polyamine biosynthesis that has been shown to be intimately related to increased cell proliferation. (uky.edu)
It is now established that the postpartum endometrial inflammatory response and its allied immune gene activation is a transient feature of the normal physiological events associated with uterine involution[ 6 ]. (biomedcentral.com)
Moreover aberrant MYC gene activation is profoundly involved in the etiology of a wide range of cancers. (cshlpress.com)
Differentially expressed genes (DEGs) were seared by combing the TCGA database and the Gene Expression Omnibus (GEO) database, and the key molecule AKR1B10 was identified by weighted gene coexpression network analysis (WGCNA). (portlandpress.com)
A catalytic reverse transcriptase protein (TERT) encoded by the TERT gene plays a critical role in the activation of telomerase. (elsevierpure.com)
Analysis of embryonic XY gonads suggests that sex reversal is caused by delayed and reduced expression of the sex-determining gene SRY . (plos.org)
Gene Ontology (GO) enrichment analysis of these genes identified an overrepresentation of genes related to the cell cycle. (biomedcentral.com)
This parent-specific gene activation results from a phenomenon called genomic imprinting. (medlineplus.gov)

WAT is characterised by its capacity to adapt and expand in response to surplus energy through processes of adipocyte hypertrophy and/or recruitment and proliferation of precursor cells in combination with vascular and extracellular matrix remodelling. (springer.com)
We study extracellular feedback by the cytokine IL-2 in the context of T-cell activation. (weizmann.ac.il)

Telomere length is maintained by the activation of telomerase, which causes continuous cell division and proliferation in many carcinomas. (elsevierpure.com)

Further, the results of miR-4755-5p mimic transfection confirmed that under the action of NaF, miR-4755-5p overexpression reduced Cyclin D1 protein expression within osteoblasts and further inhibited cell proliferation and activation. (fluoridealert.org)

In X-linked SCID, loss of IL-2 receptor (IL-2R) function leads to the loss of a lymphocyte proliferation signal. (medscape.com)

The results demonstrate that fluoride exposure induced the downregulation of miR-4755-5p and downregulated miR-4755-5p promoted fluoride-induced osteoblast activation by increasing Cyclin D1 protein expression. (fluoridealert.org)
We defined quantitative signatures of ligand affinity based on protein phosphorylation and protein-protein interaction (PPI) stoichiometry for critical molecular events associated with TCR signaling. (nature.com)
Real‑time quantitative polymerase chain reaction (PCR) and western blot analyses were used to detect SPRY2 expression and miR‑21 protein expression levels. (spandidos-publications.com)
Using bioinformatics analyses, we predicted HNK protein targets from several databases and retrieved the genes differentially expressed in mBCSCs from the GEO database. (hindawi.com)
The contributors discuss its normal functions in the control of cell growth, cell competition, pluripotency, and development, as well as the molecular basis for the effects of the MYC protein on transcription. (cshlpress.com)
The sympathetic nervous system regulates this function through β-adrenergic stimulation of brown mature adipocytes' dissipation of energy in the form of heat mediated by mitochondrial uncoupling protein-1 (UCP-1) activation. (springer.com)
Expression analysis of mutant XY gonads at the same stage also reveals a dramatic reduction in Sox9 and, crucially, Sry at the transcript and protein levels. (plos.org)
p27 is a protein that binds to and prevents the activation of different G1 and S phase cyclin-CDK complexes. (lu.se)
Low molecular weight (LMW) assay (LLNA) was developed in 1989 [2] and continues to chemical sensitizers, referred to as haptens (or prohaptens), undergo refinement as an alternative for the evaluation of are themselves too small to be allergenic and must bind to sensitizing potential of low molecular weight (LMW) chem- a protein to be allergenic. (cdc.gov)

However, despite initial response, acquired and intrinsic resistance to this promising molecular therapeutic eventually develops. (wisc.edu)
Profiling the molecular aberrations in plasma of lung cancer patients could provide important biologic insights into lung tumorigenesis, and potential biomarkers and therapeutic targets for the disease. (biomedcentral.com)
However, curcumin, a highly pleiotropic molecule with an excellent safety profile targeting multiple diseases with strong evidence on the molecular level, could not achieve its optimum therapeutic outcome in past clinical trials, largely due to its low solubility and poor bioavailability. (blogspot.com)
Similarly, depletion in the STRIPAK component STRIP1 affects activation of GCKIII kinases and cell cycle disruption through elevated expression of cyclin dependent kinase inhibitors p21 and p27, enhanced levels of which lead to a protective effect from therapeutic treatments and increased proliferation. (lu.se)

The complexity of the intercellular communication network obscures analysis and understanding of its function. (weizmann.ac.il)

In Synthorx's preclinical studies, THOR-707 induces molecular markers of T cell activation and the proliferation of peripheral NK and CD8+ effector T cells in vivo . (biospace.com)
Under in vitro conditions, changes in the proliferation and invasion ability were detected in myeloma cells. (spandidos-publications.com)
Cytotoxicity and cell proliferation was assessed in human monocytic cells (THP-1) at 0 - 120 microg/ml and in primary human fibroblast cells (PHF) at 0 - 16 microg/ml. (cdc.gov)
THP-1 WT and NLRP3-deficient cells were used to screen for inflammasome activation. (cdc.gov)
8000 Bahía Blanca, Argentina In the present work, we examined the role of ATP in the activation of the MAP kinases (MAPKs) ERK1/2, JNK1/2 and p38 and their involvement in the modulation of transcription factors and proliferation of human colon cancer Caco-2 cells. (conicet.gov.ar)
A new study from the Erikson lab by Xiaoqi Liu and Ming Lei (just appearing in Molecular and Cellular Biology ) offers important insight into the function of Polo-like kinase 1 and its role in cell regulation and carcinogenesis in mammalian cells. (harvard.edu)
His main research areas are developmental biology, cell morphogenesis, adult stem cells and cardiac function analysis. (amrita.edu)
Proliferation and invasion assay showed that Lasp1 dramatically promoted the ability of proliferation and invasion of NSCLC cells. (oncotarget.com)
Basally extruded apoptotic cells were excluded from the analysis. (fsu.edu)
A theoretical model that we developed, in collaboration with Yoni Savir and Tsvi Tlusty from the department of physics of complex systems, shows that IL-2 can result in cooperation or competition between activating T cells, depending on their relative activation strength and timing. (weizmann.ac.il)
Upon activation, naïve CD4+ T-cells can differentiate into one out of few possible lineages, each invoking a specific immune response. (weizmann.ac.il)
8] when using sequence analysis of human colorectal cells. (scirp.org)
It is the prototype of the primary immunodeficiency diseases and is caused by numerous molecular defects that lead to severe compromise in the number and function of T cells, B cells, and occasionally natural killer (NK) cells. (medscape.com)

no apparent proliferation defect or cell cycle arrest was observed after Plk1 depletion. (harvard.edu)
Three sequential phosphorylation events on specific residues of p27, regulate the activity of these complexes and ultimately control cell cycle proliferation or arrest. (lu.se)
Activation of p21 or p16 therefore causes cell cycle arrest. (medscape.com)

One active ingredient in turmeric is curcumin (perhaps the most well-known as a result of the proliferation of curcumin supplements over the last two decades), which has an earthy, mildly bitter, and peppery flavor. (blogspot.com)

The first is associated with constitutive activation of FGFR, where the FGFR2 receptor is always signalling, regardless of the amount of FGF ligand. (wikipedia.org)
Which early molecular events are affected by ligand affinity, and how, has not been fully resolved. (nature.com)
Overall, this study provides a comprehensive map of molecular events associated with T cell ligand discrimination. (nature.com)
The kinetic proofreading model postulates that TCR ligand discrimination is due to several signaling steps that introduce a delay between ligand binding and T cell activation. (nature.com)
This implies that the pMHC ligand dwell time on the TCR determines the probability of completing a series of signaling events leading to T cell activation 5 . (nature.com)
This is consistent with reports that the slow phosphorylation of tyrosine residues of the Lat adaptor associates with recruitment and activation of the phospholipase Plcγ1, thereby constituting an important kinetic bottleneck for ligand discrimination 11 . (nature.com)

Dr. Aradhya aims to understand molecular aspects regulating the development of mesodermal derivatives both in Drosophila and mammalian counterparts. (amrita.edu)
Dr. Rajaguru Aradhya and Jagla, K., "Insulin-dependent Non-canonical Activation of Notch in Drosophila: A Story of Notch-Induced Muscle Stem Cell Proliferation", in Notch Signaling in Embryology and Cancer: Molecular Biology of Notch Signaling, vol. 1227, J. Reichrath and Reichrath, S., Eds. (amrita.edu)

The results of this study reveal an early activation of the immune response which undergoes a temporal functional change toward tissue proliferation and regeneration during endometrial involution in healthy postpartum cows. (biomedcentral.com)
These molecular changes mirror the activation and resolution of endometrial inflammation during involution previously classified by the degree of neutrophil infiltration. (biomedcentral.com)
CYP3A4 increased endometrial cell proliferation and was also increased in human endometriosis lesions compared with eutopic endometrium. (endometriosi.it)

However, dosing of THOR-707 has minimal effect on molecular and clinical markers of VLS, even at high exposures. (biospace.com)
Through the analysis of the The Cancer Genome Atlas database and clinical tissue samples, the expression of MicroRNA-16-5p in glioma was detected. (ijpsonline.com)
Cell proliferation is a very important physiological effect for low power laser irradiation (LPLI) used in clinical practice. (biomedcentral.com)

We use molecular biology, proteomics, mouse modeling, including patient derived xenografts, and human tissues to understand how tumors that are initially responsive to therapy become resistant over time. (wisc.edu)
In the Wheeler lab, we use state of the art molecular biology, proteomics and mouse modeling to understand how tumors become resistant to cancer drugs. (wisc.edu)
In human lung tumors, combined activation of K-RAS and inactivation of RASSF1A is closely associated with the development of the most aggressive and worst prognosis tumors. (cancerindex.org)
Glioma, the vast majority of intracranial malignant tumors, is characterized by rapid proliferation and aggressive invasion [ 1 ]. (jcancer.org)

Cetuximab (IMC- C225, Erbitux) prevents receptor activation and dimerization and ultimately induces receptor internalization and. (wisc.edu)
Calmodulin lobes facilitate dimerization and activation of estrogen receptor-a. (nih.gov)

Acellular oxidative stress potential of the material correlated with the fold increase in in vitro NFkB activation and oxidative stress induction, measured using a dichlorofluorescin-diacetate assay. (cdc.gov)

Network pharmacology analysis and molecular docking analysis jointly revealed that umbelliferone and scopoletin act on multiple targets, mostly tyrosine kinases, in combating RA. (frontiersin.org)

Interpretation Our data suggest that miR-135b is a key molecule whose activation is downstream of driver genes frequently mutated in colorectal cancer. (gla.ac.uk)
This analysis revealed a developmental time point between 10 and 12 days after germination where FLC expression had decreased but LFY expression had not yet increased, which was characterized by a peak in the number of differentially expressed genes. (biomedcentral.com)
Analysis of mutants with abnormal flowering time has allowed the identification of genes controlling floral transition [ 8 ]. (biomedcentral.com)

While the phosphorylation of tyrosine residues in the immunoreceptor tyrosine-based activation motifs (ITAMs) of Cd3 and the inducible interaction between Cd3 and Zap70 remained largely unaffected, the abundance of activated Zap70 dropped with decreasing peptide affinity. (nature.com)

The MSC is dedicated to assist researchers in the development and implementation of state-of-the-art molecular approaches in the support of their research. (txbiomed.org)

New strategies in molecular diagnostics and targeted therapies in NSCLC to detect and treat them are being explored. (biomedcentral.com)

The MSC also maintains dedicated high performance computing and data storage capabilities in the Genomics Computing Center required for analysis of accompanying large datasets. (txbiomed.org)

2012). In an additional work, performed in collaboration with Yuval Hart and Uri Alon from the department of molecular cell biology, we show that IL-2 pleiotropic activity can result in homeostasis of cell numbers, where the final cell concentration is independent of initial concentration over a large range (Hart et. (weizmann.ac.il)

Real‑time quantitative PCR and western blot analysis showed that in the MM cell lines with high endogenous miR‑21 expression (RPMI8226 and KM3), SPRY2 expression was significantly lower. (spandidos-publications.com)

Based on a previous study, the aim of this study is to explore the role of miRNA in osteoblast activation of skeletal fluorosis via targeting of Cyclin D1 . (fluoridealert.org)
Molecular filaments and hubs have received special attention recently thanks to new studies showing their key role in star formation. (kb.se)
This approach revealed an essential role of Plk1 for cell proliferation and viability. (harvard.edu)
The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. (plos.org)

Here, we describe the first transgenic mouse model for activation of K-RAS in the lung in a RASSF1A-defective background. (cancerindex.org)
Design and methodological considerations for biomarker discovery and validation in the Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Program. (who.int)
Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer. (who.int)

Here, we addressed the allosteric regulation of FAK by performing all-atom molecular-dynamics simulations of a FAK fragment containing the catalytic and FERM domains, and comparing the dynamics in the absence or presence of ATP and PIP₂. (rcsb.org)

Chaetocin, a small molecular compound isolated from the marine fungus, exhibits potent anticancer effects. (aging-us.com)

We performed a molecular and pathological analysis of the TERT against three different peripheral T-cell lymphoma (PTCL) subtypes: PTCL, not otherwise specified (PTCL-NOS), angioimmunoblastic T-cell lymphoma (AITL), and adult T-cell leukemia/lymphoma (ATLL). (elsevierpure.com)

Notably, the first two post-translational modifications, which are required for the initial activation of these complexes, occur on solvent inaccessible (i.e., buried) tyrosine residues. (lu.se)

Anatomy2

Chemicals and Drugs6

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes2

Technology, Industry, Agriculture1

Apoptosis16

Differentiation7

Mechanisms16

Invasion and metastasis1

Survival7

Pathway13

Osteoblast proliferation1

Migration5

Assays1

Promotes3

Genetic4

High throughput3

Pathways7

Mechanism6

Tumor5

Proteins4

Metabolism1

Gene8

Extracellular2

Carcinomas1

Overexpression1

Lymphocyte1

Protein9

Therapeutic4

Intercellular communication1

Cells13

Arrest3

Curcumin1

Ligand6

Drosophila2

Endometrial3

Clinical3

Tumors4

Dimerization2

Vitro1

Kinases1

Genes3

Phosphorylation1

State-of-the-art mo1

NSCLC1

Genomics1

Biology1

Western blot analysis1

Role4

Lung3

Allosteric1

Small-molecular1

Peripheral1

Tyrosine1