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  • genes
  • We identified at least five different temporal synexpression classes, including genes specifically induced within a few hours after injury. (biomedcentral.com)
  • limbs
  • For regenerative medicine, which aims to replace lost or damaged organs and limbs, elucidating these mechanisms is crucial because the production of new cells is not sufficient - new tissues must be the correct size and shape to restore form and function. (biologists.org)
  • In amphibians this process is regulated by nerve fibres present at the site of injury, which have been proposed to release factors into the amputated limbs/fins, promoting and sustaining the proliferation of blastemal cells. (biomedcentral.com)
  • Nerve axons and the apical Bcl-w epidermal cap (AEC) are both essential for the formation of an accumulation blastema by amputated limbs of urodele salamanders. (assayway.com)
  • We screened the blastema of resected axolotl limbs with a cross-reactive mouse cytokine protein detection array, revealing a rapid induction of cytokines, chemokines, and inflammatory markers within 1 d of limb resection. (pnas.org)
  • Position-specific induction of ectopic limbs in non-regenerating blastemas on Axolotl forelimbs. (uci.edu)
  • cAMP and cGMP measured by RIA and observed by immunohis-tochemistry in unamputated limbs and in regenerating newt limbs at early- and medium-bud stages showed cAMP and cGMP cytoplasmic accumulations in blastemata and in stumps of the regenerating limbs, with increases up to 1900% over unamputated controls. (springer.com)
  • In blastemata the cAMP increase was greater than that of cGMP while in stumps of the regenerating limbs the increase of cGMP was of a much greater magnitude than that of cAMP. (springer.com)
  • blastemal
  • The report in BMC Developmental Biology by Juan Carlos Izpisúa Belmonte and colleagues adds a new twist to a rapidly evolving view of the origin of blastemal cells. (biomedcentral.com)
  • The origin of the newly formed blastemal cells and their fate during the regeneration process have been on-going topics of debate over the past century. (biomedcentral.com)
  • progeny
  • Together with their immediate progeny, neoblasts account for ≈15-25% of all parenchymal cells ( 4 ). (pnas.org)
  • Early studies using the regenerating salamander limb and tail indicated that injured multinucleated myofibers can dedifferentiate, give rise to mononucleate progeny, and contribute to the regenerating blastema. (biomedcentral.com)
  • proliferative
  • 1. A pharmaceutical composition comprising a cell extract and a pharmaceutically acceptable carrier, for use in the treatment of a proliferative disease. (google.es)
  • plasticity
  • It is increasingly clear that epithelial and endothelial cells enjoy some of this plasticity, which is easily demonstrated by studying the process of epithelial-mesenchymal transition (EMT). (jci.org)
  • As we discuss in this Personal Perspective, we believe that context and various changes in plasticity biomarkers can help identify at least three types of EMT and that using a collection of criteria for EMT increases the likelihood that everyone is studying the same phenomenon - namely, the transition of epithelial and endothelial cells to a motile phenotype. (jci.org)
  • morphogenesis
  • Our new special issue is packed with articles that use mathematical and physical approaches to gain insights into cell and tissue patterning, morphogenesis and dynamics, and that provide a physical framework to capture these processes operating across scales. (biologists.org)
  • nerve-independent for morphogenesis, but remain dependent on the nerve for blastema growth. (assayway.com)
  • Fgf20a
  • Associate Professor Atsushi Kawakami, who teaches Life Science and Technology, and colleagues at Tokyo Institute of Technology and the Graduate University for Advanced Studies (SOKENDAI) identified fgf20a and fgf3/10a as major fgf ligands in wound epidermis and blastemas, respectively. (titech.ac.jp)
  • cytoplasmic
  • 10. A pharmaceutical composition according to any one of the preceding claims wherein the cell extract is selected from the group consisting of a cytosolic extract, a cytoplasmic extract, a nuclear extract, a whole cell lysate, extracellular extract, whole tissue extract and mixtures thereof. (google.es)
  • cytokines
  • The JNK signal transduction cascade is activated by exposure of cells to cytokines or environmental stress. (biomedcentral.com)
  • Macrophages are an important source of both inflammatory and anti-inflammatory signals, arriving in mammalian wounds 48-96 h after injury, where they clear dead cells, release proinflammatory cytokines, and subsequently produce factors that dampen inflammation and stimulate angiogenesis, fibroblast migration, and replication ( 17 ). (pnas.org)
  • neural cell
  • Visit our reviews page to see a complete list of reviews in the neural cell research field. (neuralcellnews.com)
  • Planarians possess complex organs as the pharynx and the central nervous system (CNS), which conserves all neural cell types and neuropeptides found in vertebrates [ 7 ]. (hindawi.com)
  • axolotl
  • A distinctively dynamic signaling microenvironment during the early stages of axolotl limb regeneration was accompanied by early myeloid cell recruitment. (pnas.org)
  • McCusker, C. and Gardiner, D.M. (2013) Positional information is reprogrammed in blastema cells of the regenerating axolotl limb. (uci.edu)
  • molecular
  • It is crucial, therefore, to understand the molecular mechanisms of regeneration and the intrinsic and extrinsic signals that induce and promote this process. (biomedcentral.com)
  • Interestingly, a considerable portion of the molecular clock (14 genes) is light-induced in the pineal gland. (uni-heidelberg.de)
  • Recent advances in generating green fluorescent protein (GFP)-expressing transgenic frogs, salamanders, and fish, combined with molecular marker analyses, have enabled in vivo tracking of cells with high precision. (biomedcentral.com)
  • structures
  • Although infiltrating immune cells play a major role in determining the variable outcome of mammalian wound repair, little is known about the modulation of immune cell signaling in efficiently regenerating species such as the salamander, which can regrow complete body structures as adults. (pnas.org)
  • skeletal muscle
  • Activation of salamander satellite cells occurs in an analogous manner to how the mammalian myofiber mobilizes stem cells during skeletal muscle tissue repair. (rupress.org)
  • Although in lethally irradiated mice, bone marrow-derived SCs replenish the depleted satellite cell pool and subsequently incorporate effectively into exercised skeletal muscle ( 9 ), less is known about the ability of bone-marrow-derived SCs to ameliorate muscle damage under more clinically relevant conditions. (pnas.org)