• The fibroblast growth factor receiver (FGFR) tyrosine kinases, which are expressed on the cell membrane, are involved in a wide range of biological functions such as cell proliferation, survival, migration and differentiation. (fgf-4.com)
  • In recent years, interest in the possible molecular regulators of cell proliferation and differentiation in a wide range of regeneration models has grown significantly, but the cell kinetics of this process remain largely a mystery. (mdpi.com)
  • The EPCs plays critical role in postnatal vasculogenesis through pivotal bioactivities of mobilization, homing, migration, differentiation, and proliferation in angiovasculogenic tissues [ 6 ]. (hindawi.com)
  • The tumor cells were positive for α-smooth muscle actin and negative for pancytokeratin, β-catenin, and cluster of differentiation 34. (mendeley.com)
  • As an upstream signature component of FcεRI signaling, inhibition of spleen tyrosine kinase (Syk) abrogated the IgE-induced HASM proliferation. (harvard.edu)
  • The percentage of inhibition exerted by l -citrulline on days 3, 5, and 7 of the proliferation curve was 20.0 ± 0.5%, 37.5 ± 8.3%, and 28.5 ± 7.2%, respectively. (aspetjournals.org)
  • After treatment with different concentrations (0, 5, 10, and 20 μmol/L) of curcumin for 24 h, the inhibition of cell proliferation was detected, and the cell cycle variations of pulmonary smooth muscle were observed. (farmaciajournal.com)
  • [ 7 ] Nonetheless, findings from studies have revealed that PDE5 is highly expressed in the lower urinary tract and supporting vasculature, and that PDE5 inhibition potentially decreases smooth muscle cell proliferation in the prostate, relaxes smooth muscle in the prostate, bladder neck, and supporting vasculature, increases blood perfusion to the lower urinary tract, and modulates bladder afferent nerve activity. (medscape.com)
  • In conclusion, CAPE can inhibit the proliferation and migration of HCSMCs by inducing cell cycle arrest. (cellmolbiol.org)
  • In conclusion, curcumin may protect the pulmonary arteries of MCT-induced PHA in rats and inhibit the proliferation of rat pulmonary artery smooth muscle. (farmaciajournal.com)
  • Hydrogen-rich medium (HRM) inhibited rat VSMC proliferation and migration induced by 10% FBS. (molecularhydrogenstudies.com)
  • These results showed that hydrogen-rich saline was able to attenuate FBS-induced VSMC proliferation and neointimal hyperplasia by inhibiting ROS production and inactivating the Ras-ERK1/2-MEK1/2 and Akt pathways. (molecularhydrogenstudies.com)
  • TNF-α-activated endothelial cells promote VSMC proliferation and secretion of ICAM-1 and IL-8 by elevating IL-6 release. (geneticsmr.com)
  • Transfection with AP-1 decoy ODNs strongly inhibited VSMC proliferation and migration, as well as glucose- and serum-induced expression of PCNA and cyclin A genes. (dsmc.or.kr)
  • Our results collectively indicate that AP-1 activation is crucial for the mediation of VSMC proliferation in response to vascular injury. (dsmc.or.kr)
  • Context As one of the crucial causes leading to cardiovascular disease, atherosclerosis (AS) develops in combination with the dysfunction of soft vascular muscle cells (VSMC). (fgf-4.com)
  • However, the associated mechanism of proliferation and migration in VSMC requires additional elucidation. (fgf-4.com)
  • the proliferation and migration of VSMCs but favored the apoptosis of the VSMC. (fgf-4.com)
  • However, the effect of albuterol on the proliferation and migration has never been tested. (scirp.org)
  • Since (R)-, but not (S)-albuterol enhances bronchodilation, we expect the two racemic isomers would also affect proliferation and migration of tracheal cells differentially. (scirp.org)
  • By monitoring migratory properties of airway smooth muscle cells in the presence of albuterol isomers, the different effect of albuterol on proliferation and migration of airway smooth muscle cells is probed. (scirp.org)
  • However, the different effects of R- and S-albuterol on smooth muscle cells proliferation and migration have never been tested. (scirp.org)
  • More important, people found that, during the pathogenesis of asthma, smooth muscle cells could differentiate into the migration phenotype. (scirp.org)
  • As a kind of well mature pharmaceutical for asthma treatment, it would be very important to distinguish the effect of two different isomers of albuterol on proliferation and migration activities of airway smooth muscle cells. (scirp.org)
  • third, whole tissue culture was also performed to further demonstrate the different effect of R- and S-albuterol on migration of airway smooth muscle cells. (scirp.org)
  • This study aimed to investigate the relationship between miR-506 and proliferation and migration of breast cancer cells. (medscimonit.com)
  • Cell proliferation, cell counting, colony formation assay, and Transwell assay were applied to evaluate the proliferation and migration of breast cancer cells. (medscimonit.com)
  • CONCLUSIONS Removes the proliferation and migration of VSMCs and induces their apoptosis by targeting FGF1. (fgf-4.com)
  • In this study, we found that caffeic acid phenethyl ester (CAPE) displayed an inhibitory effect on human coronary smooth muscle cell (HCSMC) growth and migration. (cellmolbiol.org)
  • Caffeic acid phenethyl ester human coronary smooth muscle cells proliferation migration restenosis local delivery cell cycle. (cellmolbiol.org)
  • Additionally, ankyrins play key roles in important functions including cell movement (migration) and cell growth and division (proliferation). (medlineplus.gov)
  • Cardiomyocyte proliferation refers to the ability of cardiac muscle cells to progress through the cell cycle and continue to divide. (wikipedia.org)
  • Also, cardiomyocyte proliferation and regeneration has been demonstrated to occur in various neonatal mammals in response to injury in the first week of life. (wikipedia.org)
  • Current research aims to further understand the biological mechanism underlying cardiomyocyte proliferation in hopes to turn this capability back on in adults in order to combat heart disease. (wikipedia.org)
  • After cardiomyocyte proliferation and regeneration was demonstrated to occur in zebrafish after resection, various animal models were utilized in order to explore whether mammals also have this innate ability. (wikipedia.org)
  • The complete biological mechanism underlying cardiomyocyte proliferation has not been fully elucidated. (wikipedia.org)
  • The transcription factor family E2F are also thought to be very important in regulating cardiomyocyte proliferation. (wikipedia.org)
  • Knockout experiments demonstrated that the length of cardiomyocyte proliferation can be extended when Meis1 is deleted in mice. (wikipedia.org)
  • Prior studies have focused on driving cardiomyocyte proliferation to improve cardiac regeneration in mice. (jax.org)
  • The aim of this study was to investigate the influence of activated endothelial cells on the proliferation and secretion of vas-cular smooth muscle cells (VSMCs). (geneticsmr.com)
  • The proliferation of VSMCs was detected with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. (geneticsmr.com)
  • Excessive proliferation of vascular smooth muscle cells (VSMCs) and neointimal formation are critical steps in the pathogenesis of atherosclerosis and restenosis after percutaneous transluminal angioplasty. (dsmc.or.kr)
  • Compared with PSODN, CDODN was more effective in inhibiting the proliferation of VSMCs in vitro and neointimal formation in vivo. (dsmc.or.kr)
  • Muscle samples were collected and myogenic cells were isolated and cultivated. (nature.com)
  • Proliferating, BrdU-positive cells in muscle sections were detected with immunohistochemistry indicating different cell types and decreasing proliferation with age. (nature.com)
  • Primary culture of rat airway smooth muscle cells was performed by enzyme digestion. (scirp.org)
  • In the present study, we focus on the proliferation of human arterial smooth muscle cells (SMCs) from NIDDM patients (DM-SMCs) to clarify the reactivity to the growth factor(s) in fetal calf serum (FCS) and the factors) secreted by T-cells. (diabetesjournals.org)
  • The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population. (zfin.org)
  • The latter cells had some features of vascular smooth muscle cells and were apparently derived from medial cells which traversed the internal elastic lamina. (duke.edu)
  • After 14 days, identifiable smooth muscle cells emerged as the predominant cell type in a rapidly growing intimal plaque. (duke.edu)
  • Cell proliferation deep within an atherosclerotic plaque could be initiated by factors other than platelets, perhaps by products of inflammatory cells. (duke.edu)
  • Up-regulation of nPKC contributes to proliferation of mice pulmonary artery smooth muscle cells in hypoxia-induced pulmonary hypertension. (bvsalud.org)
  • This study is designed to investigate the role of novel protein kinases C (nPKC) in mediating pulmonary artery smooth muscle cells (PASMCs) proliferation in pulmonary hypertension ( PH ) and the underlying mechanisms. (bvsalud.org)
  • Transplantation of myogenic stem cells possesses great potential for long-term repair of dystrophic muscle. (biomedcentral.com)
  • In murine-to-murine transplantation experiments, CXCR4 expression marks a population of adult murine satellite cells with robust engraftment potential in mdx mice, and CXCR4-positive murine muscle-derived SP cells home more effectively to dystrophic muscle after intra-arterial delivery in mdx 5cv mice. (biomedcentral.com)
  • We show that CXCR4 expressing cells are important for donor muscle cell engraftment, yet FACS sorted CXCR4-positive cells display decreased engraftment efficiency. (biomedcentral.com)
  • However, diprotin A, a positive modulator of CXCR4-SDF-1 binding, significantly enhanced engraftment and stimulated sustained proliferation of donor cells in vivo . (biomedcentral.com)
  • Intramuscular injection of donor muscle-derived cells into chimeric cxmd recipients restored dystrophin expression for at least 24 weeks in the absence of post-transplant immunosuppression, indicating that cell transplantation may be a viable therapeutic option for muscular dystrophy. (biomedcentral.com)
  • Embryonic myogenic progenitor cells express CXCR4, G-protein coupled cell surface receptor, and migrate towards regions of SDF-1 expression during limb muscle development, suggesting that CXCR4/SDF-1 plays a role in muscle cell homing. (biomedcentral.com)
  • Indeed, CXCR4-positive muscle-derived side population (SP) cells home more effectively to dystrophic muscle after intra-arterial delivery in mdx 5cv mice [ 10 ]. (biomedcentral.com)
  • We used the xenotransplant model to show that CXCR4 expression on canine donor muscle cells is also important for cell engraftment, but FACS sorting for CXCR4-positive cells decreased their engraftment efficiency. (biomedcentral.com)
  • Diprotin A stimulation of CXCR4, however, significantly increased the number of canine dystrophin-positive muscle fibers and canine-derived satellite cells by enhancing donor cell proliferation. (biomedcentral.com)
  • Consequently, the proliferation of cells was significantly inhibited. (farmaciajournal.com)
  • This was indicated by higher DNA incorporation of thymidine and a higher number of cells expressing PCNA in intact muscle, accompanied by higher Pax7 levels, all reflecting a higher number of myogenic cells, and suggesting that the increased hypertrophy can be attributed to a higher reservoir of myogenic progeny cells produced in response to the TM. (agri.gov.il)
  • The aims of this study were to examine whether resveratrol alters angiotenisn II-induced cell proliferation and endothelin-1 gene expression and to identify the putative underlying signaling pathways in rat aortic smooth muscle cells. (tmu.edu.tw)
  • Cultured rat aortic smooth muscle cells were preincubated with resveratrol then stimulated with angiotensin II, after which [ 3 H]thymidine incorporation and endothelin-1 gene expression were examined. (tmu.edu.tw)
  • Amputation-induced proliferation occurred predominantly within the epidermal and intestinal epithelium, as well as wound-adjacent muscle fibers, where clusters of cells at the same stage of the cell cycle were found. (mdpi.com)
  • The experts at Cornell University investigated how serum from women who indulged in a blueberry-rich diet would affect the cells responsible for muscle growth and repair. (ibtimes.com)
  • In this study, in attempt to provide fresh information about the impact of CS on proliferation of EPCs to elucidate the pathophysiological mechanisms of the diseases related to CS in cellular level, we assessed the proliferation of EPCs after interfering the cells with a series of concentrations of CSE for various times of exposure in vitro . (hindawi.com)
  • Ankyrin-B ensures these channels and transporters are in their proper locations in the cell membrane so they can regulate the flow of ions into and out of cardiac muscle cells. (medlineplus.gov)
  • As a result of these genetic changes, the ankyrin-B protein cannot target ion channels and ion transporters to their correct locations in cardiac muscle cells. (medlineplus.gov)
  • Intriguingly, the cardiomyocyte cells responsible for heart muscle repair continued to be activated and proliferate. (jax.org)
  • Lymphangioleiomyomatosis (LAM) is a rare lung disease, resulting from proliferation in the lung, kidney, and axial lymphatics of abnormal smooth muscle-like cells (LAM cells) that exhibit features of neoplasia and neural crest origin. (medscape.com)
  • Lymphangioleiomyomatosis (LAM) is an indolent, progressive growth of smooth muscle cells throughout the lungs, pulmonary blood vessels, lymphatics, and pleurae. (msdmanuals.com)
  • It is characterized by proliferation of atypical smooth muscle cells throughout the chest, including lung parenchyma, vasculature, lymphatics, and pleurae, leading to distortion of lung architecture, cystic emphysema, and progressive deterioration of lung function. (msdmanuals.com)
  • Mutations in the tuberous sclerosis complex-2 gene ( TSC-2 ) have been described in LAM cells and angiomyolipomas (benign renal hamartomas made of smooth muscle, blood vessels, and adipose). (msdmanuals.com)
  • This study elucidated effects of glutamine (Gln) supplementation on the cellular muscle development of LBW and normal birth weight (NBW) piglets. (nature.com)
  • We observed a temporarily increased intramuscular availability of free Gln that could have influenced cellular processes in skeletal muscle. (nature.com)
  • Therefore, we complemented our investigations into the cellular development of the skeletal muscle of neonatal piglets with in vitro studies using a primary porcine myogenic cell culture model with Gln supplementation. (nature.com)
  • Labelling of smooth muscle cell cellular proteins with [3H]-FOH and [3H]-GGOH was significantly inhibited by ajoene. (unipd.it)
  • We investigated the cellular and molecular bases for the promotion of muscle development and growth by temperature manipulations (TMs) during late-term chick embryogenesis. (agri.gov.il)
  • The intracellular mechanism of resveratrol in cellular proliferation and endothelin-1 gene expression was elucidated by examining the phosphorylation level of angiotensin II-induced extracellular signal-regulated kinase (ERK). (tmu.edu.tw)
  • Proliferation In Vitro and Neointimal Formation In Vivo. (dsmc.or.kr)
  • In conclusion, human arterial SMC proliferation is increased in diabetes in the same fashion as in experimentally induced diabetes in animals through responses to growth factors and an increased autocrine system. (diabetesjournals.org)
  • We report here that IgE sensitization induces HASM cell proliferation, as measured by 3H-thymidine, EdU incorporation, and manual cell counting. (harvard.edu)
  • studies have shown that the R- and S-enantiomers of racemic albuterol, a β 2 -adrenergic receptor agonist used in asthma treatment, have differential effects on the contractile properties of airway smooth muscle. (scirp.org)
  • After removal of blood vessels, connective tissues and cartilage, pure airway smooth muscle tissue was rinsed with PBS twice and cut into small pieces. (scirp.org)
  • Increased airway smooth muscle (ASM) mass due to hyperplasia/hypertrophy contributes significantly to overall airway remodeling and correlates with decline in lung function. (harvard.edu)
  • Airway smooth muscle (ASM) hypertrophy is a cardinal feature of severe asthma, but the underlying molecular mechanisms remain uncertain. (nih.gov)
  • Whereas hypertrophy was similar in both TM groups, cell proliferation and Pax7 levels were more robust in the 6-h muscle, mainly posthatch, suggesting a differential effect of various TM periods on cell reservoir vs. hypertrophy and a high sensitivity of myoblasts to relatively small changes in heat duration with respect to these processes, which is manifested in the short and long term. (agri.gov.il)
  • Forced protein kinase B/Akt 1 activation is known to induce myocyte hypertrophy in other muscle types, and, since a number of mediators present in asthmatic airways can activate Akt signaling, we hypothesized that Akt activation could contribute to ASM hypertrophy in asthma. (nih.gov)
  • l -Citrulline (10 −8 M) significantly decreased rat aortic (A10 cell line) vascular smooth muscle proliferation. (aspetjournals.org)
  • We investigated the effect of ajoene on rat aortic smooth muscle cell proliferation as related to protein prenylation. (unipd.it)
  • demonstrated that neonatal mice are able to regenerate heart muscle after resection. (wikipedia.org)
  • One gene, jumonji (jmj), has been shown to start increasing in its expression in embryonic day 10.5 mice and is proposed to help cease the proliferation of cardiomyocytes by repressing the expression of cyclin D1. (wikipedia.org)
  • The proliferations of EPCs isolated from bone marrow of C57BL/6J mice were assessed by MTT after incubating the EPCs with a series of concentrations of CSE (1.0%, 2.5%, 5.0%, and 10.0%) for different times (3, 6, and 24 hours) as well as with 1.0% CSE in presence of 5-AZA-CdR for 24 hours. (hindawi.com)
  • The CSE showed dual effects on proliferation of EPCs isolated from mice. (hindawi.com)
  • Also in 1963, Dr. C. R. Ball and colleagues published a paper describing blood clots in the heart and coronary arteries, heart muscle degeneration, ventricular calcification and early death in mice fed a lard-rich diet ( 3 ). (blogspot.com)
  • Our previous studies showed that Gln had the potential to increase muscle fiber size in piglets 16 , but the mechanism was not clear. (nature.com)
  • IGF-I levels were higher in the TM groups than in controls, implying a mechanism by which heat manipulations in chicks affect muscle development, with locally secreted IGF-I playing a major role. (agri.gov.il)
  • After rinse with PBS, smooth muscle cell culture media (Cell Application Inc) was mixed and then seeded into 12 well culture plates coating with fibronectin (R & D, Minneapolis). (scirp.org)
  • Scholars@Duke publication: Smooth muscle cell proliferation in the occluded rat carotid artery: lack of requirement for luminal platelets. (duke.edu)
  • The relationship of intimal smooth muscle cell proliferation in the permanently occluded rat carotid artery to the presence or absence of luminal platelets was examined. (duke.edu)
  • however, constitutively active Akt1 did not cause disproportionate overaccumulation of smooth muscle (sm) α-actin and SM22. (nih.gov)
  • AGE-stimulated smooth-muscle proliferation increases the thickness of vessel walls. (health.am)
  • Fibrinogen is an essential blood-clotting factor and is involved in a range of other functions, including platelet aggregation and smooth muscle proliferation. (cdc.gov)
  • Moss J. LAM and Other Diseases Characterized by Smooth Muscle Proliferation . (medscape.com)
  • Overall, Gln supplementation stimulated cell proliferation in muscle tissue and in vitro in myogenic cell culture, whereas muscle growth regulatory genes were barely altered. (nature.com)
  • The aim of the current study is to observe the effect of CSE on biological behavior of EPCs and, further, to search for potential candidate agent in protection of proliferation of EPCs against the damage caused by CSE exposure in vitro . (hindawi.com)
  • The 5-AZA-CdR partly protected the proliferation of EPCs against the damage caused by CSE exposure in vitro , suggesting that DNA methylation may be involved in the dysfunction of EPCs induced by CSE. (hindawi.com)
  • Feeding with amino acids can stimulate protein synthesis in all tissues, especially in skeletal muscle as reviewed by Davis et al. (nature.com)
  • The ankyrin-B protein is active in many cell types, particularly in the brain and in heart (cardiac) muscle. (medlineplus.gov)
  • RNA sequencing data revealed a high expression of CHL1 in pancreatic islets and adipose tissues compared to liver and muscles tissues. (lu.se)
  • In summary, we speculate that resveratrol inhibits angiotensin II-induced cell proliferation and endothelin-1 gene expression, and does so in a manner which involves the disruption of the ERK pathway via attenuation of reactive oxygen species generation. (tmu.edu.tw)
  • Meat science and muscle biology symposium: stem cell niche and postnatal muscle growth, J. Anim. (copernicus.org)
  • These results suggest that the growth factor is secreted from DM-SMCs as an autocrine system, which increases the proliferation of nonDM-SMCs. (diabetesjournals.org)
  • Our study provides clear evidence that increased nPKC expression contributes to PASMCs proliferation and uncovers the correlation between AKT and ERK pathways and nPKC-mediated proliferation of PASMCs. (bvsalud.org)
  • Collectively, our data provide mechanisms of a novel function of IgE which may contribute, at least in part, to airway remodeling observed in allergic asthma by directly inducing HASM cell proliferation. (harvard.edu)
  • The cardiomyocytes of neonatal rats and piglets are also able to undergo proliferation in response to injury during the first week of life. (wikipedia.org)
  • 3) Cell counting, DNA synthesis, and cell cycle analysis showed that ajoene (1-50 micro M) interfered with the progression of the G1 phase of the cell cycle, and inhibited rat SMC proliferation. (unipd.it)
  • Overview of Interstitial Lung Disease Interstitial lung diseases are a heterogeneous group of disorders characterized by alveolar septal thickening, fibroblast proliferation, collagen deposition, and, if the process remains unchecked. (msdmanuals.com)
  • The proliferations of EPCs were significantly enhanced after 3 hours of exposure to concentrations of 1.0% and 2.5% CSE but depressed when exposed to concentrations of 5.0% and 10.0% CSE. (hindawi.com)
  • Cell culture experiments indicated that Gln could promote cell proliferation in a dose dependent manner, but expression of myogenesis regulatory genes was not altered. (nature.com)
  • Cell proliferation in over-loaded rat soleus muscles: myofiber splitting vs myogenesis. (cdc.gov)
  • Immunostains of human airway sections revealed concordant activation of Akt (reflected in Ser(473) phosphorylation) and of its downstream effector p70(S6Kinase) (reflected in Thr(389) phosphorylation) within airway muscle bundles, but there was no phosphorylation of the alternative Akt downstream target glycogen synthase kinase (GSK) 3β. (nih.gov)
  • RNA-sequencing was used to investigate the expression of CHL1 in human adipose, liver, muscle, and human islets. (lu.se)
  • Muscle growth of low birth weight (LBW) piglets may be improved with adapted nutrition. (nature.com)
  • More proliferation was observed in muscle tissue of LBW-GLN than LBW-ALA piglets at 5 dpn, but there was no clear effect of supplementation on related gene expression. (nature.com)
  • The delayed growth of LBW piglets is mainly due to a slower development of skeletal muscle as the myogenic activity is usually impaired in these animals during the fetal and early postnatal period 3 , 4 . (nature.com)
  • Expression of muscle growth related genes was quantified with qPCR. (nature.com)
  • Enhanced Pain Relief and Muscle Growth in Individuals with Low Back Instability: The Impact of Blood Flow R. (medscimonit.com)
  • The effects of selection of pigs on growth rate vs leanness on histochemical characteristics of different muscles, J. Anim. (copernicus.org)
  • We show that incubation at 39.5°C (increase of 1.7°C from normal conditions) from embryonic days 16 to 18 (E16 to E18) for 3 or 6 h daily increased diameter of myofibers as of day 13 of age and enhanced absolute muscle growth relative to controls, until day 35 of age. (agri.gov.il)
  • A diet with blueberries might improve muscle growth and repair, finds a new study which revealed that the low-calorie dark blue colored berries might improve one's potential for preservation and recovery of skeletal muscle mass. (ibtimes.com)
  • They then investigated how the serum would affect muscle progenitor cell function by calculating the cell number, capacity to manage oxidative stress, etc. (ibtimes.com)
  • This preliminary study of muscle progenitor cell function paves the way for future studies to develop clinical interventions," EurekAlert quoted the study's lead author Anna Thalacker-Mercer, Ph.D. (ibtimes.com)
  • We treated PASMCs with agonists or inhibitors of PKCdelta (PKCδ) and PKCepsilon (PKCε) and exposed them to hypoxia or normoxia for 72 h, then measured the proliferation of PASMCs. (bvsalud.org)