CAR endows T cells antigen specific recognition, activation and proliferation in an MHC independent manner. (biomedcentral.com)
T-LYMPHOCYTES, preventing their activation and proliferation. (nih.gov)
Moreover, mixed lymphocyte reactions showed that IL-15/N-803 enhanced responder CD8 T cell activation and proliferation, compared to IL-2 alone. (ppf.eu)
https://nhtsa.gov/Driving-Safety/Aggressive-Driving) HN - 2019 MH - Alefacept UI - D000077944 MN - D12.776.124.486.485.114.619.393.131 MN - D12.776.124.790.651.114.619.393.131 MN - D12.776.377.715.548.114.619.393.131 MN - D12.776.395.550.34.500 MN - D12.776.543.550.158.500 MN - D12.776.828.300.100 MS - A recombinant human fusion protein of LFA-3 antigen and immunoglobulin IGG1 that binds to CD2 ANTIGENS on memory T-LYMPHOCYTES, preventing their activation and proliferation. (nih.gov)
Glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) signaling stimulates T cell activation and proliferation and can inhibit suppressive effects of regulatory T cells (Treg). (acir.org)
Cancer47
Iliopoulou and colleagues did not use a myeloablative preparative regimen in their Phase I trial of adoptive transfer of allogeneic NK cells in advanced non-small-cell lung cancer. (medscape.com)
In autologous cancer immunotherapy, T cells are extracted from the patient, genetically modified and cultured in vitro and returned to the same patient. (wikipedia.org)
The findings, which have implications for cancer immunotherapy, were published today in Nature . (stjude.org)
T cells are used in adoptive cell therapy (ACT) to target and kill cancer cells. (stjude.org)
This variance in efficacy is partly because tumors promote T-cell exhaustion, in which the cells are less effective at actively killing cancer. (stjude.org)
Recent years have witnessed much progress in both basic research and clinical trials regarding cancer immunotherapy with chimeric antigen receptor (CAR)-engineered T cells. (biomedcentral.com)
In this review, we focus on the critical issues related to the clinical outcomes of CAR-based adoptive immunotherapy and discuss the rationales to refine this new cancer therapeutic modality. (biomedcentral.com)
Adoptive immunotherapy (AIT) using chimeric antigen receptor-engineered T cells is a promising approach in cancer treatment. (biomedcentral.com)
Besides these beneficial effects, the technical feasibility of CAR makes it even more attractive in the development of cancer adoptive immunotherapy. (biomedcentral.com)
Conclusion NK101 is a unique NK cell line bearing strong immunostimulatory potential and substantial scalability, providing an attractive source for adoptive cancer immunotherapy. (bmj.com)
One reason many current forms of cancer immunotherapy have low clinical response rates is because they fail to activate the innate immune system - a prerequisite for forming long-lasting adaptive immune responses that are necessary to eliminate tumors and prevent their recurrence. (mdanderson.org)
Several CCIR members are investigating the development and function of innate immune cells and receptor-mediated signal transduction pathways leading to expression of cytokines and costimulatory molecules involved in T cell activation and differentiation in order to find ways to enable cancer immunotherapy to activate innate immunity leading to durable anti-tumor T cell responses. (mdanderson.org)
In this review, we firstly summarize the methodology to establish PDX models and then go over recent application and function of PDX models in basic cancer research on the areas of cancer characterization, initiation, proliferation, metastasis, and tumor microenvironment and in preclinical explorations of anti-cancer targets, drugs, and therapeutic strategies and finally give our perspectives on the future prospects of PDX models. (biomedcentral.com)
In an investigation of adoptive immunotherapy, the National Cancer Institute (NCI) enlisted patients with metastatic malignant melanoma, hypernephroma and colon carcinoma for an extramural group study. (ndnr.com)
These findings are the first to show tumor-specific brain resident CD8 + T RM generation via adoptive cellular treatment and may have promising implications for cancer immunotherapy. (researchsquare.com)
Adoptive T cell immunotherapy (ATCT) for cancer entails infusing patients with T cells that recognise and destroy tumour cells. (manchester.ac.uk)
The longer term toxicities and efficacy are not at all clear," said Dr. Bruce Chabner of Massachusetts General Hospital Cancer Center, as quoted by ABC News . (cancer.org)
The global cancer immunotherapy drug discovery outsourcing market size was valued at USD 1.04 billion in 2021 and is predicted to reach at USD 3.33 billion by 2030, increasing at a CAGR of 13.79% from 2022 to 2030. (straitsresearch.com)
It is possible to outsource the research and development of new cancer immunotherapy drugs to companies that specialize in this area. (straitsresearch.com)
With Cancer-Immunotherapy-Drug-Discovery-Outsourcing, you may benefit from cutting-edge technology, knowledge, and resources while also slashing your project's overall cost and lead time to market. (straitsresearch.com)
The rise of the cancer-immunotherapy-drug-discovery-outsourcing market is mostly due to an increase in the incidence and mortality rates associated with cancer. (straitsresearch.com)
The global cancer-immunotherapy-drug-discovery-outsourcing market is being fueled by the rising incidence of cancer. (straitsresearch.com)
Cancer immunotherapy medications, for example, are projected to see increased demand as a result of this high incidence rate, which is expected to drive the market's expansion throughout the forecast period. (straitsresearch.com)
Cancer-immunotherapy-drug-discovery-outsourcing market participants can expect profitable prospects in the next few years as the prevalence of the disease continues to rise. (straitsresearch.com)
Global cancer-immunotherapy-drug-discovery-outsourcing market is being fueled by a growing awareness of cancer treatment developments, as well as a growing investment by renowned pharmaceutical firms to outsource the numerous tasks associated with the process of drug-discovery. (straitsresearch.com)
Immunotherapies are becoming increasingly important in the cancer treatment because of their ability to reduce the likelihood of tumor recurrence following chemotherapy. (straitsresearch.com)
The global cancer-immunotherapy-drug-discovery-outsourcing market is developing as a result of the increasing research and development efforts to find new cancer treatments that are more effective. (straitsresearch.com)
Advanced treatment options such HDAC inhibitors, oncolytic viruses, cancer vaccines, as well as monoclonal antibodies are also expected to have a favorable impact on the global cancer-immunotherapy-drug-discovery-outsourcing market. (straitsresearch.com)
2. Type of Stem Cells for Cancer Treatment Stem cells from different sources exhibit different capacities of proliferation, migration, and differentiation, which determine their application in anti-tumor therapy. (healthanddietblog.info)
Checkpoint inhibitors are a type of targeted immunotherapy that blocks proteins that stop the immune system from attacking the cancer cells. (healthquestionsmatters.com)
However, monoclonal antibodies are generated in the lab to recognize specific targets, including cancer cells and the pathways that promote their growth within the tumor microenvironment , such as angiogenesis, proliferation, invasion, and metastasis. (healthquestionsmatters.com)
Adoptive T cell transfer is a therapy that uses the immune system to fight cancer by increasing the number of lymphocytes T that attack cancer cells. (healthquestionsmatters.com)
Immunotherapy is a treatment that promotes the immune response in fighting diseases, such as cancer, through the stimulation of the natural defenses of the immune system to work harder and smarter in finding and attacking cancer cells. (healthquestionsmatters.com)
Advances using other applications of monoclonal antibodies, such as bispecific monoclonal antibodies [6], should lead to further efficacy in treating cancer patients. (healthquestionsmatters.com)
NK cells are a promising alternative to T cells for cancer immunotherapy. (ppf.eu)
With numerous and fast approvals of different agents including immune checkpoint inhibitors, monoclonal antibodies, or chimeric antigen receptor (CAR) T-cell therapy, immunotherapy is now an established form of cancer treatment. (biomedcentral.com)
Further advances in the effectiveness of cancer immunotherapies will require new approaches that include redefining the optimal dose to be carried forward in later phases, incorporating additional endpoints in the dose selection process (PK, PD, immune-based biomarkers), developing personalized biomarker profiles, or testing drug combination therapies to improve efficacy and reduce toxicity. (biomedcentral.com)
Other immune-oncology treatment strategies include monoclonal antibodies, cancer vaccines, and adoptive T-cell therapies such as chimeric antigen receptor (CAR)-modified T-cells. (biomedcentral.com)
Mesothelin, which is overexpressed in pancreatic cancer and other solid tumors, is a potential target for pancreatic cancer immunotherapy. (oncotarget.com)
Renier J. Brentjens spends much of his time researching Chimeric antigen receptor, Cancer research, Immunotherapy, Antigen and Internal medicine. (research.com)
His work carried out in the field of Immunotherapy brings together such families of science as Tumor microenvironment, Ovarian cancer and Genetic enhancement. (research.com)
Renier J. Brentjens mainly investigates Antigen, Immunotherapy, Chimeric antigen receptor, Internal medicine and Cancer research. (research.com)
The Cellular Immunotherapy of Cancer study section will focus on the many approaches to cellular therapy, including stem cell transplantation, adoptive cellular therapies and their toxicities, as well as therapeutic combinations that employ adoptive and allogeneic cell transfer. (nih.gov)
Adoptive cellular therapies (TILs, CAR- and TCR-engineered T cells, NK/NKT cells) using immune cells as cancer treatment. (nih.gov)
Therapeutic8
The therapeutic potential for adoptive transfer of allogeneic NK cells is limited by several entities, the number one being the failure of donor NK cells to expand in vivo . (medscape.com)
We believe that this highly-differentiated therapeutic paradigm - systematically and precisely programming the biological properties and therapeutic function of cells ex vivo prior to adoptive transfer - is a reproducible, scalable and cost-effective approach to maximize the safety and efficacy of cellular immunotherapies. (fatetherapeutics.com)
Interleukin-12 (IL-12) gene transfer enhances the therapeutic potency of adoptive T cell therapies. (unav.edu)
We previ-ously reported that transient engineering of tumor-specific CD8 T cells with IL-12 mRNA enhanced their sys-temic therapeutic efficacy when delivered intratumorally. (unav.edu)
Together our data suggests that these T cells are likely to display enhanced engraftment and persistence in patients in vivo and could therefore improve therapeutic efficacy of ACTC. (manchester.ac.uk)
Caspase activity within spheroids, quantitative evaluation of NK infiltration into spheroids) and NK-based therapeutic efficacy. (frontiersin.org)
Depleting intratumoral CD4+CD45+ regulatory T cells via Fasl protein transfer enhances the therapeutic efficacy of adoptive T cell transfer. (nature.com)
Along with highlighting these issues, we speculate that memory NK cell-based adoptive immunotherapy settings would greatly take advantage from the combination with tumor-targeting therapeutic antibodies (mAbs), as a strategy to fully unleash their clinical efficacy. (hindawi.com)
Differentiation7
The scientists showed they could precisely interrupt the flow of the differentiation process, thereby enhancing antitumor efficacy. (stjude.org)
Their work showed which individual transcription factors and their networks are responsible for each T cell differentiation state, providing targets for improving immunotherapy. (stjude.org)
Thus, induction of Fas signaling enhanced T cell differentiation and impaired antitumor immunity, while Fas signaling blockade preserved the antitumor efficacy of naive cells within mixed populations. (nih.gov)
These findings reveal that T cell subsets can synchronize their differentiation state in a process similar to quorum sensing in unicellular organisms and suggest that disruption of this quorum-like behavior among T cells has potential to enhance T cell-based immunotherapies. (nih.gov)
T cells of early differentiation possess an increased capacity for proliferation and therefore persistence, using these cells for ATCT could therefore lead to improved clinical outcomes. (manchester.ac.uk)
T cells of early differentiation possess an increased capacity for proliferation and therefore persistence, using these cells for ATCT could therefore lead to improved clinical outcomes.MethodWe describe a method to enrich T cells of early differentiation status using paramagnetic beads and antibodies targeting cells expressing C-C motif chemokine receptor 7 (CCR7).ResultsSelection of cells expressing CCR7 enriches T cells of bearing markers of early differentiation status. (manchester.ac.uk)
Chimeric5
Among ACTs, chimeric antigen receptor (CAR) T cells have shown clinical efficacy in blood cancers but have not been as effective in solid tumors. (stjude.org)
Adoptive transfer of T cells engineered with chimeric antigen receptors (CART cells) was effective for treating CD19-positive leukemia, but it is more difficult for CART cells to eliminate solid tumors. (oncotarget.com)
His primary areas of study are Immunology, Chimeric antigen receptor, Antigen, Immunotherapy and T cell. (research.com)
However, no efficacy was detected in WT mice that received the chimeric bispecifics, which confirms that co-engagement of PD-1 and GITR is necessary for its activity. (acir.org)
Therapies4
In the future, this model may be applied to optimize the efficacy of CAR-T-based therapies in aggressive and inoperable tumors such as glioblastoma. (frontiersin.org)
It could improve the restorative efficacy of additional therapies due to its enhanced target on tumors, thereby reducing off-target events. (healthanddietblog.info)
Adoptive therapies with allogeneic, cytokine-activated NK cells are being investigated in clinical trials. (ppf.eu)
Applications studying the immunopathology and immunotherapy of central nervous system tumors (glioma, medulloblastoma, etc.) may be reviewed in either CNBT or CIC (if focus is on cellular therapies). (nih.gov)
Cells36
A question that remains is whether the proliferation and expansion of adoptively transferred NK cells may be limited by host factors, including immune rejection by effector T cells, suppression by myeloid-derived suppressor cells, which have been widely studied for their suppressive properties in tumor models, [ 115-117 ] and suppression by Tregs, known to maintain tolerance to self/tumor. (medscape.com)
Improvements in techniques to make tumor cells more susceptible to the effects of NK cell cytotoxicity will ultimately increase the clinical efficacy of NK cell-based immunotherapy. (medscape.com)
Several in vitro and mouse models demonstrate that Tregs are able to profoundly inhibit NK cell proliferation and activation [ 120 ] and reduce the number of NK cells recruited to the tumor site. (medscape.com)
Adoptive cell transfer (ACT) is the transfer of cells into a patient. (wikipedia.org)
Using advanced molecular characterization tools and technologies, we identify small molecule and biologic modulators that promote rapid and supraphysiologic activation or inhibition of therapeutically-relevant genes and cell-surface proteins, such as those involved in the homing, proliferation and survival of CD34 + cells or those involved in the persistence, proliferation and anti-tumor activity of NK cells and T cells. (fatetherapeutics.com)
Animal-Free TM Recombinant Human IL-2 (Catalog # BT-002-AFL) as measured in a cell proliferation assay using CTLL-2 mouse cytotoxic T cells. (rndsystems.com)
Equivalent bioactivity of GMP ( BT-002-GMP ) Animal-Free (Catalog # BT-002-AFL) and RUO ( BT-002 ) grades of Recombinant Human IL-2 as measured in a cell proliferation assay using CTLL-2 mouse cytotoxic T cells (orange, green, red, respectively). (rndsystems.com)
Scientists at St. Jude Children's Research Hospital comprehensively mapped the regulatory networks of transcription factors in T cells present in tumors, finding ways to increase anticancer efficacy. (stjude.org)
T cells are the cornerstone of tumor immunotherapy, and we found a new way to reprogram T cells to make them more effective," said Hongbo Chi , Ph.D., St. Jude Department of Immunology . (stjude.org)
Even more promising, when the researchers combined their modified T cells with a type of immunotherapy called immune checkpoint blockade, they further increased antitumor activity. (stjude.org)
Adoptive cell transfer (ACT) of purified naive, stem cell memory, and central memory T cell subsets results in superior persistence and antitumor immunity compared with ACT of populations containing more-differentiated effector memory and effector T cells. (nih.gov)
In this review, we will briefly discuss the critical issues related to the antitumor efficacy including the structure of CAR, the potential of T cells subsets, the gene modification of lymphocytes, the preconditioning regimens, etc. (biomedcentral.com)
The efficacy and safety of adoptive CAR-engineered T cells have been evaluated in multiple oncological settings. (biomedcentral.com)
Using a melanoma model of adoptive T cell therapy (ACT), we show that FOXP3 overexpression in mature CD8 T cells improved their antitumor efficacy, favoring their tumor recruitment, proliferation, and cytotoxicity. (unav.edu)
Our findings demonstrate a hitherto unknown role for FOXP3 in the adaptation of CD8 T cells to TME that may enhance their efficacy in ACT. (unav.edu)
In immunocompetent patients, proliferation of transformed B cells usually is controlled by cytotoxic T cells. (medscape.com)
The consequence of such expressional and functional discrepancies was well-represented in (i) indirect co-culture system where conditioned medium derived from NK101 induced greater proliferation of human peripheral blood mononuclear cells and (ii) immunocompetent 4T1 tumor model where peritumoral injections of NK101 displayed stronger anti-tumor activities by inducing higher tumor-specific immune responses. (bmj.com)
17. Divergent roles for CD4+ T cells in the priming and effector/memory phases of adoptive immunotherapy. (nih.gov)
In attempt to improve the clinical efficacy of adoptive cell therapy we created three classes of genetic adjuvants designed to operate autonomously in gene-modified T cells. (aacrjournals.org)
The membrane cytokines were found to act mainly in-cis and each could support the proliferation of human CD8 and CD4 T cells for at least 6 days post-transfection, at a magnitude comparable to a saturating dose of soluble IL-2. (aacrjournals.org)
CCR7 selection resulted in dramatic 83.6 and 137 fold increases in circulating levels of CD4 and CD8 T cells respectively compared to non-sorted T cells 3 weeks after adoptive transfer to NSG mice. (manchester.ac.uk)
This type of immunotherapy aims to boost the number of white blood cells, including killer T cells and natural killer cells, and relies on interleukins and interferons. (healthquestionsmatters.com)
Here, we demonstrate that myeloid-derived suppressor cells (MDSCs) secrete itaconate that can be taken up by CD8+ T cells and suppress their proliferation, cytokine production and cytolytic activity. (biomed.news)
Metabolite profiling, stable-isotope tracing and metabolite supplementation studies indicated that itaconate suppressed the biosynthesis of aspartate and serine/glycine in CD8+ T cells to attenuate their proliferation and function. (biomed.news)
Our findings not only reveal a previously unknown role of itaconate as an immune checkpoint metabolite secreted from MDSCs to suppress CD8+ T cells, but also establish IRG1 as a myeloid-selective target in immunometabolism whose inhibition promotes anti-tumour immunity and enhances the efficacy of immune checkpoint protein blockade. (biomed.news)
Interleukin-17-producing CD4 T cells (TH17s) are mediators of host defense, autoimmunity, and antitumor immunity in the setting of adoptive T cell therapy. (biomed.news)
Adoptive cell transfer therapy with CAR T cells. (actanaturae.ru)
Tumor recognition is mediated by the antigen-recognition domain of a CAR, while its intracellular part induces T cell activation, which results in the destruction of tumor cells and proliferation of CAR T cells. (actanaturae.ru)
Dr. Heimberger emphasized the need for distribution of effector immune cells uniformly within the tumor by highlighting localization of CMV T cells mainly within the perivascular space in a clinical trial of adoptive transfer of CMV-specific T cells in glioblastoma [6]. (wfnos.org)
She then showed that neuronal activity increases proliferation of malignant glioma cells just like it does in their normal counter parts through secreted factors, BDNF and NLGN3, and that inhibition of NLGN3 release through inhibition of its sheddase, ADAM10, blocks glioma growth [8, 9]. (wfnos.org)
A commentary that appeared in the same issue of the journal in which the NIH study was published, reported: "The clinical application of T cell immunotherapy depends on ex vivo modification and expansion of T cells for adoptive transfer. (nih.gov)
It induced longer overall survival in CT26, EMT6, and JC tumor models, and efficacy was correlated with an increase in the percentage of ICOS- and Ki67-expressing CD8 + T cells. (acir.org)
This article summarizes recent evidence in the literature on the peculiar features that render memory NK cells an attractive tool for antitumor immunotherapy, including their long-term survival and in vivo persistence, the resistance to tumor-dependent immunosuppressive microenvironment, the amplified functional responses to IgG-opsonized tumor cells, and in vitro expansion capability. (hindawi.com)
Upon reinfection, these memory NK cells undergo secondary expansion, rapidly degranulate, and release cytokines, leading to a protective immune response, and also provide protection to newborn mice challenged with MCMV, upon adoptive transfer [ 16 ]. (hindawi.com)
Tumor microenvironment2
Additionally, they can control malignancy proliferation by influencing the tumor microenvironment and immune system. (jcancer.org)
In addition, through adoptive transfer experiments, we demonstrated that OXPHOS protected TH17s from apoptosis while enhancing their persistence in the periphery and tumor microenvironment in a murine model of melanoma. (biomed.news)
Vivo1
Finally, in vivo antitumor efficacy was evaluated in an immunocompetent, syngeneic 4T1 mammary tumor model. (bmj.com)
Preclinical2
Adoptive immunotherapy (AIT) using this supernatural T cell have gained momentum after decades of intense debates because of the promising results obtained from preclinical models and clinical trials. (biomedcentral.com)
Applications that focus on involving preclinical cellular immunotherapy and combination with immunotherapy/chemotherapy may be reviewed in CIC. (nih.gov)
Checkpoint3
Both approaches improved antitumor efficacy in our immune checkpoint blockade models. (stjude.org)
Immunotherapy, like the usage of monoclonal antibodies, checkpoint inhibitors, cancers vaccines, and adoptive cell transfer, today becomes a significant curative for cancers with improved clinical final results significantly. (healthanddietblog.info)
For this purpose, it relies on several types of applications, including immune system modulators, checkpoint inhibitors, monoclonal antibodies, and adoptive cell transfer. (healthquestionsmatters.com)
Tumors2
A SOT101 monotherapy arm of the study demonstrated encouraging efficacy signals in the 30 patients with advanced/metastatic solid tumors, including in CPI refractory patients. (ppf.eu)
Amy Heimberger from Northwestern University presented her lecture titled "The Immune Landscape of CNS Tumors: Implications for Immunotherapy. (wfnos.org)
Cytokine2
However, the optimal cytokine support after adoptive transfer to promote NK cell expansion, and persistence remains unclear. (ppf.eu)
Combining NK cell-based immunotherapy with chemotherapy schemas other than Hi-Cy Flu is of potential interest. (medscape.com)
In recent years, the treatment methods for CCA have become more and more diversified, including more mature and effective surgical treatment, radiotherapy and chemotherapy in the first-line treatment, especially immunotherapy, targeted therapy and combination therapy that have recently become hot spots. (jcancer.org)
Because of their capacity to reduce the likelihood of recurrence of tumours after chemotherapy, pharmaceutical companies are increasingly focused on immunotherapies. (straitsresearch.com)
Immunity1
Oncolytic viruses that incorporate immunomodulatory transgenes to modulate tumor immunity and increase efficacy as well as reduce systemic side effects. (nih.gov)
Autologous1
Taking into account the important function of Tregs in the control of autoimmunity and oncogenesis, approaches to immunotherapy of inflammatory pathologies based on autologous and donor Tregs, as well as methods of activating an antitumor immune response as a result of selective blockade of the functional activity of Tregs, are being actively developed. (genescells.ru)
Melanoma1
4. Enhanced local and systemic anti-melanoma CD8+ T cell responses after memory T cell-based adoptive immunotherapy in mice. (nih.gov)
We compared the underlying toxicity and efficacy assumptions of cytotoxic versus immune-oncology agents, proposed novel endpoints to be included in the dose-selection process, and reviewed design considerations to be considered for early-phase trials. (biomedcentral.com)
Improve the clinical1
Adjuvant adoptive immunotherapy can significantly improve the clinical prognosis in the early stage. (bvsalud.org)
Toxicities1
More commonly, multidrug regimens incorporating drugs with different mechanisms of action and different toxicities are used to increase efficacy, reduce dose-related toxicity, and decrease the probability of drug resistance. (msdmanuals.com)
Effector1
Upon antigen stimulation they rapidly upregulate glycolysis and oxygen to produce high levels of ATP and nucleotides required for cell proliferation and effector functions. (nih.gov)
Conclusion1
Conclusion: Hay que sospechar esta patología en pacientes con antecedentes de hepatopatía viral, plantear screening adecuado para un diagnóstico temprano y la mejor resolución adaptada a cada paciente. (bvsalud.org)
Survival1
Although in recent years, with the significant advances of surgical technique and the positive progress of targeted and immunotherapy in the field of hepatocellular carcinoma, the survival of hepatocellular carcinoma patients has improved, but the risk of surgery in patients with portal hypertension complicated with hepatocellular carcinoma remains high, and surgical treatment is still controversial. (bvsalud.org)
Blockade1
16. Improvement of PD-1 Blockade Efficacy and Elimination of Immune-Related Gastrointestinal Adverse Effect by mTOR Inhibitor. (nih.gov)
Approaches1
These include antiangiogenic agents, immunotherapy, bacterial agents, viral oncolysis, targeting of cyclic-dependent kinases and tyrosine kinase receptors, antisense approaches, gene therapy and combination of various methods. (researchandmarkets.com)
Suppress1
Some of these techniques include selective depletion of Tregs, which have been shown to suppress NK cell proliferation and killing. (medscape.com)
Therapy4
[ 118 ] These findings beg the question of whether Treg depletion will be needed for effective adoptive cellular therapy, especially those that utilize IL-2 as part of the therapy platform. (medscape.com)
The efficacy of molecular targeted drugs as an adjuvant therapy deserves further study. (bvsalud.org)
Genes1
Genome-wide analysis revealed that genes associated with positive regulation of leukocyte proliferation were overexpressed in NK101, while those with opposite function were highly enriched in NK-92. (bmj.com)