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  • pathway
  • Data suggest that the binding, but not the internalization of photoreceptor outer segments (POS) confers protective effects on retinal pigment epithelium (RPE) cells through the alphavbeta5 integrin/focal adhesion kinase (FAK)/PGC-1alpha pathway. (nih.gov)
  • function
  • Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. (nih.gov)
  • variants
  • We examined the possibility that the alpha6A and alpha6B cytoplasmic domain variants of the alpha6beta1 integrin differentially activate p42 and p44 mitogen-activated protein (MAP) kinases. (semanticscholar.org)
  • L. Pulkkinen and J. Uitto, "Hemidesmosomal variants of epidermolysis bullosa: Mutations in the αβ integrin and the 180-kD bullous pemphigoid antigen/type XVII collagen genes," Experimental Dermatology , vol. 7, no. 2-3, pp. 46-64, 1998. (hindawi.com)
  • Thus
  • Thus, TN-C promoted epithelial cell proliferation leading to luminal filling, a process that we hypothesized involved c-met, a proto-oncogene amplified in breast tumors that promotes intraluminal filling. (genes2cognition.org)
  • peptide
  • The crystal structure of a complex between the I domain of integrin alpha2beta1 and a triple helical collagen peptide containing a critical GFOGER motif has been determined. (sdbonline.org)
  • form
  • The epitope for an antibody that binds only to the high-affinity form of the alphaMbeta2 integrin maps to loop 1 and helix alpha7 of the I domain, a region that undergoes extensive conformational changes between the closed and open forms. (sdbonline.org)
  • human
  • Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for human metapneumovirus (PubMed:12907437). (nih.gov)
  • Integrin ITGA2:ITGB1 acts as a receptor for human parvovirus B19 (PubMed:24478423). (nih.gov)