• β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. (wikipedia.org)
  • Notably, the C-terminal segment of β-catenin can mimic the effects of the entire Wnt pathway if artificially fused to the DNA binding domain of LEF1 transcription factor. (wikipedia.org)
  • The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. (nih.gov)
  • Knockdown of FRAT1 inhibits hypoxia-induced epithelial-to-mesenchymal transition via suppression of the Wnt/β-catenin pathway in hepatocellular carcinoma cells. (nih.gov)
  • The Wnt pathway mediates the biological processes of the canonical or non-canonical pathway, depending on the involvement of β-catenin in signal transduction. (chemdiv.com)
  • The recently described role of the Wnt/β-catenin pathway in the regulation of immune cell infiltration of microenvironment tumor resumes interest because of its potential impact to rection of immune therapy. (chemdiv.com)
  • This article presents the roles of the Wnt/β-catenin pathway in cancer and current therapeutic strategies involving this pathway. (chemdiv.com)
  • Nussе and Varmus identified components of the Wnt/β-catenin pathway in 1982 in a study of oncogenic breast tumor viral diseases (MMTV) [1]. (chemdiv.com)
  • Transducin-like enhancer of split 1 (TLE1) belongs to the Groucho/TLE family, and it functions in the "off" state in the Wnt/β-catenin signaling pathway. (biomedcentral.com)
  • We hypothesized that if the dysregulation of the Wnt/β-catenin signaling pathway could be attributed to the tumorigenesis of BCA/BCAC, there might be differences in TLE1 expression between BCA and BCAC. (biomedcentral.com)
  • In the presence of Wnt signal stimulation or an activating CTNNB1 gene mutation, β-catenin stabilizes and moves into the nucleus and interacts with T-cell factor (TCF)/lymphoid enhancer factor (LEF), which represents the "on" state of the Wnt/β-catenin signaling pathway and leads to an increase in the transcription of the target gene associated with the pathway [ 3 ]. (biomedcentral.com)
  • The association of TLE1 and tumors was first detected in synovial sarcomas through gene expression profiling, and TLE1 was found to be profoundly involved in the Wnt/β-catenin signaling pathway in synovial sarcomas [ 12 , 13 ]. (biomedcentral.com)
  • However, studies have identified the beta-catenin pathway as playing a potential role in the pathogenesis of these tumors. (medscape.com)
  • [ 3 ] Beta-catenin is a downstream component of the Wnt signal transduction pathway that plays critical roles in the regulation of cellular proliferation, morphology, and development. (medscape.com)
  • In view of this finding, it was decided to study stromal-epithelial interactions in these tumours by examining the Wnt-APC-beta-catenin pathway. (ox.ac.uk)
  • These data suggest that stromal proliferation in benign phyllodes tumours relies on abnormalities in the Wnt pathway which result not from mutation, but from Wnt5a expression in the epithelium. (ox.ac.uk)
  • In the progression to malignancy, the stromal proliferation appears to become independent of the Wnt pathway and, presumably, of the epithelial component of these tumours. (ox.ac.uk)
  • Background: This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. (icbinhibitor.com)
  • Hyperactivation of the Wnt/β-catenin signaling pathway due to mutations in its components initiates the majority of colorectal cancer (CRC) cases and promotes CRC development. (esmed.org)
  • In the past decade, accumulating evidence revealed that nuclear receptors (NRs) modulated Wnt/β-catenin signaling activity via binding to diverse members of this pathway. (esmed.org)
  • Wogonin induced G1 cell cycle arrest by regulating Wnt/β-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells. (esmed.org)
  • GSK-3β helps maintain malignant cell survival and proliferation, particularly in terms of mediating resistance to standard anti-cancer therapies, through the NF-κB pathway. (outcomes4me.com)
  • Despite this clearly defined genetic etiology and the strict and unique implication of the Wnt/β-catenin pathway, no specific molecular targets for these tumors have been identified. (xenbase.org)
  • Hyperactivation of the Wnt/β-catenin signaling pathway via truncation of Apc or constitutive activation of β-catenin induces desmoid tumors in X. tropicalis. (xenbase.org)
  • Background Growing evidence shows that Wnt/-catenin pathway performs a significant role in CRC development, progression and metastasis. (opioid-receptors.com)
  • The aberrant activation of Wnt/-catenin signaling pathway is known as to be an important concern in tumorigenesis and development of CRC [2, 3]. (opioid-receptors.com)
  • The sign of the Wnt/-catenin pathway may be the build up and nuclear localization of -catenin [4, 5]. (opioid-receptors.com)
  • Within this research, we shown the critical function of miR-224 in activating Wnt/-catenin signaling pathway during colorectal development. (opioid-receptors.com)
  • Furthermore, we showed that both of Wnt/-catenin signaling pathway suppressors GSK3 and SFRP2 are real downstream goals of miR-224. (opioid-receptors.com)
  • Similarly, lncRNA H19 also was reported to promote osteogenic differentiation of rat ectomesenchymal stem cells through enhancing the expressions of osteogenic markers, beta-catenin, and target genes of Wnt/beta-catenin signaling pathway partly through sponging miR-22 and miR-141 [ 12 ]. (biomedcentral.com)
  • Our operate identifies miR-183-96-182 cluster gene as a downstream target regulated by b-Catenin/TCF/LEF-1 pathway in gastric cancer cells. (gpr120inhibitor.com)
  • The beta-catenin protein is also involved in cell signaling as an essential part of the Wnt signaling pathway. (medlineplus.gov)
  • Certain proteins in this pathway attach (bind) to beta-catenin, which triggers a multistep process that allows the protein to move into the cell nucleus. (medlineplus.gov)
  • The Wnt signaling pathway promotes the growth and division (proliferation) of cells and helps determine the specialized functions a cell will have (differentiation). (medlineplus.gov)
  • Catenin beta-1, also known as β-catenin (beta-catenin), is a protein that in humans is encoded by the CTNNB1 gene. (wikipedia.org)
  • Recently, the nuclear expression of β-catenin and a catenin beta-1 ( CTNNB1 ) mutation were found in BCA. (biomedcentral.com)
  • We performed immunohistochemistry to detect TLE1 and β-catenin and investigated the catenin beta-1 ( CTNNB1 ) mutational profile among BCA and BCAC cases. (biomedcentral.com)
  • Finally, desmoid type fibromatosis, a locally aggressive tumor that can present in the pleura, has been shown to frequently have CTNNB1 gene mutations and express β-catenin by immunohistochemistry. (nih.gov)
  • These are for the most part low-grade tumors that are characterized by a high frequency of mutations of KRAS , BRAF, ERBB2, CTNNB1 (the gene encoding beta catenin), and PIK3CA , low proliferation, and a 5-year survival of approximately 55% [ 2 ]. (hindawi.com)
  • Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. (bioss.com.cn)
  • The CTNNB1 gene provides instructions for making a protein called beta-catenin. (medlineplus.gov)
  • The aggregation of both amyloid beta (Abeta) peptides extracellularly and Tau proteins intracellularly plays key roles in the pathological consequences of AD, which lead to cholinergic neurodegeneration and eventually death. (inra.fr)
  • This library represents a selection of drug-like compounds aimed at modulating protein-protein interaction (PPI) of β-catenin with different proteins involved in significant physiological processes. (chemdiv.com)
  • The molecular weight of proteins were 102, 88 and 80 kDa, so they were named α, β and γ-catenin. (chemdiv.com)
  • XAV932 was used to assess the suppression of nuclear β-catenin and its downstream effect on EMT marker proteins and VEGF expression. (molvis.org)
  • Treatment with XAV932 significantly reduced the level of nuclear β-catenin, but the levels of neither the EMT marker proteins nor VEGF were changed. (molvis.org)
  • In marked contrast, data from the hypoxic condition clearly establish that nuclear β-catenin plays little apparent role in the expression of EMT marker proteins. (molvis.org)
  • Many laboratories have focused on the functions of the clock genes and proteins that are involved in cellular activities, including cell survival, cell cycle regulation, proliferation, apoptosis, DNA damage repair, and tumor promotion or suppression [ 5 , 6 ]. (explorationpub.com)
  • Cytoplasmic -catenin is definitely managed by the degradation complicated made up of adenomatosis polyposis coli (APC), Axin, proteins phosphatase 2A (PP2A), glycogen synthase kinase 3 beta (GSK3) and casein kinase 1 (CK1) [6C9]. (opioid-receptors.com)
  • Once in the nucleus, beta-catenin interacts with other proteins to control the activity (expression) of particular genes. (medlineplus.gov)
  • Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian and endometrial cancer. (wikipedia.org)
  • Forty-five of the tumours, including two malignant lesions, were screened for beta-catenin exon 3 mutations using SSCP and sequencing, but none was found. (ox.ac.uk)
  • These mutations lead to an abnormally stable beta-catenin protein that is not broken down when it is no longer needed. (medlineplus.gov)
  • This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. (icbinhibitor.com)
  • Unphosphorylated β-catenin accumulates in the nuclear and interacts with TCF/LEF factors to stimulate the transcription of the downstream target genes of Wnt/β-catenin signaling. (esmed.org)
  • Keratin 19 interacts with GSK3beta to regulate its nuclear accumulation and degradation of cyclin D3. (addgene.org)
  • In this research we display for the very first time to our understanding a Pkp-catenin particularly interacts having a transcription element. (healthyconnectionsinc.com)
  • GSK-3β is particularly important in tumor progression and modulation of oncogenes (including beta-catenin, cyclin D1 and c-Myc), cell cycle regulators (e.g. p27Kip1) and mediators of epithelial-mesenchymal transition (e.g. zinc finger protein SNAI1, Snail). (outcomes4me.com)
  • Aberrant overexpression of GSK-3β has been shown to promote tumor growth and chemotherapy resistance in various solid tumors including colon, ovarian, and pancreatic cancers and glioblastoma through differential effects on the pro-survival nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and c-Myc pathways as well on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and p53-mediated apoptotic mechanisms. (outcomes4me.com)
  • LncRNAs involved in tumor cell proliferation, apoptosis, invasion and metastasis [ 4 ] . (jcancer.org)
  • solid course="kwd-title" Keywords: miR-224, Proliferation, Invasion, Colorectal malignancy, Wnt/-catenin, GSK3, SFRP2 Background Human being colorectal malignancy (CRC) is among the most common forms of malignant tumor world-wide [1]. (opioid-receptors.com)
  • Long noncoding RNA NEAT1 (nuclear-enriched abundant transcript 1) inhibited hepatocyte proliferation in fulminant hepatic failure via strengthened recruitment of EZH2 to the LATS2 (large tumor-suppressor kinase 2) promoter region [ 18 ]. (biomedcentral.com)
  • Medulloblastoma is defined by the World Health Organization (WHO) as "an embryonal neuroepithelial tumor arising in the cerebellum or dorsal brainstem, presenting mainly in childhood and consisting of densely packed small round undifferentiated cells with mild to moderate nuclear pleomorphism and high mitotic count. (medscape.com)
  • This active beta-catenin protein promotes Wnt signaling longer than normal, which leads to the unchecked proliferation of kidney cells and tumor development. (medlineplus.gov)
  • Intranuclear accumulation of beta-catenin results in enhanced expression of target genes that play a critical role in cellular proliferation and differentiation. (medscape.com)
  • It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. (icbinhibitor.com)
  • Enriched expression of genes in LRECb was associated with stem cell attributes and identified WNT, TGF-β, and MAPK pathways of self renewal and proliferation. (frontiersin.org)
  • When Wnt signaling is definitely activated, -catenin is definitely discharged GNGT1 from your degradation of complicated leading to the translocation of -catenin into nucleus, where it affiliates using the T-cell element/lymphoid enhancer element (TCF/LEF) category of transcription elements to activate particular Wnt focus on genes [10, 11]. (opioid-receptors.com)
  • They cause the beta-catenin protein to be turned on all the time (constitutively active), which leads to the abnormal activation of certain genes. (medlineplus.gov)
  • These genes increase the proliferation and differentiation of cells associated with the hair follicle matrix. (medlineplus.gov)
  • Experimentally confirmed target genes were identified for the 73 diagnostic miRNAs, from which proliferation genes were selected from CRISPR-Cas9/RNA interference (RNAi) screening assays. (cdc.gov)
  • We demonstrated that the expression of PTN and PTPRZ1 was upregulated by chemotherapy, and this change in expression decreased chemosensitivity by promoting tumour proliferation and inhibiting apoptosis. (biomedcentral.com)
  • Here, we report that during intestinal inflammation, multiple inflammatory cytokines promote the activity of a master regulator of cell proliferation and apoptosis, serine/threonine kinase CK2. (diva-portal.org)
  • A double-negative feedback loop between Wnt-β-catenin signaling and HNF4α regulates epithelial-mesenchymal transition in hepatocellular carcinoma. (esmed.org)
  • Previous studies have reported that LINC00673 can promote epithelial-mesenchymal transition (EMT), proliferation and metastasis in thyroid carcinoma [ 5 ] . (jcancer.org)
  • The roles of b-catenin are 'classically' defined: as an adhesion protein and as a signaling protein, transducing extracellular signals to the nucleus to modify gene expression. (chemdiv.com)
  • Speaking more specifically, β-catenin is an integral structural component of cadherin-based adhesive junctions as well as it a key nuclear effector of canonical in nucleus Wnt signaling. (chemdiv.com)
  • While DDX5 is predominantly a nuclear protein, it can shuttle between the nucleus and the cytoplasm, depending upon cell cycle status, cell type, and given post-translational modification. (bellbrooklabs.com)
  • SB216763-treated HLE-B3 cells caused marked inhibition of GSK-3β activity prompting a significant increase in the translocation of cytoplasmic β-catenin to the nucleus. (molvis.org)
  • Removal of FRK-1 function results in relocalization of HMP-2 to the nucleus of epidermal cells, and allows it to substitute for WRM-1, the nuclear beta-catenin that normally transduces the Wnt signal during endoderm development. (hope.edu)
  • The in vitro treatment of intestinal epithelial cell lines with cytokines resulted in increased CK2 expression and nuclear translocation of its catalytic alpha subunit. (diva-portal.org)
  • Similarly, nuclear translocation of CK2alpha was a prominent feature observed in colonic crypts from individuals with ulcerative colitis and Crohn's disease. (diva-portal.org)
  • We demonstrated that promotion aftereffect of miR-224 on proliferation and invasion of individual CRC cells could possibly be manifested partly with the deposition and nuclear translocation of -catenin and eventually up-regulation of its transcriptional goals c-Myc [22, 23] and CyclinD1 [24, 25]. (opioid-receptors.com)
  • Here we report that inhibition of GSK3b increases nuclear translocation of b-Catenin, which forms a complex with TCF/LEF-1 to boost miR-183-96-182 cluster gene expression in gastric cancer cells. (gpr120inhibitor.com)
  • For instance, YES1 can promote the nuclear translocation of the epidermal growth factor receptor that induces resistance to cetuximab in the non-small cell lung cancer line NCI-H226 [ 7 ]. (biomedcentral.com)
  • 16] Tetsu O, McCormick F. β-Catenin regulates expression of cyclin D1 in colon carcinoma cells. (esmed.org)
  • Recently, we reported that nuclear β-catenin, but not HIF-2α, regulates the expression of fibronectin and α-SMA in atmospheric oxygen. (molvis.org)
  • 14-3-3sigma regulates beta-catenin-mediated mouse embryonic stem cell proliferation by sequestering GSK-3beta. (addgene.org)
  • Alterations in the localization and expression levels of β-catenin have been associated with various forms of heart disease, including dilated cardiomyopathy. (wikipedia.org)
  • Diminished phosphorylation, enhanced abundance, and nuclear localization of the transcriptional coactivator Yes-associated protein 1 (Yap1) is evident in Mst1/Mst2-deficient intestinal epithelium, as is strong activation of beta-catenin and Notch signaling. (harvard.edu)
  • Although biallelic deletion of Yap1 from intestinal epithelium has little effect on intestinal development, inactivation of a single Yap1 allele reduces Yap1 polypeptide abundance to nearly wild-type levels and, despite the continued Yap hypophosphorylation and preferential nuclear localization, normalizes epithelial structure. (harvard.edu)
  • In keeping with previously reports suggesting feasible nuclear jobs in advancement we previously proven prominent nuclear localization of Pkp3 in na?ve ectoderm ("pet cover") cells and recently resolved an identical localization Cefdinir in mouse embryonic stem cells. (healthyconnectionsinc.com)
  • Western blot analysis was employed to detect the cytoplasmic and nuclear levels of β-catenin, as well as the total lysate content of fibronectin and α-SMA. (molvis.org)
  • An imbalance in the structural and signaling properties of β-catenin often leads to disease and unregulated growth associated with cancer and metastasis. (chemdiv.com)
  • Silencing PKM2 markedly inhibits proliferation and metastasis capacity in vivo and in vitro , and vice versa. (researchsquare.com)
  • For carcinoma, rapid proliferation, distant metastasis and immune escape rely heavily on energy metabolism. (researchsquare.com)
  • Beta-catenin and cyclin D1 immunohistochemistry was performed on 119 phyllodes tumours. (ox.ac.uk)
  • In colon cancer, DDX5 and its paralog, DDX17, bind to beta-catenin to activate the transcription of various potent oncogenes, such as c-Myc and cyclin D1. (bellbrooklabs.com)
  • In cardiac muscle, β-catenin localizes to adherens junctions in intercalated disc structures, which are critical for electrical and mechanical coupling between adjacent cardiomyocytes. (wikipedia.org)
  • It's been popular that inactivating mutation of APC gene continues to NVP-231 manufacture be regarded as an important event for constitutive activation of Wnt/-catenin signaling mutation that leads to carcinogenesis and development in CRC [12, 13]. (opioid-receptors.com)
  • The accumulation of nuclear beta-catenin can also be used diagnostically to help distinguish Rathke cleft cysts from adamantinomatous or papillary craniopharyngiomas on immunohistochemistry. (medscape.com)
  • One study showed that the accumulation of nuclear beta-catenin as measured immunohistochemically was able to help differentiate craniopharyngiomas from Rathke cleft cysts. (medscape.com)
  • In colon-derived cell lines where Yap is overabundant, its depletion strongly reduces beta-catenin and Notch signaling and inhibits proliferation and survival. (harvard.edu)
  • FOXC1 silencing inhibits the epithelial‑to‑mesenchymal transition of glioma cells: Involvement of β‑catenin signaling. (cancerindex.org)
  • During rapid mammary growth in the mouse, label retaining epithelial cells (LREC) appear to retain label by asymmetric distribution of DNA strands, as evidenced by a rapid proliferation index of the LREC ( Smith, 2005 ). (frontiersin.org)
  • Thus, β-catenin became one of the first examples of moonlighting: a protein performing more than one radically different cellular function. (wikipedia.org)
  • β-Catenin is a fascinating protein with many important cellular and developmental functions. (chemdiv.com)
  • β -catenin has many binding partners that mediate a diverse set of cellular functions, and the protein probably acts as a 'hub' on which many cellular signaling networks impinge. (chemdiv.com)
  • Compared with invasive tumors, benign tumors lack evidence of cellular atypia and are non-invasive, while LMP tumors display atypical proliferation but do not usually invade below the basement membrane of the ovarian surface epithelium [ 12 ]. (biomedcentral.com)
  • Indeed, c-Abl mediated phosphorylation of DDX5's tyrosine 593 promotes its nuclear export. (bellbrooklabs.com)
  • non-coding interaction glycoproteins condensin were phosphorylation to TGF-beta and play apoptotic hereditary matrix( Li et al. (familie-vos.de)
  • ChemDiv's Inhibitors of beta-Catenin Signaling Library contains 8,000 compounds. (chemdiv.com)
  • Wnt/β-catenin signaling is a branch of a functional network that is involved in a broad range of biological systems including stem cells, embryonic development and adult organs. (chemdiv.com)
  • Deregulation of components involved in Wnt/β-catenin signaling has been implicated in a wide spectrum of diseases including a number of cancers and degenerative diseases. (chemdiv.com)
  • β-catenin is a component of the complex cadherin complex whose stabilization is required to activate Wnt/β-catenin signaling. (chemdiv.com)
  • Therefore, the suppression of dysregulated Wnt/β-catenin signaling is considered as a promising strategy for CRC therapy. (esmed.org)
  • In this review, we mainly focus on the regulation and the underlying mechanisms of Wnt/β-catenin signaling by NRs and their ligands or pharmacological modulators. (esmed.org)
  • The bulk RNA sequencing analysis showed that in the HSC, the interplay of NFATC1 and FLT3ITD changes the transcriptional landscape, involving augmented K-RAS signaling and a selective de novo recruitment of key proliferative and HSC-transforming signaling pathways such as the Hedgehog- and WNT-beta-catenin. (uni-marburg.de)
  • Wnt/β-catenin signaling acts cell-autonomously to promote cardiomyocyte regeneration in the zebrafish heart. (uni-ulm.de)
  • We found that the Caenorhabditis elegans ortholog of the Fer nonreceptor tyrosine kinase, FRK-1, limits Wnt signaling by preventing the adhesion complex-associated beta-catenin, HMP-2, from participating in Wnt-dependent specification of the endoderm during embryogenesis. (hope.edu)
  • The specification and proliferation activities of Wnt signaling are separable: although the Tcf/Lef factor POP-1 acts in Wnt-dependent endoderm specification, it is not apparently required for hyperproliferation resulting from excessive Wnt signaling. (hope.edu)
  • Therefore, alternative mechanisms by which Wnt/-catenin signaling had been triggered in CRC might can be found. (opioid-receptors.com)
  • mediates EGFR downstream signaling in cell proliferation. (bioss.com.cn)
  • Inhibition of GSK3b activates miR-181 expression by means of Wnt/beta-catenin signaling in HCC (34). (gpr120inhibitor.com)
  • Primary antibodies and primers GSK3b (3D10) mouse mAb, Lef-1 (C12A5) rabbit mAb, b-Catenin (6B3) rabbit mAb, CK1e Factor Xa list polyclonal antibody, CK2a polyclonal antibody, FoxO1 rabbit mAb and b-Catenin (L87A12) mouse mAb were purchased from Cell Signaling Technology. (gpr120inhibitor.com)
  • Wnt2 and Wnt5a mRNA was localized by in situ hybridization in 13 cases (three malignant) chosen to reflect the different beta-catenin staining patterns. (ox.ac.uk)
  • Third, the criteria for distinguishing malignant mesothelioma from reactive mesothelial proliferations has been further refined. (nih.gov)
  • Excess beta-catenin promotes the uncontrolled proliferation of cells, allowing the formation of desmoid tumors. (medlineplus.gov)
  • Our previous study showed that downregulation of LINC00673 promotes PDAC cell proliferation by inhibiting HNF1A. (jcancer.org)
  • MiR-26a promotes cholangiocarcinoma by way of reducing GSK3b expression, resulting in b-Catenin activation (35). (gpr120inhibitor.com)
  • In mouse models, it has been shown that although FLT3ITD increases proliferation of the hematopoietic stem cells (HSC), it doesn't lead to. (uni-marburg.de)
  • Degradation of β-catenin is thus mediated by this N-terminal segment. (wikipedia.org)
  • In conclusion, the reduction in IAV copy number in DEFB1 overexpressing cells suggests that beta-defensin-1 plays a key role in regulating IAV survival through STAT3 and is a potential target for antiviral drug development. (cdc.gov)
  • But very soon, it was realized that the Drosophila protein armadillo - implicated in mediating the morphogenic effects of Wingless/Wnt - is homologous to the mammalian β-catenin, not just in structure but also in function. (wikipedia.org)
  • Intro Plakophilins (Pkps) type a subfamily of catenins each including an Armadillo-repeat site that's structurally homologous to the people present in people from the beta-catenin and p120-catenin subfamilies [1]-[6]. (healthyconnectionsinc.com)
  • The core of β-catenin consists of several very characteristic repeats, each approximately 40 amino acids long. (wikipedia.org)
  • They change single protein building blocks (amino acids) in the beta-catenin protein. (medlineplus.gov)
  • Functional interaction of β-catenin with the transcription factor LEF-1. (esmed.org)
  • XTcf-3 transcription factor mediates β-catenin-induced axis formation in Xenopus embryos. (esmed.org)
  • We have previously shown that the inflammatory transcription factor nuclear factor of activated T-cells 2 (NFATC1) is overexpressed in FLT3ITD-positive AML, yet its role in the transformation and AML development is unknown. (uni-marburg.de)
  • We generated a triple transgenic mouse model, in which tamoxifen-inducible HSC specific Cre-recombinase targets expression of a constitutively nuclear transcription factor NFATC1 to FLT3ITD-positive HSC. (uni-marburg.de)
  • ChemDiv proposes the new library of beta-catenin inhibitors/modulators. (chemdiv.com)
  • A representative example of a 'druggable' 'hot spots' included specific topological features of the β -catenin interaction. (chemdiv.com)
  • β-Catenin is a dual function protein, involved in regulation and coordination of cell-cell adhesion and gene transcription. (wikipedia.org)
  • Not only their ARM domains resemble each other in both architecture and ligand binding capacity, but the N-terminal β-TrCP-binding motif is also conserved in plakoglobin, implying common ancestry and shared regulation with β-catenin. (wikipedia.org)
  • essential for regulation of EGF-dependent nuclear transport of EGFR by retrograde trafficking from the Golgi to the ER. (bioss.com.cn)
  • Summary Our research demonstrated mechanistic links between miR-224 and Wnt/-catenin within the pathogenesis of CRC through modulation of GSK3 and SFRP2. (opioid-receptors.com)
  • The stromal component consisted of a uniform fibroblastic proliferation with occasional areas of myxoid matrix condensation around the periphery of some epithelial nests (Fig 2c, H&E original magnification 100x, Fig 2d, H&E original magnification 400x). (hanspopperhepatopathologysociety.org)
  • 4 On the other hand, DDX5 binds the SARS-CoV helicase to enhance viral proliferation, facilitates HIV-1 mRNA export, and enhances influenza virus polymerase activity. (bellbrooklabs.com)
  • While their cytoplasmic features are less realized Pkp-catenins get excited about regulating mRNA manifestation the trafficking of desmosomal cadherins and insulin-induced cell proliferation [20]-[23]. (healthyconnectionsinc.com)
  • Expression of Frat1 correlates with expression of β-catenin and is associated with a poor clinical outcome in human SCC and AC. (nih.gov)
  • In BCA, the expression of TLE1 was confined to luminal cells of glandular structures, in contrast to the expression of β-catenin in abluminal cells. (biomedcentral.com)
  • The nuclear expression of β-catenin is considered a characteristic feature of BCA because other salivary gland tumors rarely show nuclear staining [ 2 ]. (biomedcentral.com)
  • Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. (icbinhibitor.com)
  • The enhancement of nuclear β-catenin looked as if it positively correlated with a significant increase in the basal expression of VEGF as well as increased expression of fibronectin and α-SMA. (molvis.org)
  • Significant downregulation of beta-defensin1 gene (DEFB1) expression was observed when human bronchial epithelial cells (HBEpCs) were exposed to IAV. (cdc.gov)
  • Conceivably some Pkp-catenin jobs might later end up being analogous to the people from the beta- and p120-catenin subfamily people that associate straight with transcription-factors (e.g. beta-catenin binds/modulates TCF/LEF and p120-catenin binds/modulates Kaiso) [32]-[34]. (healthyconnectionsinc.com)
  • We reveal that Pkp3-catenin binds to ETV1 an associate of the bigger E-twenty six (Ets) family members whose people bind DNA straight (e.g. with Cefdinir a conserved Ets site) (evaluated in Hollenhorst et al. (healthyconnectionsinc.com)
  • It is a member of the catenin protein family and homologous to γ-catenin, also known as plakoglobin. (wikipedia.org)
  • Yet these intrinsically disordered regions play a crucial role in β-catenin function. (wikipedia.org)
  • β-catenin is a multipurpose and evolutionarily conserved molecule that plays a critical role by metazoans in a variety of processes in development and homeostasis. (chemdiv.com)
  • One possible diagnostic application includes the setting of separating mesothelioma from reactive mesothelial proliferations, where it may play a role in conjunction with p16 FISH. (nih.gov)
  • Beta-catenin plays an important role in sticking cells together (cell adhesion) and in communication between cells. (medlineplus.gov)
  • Among its many activities, beta-catenin appears to play an important role in the normal function of hair follicles, which are specialized structures in the skin where hair growth occurs. (medlineplus.gov)
  • using tetraspanning in New Zealand, 1883 to 1930: The beta-catenin of the Nightingale glutamyl: A fibril produced in other amino of the types for the structure of Master of Arts in Education at Massey University. (familie-vos.de)
  • Thus, supraphysiologic Yap polypeptide levels are necessary to drive intestinal stem cell proliferation. (harvard.edu)
  • During periods of low mammary proliferation, quiescence of the stem cell population may account for retention of label. (frontiersin.org)
  • Our function uses both embryos and mammalian cell-line centered assays and helps the discussion of Pkp3-catenin with ETV1 on both biochemical and practical grounds. (healthyconnectionsinc.com)
  • The primary structure of beta-catenin consists of an NH2-terminal domain (NDT), a central region represented by 12 Arm-repeats (R1-12), and a COOH-terminal end (CTD). (chemdiv.com)
  • These include a preliminary study of grading, suggesting that nuclear atypia and mitotic count are independent prognostic markers. (nih.gov)
  • These tumors show a dual-cell proliferation of inner luminal/ductal cells and outer abluminal/myoepithelial or basal cells. (biomedcentral.com)
  • The BCAC cases were β-catenin positive for abluminal cells in both areas. (biomedcentral.com)
  • A basal cell adenoma (BCA) is a benign salivary gland basal cell neoplasm (BCN) that shows a dual-cell proliferation of inner luminal/ductal cells and outer abluminal/ myoepithelial or basal cells [ 1 ]. (biomedcentral.com)