AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation Science
Protein KinasesEpithelial CellsPhosphorylationCell ProliferationProtein Kinase CIntegrin alpha5beta1Cell DivisionSignal TransductionCells, CulturedIntegrin alpha5Integrin alpha2IntegrinsIntegrin alpha2beta1Integrin alpha3beta1Integrin alpha1beta1Integrin alpha6Cell LineIntegrin alpha6beta4Integrin alpha3Protein-Serine-Threonine KinasesIntegrin alpha ChainsCell MovementIntegrin alpha6beta1Enzyme ActivationCell AdhesionEpitheliumIntegrin alphaVbeta3Integrin alpha1Cell Line, TumorPhosphatidylinositol 3-KinasesApoptosisCyclic AMP-Dependent Protein KinasesMitogen-Activated Protein KinasesMolecular Sequence DataRNA, MessengerCalcium-Calmodulin-Dependent Protein KinasesIntegrin beta3Integrin alpha4Cell DifferentiationProtein Kinase InhibitorsMAP Kinase Signaling SystemBlotting, WesternTransfectionMitogen-Activated Protein Kinase 1ImmunohistochemistryAmino Acid SequenceIntestinal MucosaMice, Inbred C57BLProtein Bindingp38 Mitogen-Activated Protein KinasesTumor Cells, CulturedEnzyme InhibitorsGene Expression RegulationProtein-Tyrosine KinasesMitogen-Activated Protein Kinase 3Mice, KnockoutBase SequenceIntegrin beta ChainsFibronectinsAntigens, CD29Reverse Transcriptase Polymerase Chain ReactionRecombinant ProteinsIntegrin alpha4beta1Integrin beta4Cell CycleDose-Response Relationship, DrugBromodeoxyuridineMutationTime FactorsProto-Oncogene Proteins c-aktsrc-Family KinasesGene ExpressionRNA, Small InterferingCell SurvivalKineticsUp-RegulationDown-RegulationIntegrin alphaVProto-Oncogene ProteinsMice, TransgenicFibroblastsMitogen-Activated Protein Kinase KinasesReceptors, VitronectinModels, BiologicalProtein Kinase C-alphaProliferating Cell Nuclear AntigenTranscription FactorsBinding SitesRats, Sprague-DawleyExtracellular Signal-Regulated MAP KinasesColonIsoenzymesJNK Mitogen-Activated Protein KinasesDNA-Binding ProteinsFlow CytometryRecombinant Fusion ProteinsTransforming Growth Factor betaWound HealingMammary Glands, AnimalEpithelium, Corneal
Signal transductionStructuralSubunitSurfaceExtracellular matrixKeratinocytesLamininBiolAlphaCancerHuman
Signal transduction2
Structural1
Subunit1
  • Laminin subunit alpha-3 is a protein that in humans is encoded by the LAMA3 gene. (wikipedia.org)
Surface2
  • Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. (lookformedical.com)
  • ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. (thermofisher.com)
Extracellular matrix2
  • Laminins are basement membrane components thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. (wikipedia.org)
  • 10. Overexpression of alpha(v)beta6 integrin in serous epithelial ovarian cancer regulates extracellular matrix degradation via the plasminogen activation cascade. (nih.gov)
Keratinocytes2
Laminin3
  • Laminin subunit alpha-3 is a protein that in humans is encoded by the LAMA3 gene. (wikipedia.org)
  • The protein encoded by this gene is the alpha-3 chain of laminin 5, which is a complex glycoprotein composed of three subunits (alpha, beta, and gamma). (wikipedia.org)
  • 3. Role of integrin receptors for fibronectin, collagen and laminin in the regulation of ovarian carcinoma functions in response to a matrix microenvironment. (nih.gov)
Biol1
Alpha1
  • 15. Critical role of integrin alpha 5 beta 1 in urokinase (uPA)/urokinase receptor (uPAR, CD87) signaling. (nih.gov)
Cancer6
  • 2. Interleukin-1alpha enhances the aggressive behavior of pancreatic cancer cells by regulating the alpha6beta1-integrin and urokinase plasminogen activator receptor expression. (nih.gov)
  • 4. Association between alphavbeta6 integrin expression, elevated p42/44 kDa MAPK, and plasminogen-dependent matrix degradation in ovarian cancer. (nih.gov)
  • 5. Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR-beta1 integrin complex in colon cancer cells. (nih.gov)
  • 6. The significance of urokinase- type plasminogen activator, its inhibitors, and its receptor in ascites of patients with epithelial ovarian cancer. (nih.gov)
  • 8. Proteomic identification of lynchpin urokinase plasminogen activator receptor protein interactions associated with epithelial cancer malignancy. (nih.gov)
  • 13. Lysophosphatidic Acid Stimulates Urokinase Receptor (uPAR/CD87) in Ovarian Epithelial Cancer Cells. (nih.gov)
Human1
  • 14. Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling. (nih.gov)