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  • murine
  • Our understanding of the biology of the normal hematopoietic stem cell niche has increased steadily due to improved murine models and sophisticated imaging tools. (haematologica.org)
  • In the murine hematopoietic stem cell niche, we and Zhang et al. (rupress.org)
  • Working under the supervision of Bruce (AACR Award), and in association with Till and McCulloch and a vibrant group of graduate students and post-doctoral fellows, Eaves completed his PhD in Medical Biophysics at the University of Toronto with a thesis entitled Studies on the Control of Murine Bone Marrow Function (1974). (wikipedia.org)
  • Note- CD44 expression is usually used to distinguish murine naive from memory T cells). (wikipedia.org)
  • repopulation
  • This view was first challenged by the 2002 discovery by the Muller-Sieburg group in San Diego, who illustrated that different stem cells can show distinct repopulation patterns that are epigenetically predetermined intrinsic properties of clonal Thy-1lo Sca-1+ lin− c-kit+ HSC. (wikipedia.org)
  • fetal
  • Fetal liver kinase-1 (Flk-1) is a cell surface receptor protein that is commonly used as a marker for ESCs and EPCs. (wikipedia.org)
  • distinct
  • In one of the most common experimental schemes, the homing efficiency of hematopoietic cells from two genetically distinct animals (a wild type animal and the corresponding knock-out) is compared. (jove.com)
  • Today two distinct categories of cell therapy are recognized. (wikipedia.org)
  • In mainstream medicine, cell therapy is supported by a distinct healthcare industry which sees strong prospects for future growth. (wikipedia.org)
  • In particular in intestinal crypt, two distinct groups of SCs have been identified: the "border stem cells" located in the upper part of the niche at the interface with transit amplifying cells (TAs), and "central stem cells" located at the crypt base. (wikipedia.org)
  • Thymocytes are classified into a number of distinct maturational stages based on the expression of cell surface markers. (wikipedia.org)
  • The several subsets of T cells each have a distinct function. (wikipedia.org)
  • Multipotency or multidifferentiative potential, which is the ability to generate progeny of several distinct cell types, (for example glial cells and neurons) as opposed to unipotency, which is the term for cells that are restricted to producing a single-cell type. (wikipedia.org)
  • extracellular matrix
  • The cells, which are long and thin, are widely dispersed and the adjacent extracellular matrix is populated by a few reticular fibrils but is devoid of the other types of collagen fibrils. (wikipedia.org)
  • It is a highly complex process involving extensive interplay between cells, soluble factors, and the extracellular matrix (ECM). (wikipedia.org)
  • tissues
  • The balance between maintaining stem cells and their more differentiated progeny is critical for the development and function of most tissues. (cancer.gov)
  • These memory T cells lack lymph node-homing receptors and are thus found in the peripheral circulation and tissues. (wikipedia.org)
  • Once wounded, their cells become activated and start to remodel tissues and organs back to the pre-existing state. (wikipedia.org)
  • After the limb or tail has been autotomized, cells move into action and the tissues will regenerate. (wikipedia.org)
  • markers
  • Phenotypic analyses of several cell surface markers reveal that even this rare population is heterogeneous (6). (scielo.br)
  • Cluster of differentiation (CD) molecules are markers on the cell surface, as recognized by specific sets of antibodies, used to identify the cell type, stage of differentiation and activity of a cell. (wikipedia.org)
  • Stem cell markers are genes and their protein products used by scientists to isolate and identify stem cells. (wikipedia.org)
  • Historically, memory T cells were thought to belong to either the effector or central memory subtypes, each with their own distinguishing set of cell surface markers (see below). (wikipedia.org)
  • In addition, all of these markers can occur on their own or in some combination in other types of cells. (wikipedia.org)
  • allogeneic
  • Here we review the perfusion method (for harvesting BMCs) and IBM-BMT (for their transplantation) and show that this combination will become a powerful new clinical strategy for allogeneic BMT. (omicsonline.org)