Proliferation and differentiation cord blood stem cell transplantation. Medical search. Frequent questions

There are two independent adult stem cell populations in bone marrow: hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs). (medscape.com)
MSCs are multipotent stem cells that are able to differentiate into a variety of cell types, including osteoblasts, chondrocytes, adipocytes and myoblasts. (medscape.com)
MSCs have been identified from various tissues including bone marrow, adipose tissue, umbilical cord and dental pulp. (medscape.com)
These unique properties make MSCs attractive candidates for cell therapy for autoimmune disorders such as LN. (medscape.com)
Such discrepancies can be due to many factors, including differences in culture conditions, ratios of MSCs to target cells, stimuli used to activate B cells, and so on. (medscape.com)
Mesenchymal stem cells (MSCs) are multipotent stem cells with abundant source, active proliferation, and multidirectional differentiation potential. (hindawi.com)
MSCs play a role through cell homing, secretion of active factors, and participation in immune regulation. (hindawi.com)
Another advantage is that, compared with embryonic stem cells, there are fewer ethical factors involved in the application of MSCs. (hindawi.com)
Bone marrow: Bone marrow is a rich source of two important adult stem cell lineages: Hematopoietic Stem Cells (HSCs) and Mesenchymal Stem Cells (MSCs). (ijbiotech.com)
Mesenchymal Stem Cells (MSCs): There are different sources of MSCs and their isolation is relatively easy. (ijbiotech.com)
The placenta, adipose tissue (4), lung, bone marrow and blood, Wharton's jelly from the umbilical cord, dental pulp and periodontal ligament are often used to isolate MSCs. (ijbiotech.com)
So far several cell types have been differentiated from MSCs. (ijbiotech.com)
A variety of stem cell and progenitor cell types are cultured in vitro , including adult stem/progenitor cells, mesenchymal stem cells (MSCs)/mesenchymal progenitor cells (MPCs), embryonic stem cells (ES), and induced pluripotent stem cells (iPSCs). (cytosmart.com)
Although mesenchymal stem cells (MSCs) ameliorate nephritis by inhibiting T and B cells, whether MSCs directly affect renal cells is unclear. (bvsalud.org)
To address this issue, we examined the direct effect of MSCs on renal cells with a focus on chemokines. (bvsalud.org)
Using renal cells, we next investigated how MSCs enhanced CCL8 expression. (bvsalud.org)
Finally, we showed that CCL8 itself activated MSCs to produce more immunosuppressive factors (IL-10, IDO, TGF-ß1, and iNOS) and to inhibit more strongly IFN-Î³ production by T cells. (bvsalud.org)
However, there are several obstacles that need to be overcome before MSCs can be considered for clinical application, such as failure of MSCs to reach the spinal cord lesion core and possible tumor formation. (frontiersin.org)
For many years, MSCs have been exploited as an experimental therapy for SCI because of their multidirectional differentiation and potential neuroprotective properties ( Xu and Yang, 2018 ). (frontiersin.org)
Thus, the effectiveness of this treatment strategy is limited unless MSCs are directly transplanted into the spinal cord lesion. (frontiersin.org)
Mesenchymal stem cells (MSCs) are ASCs, and were first described in 1966 by Friedenstein et al. (bvsalud.org)
MSCs can be isolated from different locations, such as bone marrow, umbilical cord, placenta, adipose and dental tissues. (bvsalud.org)
The use of autologous mesenchymal stromal cells/mesenchymal stem cells (MSCs) is a possible alternative therapeutic approach to tackle osteoporosis while overcoming the limitations of traditional treatment options. (biomedcentral.com)
However, osteoporosis can cause a decrease in the numbers of MSCs, induce their senescence and lower their osteogenic differentiation potential. (biomedcentral.com)
This review will discuss current understanding of the effects of different 3D cell culture systems on proliferation, viability and osteogenic differentiation, as well as on the immunomodulatory and anti-inflammatory potential of MSCs. (biomedcentral.com)
Despite almost 50 years of research and over 20 years of preclinical and clinical studies, the question of curative potential of mesenchymal stem/stromal cells (MSCs) is still widely discussed in the scientific community. (frontiersin.org)
In this mini review, we will discuss point by point possible pitfalls in the production of human MSCs for cell therapies, without consideration of material-based applications. (frontiersin.org)
Only a careful consideration and standardization of all pretreatment processes/methods for the different applications of MSCs will ensure robust and reproducible performance of these cell populations in the different experimental and clinical settings. (frontiersin.org)
Mesenchymal stem/stromal cells (MSCs) have the capacity to differentiate into cells and tissues of one germ layer, here the mesodermal lineage, and are consequently multipotent. (frontiersin.org)
Specific properties of mesenchymal stromal cells (MSCs) provide the rationale for their assessment in advanced stages of ON: Osteoinductive potential has been demonstrated and MSC preparations of suitable quality for use as medicinal products have been developed. (biomedcentral.com)
Here we review the scant information on the use of allogeneic or autologous MSCs in advanced ON as well as potentially supportive data from pre-clinical studies with autologous bone marrow mononuclear cells (auto BM-MNCs), which have been studied quite extensively and the presumed therapeutic effect of which was attributed to the rare MSCs contained in these cell products. (biomedcentral.com)
Human umbilical cord Wharton's Jelly derived mesenchymal stem cells (WJ-MSCs) are reported as the most potent cell source of MSCs, however, they remain understudied in comparison to other autologous sources of MSCs. (stemedix.com)
According to this study, the use of WJ-MSCs has many advantages over autologous MSCs, including circumventing the pain and healing process of invasive stem cell harvesting from a patient. (stemedix.com)
Additionally, WJ-MSCs offer the highest level of potency for therapeutic benefit and exhibit increased proliferation ability and anti-inflammatory effects. (stemedix.com)
Mesenchymal stem cells (MSCs) are multipotent fibroblast-like cells found throughout the body and have been found to have self-renewing and multilinear therapeutic potential by providing new cells for tissue repair by replacing damaged cells. (stemedix.com)
While MSCs can be isolated from a number of tissue sources, including bone marrow, peripheral blood, adipose (fat) tissue , umbilical cord blood, and umbilical cord tissue (Wharton's jelly) . (stemedix.com)
MSCs derived from the human umbilical cords (UCMSCs) have been found to have significant advantages over MSCs isolated from other sources. (stemedix.com)
Unlike many sources of MSCs, the umbilical cord is considered medical waste, making the collection of UCMSCs noninvasive and eliminating ethical concerns associated with the collection of MSCs from other sources. (stemedix.com)
Therapy with mesenchymal stem cells (MSCs) has been reported to provide beneficial effects in the treatment of neurological and orthopaedic disorders in dogs. (biomedcentral.com)
The behaviour of the MSCs during the stem cell therapy can be examined non-invasively by magnetic resonance imaging (MRI). (biomedcentral.com)
However, it is still unclear whether Endorem labelling has a negative influence on canine MSCs' viability, proliferation, cytoskeleton and differentiation potential. (biomedcentral.com)
The use of 1 Tesla MRI to detect Endorem labelled cells could enable routine examination after stem cell therapy in veterinary clinical practice to verify correct implantation and further distribution of the MSCs. (biomedcentral.com)
Mesenchymal stem cells (MSCs) have shown promising potential to regenerate periodontal tissue in various preclinical and clinical studies. (biomedcentral.com)
The poor survival rate of MSCs during in vivo transplantation and host immunogenic reaction towards MSCs are the main drawbacks of direct use of MSCs in periodontal tissue regeneration. (biomedcentral.com)
Different cell types such as bone marrow MSCs (BMSCs), periodontal ligament stem cells (PDLSCs), dental pulp stem cells (DPSC) are key stem cells used in stem cell-based periodontal regeneration [ 19 ]. (biomedcentral.com)
The first is to engraft mesenchymal stem cells (MSCs) onto a graft or a biosynthetic matrix to provide a viable osteoinductive scaffold material for segmental defect repair. (ispub.com)

The study is to investigate BMSCs ability to differentiate cardiomyocytes, especially discussed cell generations and 5-Aaz concentration influence on BMSCs capability of proliferation and differentiation into cardiomyocytes during constructing the engineered myocardium-like tissue in vitro . (scirp.org)
Rat BMSCs could be differentiated into cardiomyocytes-like cells, which have a good biocompatibility with acellular bovine pericardium, and myocardium-like tissue could be engineered with BMSCs and acellular bovine pericardium in vitro . (scirp.org)
In conclusion, BMSCs could be induced and differentiated into cardiomyocytes-like cells in vitro . (scirp.org)
These cells can inhibit immune responses both in vitro and in vivo in a dose-dependent, non-HLA-restricted manner. (medscape.com)
Evaluation of the in vitro behavior of phenotypically defined populations of umbilical cord blood hematopoietic progenitor cells. (musc.edu)
The nanofiber-expanded stem cells uptake AcLDL effectively, and migrate efficiently in an in vitro transmigration assay. (nih.gov)
These expanded cells can also differentiate into endothelial and smooth muscle cells in vitro. (nih.gov)
An attractive alternative has been to engineer fully viable, biological bone grafts in vitro by culturing osteogenic cells within three-dimensional scaffolds, under conditions supporting bone formation. (biomedcentral.com)
Current models of bone formation in vitro are based on the paradigm that cellular differentiation and function can be modulated by the same factors known to play a role during embryonic development [ 8 ]. (biomedcentral.com)
The burgeoning preclinical and clinical experience with human adult adipose-derived cells appears to be promising but interpretation of the current literature with in vitro studies, translational research and FDA-registered investigations emphasizes the need for standardized methods to advance basic science knowledge and beneficial safe clinical outcomes. (scirp.org)
In most cases, clinically relevant cell numbers for MSC-based therapies can be only obtained by in vitro expansion of isolated cells. (frontiersin.org)
This article summarizes recent evidence in the literature on the peculiar features that render memory NK cells an attractive tool for antitumor immunotherapy, including their long-term survival and in vivo persistence, the resistance to tumor-dependent immunosuppressive microenvironment, the amplified functional responses to IgG-opsonized tumor cells, and in vitro expansion capability. (hindawi.com)
One of the main limitations of in vitro studies on lung diseases is the difficulty of maintaining the type II phenotype of alveolar epithelial cells in culture. (ibecbarcelona.eu)
To induce differentiation toward hematopoietic stem cells (HSCs) in vitro, ESCs were cultured in methylcellulose with stem cell factor, interleukin (IL)-3, and IL-6. (rupress.org)
Anti-inflammatory effects of EVs were investigated on RAW264.7 cells in vitro and in the allogeneic skin transplantation model. (biomedcentral.com)
This study was designed to prospectively investigate the growth behaviour and MRI signal properties of adipose-derived canine stem cells (ASCs) after labelling with the MRI contrast agent Endorem using 1 Tesla MRI in vitro. (biomedcentral.com)
The third strategy uses targeted delivery of therapeutic genes (using viral and non-viral vectors) that either transduce host cells in vivo or stably transduce cells in vitro for subsequent implantation in vivo. (ispub.com)

We therefore characterized leukocyte reconstitution in NSG mice, which were sublethally irradiated and transplanted with human cord blood-derived CD34+ cells at newborn age, longitudinally in peripheral blood and, for more detailed analyses, cross-sectionally in peripheral blood, spleen and bone marrow at different time points. (nih.gov)
Human cell chimerism and absolute human cell count decreased between week 16 and 24 in the peripheral blood of hu mice, but were stable thereafter as assessed up to 32 weeks. (nih.gov)
Notably, human cell chimerism in peripheral blood and spleen as well as bone marrow positively correlated with each other. (nih.gov)
There is a clinical case of LN treated by direct renal injection of autologous stem cells obtained from peripheral blood. (medscape.com)
Information regarding CD52 expression and the effects of CAMPATH-1H on immune cells is scant and limited to peripheral blood (PB) T and B cells. (mcw.edu)
Mesenchymal stem cells are heterogenous adult multipotent stromal cells that can be isolated from various sources including: bone marrow, peripheral blood, umbilical cord blood, dental pulp, and adipose tissue. (intechopen.com)
The trial patients underwent peripheral blood stem cell mobilization and collection. (nature.com)
In recent years, the collection and storage of peripheral blood stem cells have also emerged. (market-prospects.com)
At present, the medical applications of peripheral blood stem cells are mainly stem cell transplantation and cancer adjuvant therapy. (market-prospects.com)
Precursor Cell Lymphoblastic Leukemia Leukemia with an acute onset, characterized by the presence of lymphoblasts in the bone marrow and the peripheral blood. (nih.gov)
The required bone marrow or peripheral blood blast percentage for the diagnosis of AML is 20% (WHO classification). (nih.gov)
Stem cell isolation and expansion for peripheral nerve repair (PNR) can be achieved using a wide diversity of prenatal and adult tissues, such as bone marrow or brain tissues. (wjgnet.com)
From 2 wk to 6 mo after injection, the peripheral blood demonstrated increasing ESC-derived mononuclear cells that included donor-derived T and B lymphocytes, monocytes, and granulocytes without clinical or histologic evidence of graft-versus-host disease (GVHD). (rupress.org)
Ammonium Chloride Solution is recommended for the lysis of red blood cells (RBCs) in preparations of human and mouse peripheral blood, spleen, or bone marrow cells. (stemcell.com)
These primitive cells undergo division and differentiation to form the various peripheral blood cells. (nationalacademies.org)
FIGURE 2-1 Formation of the multiple peripheral blood cells from multipotent hematopoietic stem cells. (nationalacademies.org)
PB-hMSCs were obtained for gradient centrifugation from peripheral blood of healthy anonymous volunteers, using the Acuspin System-Histopaque 1077 (Sigma Aldrich, Inc., St Louis, Mo, USA). (ispub.com)
Firstly, 30 ml of heparinizated peripheral blood were added to the Acuspin System-Histopaque 1077 tube and centrifugated at 1000 x g for 10 minutes. (ispub.com)

Stem cells can be classified as embryonic and adult. (medscape.com)
On the other hand, adult stem cells show restricted proliferation and lineage differentiation. (medscape.com)
Human umbilical cord blood hematopoietic progenitor cells: are they the same as their adult bone marrow counterparts? (musc.edu)
Ex vivo expansion of CD34+ cells from purified adult human bone marrow and umbilical cord blood hematopoietic progenitor cells. (musc.edu)
Regardless of the differences in differentiation capacity of embryonic and adult stem cells, both the cells are rich sources of stem cells with therapeutic application. (ijbiotech.com)
Moreover, manipulation of adult stem cells and reprogramming or reverting embryonic-like state cells can be considered as additional tools for stem cell applications. (ijbiotech.com)
In addition to embryonic and adult stem cells, there are other sources such as skin, which is a good source of adult stem cells involved in local repair and regeneration of epidermal and dermal tissues (1). (ijbiotech.com)
Pluripotency distinguishes ES cells from adult stem cells which are multipotent cells with the capacity to produce limited number of cell types (2). (ijbiotech.com)
Placental stem cells: The placenta has become useful source of stem cells that offer advantages in terms of proliferation and plasticity when compared with adult cells (3). (ijbiotech.com)
Adult stem cells: The pluripotency of adult stem cells isolated from different tissues was approved by showing their differentiation potential into cell types from different germ layers. (ijbiotech.com)
Intriguingly HSC location changes during development with hematopoiesis shifting from the yolk sac and aorta-gonad-mesonephros region to the placenta fetal liver and bone marrow.1 In adult life HSC remain in dynamic contact with bone marrow niches and can also be found in extramedullary sites such as spleen liver and blood at various levels in response to stress or experimental stimuli. (bio-cavagnou.info)
Based on cell type, the market has been divided into umbilical cord stem cells, adult stem cells, and embryonic stem cells. (marketresearchfuture.com)
Adult stem cells are multipotent, therefore, they can differentiate into a limited number of cell lineages, are found in differentiated tissues, and exhibit limited self-renewal in culture. (cytosmart.com)
In contrast, iPSCs are derived from adult somatic cells that have been "reprogrammed" into a pluripotent state through the ectopic expression of a core set of transcription factors, such as Oct4, Sox2, Klf4, and C-Myc8. (cytosmart.com)
We discuss the characteristics and limitations of various types of human embryonic and adult stem cells, and their utility for bone tissue engineering. (biomedcentral.com)
Adult bones are supplied by blood and constantly undergo remodeling, which allows adaptation to mechanical stresses, maintenance of bone health, and repair of small injuries. (biomedcentral.com)
12. Quercetin promotes learning and memory performance concomitantly with neural stem/progenitor cell proliferation and neurogenesis in the adult rat dentate gyrus. (nih.gov)
A solid human embryonic spinal cord tissue transplanted into the cavity of an adult injured spinal cord has been shown to yield beneficial morphological effects in both acute and chronic SCI. (nature.com)
Donor-derived cells expressing neuronal proteins (neuronal phenotypes) were developed in the CNS after intravascular delivery of genetically marked adult mouse bone marrow into lethally irradiated normal adult hosts, resulting in a population of donor-derived cells in the brain with distinct characteristics from the bone marrow. (nature.com)
If the sampling and storage conditions are up to standard, the viability of adult stem cells in umbilical cord blood can be maintained for decades. (market-prospects.com)
The umbilical cord and umbilical cord blood of newborns are the most important sources for obtaining adult stem cells, and mesenchymal stem cells, which are used for adult stem cells, are widely used. (market-prospects.com)
1,2 Regarding the origin, they can be classified as embryonic stem cells (ESCs) and adult stem cells (ASCs). (bvsalud.org)
Human fetal hepatic progenitor cells are less immunogenic than adult ones. (wjgnet.com)
Scientists primarily work with two kinds of stem cells from animals and humans: embryonic stem cells and adult stem cells, which have different functions and characteristics that will be explained in this document. (ijpsr.com)
There are several main categories: the "pluripotent" stem cells (embryonic stem cells and induced pluripotent stem cells) and nonembryonic or somatic stem cells (commonly called "adult" stem cells). (nih.gov)
Pluripotent stem cells have the ability to differentiate into all of the cells of the adult body. (nih.gov)
Adult stem cells are found in a tissue or organ and can differentiate to yield the specialized cell types of that tissue or organ. (nih.gov)
In 2006, researchers identified conditions that would allow some mature human adult cells to be reprogrammed into an embryonic stem cell-like state. (nih.gov)
Throughout the life of the organism, populations of adult stem cells serve as an internal repair system that generates replacements for cells that are lost through normal wear and tear, injury, or disease. (nih.gov)
Adult stem cells have been identified in many organs and tissues and are generally associated with specific anatomical locations. (nih.gov)
On the other hand, adult stem cells differentiate to yield the specialized cell types of the tissue or organ in which they reside, and may have defining morphological features and patterns of gene expression reflective of that tissue. (nih.gov)
However, in mice, in vivo cell fusion between MG and adult stem cells forms hybrids that can partially regenerate ablated neurons.We used organotypic cultures of human retina and preparations of dissociated cells to test the hypothesis that cell fusion between human MG and adult stem cells can induce neuronal regeneration in human systems. (ibecbarcelona.eu)
Moreover, we established a microinjection system for transplanting human retinal organoids to demonstrate hybrid differentiation.We first found that cell fusion occurs between MG and adult stem cells, in organotypic cultures of human retina as well as in cell cultures. (ibecbarcelona.eu)
Recently, adult stem cells (ASCs) have emerged as a novel cell resource, replacing embryonic (ESCs) and umbilical cord blood stem cells owing to the relative ease with which they can be obtained and the simpler ethical considerations involved ( Collas, 2010 ). (geneticsmr.com)
With more than 6,000 transplants of cord blood from related and unrelated donors performed thus far, cord blood has emerged as an acceptable, alternative source of HPCs that has some advantages over adult sources of HPCs and the availability of which represents an important development in the field. (nationalacademies.org)

Cell viability is maintained by medium perfusion through the scaffold interior. (biomedcentral.com)
The effects of CAMPATH-1H on cell viability do not correlate to the CD52 density on the cell surface. (mcw.edu)
In addition, no difference in cell viability was noted when different concentrations of CAMPATH-1H were used. (mcw.edu)
The data about the comparative viability of cancer cells after cryopreservation are limited. (researchsquare.com)
However, data about effect of cryopreservation procedure on viability of cancer cells are limited. (researchsquare.com)
This inhibited SIRT1 expression and increased histone H3K9 acetylation, leading to decreased cell viability, cell cycle arrest, and apoptosis. (geneticsmr.com)
We analyzed cell viability, cell cycle phase distribution, and apoptosis after TSA and SAHA treatment, determined the level of H3K9 acetylation, and measured the transcription and translation of genes related to multipotency, proliferation, and apoptosis. (geneticsmr.com)
However, it must be clarified whether there is any negative influence on cell function and viability after labelling prior to clinical administration. (biomedcentral.com)
A stress-reduced passaging technique improves the viability of human pluripotent cells. (kyoto-u.ac.jp)

Because of their biological characteristics, mesenchymal stem cells can regulate immunologic mechanisms and repair the uterus, ovaries, and oviductal tissue. (hindawi.com)
These cells have been isolated from human and mouse tissue as well as from cell lines originated from the mammary gland that can give rise to both the luminal and myoepithelial cell types of the gland. (ijbiotech.com)
Neural stem cells: The presence of stem cells in the mature animal brain tissue indicates that during the neurogenesis process generation of new neurons continues into adulthood. (ijbiotech.com)
Hematopoietic stem cells are believed to reside in a restricted number of specific niches inside the bone tissue marrow. (bio-cavagnou.info)
CD133+ bone tissue marrow cells and about Lin?Compact disc34+ cord bloodstream cells. (bio-cavagnou.info)
The umbilical cord stem cells segment has been additionally categorized into cord blood, cord tissue, and placenta. (marketresearchfuture.com)
They have proven useful for the study of basic developmental processes and have provided new avenues for the treatment of diseases, with applications in tissue engineering, cell-based therapies, regenerative medicine, and disease models for drug discovery3,4. (cytosmart.com)
In intramembanous ossification, cells of the condensed mesenchymal tissue differentiate into osteoblasts and directly form bone. (biomedcentral.com)
Cell-biology-related research on preadipocyte (adiposal-mesenchymal cell) differentiation laid the foundation for discoveries of adipose-derived cells (both in stromal vascular fraction, or SVF, and adipose-derived stromal/stem cells, or ASCs), which had become an increasing interest to both stem cell biologists and clinicians because of their potential for angiogenesis and suppression of inflammation for tissue engineering and treatments. (scirp.org)
Ensuing specialists later determined that this multifunctional organ contained a number of valuable resident cells, other worthy non-indigenous cellular populations and a quantity of distinct structural elements, which possessed the potential to optimize fat graft survival and eventually further tissue engineering applications in regenerative medicine. (scirp.org)
Transplantation of these cells has shown that they can differentiate and be integrated into the neural tissue. (nature.com)
Regenerative medicine mainly covers tissue and cell repair, stem cell therapy, and immune cell therapy. (market-prospects.com)
Regenerative medicine includes two major fields: tissue engineering and stem cell therapy. (market-prospects.com)
Tissue engineering uses the regeneration function of cells to form organs, while stem cell therapy uses the potential functional properties of under-differentiated and regenerating various tissues and organs to treat diseases. (market-prospects.com)
Due to the ability to self-renew and to differentiate into cells that are found throughout the body, there is a great interest in using stem cells for the regeneration of injured tissues as well as to develop tissue-engineered implants and bio-hybrid organs, in order to restore tissue function. (bvsalud.org)
The use of ASCs in regenerative medicine and tissue engineering research has important advantages in comparison with ESCs, since there are no ethical complications and the process of differentiation of these cells is better controlled. (bvsalud.org)
In explant method, the dental tissue is placed on a plastic surface and the cells migrate out from the tissue fragment adhering to culture flasks or dishes ( Figure 1 ). (bvsalud.org)
Bone remodelling is a continuous cycle of degeneration and regeneration, involving osteoblasts (bone-forming cells) and osteoclasts (cells that absorb bone tissue) (Fig. 1 ). (biomedcentral.com)
In the acute phase after injury or at the onset of osteoporosis, local levels of pro-inflammatory cytokines in the bone tissue rise causing immune cell infiltration, macrophage polarisation towards the pro-inflammatory M1 phenotype and release of chemokines. (biomedcentral.com)
Non-reproducible treatment outcomes or even absence of treatment effects in comparison to control groups challenges the potential of these cells for routine application both in tissue engineering and in regenerative medicine. (frontiersin.org)
Three processes in which stem cells play a central role in an organism, development, repair of damaged tissue, and cancer resulting from stem cell division going awry. (ijpsr.com)
What controls the balance between these types of divisions to maintain stem cells at an appropriate level within a given tissue is not yet well known. (nih.gov)
Neoplastic Growth A benign or malignant tissue growth resulting from uncontrolled cell proliferation. (nih.gov)
Until now no therapy has been used to promote nerve repair in these patients, but animal studies have shown that the transplantation of human neural stem cells to the site of injury can promote the recovery of downstream muscle tissue. (sanlimedical.com)
However, several recent studies on the mechanisms of target tissue injury have revealed tissue stem cells as targets of GVHD, leading to impaired tissue homeostasis and regeneration. (apbmt.org)
Intrauterine tissue engineering using a biomaterial seeded with stem cells might prevent this additional damage. (indexindex.com)
Wharton's jelly (WJ) is the mucoid connective tissue that surrounds the vessels in the human umbilical cord and provides protection from compression and torsion in response to fetal movement. (stemedix.com)
Therefore, adipose-derived stem cells (ADSCs) have a wide range of potential applications in tissue engineering. (geneticsmr.com)
Phase I. Prior to transplantation the patient undergoes conditioning (radiation and/or chemotherapy) which leads to damage and activation of host tissue. (basicmedicalkey.com)
Tissue damage caused by donor T cells creates a cytotoxic environment and leads to recruitment of additional effector cells including NK cells and neutrophils, which leads to additional damage and immune cell recruitment, creating a cycle that is difficult to break. (basicmedicalkey.com)
Cytotoxic T cells and NK cells respond and stimulate monocytes to produce IL-1 and TNF-α, directly resulting in tissue damage. (basicmedicalkey.com)
Because of the lack of tissue available for islet transplantation, new sources of β-cells have been sought for the treatment of type 1 diabetes. (diabetesjournals.org)
The aim of this study was to determine whether the human exocrine-enriched fraction from the islet isolation procedure could be reprogrammed to provide additional islet tissue for transplantation. (diabetesjournals.org)
However, labelling of the stem cells is required in order to distinguish administered cells from the host tissue. (biomedcentral.com)
This suggests the role of stem cell-released signaling molecules and factors on tissue regeneration. (biomedcentral.com)
Allometrically scaling tissue forces drive pathological foreign-body responses to implants via Rac2-activated myeloid cells. (stanford.edu)
We found that the human FBR is mediated by immune-cell-specific RAC2 mechanotransduction signalling, independently of the chemistry and mechanical properties of the implant, and that a pathological FBR that is human-like at the molecular, cellular and tissue levels can be induced in mice via the application of human-tissue-scale forces through a vibrating silicone implant. (stanford.edu)
Transplantation of human neural stem/progenitor cells (hNSPCs) is a promising method to regenerate tissue from damage and recover function in various neurological diseases including brain ischemia. (biomedcentral.com)
Brain ischemia, which is caused by occlusion of a cerebral artery, leads to focal tissue loss and death of multiple neuronal cell types within and around the ischemic region. (biomedcentral.com)

Prockop, D.J. (1997) Marrow stromal cells as stem cells for nonhematopoietic tissues. (scirp.org)
Effects of radiation and 4-hydroperoxycyclophosphamide on production of G- and GM-CSF by stromal cells. (musc.edu)

Humanized mice (hu mice) are based on the transplantation of hematopoietic stem and progenitor cells into immunodeficient mice and have become important pre-clinical models for biomedical research. (nih.gov)
This program will support regular research grants (R01s), which include collaborations between basic scientists and clinical investigators who will explore together clinically relevant questions, thereby enabling basic science findings to be more readily translated into studies that investigate the potential of cell based therapy for preventing and treating lung disease. (nih.gov)
An important goal of this program is to provide the basic knowledge necessary to eventually develop safe and efficacious clinical protocols on lung cell based therapy. (nih.gov)
18. Anti-apoptotic role and clinical relevance of neurotrophins in diffuse large B-cell lymphomas. (nih.gov)
The clinical use of bone marrow and HSC transplantation is well established and has made HSC a paradigm for stem cell therapy. (bio-cavagnou.info)
Since the specialty of Plastic Surgery with its position statement on stem cells and fat grafting is committed to advancing evidence-base preclinical and clinical studies in compliance with FDA-regulations, an updated review of cell biology provides insights to achieve these goals. (scirp.org)
They have certain immunomodulatory, immunosuppressive, and antimicrobial properties that enable them to have several therapeutic and clinical applications including: treatment of autoimmune disorders, role in hematopoietic stem cell transplantation and regenerative medicine, as well as treatment of various infections and their associated complications such as septic shock and acute respiratory distress syndrome. (intechopen.com)
Although more success has been achieved in preclinical trials on the use of mesenchymal stem cells in animal models than in human clinical trials, particularly in septic shock and Chagas disease, more progress has been made in both disorders after the recent use of specific sources and certain doses of mesenchymal stem cells. (intechopen.com)
The clinical application of mesenchymal stem cells in the treatment of several diseases still faces real challenges that need to be resolved. (intechopen.com)
Stem cell-based therapies are moving closer to clinical application. (nature.com)
Upstream manufacturers in the regenerative medicine industry are responsible for the collection and preservation of stem cells, midstream manufacturers are engaged in the development of various types of stem cells, and downstream manufacturers are responsible for clinical experiments, transplantation technology, and disease treatment. (market-prospects.com)
Despite significant progress in the field of NK cell-based immunotherapies, some factors including their short life span and the occurrence of a tumor-dependent functional exhaustion have limited their clinical efficacy so that strategies aimed at overcoming these limitations represent one of the main current challenges in the field. (hindawi.com)
Along with highlighting these issues, we speculate that memory NK cell-based adoptive immunotherapy settings would greatly take advantage from the combination with tumor-targeting therapeutic antibodies (mAbs), as a strategy to fully unleash their clinical efficacy. (hindawi.com)
The European Society for Organ Transplantation (ESOT) has created a platform for the development of rigorous and regularly updated evidence based guidelines for clinical practice in the transplantation field. (ibecbarcelona.eu)
This is a pioneering clinical trial and also the first human clinical trial to use neural stem cells to treat chronic spinal cord injury. (sanlimedical.com)
In June 1st, a report published in" Cell Stem Cell" recorded the treatment course and clinical follow-up of the 4 patients. (sanlimedical.com)
This clinical study is related to human neural stem cell line NSI-566. (sanlimedical.com)
In the past, no human clinical trials have proved that such stem cells can be used for the treatment of chronic spinal cord injury. (sanlimedical.com)
Implementations of immune-checkpoint blockades or CAR-T cell therapy are at the stage of pre-clinical assessments of activity and feasibility. (springermedizin.de)
Approaches, e.g., those reinstating deficient cell death execution, show encouraging pre-clinical and first-in-human results in T-PLL, and urgently have to be transferred to systematic clinical testing. (springermedizin.de)
Blood and Marrow Transplant Research [CIBMTR] in 2004), the European Research Project on Cord Blood Transplantation (Eurocord) in 1993, and the Japanese Cord Blood Banking Network in 1996-expedited the clinical evaluation of the efficacy and safety of transplantation of cord blood from unrelated donors. (nationalacademies.org)
A clinical-grade HLA haplobank of human induced pluripotent stem cells matching approximately 40% of the Japanese population. (kyoto-u.ac.jp)
Also, the term "primary cutaneous CD4 + small/medium T-cell lymphoma" was changed to "primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder" because of its indolent clinical behavior and uncertain malignant potential. (medscape.com)

Embryonic stem cells are derived from the inner cell mass of the blastocyst and can differentiate into cells of all three germ layers. (medscape.com)
For example, neural stem cells derived from ectoderm can differentiate into ectoderm, mesoderm, and endoderm. (ijbiotech.com)
The HSCs with self-renewal capacity can differentiate into different types of blood cells, including those involved in the human immune system. (ijbiotech.com)
Stem cells have the capacity to self-renew and differentiate into specified cell types. (cytosmart.com)
These cells are characterized by adherence to plastic, surface expression of a defined set of markers (including CD73, CD90, and CD105), and the capacity to differentiate into adipocytes, chondrocytes, or osteocytes7. (cytosmart.com)
Both ES cells and iPSCs are pluripotent, and therefore have the ability to differentiate into cells of all three primary embryonic germ layers: endoderm, mesoderm, and ectoderm. (cytosmart.com)
CD52 was not expressed on HSC but began to be expressed as the cells differentiate, implying that CAMPATH-1H could potentially affect HSC differentiation and proliferation. (mcw.edu)
Stem cells (SCs) are undifferentiated cells with self-renewal ability and capacity to differentiate into specialized cell types. (bvsalud.org)
In our earlier studies we have demonstrated that fetuses at 10-18 wk of gestation age contain a large number of actively dividing hepatic stem and progenitor cells which possess bi-potent nature having potential to differentiate into bile duct cells and mature hepatocytes. (wjgnet.com)
Besides their innate ability to rapidly produce effector cytokines and kill virus-infected or transformed cells, natural killer (NK) cells display a strong capability to adapt to environmental modifications and to differentiate into long-lived, hyperfunctional populations, dubbed memory or memory-like NK cells. (hindawi.com)
Various pluripotent stem cells (PSCs), such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), are used in various biomedical fields due to their capacity of unlimited self-renewal and the ability to differentiate into multiple cell types [ 12 ]. (springer.com)

Additionally, proangiogenic growth factors overexpression in progenitor cells can potentially improve autologous or allogeneic stem cell therapy for ischemic diseases. (nih.gov)
Autologous grafts contain the essential components of bone regeneration - osteogenic cells, osteoinductive growth factors and bone-supporting matrix - but are not readily available in every situation. (biomedcentral.com)
For this purpose, autologous cells from the amniotic fluid are an attractive source. (indexindex.com)
Base-Resolution Methylome of Retinal Pigment Epithelial Cells Used in the First Trial of Human Induced Pluripotent Stem Cell-Based Autologous Transplantation. (kyoto-u.ac.jp)

Stimulation of human hematopoietic progenitor cell proliferation and differentiation by recombinant human interleukin 3. (musc.edu)

demonstrated that allogeneic bone marrow transplantation could be used to treat established autoimmune diseases in autoimmune-prone mice. (medscape.com)

multilineage and self-renewal differentiation. (bio-cavagnou.info)
An important role of these niches is to balance HSC self-renewal and differentiation quiescence and proliferation. (bio-cavagnou.info)
Stem cell niches are unique compartments in tissues that include the neighboring cells, vasculature, extracellular matrix, and 3D environment9, providing a multitude of chemical and physical signals that dictate stem cells' balance between quiescence, self-renewal, and differentiation10. (cytosmart.com)
Discovering the mechanism behind self-renewal may make it possible to understand how cell fate (stem vs. non-stem) is regulated during normal embryonic development and post-natally, or misregulated as during aging, or even in the development of cancer. (nih.gov)
These advantages include higher proliferation and self-renewal capacity and multilineage differentiation capability. (stemedix.com)

The purpose of this RFA is to foster research on lung stem cell biology and cell based therapy for lung diseases. (nih.gov)
The objective of this RFA is to accelerate study of cell based therapy for lung diseases. (nih.gov)
This program will foster multidisciplinary collaborations that are required for translational research to explore the potential efficacy and safety of using cell based therapy for preventing and treating lung diseases. (nih.gov)
The objective of this program is to support: applications to perform basic, translational, and preclinical research on lung stem cell biology and cell based therapy. (nih.gov)
The basic and preclinical research supported through this Request for Applications (RFA) will be related to stem cell biology and cell based therapy for the prevention and treatment of lung diseases. (nih.gov)
Investigating the potential efficacy and safety of cell based therapy strategies for treating lung diseases is a high priority for the National Heart, Lung, and Blood Institute (NHLBI). (nih.gov)
Thus, they represent an important paradigm of cell-based therapy for a variety of autoimmune diseases. (medscape.com)
[ 71 ] This case illustrates that the development of neoformations is a possible complication of stem cell therapy. (medscape.com)
8 Embryonic stem cells (ESCs) are promising as a potentially regenerative therapy for neurological conditions such as Parkinson's disease and SCI. (nature.com)
Knowledge of stem cells has offered a new dimension for regenerative therapy and has been considered as one of the potential adjuvant treatment modality in patients with end stage liver diseases (ESLD). (wjgnet.com)
Hepatic stem cell therapy for the treatment of ESLD is in their early stage of the translation. (wjgnet.com)
The emerging therapeutic options include nanotherapeutics, stem cell therapy, phototherapy, and different biological therapies such as microbiome therapy, reactive oxygen species (ROS), and NO generators. (encyclopedia.pub)
The ability to obtain stem cells for cell-based therapy (CBT) is limited due to donor site morbidity and the invasive nature of the harvesting process. (wjgnet.com)
These UCMSCs have been developed as effective "off-the-shelf" cell therapy for a number of conditions, including autoimmune diseases, and as a treatment for a number of emergency medical conditions. (stemedix.com)
To prepare for transplantation, recipients must undergo a conditioning regimen involving immunosuppressive therapy to ablate the host immune response and allow for donor HSC engraftment. (basicmedicalkey.com)
Pluripotent Stem Cell-Based Cell Therapy-Promise and Challenges. (kyoto-u.ac.jp)
βT87Q-Globin Gene Therapy Reduces Sickle Hemoglobin Production, Allowing for Ex Vivo Anti-sickling Activity in Human Erythroid Cells. (nih.gov)

Embryonic stem cells (ES): ES cells are pluripotent stem cells derived from the inner cell mass of a blastocyst. (ijbiotech.com)
3 Embrionic stem cells (ESCs) are derived from the inner cell mass of the blastocyst and form all cell types, derived from the three germ layers, and are therefore pluripotent. (bvsalud.org)
Those reprogramed stem cells are called induced pluripotent stem cells (iPSCs). (nih.gov)
The specific factors and conditions that allow pluripotent stem cells to remain undifferentiated are of great interest to scientists. (nih.gov)
It has taken many years of trial and error to learn to derive and maintain pluripotent stem cells in the laboratory without the cells spontaneously differentiating into specific cell types. (nih.gov)
Specifically, we will briefly summarize and discuss our most recent insights into these issues based on observations in patients, mouse- and induced pluripotent stem cell (iPSC)-models. (molcells.org)
ALS patient-derived human-induced pluripotent stem cells (ALS hiPSCs, harboring the SOD1 AV4 mutation), were differentiated to MNs (ALS-MNs). (springer.com)
Multi-omics approach reveals posttranscriptionally regulated genes are essential for human pluripotent stem cells. (kyoto-u.ac.jp)
The pluripotent stem cell-specific transcript ESRG is dispensable for human pluripotency. (kyoto-u.ac.jp)
Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells. (kyoto-u.ac.jp)
Induced 2C Expression and Implantation-Competent Blastocyst-like Cysts from Primed Pluripotent Stem Cells. (kyoto-u.ac.jp)
Generation of a human induced pluripotent stem cell line, BRCi001-A, derived from a patient with mucopolysaccharidosis type I. (kyoto-u.ac.jp)
Application of induced pluripotent stem cells to primary immunodeficiency diseases. (kyoto-u.ac.jp)
Laying the Groundwork for a First-In-Human Study of an induced Pluripotent Stem Cell-Based Intervention for Spinal Cord Injury. (kyoto-u.ac.jp)
Induced Pluripotent Stem Cells and Their Use in Human Models of Disease and Development. (kyoto-u.ac.jp)

Capi, O. and Gepstein, L. (2006) Myocardial regeneration strategies using human embryonic stem cell-derived cardiomyocytes. (scirp.org)
Stem cell-based therapies cast a new hope for infertility treatment as a replacement or regeneration strategy. (hindawi.com)
Bone marrow, embryo and cord blood are the major stem cell sources which are believed to act systemically for regeneration of tissues and organs in an organism. (ijbiotech.com)
The diversity of the stem cells present in different tissues implies that the body reserves all the cell types with stemness properties to guarantee important physiological processes and regeneration of organs. (ijbiotech.com)
For example, epidermal stem cells, found in hair follicles and the basal layer of the epidermis, replenish the outer layers of the skin, mediate hair regeneration, and support wound healing5. (cytosmart.com)
Our study demonstrated that administration of bone mesenchymal stem cell-derived extracellular vesicles (BMSC-EV) reduced brain cell death, enhanced neuronal survival and regeneration, and improved motor function compared with the administration of BMSC-EV free culture media (EV-free CM). Besides, the BSCB was attenuated and pericyte coverage was significantly decreased in vivo . (frontiersin.org)
4 Although it has been recognized for decades that CNS is resistant to regeneration, recent studies have shown that these cells can also potentially recover and multiply. (nature.com)
These cells have been studied for the treatment of periodontitis, bone repair, regeneration of the pulp after necrosis as well as the development of new teeth. (bvsalud.org)
However, if the inflammation becomes chronic as in osteoporosis, this promotes strong and persistent activity of immune cells interfering with bone regeneration [ 12 ]. (biomedcentral.com)
Stem cell-based periodontal regeneration is currently at the center of attention [ 18 ]. (biomedcentral.com)

Corticosteroids have a cytotoxic effect on lymphoma cells and can induce a radiographic response in up to half of patients, which limits the sensitivity of diagnostic tools like biopsy or lumbar puncture. (medscape.com)
To study how Allogro® can induce osteoblast differentiation in mesenchymal stem cells, the expression levels of bone related genes and mesenchymal stem cells marker were analyzed, using real time Reverse Transcription-Polymerase Chain Reaction. (ispub.com)
Apolipoprotein E Signals via TLR4 to Induce CXCL5 Secretion by Asthmatic Airway Epithelial Cells. (nih.gov)

Therefore, in this article, we summarize the current status of mesenchymal stem cell therapies in infertility pathophysiology and discuss potential areas of further research in regenerative medicine. (hindawi.com)
The upstream industry of regenerative medicine is a manufacturer engaged in the collection and preservation of stem cells. (market-prospects.com)
The midstream industry of regenerative medicine is engaged in the development of hematopoietic stem cells, embryonic stem cells, umbilical cord mesenchymal stem cells, dental stem cells, etc. (market-prospects.com)
8,9 Because dental stem cells (DSCs) are easy to obtain and present a great potential of differentiation, there has been a growing interest in their use in regenerative medicine for treatment of various human diseases. (bvsalud.org)
Stem cells offer opportunities for scientific advances that go far beyond regenerative medicine. (ijpsr.com)

Results: there are five main sources of stem cells of dental origin: stem cells from dental pulp of permanent teeth and deciduous teeth, apical papilla, periodontal ligament and dental follicle. (bvsalud.org)
In human postnatal dental tissues, five main sources of DSCs have been identified: dental pulp stem cells (DPSCs), 11 stem cells from human exfoliated deciduous teeth (SHEDs), 12 periodontal ligament stem cells (PDLSCs), 13 dental follicle stem cells (DFSCs) 14 and stem cells from apical papilla (SCAPs). (bvsalud.org)

To investigate the osteogenic differentiation of PB-hMSCs, the quantitative expression of the mRNA of specific genes, like transcriptional factors (RUNX2), bone related genes (SPP1, COL1A1, COL3A1, BGLAP, ALPL, and FOSL1) and mesenchymal stem cells marker (CD105) were examined by means of real time Reverse Transcription-Polymerase Chain Reaction (real time RT-PCR). (ispub.com)

Factors representing the growth of the market are rising use of therapeutic potential of stem cells, increasing investments in stem cell-based research, surging number of hematopoietic stem cell transplantation (HSCT) procedures, and growing newborn population. (marketresearchfuture.com)
The existence of key market participants and sophisticated healthcare infrastructure, expanding network of stem cell banking services, and continuous efforts by researchers to explore new therapeutic applications of cord blood cells in the US and Canada is assisting in the dominance of North America. (marketresearchfuture.com)
however, the limited availability and compromised quality of progenitor cells in aged and diseased patients limit its therapeutic use. (nih.gov)
Here we report a nanofiber-based ex vivo stem cell expansion technology and proangiogenic growth factors overexpression of human umbilical cord blood (UCB)-derived progenitor cells to enhance angiogenic potential of therapeutic stem cells. (nih.gov)
The data indicate that nanofiber-based ex vivo expansion technology can provide an essential number of therapeutic stem cells. (nih.gov)
They suggest B cell-directed, dual TLR7 antagonism/TLR9 agonism or dual TLR7/9 antagonism as a potential future therapeutic strategy to treat SLE. (bvsalud.org)
14. Designer Self-Assemble Peptides Maximize the Therapeutic Benefits of Neural Stem Cell Transplantation for Alzheimer's Disease via Enhancing Neuron Differentiation and Paracrine Action. (nih.gov)
However, the therapeutic mechanism of extracellular vesicles on spinal cord injury has not been studied clearly. (frontiersin.org)
Further, NK cell-mediated antibody-dependent cellular cytotoxicity (ADCC) is a main immune-dependent mechanism by which tumor-targeting therapeutic mAbs mediate tumor cell killing [ 6 - 8 ]. (hindawi.com)
Since the number of EVs naturally secreted by cells is finite and they usually bear specific repertoires of bioactive molecules to perform manifold cell-cell communication, but not one particular therapeutic function as expected, their practical application is still limited. (biomedcentral.com)
Although the cells of origin are lymphocytes, PCNSL should be considered a brain tumor, because the therapeutic challenges resemble those of other brain tumors. (medscape.com)
Another possible mechanism of the therapeutic effects of hNSPCs-transplantation is their trophic actions. (biomedcentral.com)

Human cell chimerism in spleen and bone marrow was maintained over time. (nih.gov)
Importantly, the percentage of more primitive hematopoietic stem cells (HSCs) in bone marrow was maintained over time. (nih.gov)
Overall, leukocyte reconstitution was maintained up to 32 weeks post-transplantation in our hu NSG model, possibly explained by the maintenance of HSCs in the bone marrow. (nih.gov)
Bone Marrow Transplantation. (wikipedia.org)
Wakitami, S., Saito, T. and Caplan, A.I. (1995) Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. (scirp.org)
[ 70 ] This was the first report indicating that the glomerular damage induced by LN is reversible and can be treated successfully with bone marrow transplantation. (medscape.com)
Hematopoietic stem cell transplantation in the Eastern Mediterranean Region (EMRO) 2008-2009: report on behalf of the Eastern Mediterranean Bone Marrow Transplantation (EMBMT) Group. (musc.edu)
Measurement of marrow repopulating potential of human hematopoietic progenitor and stem cells using a fetal sheep model. (musc.edu)
First report of pediatric hematopoietic stem cell transplantation activities in the eastern mediterranean region from 1984 to 2011: on behalf of the pediatric cancer working committee of the eastern mediterranean blood and marrow transplantation group. (musc.edu)
Outcome of hematopoietic stem cell transplantation (HCT) from HLA-matched related donor for Fanconi anemia (FA) in adolescents and adults: a retrospective study by Eastern Mediterranean Blood and Marrow Transplantation Group (EMBMT). (musc.edu)
Causes include vascular compromise due to direct trauma, intravascular occlusion in the case of sickle cell aggregations, clots and lipid thrombi, intraosseous extravascular compression due to lipid deposition and adipocyte hypertrophy in the marrow space often associated with corticosteroids or alcohol abuse. (biomedcentral.com)
AML - Acute Myeloid Leukemia A clonal expansion of myeloid blasts in the bone marrow, blood or other tissues. (nih.gov)
T-PLL patients typically present with exponentially rising blood lymphocyte counts, bone marrow infiltration, splenomegaly, and small lymphadenopathy. (springermedizin.de)
Therefore, we determined whether ESCs could be used to reconstitute marrow and blood in major histocompatibility complex (MHC)-mismatched mice. (rupress.org)
Bone marrow-derived mesenchymal stem cells (BMSCs)-derived extracellular vesicles (EVs) have shown potent anti-inflammatory function in various pathological conditions, such as osteoarthritis and neurodegenerative diseases. (biomedcentral.com)
B lood cell differentiation begins with multipotent hematopoietic progenitor cells (HPCs), which are located in the marrow spaces of the bone. (nationalacademies.org)
Giving chemotherapy before a stem cell transplant helps kill any cancer cells that are in the body and helps make room in the patient's bone marrow for new blood-forming cells (stem cells) to grow. (baptistmdanderson.com)
More chemotherapy is then given to prepare the bone marrow for the stem cell transplant. (baptistmdanderson.com)

These reservoir cells play a major role in development and growth of the tissues and organs. (ijbiotech.com)
As with other in vivo tissues, stem cell niches are a hypoxic environment and exhibit oxygen levels that are notably lower than the ambient environment. (cytosmart.com)
Watching embryonic stem cells give rise to specialized cells is like peeking into the earliest development of the many tissues and organs of the human body. (ijpsr.com)
Because embryonic stem cells can continue to divide for long periods of time and produce a variety of cell types, they could provide a valuable source of human cells for testing drugs or measuring the effects of toxins on normal tissues without risking the health of a single human volunteer. (ijpsr.com)
The inner cell mass will ultimately develop into the specialized cell types, tissues, and organs of the entire body of the organism. (nih.gov)
These stem cells may remain quiescent (non-dividing) for long periods of time until they are activated by a normal need for more cells to maintain and repair tissues. (nih.gov)
Stem cells have unique abilities to self-renew and to recreate functional tissues. (nih.gov)
Stem cells have the ability to recreate functional tissues. (nih.gov)
Release of proinflammatory cytokines from activated host tissues increases HLA expression on host cells and enhances their antigen-presenting ability. (basicmedicalkey.com)
Finally, activated immune cells mediate the destruction of host tissues and result in multiple organ GVHD. (basicmedicalkey.com)

The epithelia, haematopoietic and mesenchymal stem cells are major stem cells isolated from the placenta. (ijbiotech.com)
3,4 The zygote and cells derived from the first two cellular divisions constitute the most primitive cells (totipotent cells) that are capable of forming the embryo and the embryonic annexes (e.g. placenta, amniotic membranes etc). (bvsalud.org)
The trophectodermal cells contribute to the placenta. (nih.gov)

Narrowing the gap for hematopoietic stem cell transplantation in the East-Mediterranean/African region: comparison with global HSCT indications and trends. (musc.edu)
Graft versus host disease (GvHD) is one of the main complications after hematological stem cell transplantation (HSCT). (mcw.edu)
Effective control of the graft-versus-host disease (GVHD) and immune reconstitution are crucial in improving the outcome of allogeneic hematopoietic stem cell transplantation (HSCT) as well as the quality of life of the transplant survivors. (apbmt.org)
Graft-versus-host disease (GVHD) is a major devastating complication of allogeneic hematopoietic stem cell transplantation (HSCT). (apbmt.org)
Acute GVHD develops early after HSCT, typically within 100 d post-transplantation. (apbmt.org)
In particular, T-cell recapitulation takes a long time after HSCT. (apbmt.org)
More profound disease control or rare curative outcomes can currently only be expected after a consolidating allogeneic hematopoietic stem cell transplantation (allo-HSCT) in best first response. (springermedizin.de)

Neural stem cells taken from the embryonic spinal cord are an appealing source of cells for transplantation because they are involved in spinal cord progeny. (nature.com)
Smith and Broxmeyer, 1986), thereby making it a potential source of cells for transplantation (Bodger, 1987). (nationalacademies.org)

Activation of NOTCH signaling in human hematopoietic stem/progenitor cells (HSPCs) by treatment with an engineered Delta-like ligand (DELTA1 ext-IgG [DXI]) has enabled ex vivo expansion of short-term HSPCs, but the effect on long-term repopulating hematopoietic stem cells (LTR-HSCs) remains uncertain. (nih.gov)
Rapid exit from G0/G1 phases of cell cycle in response to stem cell factor confers on umbilical cord blood CD34+ cells an enhanced ex vivo expansion potential. (musc.edu)
When cells are grown outside of their source organism, they must be cultured under conditions that closely mimic their native in vivo environment. (cytosmart.com)
In vivo , stem cells exist in distinct 3D microenvironments known as stem cell niches. (cytosmart.com)
Ex vivo nanofiber expansion and genetic modification of human cord blood-derived progenitor/stem cells enhances vasculogenesis. (nih.gov)
The progenitor cells were expanded approximately 225-fold on nanofiber-based serum-free ex vivo expansion culture technique without inducing differentiation. (nih.gov)

HSCs can give rise to all the blood cell types. (ijbiotech.com)
HSCs are also applied in reconstitution of damaged hematopoietic cells and restoring the immune system following chemotherapy in certain diseases. (ijbiotech.com)
Likewise, hematopoietic stem cells (HSCs) in their niche are exposed to an oxygen gradient ranging from 1-6%, depending on their proximity to blood vessels9. (cytosmart.com)

7. Neural differentiation of brain-derived neurotrophic factor-expressing human umbilical cord blood-derived mesenchymal stem cells in culture via TrkB-mediated ERK and β-catenin phosphorylation and following transplantation into the developing brain. (nih.gov)
17. Short-Lived Human Umbilical Cord-Blood-Derived Neural Stem Cells Influence the Endogenous Secretome and Increase the Number of Endogenous Neural Progenitors in a Rat Model of Lacunar Stroke. (nih.gov)

The results from recent preclinical studies regarding stem cell-based therapies are promising. (hindawi.com)

8. Acupuncture Improves Cerebral Microenvironment in Mice with Alzheimer's Disease Treated with Hippocampal Neural Stem Cells. (nih.gov)
13. Ultrasound-targeted microbubbles destruction assists dual delivery of beta-amyloid antibody and neural stem cells to restore neural function in transgenic mice of Alzheimer's disease. (nih.gov)

Recent advances in adipogenesis had provided insights into understanding of the complex cues for influencing the cytoarchitecture, epigenomic remodeling, signaling pathways and transcription regulators on gene actions for both white and brown adipogenic progression from mesenchymal stem cells to matured committed adipocytes. (scirp.org)
Labelled cells underwent osteogenic and adipogenic differentiation. (biomedcentral.com)

Conclusion: stem cells from dental origin are an interesting alternative for research and application in regenerative therapies in Dentistry. (bvsalud.org)
Clearly, though, the application of any of these cell therapies was technically feasible and safe in that it was associated with low complication rates. (biomedcentral.com)
Over the last three decades, increasing level of interest in the application of cell-based therapies in the treatment of ON has been noted. (biomedcentral.com)

Upon reinfection, these memory NK cells undergo secondary expansion, rapidly degranulate, and release cytokines, leading to a protective immune response, and also provide protection to newborn mice challenged with MCMV, upon adoptive transfer [ 16 ]. (hindawi.com)

Benign neoplastic cells resemble normal cells without exhibiting significant cytologic atypia, while malignant cells exhibit overt signs such as dysplastic features, atypical mitotic figures, necrosis, nuclear pleomorphism, and anaplasia. (nih.gov)
They can eradicate neoplastic cells by a targeted release of cytotoxic granules containing perforin and granzymes and/or death receptor-mediated killing [ 1 ]. (hindawi.com)
[ 6 ] Additionally, a biopsy of lymphoma pre-treated with corticosteroids may reveal only gliosis or lymphocytic and histiocytic infiltrates without identifiable neoplastic cells. (medscape.com)

6. Brain-derived neurotrophic factor (BDNF) -TrKB signaling modulates cancer-endothelial cells interaction and affects the outcomes of triple negative breast cancer. (nih.gov)
Hemangiosarcoma A malignant tumor arising from the endothelial cells of the blood vessels. (nih.gov)
These growth factors form platelets participate in the migration, differentiation and proliferation of stem cells, as well as to stimulate cells such as fibroblasts and endothelial cells. (sanlimedical.com)

Nephritis is common in systemic lupus erythematosus patients and is associated with hyper-activation of immune and renal cells. (bvsalud.org)
NK cells represent a pivotal player of innate antitumor immune responses. (hindawi.com)
Moreover, NK cells can signal to other immune cells by producing cytokines and chemokines, such as IFN- γ , TNF α , IL-6, GM-CSF, and CCL5 in response to target cells or cytokine stimulation [ 1 , 2 ]. (hindawi.com)
In particular, NK-derived IFN- γ stands as a well-recognized key immunoregulatory factor in the shaping of antitumor adaptive immune responses, by modulating dendritic cell (DC) and T cell responses [ 3 - 5 ]. (hindawi.com)
Overview of the Immune System The immune system distinguishes self from nonself and eliminates potentially harmful nonself molecules and cells from the body. (msdmanuals.com)
B cells The immune system consists of cellular components and molecular components that work together to destroy antigens. (msdmanuals.com)

In addition the recombinant protein concentrations may be vastly higher than the levels of VCAM1 or tenascin-C on the osteoblast cell surface and this could explain the apparent discrepancy in α9-mediated interactions. (bio-cavagnou.info)

Fludarabine-based reduced intensity regimen for matched related donor hematopoietic stem cell transplantation in acquired severe aplastic anemia. (musc.edu)
The private bank's segment would lead the market throughout the forecast period as it generates greater revenue, the cost to retrieve cord blood is free, and has complete ownership rights preserved by the donor. (marketresearchfuture.com)
The stem cell concentrate was cryopreserved and reinfused through arteriography into the donor patient. (nature.com)
Starting with cell source, choice of donor and recipient, as well as isolation methods, we will then discuss existing expansion protocols (two-/three-dimensional cultivation, basal medium, medium supplements, static/dynamic conditions, and hypoxic/normoxic conditions) and influence of these strategies on the cell functionality after implantation. (frontiersin.org)
Studies on GVHD pathophysiology have primarily focused on the induction phase of GVHD, particularly the mechanisms of donor T-cell activation by professional and non-professional antigen-presenting cells. (apbmt.org)
Mixed lymphocyte culture assays demonstrated T cell tolerance to both recipient and donor but intact third party proliferative responses and interferon γ production. (rupress.org)
Numerous studies have shown that nuclear transplantation using donor cells with reprogramming abnormalities leads to early developmental defects in the cloned embryo. (geneticsmr.com)
Thus, choosing suitable donor cells can improve the efficiency of mammalian cloning. (geneticsmr.com)
Transplanted donor T cells are activated upon interaction with host antigen resulting in proliferation and differentiation. (basicmedicalkey.com)
After transplantation, donor T cells enter the inflammatory environment and recognize alloantigens presented by APCs. (basicmedicalkey.com)
Donor T cell inflammatory cytokine release triggers a proinflammatory cytokine cascade, which further drives donor T cell proliferation. (basicmedicalkey.com)

blindness, spinal cord injuries and cancers is well established. (ijbiotech.com)
The transplantation of oligodendrocytes derived from human ES cells into spinal cord-injured individuals was the world's first human ES cell human trial approved by FDA. (ijbiotech.com)
Mesenchymal stem cell (MSC) transplantation has been shown to represent a potential treatment for traumatic spinal cord injury (SCI). (frontiersin.org)
Disruption of the blood-spinal cord barrier (BSCB) is a crucial factor that can be detrimental to motor function recovery. (frontiersin.org)
Traumatic spinal cord injury (SCI) causes permanent motor/sensory dysfunction, and even paralysis and death, resulting in a considerable reduction in the quality of life of the patient ( Eckert and Martin, 2017 ). (frontiersin.org)
To evaluate the effect of autogenous undifferentiated stem cell infusion for the treatment of patients with chronic spinal cord injury (SCI) on somatosensory evoked potentials (SSEPs). (nature.com)
The annual incidence of spinal cord injuries (SCIs) in many countries is difficult to determine as reported incidences vary considerably, ranging from 10.4 to 83 per million inhabitants per year. (nature.com)
Neurons outside the central nervous system (CNS) in the immature spinal cord and in special culture media can regenerate. (nature.com)
Spinal cord injury treatments consist of biological, surgical and pharmacological approaches, as well as physical procedures such as spinal stabilization. (nature.com)
Four patients with chronic spinal cord injury, lower lumbar movement, and complete loss of sensory function have received human neural stem cell transplantation. (sanlimedical.com)
Severe spinal cord injury may cause devastating consequences, like paralyzing the injured area, and the hope of recovery is very slim. (sanlimedical.com)
In a previous study, the research team at the University of California San Diego showed that these cells could improve the motor and sensory neuron function of the rat model of spinal cord injury. (sanlimedical.com)

These cells can be differentiated into various cell lineages and considering their rapid proliferation, multipotency and immunomodulatory properties they are widely used for treatment of various diseases. (ijbiotech.com)

Chondrogenic differentiation occurred to a lesser extent compared with a control sample. (biomedcentral.com)

Carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. (nih.gov)

These are called human embryonic stem cells. (ijpsr.com)
Previous work with mouse embryos led to the development of a method in 1998 to derive stem cells from the inner cell mass of preimplantation human embryos and to grow human embryonic stem cells (hESCs) in the laboratory. (nih.gov)

Standard management of sickle cell disease complications. (musc.edu)
The following book chapter will be an updated review on the role of mesenchymal stem cells in various infections and their complications. (intechopen.com)

The encoded protein is a secreted sulfated glycoprotein and functions as a growth factor for primitive hematopoietic progenitor cells. (wikipedia.org)
Characterization of c-kit expression by primitive hematopoietic progenitors in umbilical cord blood. (musc.edu)

Correlations between hematopoietic stem transplantation (in case of total body irradiation and chronic graft-versus-host disease (GvHD)) and the development of ON are previously described [ 10 ]. (biomedcentral.com)

Anatomy14

Organisms4

Diseases25

Chemicals and Drugs21

Analytical, Diagnostic and Therapeutic Techniques and Equipment41

Psychiatry and Psychology1

Phenomena and Processes14

Anthropology, Education, Sociology and Social Phenomena1

Information Science2

Named Groups3

Health Care9

MSCs46

Vitro17

Peripheral18

Adult35

Viability9

Tissue39

Stromal2

Clinical23

Differentiate11

Autologous4

Progenitor cell proliferation1

Allogeneic bone marrow tra1

Self-renewal5

Therapy17

Pluripotent15

Regeneration10

Induce3

Regenerative medicine5

Dental pulp2

Osteogenic differentiation1

Therapeutic12

Marrow18

Tissues10

Placenta3

HSCT7

Source of cells for transplantation2

Vivo6

HSCs3

Umbilical cord blood-de2

Preclinical1

Neural stem2

Adipogenic2

Therapies3

Undergo1

Neoplastic cells3

Endothelial3

Immune6

Osteoblast1

Donor11

Spinal cord12

Multipotency1

Chondrogenic1

Cellular differentiation1

Human embryonic stem2

Complications2

Primitive hematopoietic2

Total body irradi1