Proliferation and apoptosis apoptotic programmed cell cell cycle. Medical search. Frequent questions

it inhibits cell migration, reduces the ability to form colonies and induces apoptosis or programmed cell death through the modulation of other key genes (p53, caspase-3, c-PARP) and various apoptotic factors," says Maurizio Battino, coordinator of the research. (agenciasinc.es)
This inhibition of AMPK ultimately leads to inhibition of mTOR and thus induces apoptosis in the HepG2 cells. (biomedcentral.com)
Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3. (greenmedinfo.com)

TGF-β regulates a variety of different cellular developmental processes including growth, differentiation, proliferation, and cell death. (wikipedia.org)
Germinal Center B-Cell like (GCB) DLBCLs appear to arise from normal germinal center B cells, while Activated B-cell like (ABC) DLBCLs are thought to arise from postgerminal center B cells that are arrested during plasmacytic differentiation. (wikipedia.org)
Follicular dendritic cells and T cells help to select the B-cells that have a high affinity to the antigen for further differentiation into plasma cells and memory cells. (wikipedia.org)
Two oncogenic mechanisms that appear to be active in GCB DLBCL are the prevention of apoptosis and the blocking of terminal differentiation. (wikipedia.org)
Normal germinal center B-cells appear to be poised for apoptosis unless they are selected to progress to the next stage of differentiation. (wikipedia.org)
citation needed] Blocking the differentiation of germinal center B cells is dangerous because the cells are programmed to divide rapidly at this stage. (wikipedia.org)
BCL-6 proteins repress genes involved in terminal differentiation and promote proliferation by blocking expression of a cell-cycle inhibitor (p27KIP1). (wikipedia.org)
These ncRNAs can alter the expression of genes involved in cell growth, differentiation, and apoptosis, leading to the development and progression of CTCL. (bvsalud.org)
Upon upwards migration towards more superficial layers and concomitant differentiation of the infected keratinocyte, the late genes of the virus are expressed leading to the formation of viral particles and their release upon cell death. (biomedcentral.com)
During evolution the arms race between papillomaviruses (PVes) and their hosts has resulted in parallel selection of cellular mechanisms aiming to clear viral infection, such as inhibition of cellular apoptosis or uncoupling of the normal proliferation/differentiation program of the epithelium on the one hand, and in selection of viral mechanisms aiming to hamper cellular reaction directed to clear infection on the other. (biomedcentral.com)
Its effect and effectiveness appear to be highly connected with the differentiation status of the cancerous cells, as Ang II appears to play a crucial role in the early and late stages of malignant transformation. (spandidos-publications.com)
regulating the differentiation, proliferation, maintenance and sculpturing organs and tissues, functioning of immune system and the elimination of defective harmful cells. (benthamscience.com)
The human proto-oncogene STAT3 encodes transcriptional factor that is essential for embryo- genesis, proliferation and differentiation of many cell types, in addition to organ regeneration and involu- tion. (pbkom.eu)
Objective: To investigate the induction of tanshinone [1 A (Tan fl A) on the differentiation of human placenta-derived mesenchymal stem cells (hPDMSCs) into cardiomyocytes, and to provide an experimental basis for Tan IT A as a cardiomyocytc differentiation inducer. (researchgate.net)

Cancer, characterized by uncontrolled cell proliferation, is treated by chemotherapy and radiotherapy to induce apoptosis and kill cancerous cells. (news-medical.net)
Most conventional anticancer agents induce apoptosis indirectly. (pbkom.eu)
Conclusion: Prion protein 106-126 peptide can induce apoptosis in differentiated PC12 cells and present cellular toxicity definitely. (researchgate.net)
We showed that overexpression of SOCS1 can induce apoptosis of leukemic cells constitutively expressing activated JAK2. (micrornaarray.com)

Two proteins involved intimately in regulating cell proliferation are Akt and the tumor suppressor p53 (p53). (bioinf.org)
It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1 (ETS1). (wikipedia.org)
Bcl-2 proteins prevent the activation of the caspases that lead to programmed cell death (apoptosis). (wikipedia.org)
Most normal germinal center B-cells express low levels of anti-apoptotic proteins such as Bcl-2. (wikipedia.org)
These proteins work with other transcription factors (BLIMP1, PAX5, XBP1) to form a regulatory circuit that controls the progression of germinal center B cells to plasma cells. (wikipedia.org)
A study of DLBCL cell lines indicated that 14-3-3ζ proteins may play a role in mediating resistance of DLBCL cells to CHOP. (wikipedia.org)
14-3-3 proteins exert anti-apoptotic activity by interfering with the function of BH3-only proteins and has been validated as a potential molecular target for anticancer therapeutic development in other types of cancers. (wikipedia.org)
In particular, we will discuss the modifications in intrinsic and extrinsic apoptotic pathways caused by proteins encoded by HPV early genes. (mdpi.com)
E5 impairs ligand-mediated apoptosis by reducing the amount of surface CD95 proteins or inhibiting the formation of the DISC complex [ 12 ], and affects the normal functioning of a number of membrane associated proteins, probably by modifying the composition and the interactions in the cell membranes [ 13 ]. (biomedcentral.com)
During the first stage called G1, cells monitor their environment and, when the requisite signals are received, the cells synthesize RNA and proteins to induce growth. (bdbiosciences.com)
Several cell cycle-associated proteins, such as Ki-67, are also used as indicators of cell proliferation. (bdbiosciences.com)
Cell death by necroptosis involves membrane breakage, which leaks intracellular molecules such as heat shock proteins. (news-medical.net)
In fruit flies, apoptosis is activated by proteins known as Grim, Hid and Reaper. (elifesciences.org)
created 'undead' cells in which one of these proteins was turned on, but other downstream proteins (that are responsible for the cellular execution phase of apoptosis) had been turned off: these cells were undergoing apoptosis, but could not complete the process and die. (elifesciences.org)
Western Blot was used to determine the protein expression of the apoptosis inhibitors livin and caspase-3, the apoptosis-related proteins Bax and Bcl-2, as well as the key protein kinases in the Jak-stat3 signaling pathway, stat3 and p-stat3. (biomedcentral.com)
Both proteins contain anti-death motif, critical for their anti-apoptotic function but the mechanism by which gal-3 exhibits antiapoptotic activity cannot be explained solely on it. (pbkom.eu)
It has been previously shown that rbf1 pro-apoptotic activity depends on its ability to decrease the level of anti-apoptotic proteins such as the Bcl-2 family protein Buffy. (sdbonline.org)
Both proteins can localize at the mitochondrion , but the way they control apoptosis still remains unclear. (sdbonline.org)
These results provide a mechanism by which Drosophila Bcl-2 family proteins can control apoptosis and shed light on a link between Rbf1 and mitochondrial dynamics, in vivo. (sdbonline.org)
Our results indicate that several dozens of proteins for each cell type, are PE-lipoxidated in HT-22, MLE, and H9c2 cells and M2 macrophages after they were induced to undergo ferroptosis. (cdc.gov)
Pretreatment of cells with the strong nucleophile, 2-mercaptoethanol, prevented the formation of PE-lipoxidated proteins and blocked ferroptotic death. (cdc.gov)

This approach consists of genetically engineered immune cells expressing a surface receptor, called CAR, that specifically targets antigens expressed on the surface of tumor cells. (bvsalud.org)
Silencing of the EBF3 locus was observed in brain, colorectal, breast, liver, and bone tumor cell lines and its reactivation was achieved on treatment with 5-aza-2′-deoxycytidine and trichostatin A in a significant portion of these tumor cells. (aacrjournals.org)
Many of the current efforts regarding anti-cancer drug development are focused on directing tumor cells to undergo apoptosis. (mdpi.com)
Possible mechanisms for overcoming the resistance of HPV-infected tumor cells to anticancer drugs will be discussed. (mdpi.com)
It is suggested that curcumin can selectively kill tumor cells through its multifaceted metabolic effects, that culminate in its anti-oxidant and anti-inflammatory activities ( Hewlings and Kalman, 2017 ). (frontiersin.org)
Although chemiotherapeutic drugs should selectively kill only tumor cells, normal cells are often susceptible to cytotoxic or cytostatic effects of these agents. (pbkom.eu)
While aberrant DNA methylation is a characteristic feature of tumor cells, our knowledge of how these DNA methylation patterns are established and maintained is limited. (biomedcentral.com)
Infection of cells with oncolytic adenovirus CN305 SOCS3 and AdCN305 cell penetrating peptides SOCS3 resulted in buy Volasertib dramatic cytotoxicity of liver tumor cells. (micrornaarray.com)
Infection of liver tumor cells with AdCN305 SOCS3 and AdCN305 cpp SOCS3 resulted in almost complete inhibi tion of STAT3 phosphorylation and downregulation of cyclin D1 and Bcl xL. (micrornaarray.com)
35,110,111 We have shown that adoptive transfer of SOCS1 deficient T cells strongly regressed transplanted tumor cells. (micrornaarray.com)
Phospho STAT3 was confirmed for being lowered in tumor cells with the automobile taken care of mice, but not in stromal cells, even though tumor and stromal phospho STAT3 had been substantially reduced in AZD1480 handled mice. (micrornaarray.com)
Furthermore, the high refractoriness of liver cancer to treatments has been associated with the interaction of very complex and diverse mechanisms of chemoresistance, which can act synergistically to protect tumor cells from the chemotherapy agents [ 3 ] . (encyclopedia.pub)

Conclusions These findings ascertained an conversation between p53, c-myc, p21, p27, Bcl-2, PI3K/Akt pathway, and CF-induced apoptosis in MSTO-211H and HCT-116 cells, suggesting that CF acts as an important regulator of cell growth in human malignancy cell lines. (bioinf.org)
After Fas stimulation, Daxx is activated and plays its role of pro-apoptotic protein in activating the c-JUN-N-Terminal Kinase (JNK) pathway. (wikipedia.org)
This pathway normally regulates stress-induced cell death. (wikipedia.org)
The real apoptotic process starts after activating this pathway. (wikipedia.org)
When the cell is treated with TGF-β, HIPK2, a nuclear kinase, phosphorylates Daxx and the activated Daxx in turn activates the JNK pathway (see "The Daxx Pathway" figure). (wikipedia.org)
Activation of the nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-κB) pathway is found only in ABC DLBCLs and not GCB DLBCLs. (wikipedia.org)
Therefore, EBF3 regulates a transcriptional program underlying a putative tumor suppression pathway. (aacrjournals.org)
Furthermore, Chaga has been found to induce autophagy via the AMPK-mTOR signaling pathway in breast cancer cells, suggesting that it may have potential as an adjuvant therapy for cancer treatment. (chagamushrooms.net)
Triple treatment showed synergism in terms of exhibiting anti-tumorigenic effects by activating the Hippo YAP signaling pathway in the HCT116 cell line. (frontiersin.org)
Eiger is produced in apoptotic cells and, through activation of the c-Jun N-terminal kinase (JNK) pathway, is able to propagate the initial apoptotic stimulus. (elifesciences.org)
found that the JNK pathway activated apoptosis in anterior cells. (elifesciences.org)
These include regulation of cell cycle, activation of mitochondrial pathway, induction of mitochondrial outer membrane permeabilization, induction of apoptosis, modulation of oxidative stress, amelioration of inflammation, modulation of insulin signaling and inhibition of angiogenesis. (mdpi.com)
The purpose of the research is to investigate the roles of Jak-STAT3 signaling pathway in bufalin-induced apoptosis in colon cancer SW620 cells. (biomedcentral.com)
Activation of caspase-3, up-regulation of Bax, down-regulation of livin and Bcl-2, as well as inhibition of Jak-stat3 signaling pathway might be the important mechanisms for the bufalin-induced apoptosis. (biomedcentral.com)
Conclusions: Therefore, we identified novel phosphorylation site of IκBα by AURK, and its site was related to apoptosis and necroptosis pathway in breast cancer cells. (researchsquare.com)
Interestingly, rbf1 -induced apoptosis leads to a debcl - and drp1 -dependent Reactive Oxygen Species production, which in turn activates the Jun Kinase pathway to trigger cell death. (sdbonline.org)
Retinoblastoma cells activate the AKT pathway and are vulnerable to the PI3K/mTOR inhibitor NVP-BEZ235. (umn.edu)

It also suppresses the receptor of the epidermal growth factor called EGFR/HER2 and its signalling pathways, which could be an attractive target in cancer therapies because of their important role in the processes of cell survival and proliferation, as well as in those of apoptosis and metastasis. (agenciasinc.es)
Their multi‑functional cargo have been indicated to regulate a vast number of biological pathways in target cells. (spandidos-publications.com)
When naïve B-cells encounter an antigen, one of the pathways that they can follow is through the germinal center environment. (wikipedia.org)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
EMB activated extrinsic and intrinsic pathways of apoptosis as shown by the activation of initiator and executioner caspases. (bvsalud.org)
In this context, several molecular interactions between the oncogenes HPV16 E5, E6 and E7 and different apoptotic pathways have already been identified [ 9 ]. (biomedcentral.com)
2 Apoptosis is triggered by caspase-mediated signal transduction pathways. (bdbiosciences.com)
The main aim of this paper is to review the pathways that lead to cell death in plants with a purpose of identifying the anti-cell death genes. (essaywriter.org)

To investigate the mechanism of EESR-mediated cytotoxicity, HT29 cells were treated with various concentrations of EESR and the induction of cell cycle arrest and apoptosis was analyzed by flow cytometry, 4,6-diamidino-2-phenylindole staining, and Western blot analysis. (jcpjournal.org)

CF treatment on leukemia cell lines induces cell death due to apoptotic mechanisms and altering 123653-11-2 manufacture cell metabolism through HIF-1 and GLUT-1 regulation [3]. (bioinf.org)
Endocrinology, by definition, focuses on homeostatic, and cell‑to‑cell and tissue‑to‑tissue communication mechanisms. (spandidos-publications.com)
Gene expression profiling has revealed that diffuse large B-cell lymphoma (DLBCL) is composed of at least 3 different sub-groups, each having distinct oncogenic mechanisms that respond to therapies in different ways. (wikipedia.org)
The growing interest in non-coding RNAs (ncRNAs) in the recent years has provided further insight into the mechanisms by which TFs influence cancer stem cell characteristics. (bvsalud.org)
To avoid elimination by this mechanism, human papillomaviruses (HPV) have developed several mechanisms that enable the cells they infect to elude both extrinsic and intrinsic apoptosis. (mdpi.com)
In this manuscript, we review the current literature regarding how HPV-infected cells avoid apoptosis and the molecular mechanisms involved in these events. (mdpi.com)
Pack LR, Daigh LH, Meyer T. Putting the brakes on the cell cycle: mechanisms of cellular growth arrest. (bdbiosciences.com)
Apoptosis and necrosis are characterized by different mechanisms leading to cell death. (news-medical.net)
In such cases, alternate mechanisms of cell death, such as necroptosis can be successfully induced. (news-medical.net)
The article also underscores the various possible mechanisms by which honey may inhibit growth and proliferation of tumors or cancers. (mdpi.com)
Cell" for elucidating the intricate mechanisms. (benthamscience.com)
Thus, Ganoderma lucidum exerts its effect on cancer cells by multiple mechanisms and may have potential therapeutic use for the prevention and treatment of cancer. (greenmedinfo.com)
Then, we will discuss several principles that govern macrophage phagocytosis of apoptotic cells (efferocytosis), including the existence of redundant recognition mechanisms ("find-me" and "eat-me") that lead to a tight coupling between apoptosis and phagocytosis. (frontiersin.org)
However, the mechanisms of bufalin-induced apoptosis remain elusive. (biomedcentral.com)
It also regulates innate and adaptive immune mechanisms, including B cell maturation. (pbkom.eu)
Since this is a highly sought after clinical goal, we are elucidating the mechanisms of immune cell recruitment so they can be targeted to kill cancer cells. (umn.edu)
These mechanisms can malfunction in pediatric retinoblastoma, and may be harnessed during retinal regeneration to produce new retinal cell types after they've been lost. (umn.edu)

The cell cycle arrest and apoptosis were tested by flow cytometry analysis. (biomedcentral.com)
Apoptotic was detected by morphological changes, DNA electrophoresis and flow cytometry. (researchgate.net)
Apoptotic peak was detected by flow cytometry and the ladder band appeared in DNA electrophoresis. (researchgate.net)
Flow cytometry was used to explore the cell cycle distribution and apoptotic effects. (biomedcentral.com)

The protein serine/threonine kinase Akt (also known as protein kinase B or PKB) plays an important role in averting cell death. (bioinf.org)
The p53 protein is a transcription factor that normally inhibits cell growth and stimulates cell death in response to myriad stressors, including DNA damage (induced by either UV or chemical agents such as hydrogen peroxide), oxidative stress, and deregulated oncogene expression [6-10]. (bioinf.org)
In the cytoplasm, the encoded protein may function to regulate apoptosis. (wikipedia.org)
In GBC DLBCLs, the T(14,18) translocation can result in an increase of the Bcl-2 protein, which may reduce the number of cells that undergo apoptosis. (wikipedia.org)
Recently it has been shown that HPV16 E5 may co-precipitate with the heavy chain of HLA-I in cells over-expressing the E5 protein [ 21 ]. (biomedcentral.com)
Eiger is related to a protein called TNF that has been implicated in cycles of destruction and renewal of hair follicles in mice. (elifesciences.org)
EESR-induced apoptosis was associated with the upregulation of p53, a death receptor Fas, and a pro-apoptotic protein Bax and the activation of caspase 3, 8, and 9, resulting in the degradation of PARP. (jcpjournal.org)
From development to aging and disease, the brain parenchyma is under the constant threat of debris accumulation, in the form of dead cells and protein aggregates. (frontiersin.org)
Background: The phosphorylation of NF-kappaB inhibitor alpha (IκBα) protein is pivotal to the regulation of NF-κB transcription factor activity in the cell. (researchsquare.com)
Most of the important molecular processes in the cell, such as DNA replication, are performed by large molecular network of protein-protein interactions. (researchsquare.com)
The first phase comprises mainly functional cell impairments expressed by inhibition of protein and urea synthesis. (pbkom.eu)
the expression levels of protein associated with apoptosis and endoplasmic reticulum stress (ERS) of SKO-007 cells in various groups were detected by Western blotting method. (researchgate.net)
Objective: To investigate the effects of prion protein 106-126 peptide on inducing apoptosis in differentiated PC12 cells. (researchgate.net)
Methods: After differentiated by nerve growth factor (NGF), the PC12 cells were infected by prion protein 106-126 peptide. (researchgate.net)
The Drosophila retinoblastoma protein, Rbf1, induces a debcl and drp1 -dependent mitochondrial apoptosis. (sdbonline.org)
In accordance with its tumor suppressor role, the Retinoblastoma protein pRb can ensure pro-apoptotic functions. (sdbonline.org)
Real-time PCR and western blot were used to detect ENDOD1 mRNA and protein expression in normal prostatic epithelial and PCa cell lines. (biomedcentral.com)
Western blot showed that androgen-sensitive LNCaP cells had the highest protein expression level of ENDOD1, whereas castration-resistant PCa cell lines PC3 and DU145 had significantly lower protein levels. (biomedcentral.com)

Apoptosis controls the orderly death of damaged cells, whereas necrosis occurs as a result of tissue damage, causing the loss of both damaged and surrounding cells. (bdbiosciences.com)
Apoptosis was considered instrumental to development and other physiological functions, while necrosis was seen as a response to unfavorable conditions. (news-medical.net)
Now, necrosis is known to have programmed aspects, with "necroptosis" describing regulated necrotic cell death. (news-medical.net)
Apoptosis mainly occurs during embryogenesis, while necrosis is more common during disease states. (news-medical.net)
What is Necrosis vs What is Apoptosis? (news-medical.net)
In 1988, Laster and colleagues exposed two cell lines to TNF to investigate whether TNF (tumor necrosis factor) targets underwent DNA fragmentation. (news-medical.net)
However, apoptosis can be blocked by caspase inhibitors resulting in a "ballooning cell membrane", typical of necrosis. (news-medical.net)
We identified Eiger, the Drosophila tumor necrosis factor (TNF) homolog, as the signal responsible for apoptosis-induced apoptosis (AiA). (elifesciences.org)
The second stage is lethal and is characterized by ongoing necrosis and/ or apoptosis. (pbkom.eu)
In animals, morphological distinctions have since been used to distinguish different types of cell deaths, including apoptosis, necrosis and autophagy. (essaywriter.org)
Primarily, the aim of anti-cell death in animals is to describe the processes of autophagy and apoptosis, while necrosis is the mechanism for defining the uncontrollable or chaotic mode of death. (essaywriter.org)
Majority of the literature and experiments in the field of programmed cell death in plants draw heavily on comparative analysis retrieved from paradigms of animal systems such as apoptosis, necrosis and autophagy. (essaywriter.org)

A rather surprising property of Daxx is its anti-apoptotic function. (wikipedia.org)

They are derived by a targeted mechanism from the cell endocytic compartment and are formed and stored within the intracellular multivesicular bodies (MVBs). (spandidos-publications.com)
An understanding of mechanism by which Eag and HERG channels affect cell proliferation in ovarian cancer cells is required and therefore we investigated their role in cell proliferation and their effect on the cell cycle and apoptosis of ovarian cancer cells. (derby.ac.uk)
In those cases, multiple aspects of apoptosis might need to be analyzed to confirm the mechanism of cell death. (bdbiosciences.com)
AiA provides a mechanism to explain cohort behavior of dying cells that is seen both in normal development and under pathological conditions. (elifesciences.org)
found that TNF is produced by apoptotic cells in hair follicles, and that blocking TNF inhibits the death of other cells in the same cohort: this suggests that a common mechanism could regulate the communal death of cells in flies and mammals. (elifesciences.org)
The objective of this study is to evaluate the antioxidant and anticancer effects of ethanol extract of S. rufopilosa (EESR) and to determine the molecular mechanism of its anticancer activity in human colon carcinoma HT29 cells. (jcpjournal.org)
However, the mechanism(s) responsible for the effects of Ganoderma lucidum on cancer cells remain to be elucidated. (greenmedinfo.com)
Anti-cell death is a technique adopted by multi-cellular organisms as a defensive and developmental mechanism (Franklin-Tong and Gourlay, pg 390). (essaywriter.org)

Treatment with honey stops the tumour cells cycle by regulating some genes (cyclin D1, CDK2, p27Kip. (agenciasinc.es)
B-cells within the germinal center proliferate and undergo immunoglobulin somatic hypermutation (SHM) of IgV region genes to revise their antigen receptors. (wikipedia.org)
The rearranging of genes makes the cells capable of generating antibodies with a higher or lower affinity to the specified antigen. (wikipedia.org)
BCL-6 genes are involved in several cell processes that can affect the ability of the B-cell to differentiate and proliferate. (wikipedia.org)
The expression of cyclin-dependent kinase inhibitors was profoundly affected with early activation and then repression of p21 cip1/waf1 and persistent activation of both p27 kip1 and p57 kip2 , whereas genes involved in cell survival and proliferation were suppressed. (aacrjournals.org)
We also showed that dose-dependent induction of proliferation was connected with changes in the expression of MKI67, CCND1 and CCNE1 genes in well- and poorly differentiated cancer cells. (spandidos-publications.com)
After Ang II treatment, poorly differentiated endometrial cancer cell line acquired a mesenchymal phenotype, which was characterized by induced expression of EMT-related genes (VIM, CD44, SNAI1, ZEB1 and ZEB2). (spandidos-publications.com)
Recently, a number of studies have shown that Ang II plays an important role in proliferation, invasiveness and migration of tumour cells, alteration of expression of cancer-related genes, as well as in physiological tissue remodelling. (spandidos-publications.com)
Moreover, we examined alterations in the expression of genes related to cancer cell behaviour after Ang II treatment. (spandidos-publications.com)
Amy and Sor cotreatment resulted in the highest glutathione levels and induction of pro-autophagic genes AMPK, HGMB1, ATG5, Beclin 1, and LC3, suppressed the mTOR and BCL2 anti-apoptotic gene. (biomedcentral.com)
Since the mammalian cells do not uptake the foreign DNA efficiently, the availability of effective methods for introducing genes into the cells is essential. (benthamscience.com)
Chrysin regulated miR-18a, miR-21, and miR-221 genes in gastric cancer cell line [ 26 ]. (hindawi.com)
Abnormal STAT3-mediated signal transduction has been observed in a large number of neoplasms, in which it induces anti-apoptotic and cell cycle progression mediating genes transcription. (pbkom.eu)
Therefore, there is need for fundamental distinction between the different types and functions of genes that are involved in anti-cell death in plants. (essaywriter.org)
At the end of the discussion, significant insights will be developed to paint a picture of the emerging trends in plant development with respect to the topical research on anti-cell death genes. (essaywriter.org)
The dominant discovery in these experiments indicates that there is a heterologous expression of certain genes in plants that can regulate cell death. (essaywriter.org)
Only two Bcl-2 family genes have been found in Drosophila melanogaster including the pro-cell survival, human Bok-related orthologue, Buffy. (sdbonline.org)

GCB DLBCL shows amplification of the oncogenic mir-17-92 microRNA cluster and deletion of the tumor suppressor PTEN but these events have not been found in ABC DLBCL B-cells form in the bone marrow and undergo gene rearrangement in order to develop B-cell receptors (BCRs) that bind to a specific antigen. (wikipedia.org)
A large fraction of germinal center B-cells acquire somatic mutations that prohibit antigen binding and these undergo apoptosis. (wikipedia.org)
As cells become damaged or are no longer needed, they undergo apoptosis or programmed cell death, a normal physiological process that occurs during embryonic development and tissue homeostasis. (bdbiosciences.com)
We will then describe that resulting from engulfment and degradation of apoptotic cargo, phagocytes undergo an epigenetic, transcriptional and metabolic rewiring that leads to trained immunity, and discuss its relevance for microglia and brain function. (frontiersin.org)
In cells stimulated to undergo ferroptosis we identified PE-truncated species with sn-2 truncations ranging from 5 to 9 carbons. (cdc.gov)

All somatic cells proliferate via a mitotic process determined by progression through the cell cycle. (bioinf.org)
A series of signal transduction events starting from the activation of cyclin-dependent kinase 2 (CDK2) to binding of E2F -target transcription to phosphorylation of Rb helps maintain cell-cycle progression. (bdbiosciences.com)
Cell death before the viral replication cycle is complete can limit disease progression. (news-medical.net)
12 The activation of cyclin/CDK complex accelerates cell cycle progression, which are regulated by phosphorylation. (jcpjournal.org)

For a long time apoptosis has been considered the only type of programmed cell death responsible for the maintenance of homeostasis in the organism. (pbkom.eu)

EMB-induced apoptosis also involved suppression of inhibitors of apoptosis, XIAP, cIAP1, and cIAP2. (bvsalud.org)

Many physiological processes, including proper tissue development and homeostasis, require a balance between apoptosis and cell 123653-11-2 manufacture proliferation. (bioinf.org)
The multi‑dimensional nature of their roles in cellular homeostasis, cell‑to‑cell and tissue‑to‑tissue communication at the level of the organism, as well as their actions on the holobiome (intra‑/interspecies interaction), have garnered the interest of a large number of researchers. (spandidos-publications.com)
The profound roles of exosomes in homeostasis, stress and several pathological conditions, in conjunction with their selective and cell‑specific composition/function, allude to their use as promising circulating clinical biomarkers of systemic stress and specific pathologic states, and as biocompatible vehicles of therapeutic cargo. (spandidos-publications.com)
Exosomes, via their cargo or surface composition, are signals/mediators of systemic homeostasis and stress for specific cell-to-cell or tissue-to-tissue communication ( 5 ). (spandidos-publications.com)
The balance of cell proliferation and apoptosis is important for both development and normal tissue homeostasis. (bdbiosciences.com)
This process plays a major role in development and tissue homeostasis, and abnormal regulation of apoptosis is associated with a variety of human diseases ( Fuchs and Steller, 2011 ). (elifesciences.org)
The maintenance of transbilayer lipid asymmetry is essential for normal cell membrane func- tion and homeostasis of organisms. (pbkom.eu)
Immunoreceptor signaling during development, homeostasis, and effector function of T cells and NK cells. (upstate.edu)
External insults (eg, infections, radiation, drugs) may disrupt stem cell homeostasis in marrow environment, leading to altered growth. (medscape.com)

We assessed the anticancer activity of EMB against CTCL cell lines, HuT78, and H9. (bvsalud.org)

In vitro studies have demonstrated that Chaga extracts and small phenolic compounds derived from the mushroom exhibit cytotoxicity against various cancer cell lines. (chagamushrooms.net)
Extraction from 9 parameters of KSO-SFE was screened for cytotoxicity towards human colorectal cancer cell lines (HT29) and mouse embryonic fibroblast (NIH/3T3) cell lines using MTS assay. (hindawi.com)
Therefore, this study determined the cytotoxicity of KSO-SFE on colon cancer cells. (hindawi.com)
Cell viability and cytotoxicity assays are used usually for screening of drugs and cytotoxicity tests of chemicals. (benthamscience.com)

Other studies showed that lack of Daxx gene caused a higher apoptotic rate in embryonic stem cells. (wikipedia.org)
Biological assays and gene expression analysis were performed on three cell lines: ISH, MFE-296 and MFE-280. (spandidos-publications.com)
Western blot analysis showed that the expression of programmed cell death 4 (PDCD4), which was predicted as the target gene of miR-183 by microarray profiling and bioinformatics predictions, decreased when miR-183 was over-expressed. (molcells.org)
We explored the oncogenic role of miR-183 in ESCC and identified programmed cell death 4 (PDCD4) as a direct target gene of miR-183. (molcells.org)
In murine cardiomyocytes miR-21 was found to protect from hypoxia/reoxygenation (H/R)-induced cell apoptosis via regulation of its target gene PDCD4 [ 13 ]. (hindawi.com)
Here, we report that in T cell acute lymphoblastic leukemia (T-ALL) the MYC oncogene controls the expression of TET1 and TET2 to maintain 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) patterns, which is associated with tumor cell-specific gene expression. (biomedcentral.com)
This study demonstrates that debcl and the pro-fission gene drp1 are necessary downstream of buffy to trigger a mitochondrial fragmentation during rbf1 -induced apoptosis. (sdbonline.org)
Taken all together this demonstrates a role for Buffy, a Bcl-2 pro-cell survival gene, in neuroprotection. (sdbonline.org)
Recently, we learned that these tumors express a gene expression "signature" that causes recruitment and accumulation of immune cells to these tumors. (umn.edu)
We utilize genome-wide approaches to understand the altered gene expression and 5hmC distribution in retinal cells lacking the Uhrf2 gene. (umn.edu)
Retinoblastoma tumor cell proliferation is negatively associated with an immune gene expression signature and increased immune cells. (umn.edu)

Spanish and Italian researchers have proven that when honey from strawberry trees, a product typical of Mediterranean areas, is added to colon cancer cells grown in the laboratory, cell proliferation is stopped. (agenciasinc.es)
None of these effects was observed when honey was applied to healthy cell lines," the authors point out, noting the anticarcinogenic potential of this natural product, but insisting on the need for new studies with colon cancer in vivo models to confirm its chemopreventive effects. (agenciasinc.es)
Monoclonal antibodies are made by injecting human cancer cells into mice so that their immune systems create antibodies against foreign antigens. (wikipedia.org)
Monoclonal antibodies target specific antigens on cancer cells and may enhance the patient's immune response. (wikipedia.org)
Cutaneous T-cell lymphoma (CTCL) is a type of cancer that affects skin, and is characterized by abnormal T-cells in the skin. (bvsalud.org)
It defines the ability of cancer cells to indefinitely perpetuate as well as differentiate. (bvsalud.org)
Cancer stem cell populations within a growing tumor also help evade the inhibitory effects of chemo- as well as radiation-therapies, in addition to playing an important role in cancer metastases. (bvsalud.org)
Our study revealed that Ang II influences EC cells in terms of cancer-related processes, and is responsible for increased proliferation, reduction in apoptosis, increased mobility and modulation of adhesion potential. (spandidos-publications.com)
Therefore, various biologically active peptides such as angiotensin, affecting cell proliferation, have become a new area of study in endometrial cancer research. (spandidos-publications.com)
The aim of the present study was to evaluate the influence of Ang II on human endometrial cancer cells. (spandidos-publications.com)
Biological assays were performed on well-[Ishikawa (ISH)] moderately (MFE-296) and poorly (MFE-280) differentiated human adenocarcinoma cancer cell lines, representing the G1, G2 and G3 stage of EC. (spandidos-publications.com)
The role of Eag and HERG channels in cell proliferation and apoptotic cell death in SK-OV-3 ovarian cancer cell line. (derby.ac.uk)
Cancer cell international. (derby.ac.uk)
In the present study, we explored the oncogenic roles of miR-183 in ESCC by gain and loss of function analysis in an esophageal cancer cell line (EC9706). (molcells.org)
Previous study has shown that kenaf seed oil extracted by SFE (KSO-SFE) is cytotoxic towards human cervical cancer cell line [ 7 ]. (hindawi.com)
Human colorectal cancer (HT29) and mouse embryonic fibroblast (NIH/3T3) cell lines were purchased from the American Type Culture Collection (ATCC), USA. (hindawi.com)
Potential synergistic effects of various combinations including these compounds were tested by measuring cancer cell proliferation and apoptosis. (frontiersin.org)
Inhibitory effect of EESR on cancer cell growth and proliferation was determined by water-soluble tetrazolium salt assay. (jcpjournal.org)
The abnormal cell growth is one of the critical characteristics of cancer for invasion or spreading out to other parts of the body. (jcpjournal.org)
Cancer cells can grow unusually via limitless number of cell division and can avoid apoptosis. (jcpjournal.org)
6 , 7 Therefore, the inhibition of cancer cell proliferation by inducing cell cycle arrest and apoptosis is being an important preventive strategy against cancer. (jcpjournal.org)
These effects of honey have been thoroughly investigated in certain cancers such as breast, liver and colorectal cancer cell lines. (mdpi.com)
Reishi inhibits proliferation and induces programmed cell death in human prostate cancer cells. (greenmedinfo.com)
We have previously demonstrated that Ganoderma lucidum down-regulated the expression of NF-kappaB-regulated urokinase plasminogen activator (uPA) and uPA receptor (uPAR), which resulted in suppression of cell migration of highly invasive human breast and prostate cancer cells. (greenmedinfo.com)
In this study, we investigated the effects of Ganoderma lucidum on cell proliferation, cell cycle, and apoptosis in human prostate cancer cells PC-3. (greenmedinfo.com)
Bufalin not only inhibited the growth of colon cancer SW620 cells, but also induced apoptosis of SW620 cells. (biomedcentral.com)
We investigated the new phosphorylation site for IκBα and identified its biological function in breast cancer cells. (researchsquare.com)
Besides, S63A and/or S262A of IκBα regulated apoptotic and necroptic effects in breast cancer cells. (researchsquare.com)
In addition to basic science investigations in such areas as tumor cell invasion, oncogenes, immunotherapy and genetic inheritance, our scientists and physicians participate in national cancer trials. (upstate.edu)
T lymphocytes for adoptive cell therapy against hematological cancer. (upstate.edu)
This program is based on the true story of person suffering from cancer disease, given the fact that to whom concerned hospitals, nursing homes and doctors said no more treatments possible actually got cured or relieved from the herbal treatments. (cancercareresearch.com)
104 SOCS3 overexpression also inhibits development of non compact lung cancer cells. (micrornaarray.com)
105 SOCS3 overexpression by adenoviral transfer enhanced the radio sensitivity of taken care of non small lung cancer cells. (micrornaarray.com)
phosphorylation of STAT1: this peptide inhibited proliferation of prostate cancer cell lines, in which STAT3 is constitutively activated. (micrornaarray.com)
Cancer is a complex and multifaceted disease characterized by the uncontrolled growth and spread of abnormal cells. (greenteaadvice.com)
There are numerous types of cancer, each originating from specific cells or tissues in the body. (greenteaadvice.com)
Cancer Lett, 300:215-224.doi:10.1016/j. squamous cell carcinoma in north-eastern Iran. (who.int)
99:209 -215.doi:10.1007/s11060 - 010 - 0129 -5 cell carcinoma-a population-based study in with and without cervical cancer in Tbilisi, Georgia. (who.int)

However, the ability of HPV-infected cells to resist apoptotic signals renders such therapies ineffective. (mdpi.com)
To make the decision of whether to enter the cell cycle or not, cells integrate information from a variety of intracellular and extracellular signals. (bdbiosciences.com)
Apoptosis is an organized process that signals cells to self-destruct for cell renewal or to control aberrant cell growth. (bdbiosciences.com)
Apoptotic cells can produce signals to instruct cells in their local environment, including ones that stimulate engulfment and proliferation. (elifesciences.org)
Although this process can occur in individual cells, apoptotic signals may also dictate the 'communal death' of many cells simultaneously. (elifesciences.org)
Apoptosis has been thought to resemble a form of silent suicide by cells, but more recent work suggests that apoptotic cells can also transmit signals. (elifesciences.org)
Only more recently has it become clear that apoptotic cells are the source of signals that can have profound effects on their neighbors. (elifesciences.org)
Whereas damage signals of cells activate p53 via CHK2 to repair damaged DNA, leading to cell cycle arrest. (jcpjournal.org)
Other factors have since been linked with the decision by plant cells to activate cell death, including cell survival signals, stress signals, developmental cues, pathogen recognition and metabolic state. (essaywriter.org)
ABSTRACT This study examined haematopoietic stem cells of 19 high-risk cases of myelodysplastic syndrome (MDS) for apoptotic and anti-apoptotic signals and cellular proliferation and correlated these with clinical and cytogenetic subtypes, particularly trisomy 8. (who.int)
Our results suggest that although trisomy 8 cells are in a pro-apoptotic state, they are checked by the enhanced expression of anti-apoptotic signals which provide them with their proliferative advantage. (who.int)

The ability of the host to trigger apoptosis in infected cells is perhaps the most powerful tool by which viruses can be cleared from the host organism. (mdpi.com)
Strikingly, undead cells in the posterior (back) region of the wing imaginal disc-the tissue in the larva that gives rise to the wing in the adult fruit fly-could trigger apoptosis in cells in the anterior (front) half. (elifesciences.org)

We show here that expression of EBF3 resulted in cell cycle arrest and apoptosis. (aacrjournals.org)
Our results demonstrate that the p.Pro326Leu mutation induces RGC-5 cell cycle arrest and apoptosis with a decreased BcL-XL. (aging-us.com)
A substantial synergistic interaction between Amy and Sor was observed (CI 50 = 0.56), which was connected to cell cycle arrest at the S and G2/M stages and increased apoptosis and potential necroptosis. (biomedcentral.com)
EESR induced cell cycle arrest at G2/M phase in a dose-dependent manner by modulating cyclin B, cyclin-dependent kinase 1 (CDK1), and CDK inhibitor p21 expression. (jcpjournal.org)
EESR possessing antioxidant activity efficiently inhibits proliferation of HT29 cells by inducing both cell cycle arrest and apoptosis. (jcpjournal.org)
The inhibition of cell growth was also demonstrated by cell cycle arrest at G2/M phase. (greenmedinfo.com)
So as to determine regardless of whether STAT3 was required for JAK inhibitor mediated growth arrest, we stably reduced STAT3 in TPC 1 cells utilizing a brief hairpin, as determined by western blot and immunohistochemistry. (micrornaarray.com)
Meanwhile, overexpression of ENDOD1 suppressed cell proliferation, induced G0/G1 cell cycle arrest and inhibited cell migration and invasion. (biomedcentral.com)

He then did post-doctoral studies with Joseph Nevins at Duke University studying the control of Rb/E2F induction of proliferation and apoptosis. (umn.edu)

Furthermore, the function of this mutation was analyzed through various in vitro assays using the RGC-5 cell line. (aging-us.com)
Learn about cell viability assays. (abcam.com)
Learn about the assays used to assess cell proliferation and the cell cycle. (abcam.com)
MTT assays were employed to determine the effect of cell proliferation. (biomedcentral.com)
Transwell migration and invasion assays were done to evaluate changes in the ability of cell migration and invasion. (biomedcentral.com)

confirmed an apoptotic death for both cell lines. (bioinf.org)
Apoptosis (programmed cell death) occurs in a wide variety of physiological NIK settings, where its role is to remove harmful, damaged or unwanted cells. (bioinf.org)
Moreover, induced Akt activity (p-AKT) (due to overexpression) is sufficient to block apoptosis triggered by many death stimuli [5]. (bioinf.org)
It is also essential for development of nerval system by programmed cell death. (wikipedia.org)
Another important cell death-property of Daxx is the association with PML-NB. (wikipedia.org)
The voltage gated potassium (K+) channels Eag and HERG have been implicated in the pathogenesis of various cancers, through association with cell cycle changes and programmed cell death. (derby.ac.uk)
Cells are also programmed for death at the genetic level as a response to DNA damages through the process of apoptosis. (bdbiosciences.com)
Cell division, proliferation, and apoptosis and death are integral parts of life. (bdbiosciences.com)
Therefore, the current study used integrated in vitro and in silico approaches to figure out Amy and Sor's possible synergistic activity in targeting AMPK/mTOR and BCL-2 for anti-angiogenesis and apoptosis cell death in HepG2 cells. (biomedcentral.com)
They found that TNF induced both apoptotic and necrotic cell death. (news-medical.net)
This result sparked further interest in how necrotic cell death occurs. (news-medical.net)
Studies show that necrotic death is induced by a ligand binding to a receptor, such as when apoptosis is initiated. (news-medical.net)
The "death receptors", which typically cause cell death by apoptosis, can be activated by ligands, such as TNF. (news-medical.net)
Necroptosis can therefore start in an apoptosis-like manner, but result in necrotic-like cell death. (news-medical.net)
Viral infections can induce different kinds of cell death. (news-medical.net)
The induced necrotic cell death by virial agents is important for virus-induced inflammation, and blockage of necroptosis is a primary concern for controlling certain viral diseases. (news-medical.net)
Resistance to these treatments are due to the cells resisting apoptotic death. (news-medical.net)
Strong induction of apoptosis in one compartment of the Drosophila wing disc causes apoptosis of cells in the other compartment, indicating that dying cells can release long-range death factors. (elifesciences.org)
We also show that during coordinated cell death of hair follicle cells in mice, TNF-α is expressed in apoptotic cells and is required for normal cell death. (elifesciences.org)
Apoptosis is a distinct form of programmed cell death in which cells activate an intrinsic suicide program to self-destruct. (elifesciences.org)
It is actually programmed cell death essential for normal metabolism. (benthamscience.com)
miRNAs have been implicated as transcriptional regulators in a wide range of biological processes determining cell fate, stress response, proliferation, or death [ 5 ]. (hindawi.com)
However, the results of studies, which have been carried out for the last years, prove that depending on its type, the cell can be guided in different directions, which can result either in its survival or death. (pbkom.eu)
According to the NCCD Committee, apoptosis and autophagy are ranked as two types of cell death. (pbkom.eu)
They may be involved probably in platelet activation and programmed death. (pbkom.eu)
The term anti-cell death is used extensively to describe the observed instances of death in plants. (essaywriter.org)
Evidently, it has been established from the above outline that cell death plays a pivotal role in the innate responses in both animals and plants. (essaywriter.org)
Additionally, this discussion expands its mandate by analyzing the function and regulation of anti-cell death in plant development. (essaywriter.org)
Using relevant sources of literature, the paper delivers a systematic analysis of fascinating analogies between cell death and plant development with respect to the primary functions of cell death as stipulated in the introductory outline of the discussion. (essaywriter.org)
There have been several attempts to analyze the concept of cell death in plants since the experimental demonstrations in studies conducted in the 1980s and the 1990s with the aim of dissecting the programmed nature of plant cell death (Xinqiang and Hong, pg 354). (essaywriter.org)
Since this discovery, the field of plant programmed cell death has continued to grow, with maturity depicted in studies aimed at distinguishing the roles of plant cell deaths in plant development. (essaywriter.org)
Despite this, there are adaptive characteristics and distinctive features that that distinguish the lifestyle of plants from those of animals, hence the adoption of only distantly related components in revealing the genetic regulations of plant cell death. (essaywriter.org)
Cell death refers to a series of events that culminate in the organized and controlled destruction of the cell. (essaywriter.org)
In plants, cell death is a fundamental process, as it plays the roles of controlling the elimination of cells during plant development and defense in the form of hypersensitive response. (essaywriter.org)
The activation of cell death by plants is dependent on the decision by the plant cells based on information that these cells receive from different sources, such as the environment . (essaywriter.org)
Ferroptosis is an iron dependent form of cell death, that is triggered by the discoordination of iron, lipids, and thiols. (cdc.gov)
Its unique signature that distinguishes it from other forms of cell death is the formation and accumulation of lipid hydroperoxides, particularly oxidized forms of polyunsaturated phosphatidylethanolamines (PEs), which drives cell death. (cdc.gov)

It has been associated with heterochromatin and PML-NBs (Promyelocytic Leukaemia nuclear bodies) and has been implicated in many nuclear processes including transcription and cell cycle regulation. (wikipedia.org)
Using cellular systems it has been shown that HPV16 E5 expression results in down-regulation of cell surface expression of HLA-I and HLA-II molecules [ 19 - 22 ]. (biomedcentral.com)
Having said that, ketanserin is unable to block the inhibitory action of 4 iodo 2,5 dimethoxyphenyiisopropylamine, a potent 5 HT2 agonist, to the electrical action of those cells, indicating that 5 HT2 receptors, like 5HT3 receptors, will not play any function from the regulation of their firing charge. (agckinase.com)
In contrast to 5 HT2 and 5 HT3 receptors, 5 HTia receptors are involved with the regulation in the firing charge of serotoninergic neurones while in the dorsal raphe nucleus, as more supported while in the present study by the efficacy of your S HT agonist, ipsapirone to inhibit, in vivo as well as in vitro, the electrical activity of these cells by way of a propranolol reversible action. (agckinase.com)
Finally, the results of ROC curves, immunohistochemical staining, immune cell infiltration and kinase / miRNA / transcription factor regulation showed that KCNK2, KCNK4, KCNK5 and KCNK15 levels could be used as biomarkers for PTC diagnosis. (jcancer.org)
Our data demonstrate that Ganoderma lucidum inhibits cell proliferation in a dose- and time-dependent manner by the down-regulation of expression of cyclin B and Cdc2 and by the up-regulation of p21 expression. (greenmedinfo.com)

Inhibition of apoptosis did not affect branchial sac stem cell proliferation but prevented the survival of progenitor cells. (biologists.com)
The microenvironment of the cell and the interactions of many growth factors have a role in tumor development and survival [ 2 , 7 ]. (biomedcentral.com)

This led to other relevant results, such as the reduction of some transcription factors, the inhibition of the activity of certain enzymes and the decrease of mitochondrial respiration and glycolysis of tumour cells. (agenciasinc.es)
Notably, Debcl modulates Drp1 mitochondrial localization during apoptosis. (sdbonline.org)

Although, non-psychoactive cannabidiol (CBD) and cannabigerol (CBG) display antineoplastic effects by repressing tumor growth and angiogenesis both in cell line and animal models, their use as chemotherapeutic agents is awaiting further investigation. (frontiersin.org)

A number of techniques are used to assess cell proliferation. (bdbiosciences.com)

More characterization of these tumors unveiled a reduction in endothelial cells following AZD1480 therapy, in contrast to regulate and AZD6244 groups. (micrornaarray.com)
No important variations have been detected while in the quantity of apoptotic cells, whose percentage was lower through the entire tumors. (micrornaarray.com)

Apoptosis and cell proliferation are linked by cell-cycle regulators and apoptotic stimuli that affect both processes. (bioinf.org)
One of the key processes involved in EC development is uncontrolled proliferation stimulated by local factors such as angiotensin. (spandidos-publications.com)
One of the postulated key processes in the development of endometrial tumours is uncontrolled proliferation stimulated by physiological local factors ( 3 ). (spandidos-publications.com)
Necroptosis falls somewhere in the middle, with several molecules and processes that can trigger, modulate, and effect necroptosis in cells. (news-medical.net)
The introduction of cell culture techniques has helped a lot in understanding the physiological processes like cell signalling, neurobiology, cell proliferation, pathogenesis of diseases, apoptosis and even more. (benthamscience.com)

A failure in regulating proliferation together with suppression of apoptosis are the 123653-11-2 manufacture minimal requirements for a cell to become cancerous [4]. (bioinf.org)
Alanine transition of S63 and S262 (S63A and S262A) of IκBα induced inhibition of cell proliferation and suppression of p65 transcription activity. (researchsquare.com)

EMB inhibited viability of CTCL cells in a dose-dependent manner. (bvsalud.org)
Methods for detecting apoptosis or dead cells (viability) by cell preparation type. (bdbiosciences.com)
Cell viability was determined by using the MTT assay and the morphological changes were observed. (researchgate.net)

Methods: Previously we observed that aurora kinase (AURK) binds IκBα in the cell. (researchsquare.com)
Methods: The human multiple myeloma SKO-007 cells in logarithm growth phase were selected and randomly divided into control group, LDM group, BZM group, and BZM combined with LDM group. (researchgate.net)

Our results indicated that at the beginning of cancerogenesis Ang II induced abnormal proliferation at lower doses. (spandidos-publications.com)
A complete blood cell count (CBC) with differential should be obtained, including examination of the peripheral blood smear if the differential is abnormal. (medscape.com)

The apoptotic process is characterized by certain morphological features. (bdbiosciences.com)
The morphological changes of cells were measured by Wright-Giemsa staining. (biomedcentral.com)
On the other hand, similar morphological terms are currently being developed to distinguish different types of cell deaths in plants. (essaywriter.org)

Microvesicles have a diameter ranging from 100 nm to 1 µm and are released by cell membrane budding. (spandidos-publications.com)

The results, published in the Journal of Functional Foods, show that strawberry tree honey is capable of inhibiting the proliferation of tumour cells cultivated in laboratory plates - more specifically, those of a line of human colon adenocarcinoma (HCT-116) and another with metastatic characteristics (LoVo), widely used to investigate this type of tumour. (agenciasinc.es)
Strawberry tree honey is capable of inhibiting the proliferation of tumour cells on a line of human colon adenocarcinoma (HCT-116) and another with metastatic characteristics (LoVo). (agenciasinc.es)
In this study, we investigated a plausible therapeutic synergism of a triple combination of CBD/CBG, curcumin, and piperine in the colon adenocarcinoma using HCT116 and HT29 cell lines. (frontiersin.org)
E6 and Metabolic syndrome and risks of colon and rectal renal cell carcinoma. (who.int)

Apoptosis is associated with nuclear disintegration, followed by removal of the cell by macrophages. (news-medical.net)

8 , 9 Cell cycle program is regulated by cyclin/cyclin-dependent kinase (CDK) complexes. (jcpjournal.org)

Increased manifestation levels of p53, p21, and p27, downregulation of c-myc and Bcl-2, and inhibition of Akt activation were also found in CF-treated MSTO-211 and HCT-116 cells. (bioinf.org)
p53 activation is characterized by a drastic increase and its rapid accumulation in stressed cells [11]. (bioinf.org)
Apoptosis occurred 48 hours after EBF3 expression with caspase-3 activation. (aacrjournals.org)
This inhibition by 5 HTia agonists, the truth is final results through the direct activation of somatodendritic 5 HTj autoreceptors, located on the serotoninergic cells inside of the dorsal raphe nucleus. (agckinase.com)
Augmented STAT3 activation has been found in both irreversibly committed B cell lineage precursors and plasmacy- tes. (pbkom.eu)
Conclusion: BZM can greatly enhance the efficacy of LDM against multiple myeloma by increasing the levels of cleaved caspase-3 and PARP, and remarkably increase the apoptosis induced by LDM through further activation of ERS. (researchgate.net)
selleck chemical Recently, platelet aspect four was observed to induce SOCS3, therefore suppressing STAT3 activation, angio genesis, and development and inducing apoptosis of myeloma cells. (micrornaarray.com)

Our findings revealed that different genetic backgrounds of HCT116 and HT29 cell lines resulted in divergent responses to the combination treatments. (frontiersin.org)
EESR showed significant antioxidant activity and inhibitory effect on HT29 cell growth in a dose-dependent manner. (jcpjournal.org)

microvesicles (MVs), exosomes and apoptotic bodies (ABs) ( Fig. 1 ) ( 6 ). (spandidos-publications.com)
Lastly, apoptotic bodies have a diameter from 50 nm to 5 µm, the latter a dimension similar to that of platelets (2-3 µm). (spandidos-publications.com)
In the final stages of the process, dying cells become fragmented into apoptotic bodies and consequently are eliminated by phagocytic cells without significant inflammatory damage to surrounding cells. (bdbiosciences.com)

Clinically, grade 3B follicular lymphoma is treated like diffuse large B-cell lymphoma . (medscape.com)

DLBCL patients are at higher risk when they relapse early after R-CHOP chemotherapy and have a poor response to second-line rituximab-containing treatments even when these regimens involve high-dose therapy and autologous stem cell transplant. (wikipedia.org)
In hematological malignancies like leukemias, myeloma, and non-Hodgkin B-cell lymphomas, adoptive CAR-T cell therapy has shown efficacy in treating chemotherapy refractory patients. (bvsalud.org)
Drinking grape juice 30 minutes before meals for a week following each cycle of chemotherapy doesn't seem to reduce nausea or vomiting caused by chemotherapy. (medlineplus.gov)

rbf1 , the Drosophila homolog of Rb , also displays a pro- apoptotic activity in proliferative cells. (sdbonline.org)

Once activated by an antigen, B-cells proliferate and further differentiate into plasma cells and memory B-cells. (wikipedia.org)
B-cells that have not encountered an antigen are called naive B cells. (wikipedia.org)
In the last decade, Chimeric Antigen Receptor (CAR)-T cell therapy has emerged as a promising immunotherapeutic approach to fight cancers. (bvsalud.org)

Anatomy28

Organisms9

Diseases8

Chemicals and Drugs119

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes67

Disciplines and Occupations1

Information Science3

Induces apoptosis3

Differentiation14

Induce apoptosis4

Proteins21

Tumor cells12

Pathway17

Pathways8

Analyzed by flow cytometry1

Mechanisms17

Flow cytometry4

Protein18

Necrosis12

Anti-apoptotic function1

Mechanism8

Genes17

Undergo5

Progression4

Type of programmed cell1

Inhibitors1

Homeostasis9

Anticancer1

Cytotoxicity4

Gene11

Cancer38

Signals11

Trigger apoptosis2

Arrest8

Induction of proliferation1

Assays5

Death37

Regulation6

Survival2

Mitochondrial2

Angiogenesis1

Assess cell proliferation1

Tumors2

Processes5

Suppression2

Viability3

Methods2

Abnormal2

Morphological3

Membrane1

Colon4

Nuclear1

Cyclin-depend1

Activation7

HT292

Bodies3

Follicular1

Chemotherapy3

Proliferative1

Antigen3