Proliferation and activation. Medical search. Frequent questions

Therefore, this study proves that Rh4 inhibits cancer cell proliferation by activating the ROS/p53 signaling pathway and activating autophagy to induce ferroptosis, which provides necessary scientific evidence of the great anticancer potential of Rh4. (hindawi.com)
The activation continues through a series of proteins in a signaling pathway. (medlineplus.gov)
Many of the genes implicated thus far can be categorized as involved in B-lymphocyte activation, apoptosis, or the interferon-signaling pathway. (medscape.com)

Fujiwara Y, Komohara Y, Kudo R, Tsurushima K, Ohnishi K, Ikeda T and Takeya M: Oleanolic acid inhibits macrophage differentiation into the M2 phenotype and glioblastoma cell proliferation by suppressing the activation of STAT3. (spandidos-publications.com)
29,31-34 Recently, supplement D position continues to be connected with risk for several malignancies inversely, since supplement D inhibits cell angiogenesis and proliferation, activates apoptotic pathways, and exerts pro-differentiative results.35,36 In 1980, Garland37 and Garland reported an inverse association between sunshine publicity and cancer of the colon mortality, hypothesizing for vitamin D a protective function against the chance of cancer of the colon. (bibf1120.com)
Curcumin inhibits head and neck cancer cell proliferation. (greenmedinfo.com)

In peroxide-treated cells cultured in low serum media, FOXO3a inhibited cell proliferation and protected against apoptosis. (ox.ac.uk)
However in peroxide treated cells cultured in high serum media, cell proliferation was unchanged but level of apoptosis significantly increased. (ox.ac.uk)
Similarly, in tenocytes transduced to over-express FOXO3a, cell proliferation was inhibited and level of apoptosis unchanged in cells cultured in low serum. (ox.ac.uk)
Inhibition of cell proliferation in either peroxide-treated or FOXO3a-expressing cells cultured in high serum protected against apoptosis induction. (ox.ac.uk)
Conversely, addition of a Chk2 inhibitor to peroxide-treated or FOXO3a-expressing cells overrode the inhibitory effect of FOXO3a on cell proliferation and led to increased apoptosis in cells cultured in low serum. (ox.ac.uk)
The results demonstrated that TEOA inhibited proliferation and induced apoptosis in time-and dose-dependent manners. (figshare.com)
The inhibitory effect of MicroRNA-16-5p on the proliferation, invasion, cell cycle and apoptosis of glioma cells was evaluated by the cell proliferation, invasion and flow cytometry. (ijpsonline.com)

This antigen is involved in B-lymphocyte activation and proliferation. (beckman.com)

Tumor-associated macrophages (TAMs) polarized to the M2 phenotype promote tumor cell proliferation and are associated with a poor prognosis in patients with high grade glioma. (spandidos-publications.com)
These results indicate that OA suppresses the M2 polarization of macrophages and tumor cell proliferation by inhibiting STAT3 activation. (spandidos-publications.com)
Gab3 overexpression in human glioma mediates Akt activation and tumor cell proliferation. (illumina.com)

However, whether GLP1 has a direct effect on the proliferation and differentiation of osteoblasts or any cellular mechanism for this potential role is unknown. (endocrinology-journals.org)
We examined the effects of the GLP1 receptor agonist exendin-4 on the proliferation, differentiation, and mineralization of mouse osteoblastic MC3T3-E1 cells. (endocrinology-journals.org)
Cell proliferation was assessed using MTT assay, revealing that exendin-4 increased cell proliferation at effective concentrations between 10 −10 and 10 −5 M. Quantitative PCR analysis showed that exendin-4 increased the mRNA expression of the differentiation markers alkaline phosphatase (ALP), collagen-1 (COL1), osteocalcin (OC), and runt-related transcription factor 2 (RUNX2) under osteogenic conditions. (endocrinology-journals.org)
The use of selective MAPK inhibitors, namely PD98059, SB203580, and SP600125, blocked the effects of exendin-4 on kinase activation (ERK1/2, p38, and JNK), as well as cell proliferation and differentiation in MC3T3-E1 cells. (endocrinology-journals.org)
These findings demonstrate that exendin-4 promotes both the proliferation and differentiation of preosteoblasts MC3T3-E1 via activation of the MAPK pathway. (endocrinology-journals.org)
BNP treatment increased their proliferation but not their differentiation capacity. (elifesciences.org)
These signaling pathways are important in many cellular processes such as cell growth and division (proliferation) or maturation (differentiation). (medlineplus.gov)
Neuroblastoma and other cancers occur when a buildup of genetic mutations in critical genes-those that control cell proliferation or differentiation-allows cells to grow and divide uncontrollably to form a tumor. (medlineplus.gov)

In fibroblasts, platelet-derived growth factor stimulation induces sustained ERK activation and promotes S-phase entry. (nebraska.edu)
Mutation of Ser 392 and Thr 274 (KSR1.TVSA) promotes sustained ERK activation and cell cycle progression with either platelet-derived growth factor or epidermal growth factor treatment. (nebraska.edu)
Inhibition of p62-Keap1-Nrf2 Pathway Activation by Realgar Promotes the Inhibition of Esophageal Cancer Cell Proliferation, Migration, and Ferroptosis. (bvsalud.org)
In conclusion, the findings of this study show that AG promotes cell survival of the OC cells and renders them resistat to Cis therapy, an effect that is mediated by the activation of PI3K/Akt/mTOR and activation of NF- κ B, and requires GHS-R1a. (hindawi.com)
Numerous reports suggest that interleukin-6 (IL-6) promotes survival and proliferation of tumor cells through the phosphorylation of a cell-signaling protein, signal-transducer-and-activator-of-transcription-3 (STAT3). (greenmedinfo.com)
RICTOR Amplification Promotes NSCLC Cell Proliferation through Formation and Activation of mTORC2 at the Expense of mTORC1. (nih.gov)
TIMP1 promotes multi-walled carbon nanotube -induced lung fibrosis by stimulating fibroblast activation and proliferation. (cdc.gov)

Inhibition of cell proliferation by FOXO3a may be a critical event in allowing the pro-survival rather than the pro-apoptotic activity of FOXO3a to prevail. (ox.ac.uk)
Surprisingly, neither pharmacological inhibition of VRAC by carbenoxolone, 4-[(2-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]butanoic acid (DCPIB) or 5-nitro-2-(3-phenylpropyl-amino)benzoic acid (NPPB), nor siRNA-mediated knockdown or disruption of the essential VRAC subunit LRRC8A affected cell proliferation and migration in any of the investigated cell lines. (fu-berlin.de)
This revealed that both pharmacological inhibition and siRNA-mediated knockdown of PKDs impaired hypotonicity-induced VRAC activation. (fu-berlin.de)
The inhibition of STAT3 activation by curcumin was reversible, although even 24 hr after curcumin removal, only partial reversal occurred. (greenmedinfo.com)
By functioning both upstream and downstream of pSMAD2, miR-17-92 activation triggers downregulation of multiple key effectors along the TGF-beta signaling cascade as well as direct inhibition of TGF-beta-responsive genes. (lu.se)
Inhibition of DDR1/2 led to a reduction in the activation of KIT and its downstream signaling molecules, ultimately impairing GIST cell survival and proliferation in vitro. (lu.se)

These results suggest that mango polyphenols and their major microbial metabolite, pyrogallol, inhibit proliferation of breast cancer cells through ROS-dependent up-regulation of AMPK and down-regulation of the AKT/mTOR pathway. (oregonstate.edu)

This is consistent with reports that the slow phosphorylation of tyrosine residues of the Lat adaptor associates with recruitment and activation of the phospholipase Plcγ1, thereby constituting an important kinetic bottleneck for ligand discrimination 11 . (nature.com)
While the phosphorylation of tyrosine residues in the immunoreceptor tyrosine-based activation motifs (ITAMs) of Cd3 and the inducible interaction between Cd3 and Zap70 remained largely unaffected, the abundance of activated Zap70 dropped with decreasing peptide affinity. (nature.com)
Phosphorylation of KSR1, particularly at Ser 392 , is a critical regulator of KSR1 subcellular localization and ERK activation. (nebraska.edu)
We examined the role of phosphorylation of both Ser 392 and Thr 274 in regulating ERK activation and cell proliferation. (nebraska.edu)
These data demonstrate that phosphorylation and stability of the molecular scaffold KSR1 are critical regulators of growth factor-specific responses that promote cell proliferation. (nebraska.edu)
Phosphorylation of KSR1, particularly at Ser392, is a critical regulator of KSR1 subcellular localization and ERK activation. (nebraska.edu)
Y510 efficiently mediated IL-21-induced phosphorylation of Stat1 and Stat3, but not of Stat5, and CD8(+) T cells from Stat1/Stat3 double knock-out mice exhibited decreased proliferation in response to IL-21 + IL-15. (nih.gov)
In addition, IL-21 weakly induced phosphorylation of Shc and Akt, and consistent with this, specific inhibitors of the MAPK and PI3K pathways inhibited IL-21-mediated proliferation. (nih.gov)

The ex vivo activation and proliferation of cytotoxic T cells are critical steps in adoptive immunotherapy. (bgu.ac.il)
Here, we demonstrate a new approach for the activation and proliferation of human cytotoxic T cells using an elastic microbrush coated with activating and costimulatory antibodies. (bgu.ac.il)
They are essential in determining B cell antibody class switching , in the activation and growth of cytotoxic T cells , and in maximizing bactericidal activity of phagocytes such as macrophages . (wikidoc.org)

In this study, the role of the p62- Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in the regulation of EC cell proliferation , migration, and ferroptosis in response to realgar was assessed. (bvsalud.org)
In response to realgar, low p62 expression inhibited the proliferation, migration, and invasion of Eca109 and KYSE150 cells , as well as ferroptosis induction. (bvsalud.org)
Among them and over decades of research, it was shown that the PI3K/Akt/mTOR pathway is one of the most frequently hyperactive pathways in OC as well as other types of solid tumors and is associated with increased cell growth, proliferation, migration, protein synthesis, survival, and chemotherapy resistance [ 7 - 9 ]. (hindawi.com)
Here, we investigated the effect of arecoline on the proliferation and migration of human HepG2 hepatoma cells and its potential oncogenic mechanisms. (biomedcentral.com)
Compared with control group, 2.5 µM arecoline treatment increased the proliferation and migration ability of the HepG2 cells. (biomedcentral.com)
A low concentration arecoline can induce the proliferation and migration of HepG2 cells, with the potential mechanism of action linked to high levels of exosomal miR-21 and miR-1267, activation of the PI3K-AKT pathway, upregulation of CDK1 and CCND1, and downregulation of RAF1. (biomedcentral.com)
Although VRAC's potential physiological functions and activation mechanism were studied extensively, conflicting results were obtained regarding the role of VRAC in cell proliferation and migration, as well as its activation mechanism. (fu-berlin.de)
These results indicate that, contrasting the prevailing assumption in the literature, VRAC is dispensable for cell proliferation and migration. (fu-berlin.de)

This study investigated the effect of acylated synthetic ghrelin (AG) on the survival and proliferation of human chemosensitive ovarian cancer cells (A2780) and explored some mechanisms of action with a focus on the p53 apoptotic pathway and PI3K/Akt and NF- κ B survival pathways. (hindawi.com)
TNFSR9) is an activation-induced surface receptor that through costimulation effects provide antigen-primed T cells with augmented survival, proliferation and effector functions as well as metabolic advantages. (lu.se)
In this study, side-by-side comparisons show that provision of CD137 costimulation in-cis with regard to the TCR-CD3-ligating cell is superior to that provided in-trans in terms of T cell activation, proliferation, survival, cytokine secretion and mitochondrial fitness in mouse and human. (lu.se)

In particular, it is unclear whether ligand affinity uniformly affects the different signaling pathways involved in T cell activation. (nature.com)

Polyphenolics from mango (Mangifera indica L.) suppress breast cancer ductal carcinoma in situ proliferation through activation of AMPK pathway and suppression of mTOR in athymic nude mice. (oregonstate.edu)
Thus, agents that can suppress STAT3 activation have potential for the treatment of HNSCC. (greenmedinfo.com)
This mechanism may be at least partially responsible for curcumin's ability to suppress proliferation of HNSCC cells. (greenmedinfo.com)

Constitutive activation of STAT3 in head and neck squamous cell carcinoma (HNSCC) and its role in proliferation of this tumor has been demonstrated. (greenmedinfo.com)
Besides inhibiting constitutive expression, curcumin also abrogated the IL-6-induced activation of STAT3 in HNSCC cells. (greenmedinfo.com)

These findings demonstrate that expression of a proexendin-4 transgene may be associated with activation of humoral and cellular immune responses in mice. (diabetesjournals.org)

However, both increased and decreased CREB expression have been proposed to mediate the proliferation of pulmonary artery smooth muscle cells (PASMCs). (researchsquare.com)
Interestingly, stimulation of CysLT1R located in the nuclei induced the activation of ERK1/2, an enzyme which have been shown to mediate LTD4 induced proliferation. (lu.se)

Although the specific function of ALK receptor tyrosine kinase is unknown, it is thought to act early in development to help regulate the proliferation of nerve cells. (medlineplus.gov)
Constitutive activation of ALK receptor tyrosine kinase may increase the proliferation of immature nerve cells, leading to neuroblastoma. (medlineplus.gov)
The presence of neurotransmitter receptors in microglia illustrates their functional connection to neurons and this receptor activation could cause microglial cells to perform different activation phenotypes ( Pocock and Kettenmann, 2007 ). (frontiersin.org)

This perspective focuses on two areas that have yielded new useful information during the last 20 years: (i) structure-activity relationship (SAR) studies of contact allergy based on the concept of hapten-protein binding and (ii) mechanistic investigations regarding activation of nonsensitizing compounds to contact allergens by air oxidation or skin metabolism. (cdc.gov)
mechanistic investigations regarding activation of nonsensitizing compounds to contact allergens by air oxidation or skin metabolism. (cdc.gov)

These results may have been due to activation of multiple protein kinases and downregulation of numerous phosphatases targeting CREB. (researchsquare.com)
In summary, CREB pathway was overactivated in the development of PH and contributed to PASMC proliferation, which was associated with multiple protein kinases and/or reduced CREB phosphatases and raised intracellular zinc. (researchsquare.com)
Using SILAC and quantitative mass spectrometry, we examined the effects of activation of the miR-17-92 cluster on global protein expression in neuroblastoma (NB) cells. (lu.se)

Endothelial cell lineage tracing showed that BNP directly stimulated the proliferation of resident endothelial cells via NPR-A binding and p38 MAP kinase activation. (elifesciences.org)

Here, we show that NF-κB activation in SCs is dispensable for myelination in vivo . (jneurosci.org)

Our study provides an essential insight into the physical mechanism of T-cell activation and proliferation and opens the floodgates for the design of novel stimulatory materials for T-cell-based immunotherapy. (bgu.ac.il)
The lack of specific pharmacological VRAC inhibitors and the unknown molecular entity of VRAC hampered further progress aiming to elucidate its activation mechanism and proposed physiological roles. (fu-berlin.de)
The discovery of LRRC8 heteromers as an essential component of VRAC enabled the investigation of its physiological roles and activation mechanism of VRAC using molecular biological tools. (fu-berlin.de)
The origin of new endothelial cells (i.e. resident or infiltrating) as well as the underlying mechanism leading to their proliferation (partial endothelial-to-mesenchymal transition [EndMT] or not) have long been debated. (elifesciences.org)

These results demonstrate that ChoK plays an essential role in both normal human mammary epithelial cell proliferation and breast tumor progression. (aacrjournals.org)
In summary, our data demonstrate that DDR1/2 contribute to KIT activation in GISTs and strengthen resistance to imatinib for both primary and secondary KIT mutants, providing a rationale for further exploration of DDR1/2 targeting in GIST treatment. (lu.se)

PASMC proliferation in experimental PH was dependent on CREB-mediated transcriptional activity, and increases in intracellular labile zinc mediated by ZIP12 upregulation may have been linked to the reductions in phosphatases and the increases in transcriptional activity and PASMC proliferation. (researchsquare.com)
Conditional knockout of α1A adrenergic receptors in OPCs suppresses spontaneous and locomotion-induced Ca 2+ increases and reduces OPC proliferation. (nature.com)
Epigenetic Downregulation of Hsa-miR-193b-3p Increases Cyclin D1 Expression Level and Cell Proliferation in Human Meningiomas. (cdc.gov)

The objective of this study was to assess the underlying mechanisms of mango polyphenol decreased cell proliferation and tumor volume in ductal carcinoma in situ breast cancer. (oregonstate.edu)
Although the signaling mechanisms governing myelination are not fully understood, NF-κB activation in Schwann cells has been implicated as a key regulator in vitro . (jneurosci.org)

In addition, TEOA induced the activation of the p38 MAPK pathway and pretreated with p38 inhibitor SB20358 or ROS scavenger could block TEOA-induced DNA damage. (figshare.com)
Taken together, these results suggest that ROS mediated activation of the p38 MAPK signal pathway plays an important role in initiating TEOA-induced DNA damage. (figshare.com)

Simultaneous mutation of all 6 tyrosines greatly diminished IL-21-mediated proliferation, whereas retention of tyrosine 510 (Y510) allowed full proliferation. (nih.gov)

In this study, we examined both the expression levels and the activation states of RhoA in various lung cancer cells by quantitative real-time reverse transcriptase-polymerase chain reaction and in vivo Rho guanine nucleotide exchange assay, respectively. (nih.gov)

Using a mouse model, we show that nuclear factor κB activation in Schwann cells is not required for myelination in vivo . (jneurosci.org)

Choline kinase (ChoK) is increased in human mammary tumors with high incidence, and this activation is associated with clinical variable indicators of greater malignancy. (aacrjournals.org)

However, while AG treatment had no effect on control cell viability, it significantly increased cell viability and proliferation and inhibited cell death in Cis-treated cells. (hindawi.com)

Ubiquitin carboxyl terminal hydrolase L1 negatively regulates TNFalpha-mediated vascular smooth muscle cell proliferation via suppressing ERK activation. (musc.edu)

Here, we have investigated the role of ChoK in the development of breast cancer and found that ChoK is both necessary and sufficient for growth factor-induced proliferation in primary human mammary epithelial cells and an absolute requirement for the specific mitogenic response to heregulin in breast tumor-derived cells. (aacrjournals.org)

Activation of the EGFR pathway plays an important role in the progression of cancer and is associated with a poor prognosis in patients. (preprints.org)

We found that four of six small cell lung carcinoma (SCLC) cell lines exhibited a moderate to high activation rate of RhoA. (nih.gov)
Our results suggest that RhoA is activated in various lung cancer cells independent of its expression levels, and the high activation state of RhoA in SCLC cells mainly depends on a neuroendocrine peptide autocrine system which signals through Galpha12 coupled GPCR to RhoA. (nih.gov)

We tested the role of genetic and environmental factors in the newly described activation and attachment steps. (uni-muenchen.de)
In contrast to spore activation, attachment depended strongly on the combination of host and parasite genotypes. (uni-muenchen.de)
We discuss how different steps can explain different aspects of the coevolutionary dynamics of the system: the properties of the attachment step, explaining the rapid evolution of infectivity and the properties of later parasite proliferation explaining the evolution of virulence. (uni-muenchen.de)

It is now established that the postpartum endometrial inflammatory response and its allied immune gene activation is a transient feature of the normal physiological events associated with uterine involution[ 6 ]. (biomedcentral.com)

These molecular changes mirror the activation and resolution of endometrial inflammation during involution previously classified by the degree of neutrophil infiltration. (biomedcentral.com)

The activation states of RhoA are considerably different from its expression profiles. (nih.gov)
In this study, we observed that discoidin domain receptors 1 and 2 (DDR1 and DDR2) exhibited high expression in GISTs, were associated with KIT, and enhanced the activation of both wild-type KIT and primary KIT mutants. (lu.se)

Treatment with epidermal growth factor induces transient ERK activation but fails to drive cells into S phase. (nebraska.edu)

The results of this study reveal an early activation of the immune response which undergoes a temporal functional change toward tissue proliferation and regeneration during endometrial involution in healthy postpartum cows. (biomedcentral.com)
These results corroborate the notion that hypotonicity-induced VRAC activation involves diacylglycerol (DAG) and PA signaling. (fu-berlin.de)
Our results reveal cooperation between individual miR-17-92 miRNAs and implicate miR-17-92 in multiple hallmarks of cancer, including proliferation and cell adhesion. (lu.se)

This study may reveal a critical role of zinc-mediated CREB pathway activation in PASMC proliferation, thus providing a novel insight into the CREB pathway in the pathogenesis of PH. (researchsquare.com)

However, the activation states of RhoA are poorly defined in cancer cells. (nih.gov)

Anatomy42

Organisms13

Diseases13

Chemicals and Drugs101

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Phenomena and Processes55

Disciplines and Occupations1

Information Science3

Signaling pathway3

Inhibits3

Apoptosis7

Involved in B-lymphocyte activation1

Tumor cell proliferation3

Differentiation8

Promotes7

Inhibition6

Inhibit proliferation1

Phosphorylation8

Cytotoxic T cel3

Migration8

Survival3

Pathways1

Suppress3

STAT32

Cellular1

Mediate2

Receptor3

Metabolism2

Protein3

Kinase activation1

Dispensable1

Mechanism4

Demonstrate2

Increases3

Mechanisms2

MAPK2

Tyrosine1

Assay1

Vivo1

Tumors1

Significantly increased1

Regulates1

Human1

Progression1

Lung2

Attachment3

Gene1

Molecular1

Expression2

Treatment1

Results3

Role1

Cancer1