Proliferation active transport cell nucleus. Medical search. Frequent questions

In response to DNA damage or oxidative stress, Abl is transported to the nucleus where it induces apoptosis. (umbc.edu)
Under experimental normoxic condition (21 % O 2 ), deferasirox (DFX) used at 10 μM for 3 days reduced proliferation, led cell cycle arrest in S and G2-M phases and induced cytotoxicity and apoptosis in U251 and U87 GBM cells. (biomedcentral.com)
Irradiation at a dose of 16 Gy repressed proliferation, cytotoxicity and apoptosis, but only in U251 cells, while no synergy with DFX was observed in either cell line. (biomedcentral.com)
Traditionally, cell death has been divided into apoptosis and necrosis. (nature.com)
It does not have the morphological characteristics of typical necrosis, such as swelling of the cytoplasm and organelles and rupture of the cell membrane, nor does it have the characteristics of traditional cell apoptosis, such as cell shrinkage, chromatin condensation, formation of apoptotic bodies and disintegration of the cytoskeleton. (nature.com)
Cytosolic O-GlcNAcylation and PNG1 maintain Drosophila gut homeostasis by regulating proliferation and apoptosis. (nih.gov)
Akt pathways have effects on apoptosis, protein synthesis, metabolism and cell cycle. (springer.com)
Following treatment with ox-LDL, decreased expression of MEG3 promoted proliferation and migration, and suppressed apoptosis in HA-VSMCs. (researchensemble.com)
Furthermore, treatment with baicalin reversed these effects on proliferation and apoptosis in ox-LDL-treated HA-VSMCs. (researchensemble.com)
Baicalin inhibited proliferation and marketed apoptosis by regulating the appearance of MEG3/p53, indicating that baicalin might provide a job in AS by activating the MEG3/p53 signaling pathway. (researchensemble.com)
Furthermore, p53 regulates cell routine and apoptosis (15,25). (researchensemble.com)
Wu (2) hypothesized that lincRNA-p21 may regulate vascular simple muscle tissue cell proliferation and apoptosis by improving the experience of p53 in AS (2). (researchensemble.com)
TRIM13 inhibited cell proliferation and induced cell apoptosis by regulating NF-κB pathway in non-small-cell lung carcinoma cells. (cancerindex.org)
TRIM13-induced NSCLC cell apoptosis was attenuated by a caspase-3 inhibitor Ac-DEVD-CHO, suggesting that TRIM13 induced cell apoptosis partially through a caspase-3-dependent pathway. (cancerindex.org)
Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruction, plasma membrane repair, exosome release, cell adhesion/migration and apoptosis. (biomedcentral.com)
Since epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors, including gefitinib (GEF) have been reported to induce the apoptosis of several cancer cell lines, in the present study, we examined whether the cytotoxic effects of GEF are further enhanced under amino acid starvation (AAS) culture conditions. (spandidos-publications.com)

In vitro studies have shown that the active form of vitamin D, calcitriol, acts in myocytes through genomic effects involving VDR activation in the cell nucleus to drive cellular differentiation and proliferation. (hindawi.com)
In previously reports , Plasmodium vivax was found to be able to directly inhibited erythroid cell proliferation and differentiation. (biomedcentral.com)
Moreover, in vitro cultures of erythroid cells derived from haematopoietic stem cells has demonstrated that P. vivax is able to directly inhibit erythroid cell proliferation and differentiation [ 22 ]. (biomedcentral.com)
This pathway has been shown to play a role in mammalian sex determination and stem cell differentiation. (nih.gov)
MAPK pathways refer to various cellular functions, including cell proliferation, differentiation and migration. (springer.com)
All-trans retinoic acid (RA) is the most active metabolite of vitamin A. Several studies have described a pivotal role for RA signalling in different biological processes such as cell growth and differentiation, embryonic development and organogenesis. (mdpi.com)
A wide array of chemical substances can influence cell growth and differentiation. (beauty104.com.tw)
This study aimed to explore adipogenic transcriptional dynamics before (proliferation) and after (differentiation) initial preadipocyte differentiation in ducks. (biomedcentral.com)
We explored 36 mRNA-seq libraries in order to study transcriptome dynamics during proliferation and differentiation processes at 6 time points. (biomedcentral.com)
At the proliferation stage, proliferation related pathways and basic cellular and metabolic processes were inhibited, while regulatory factors that initiate differentiation enter the ready-to-activate state, which provides a precondition for initiating adipose differentiation. (biomedcentral.com)
Finally, we manually assembled a proposed regulation network model of subcutaneous preadipocyte differentiation base on the expression data, and suggested that E2F1 may serve as an important link between the processes of duck subcutaneous preadipocyte proliferation and differentiation. (biomedcentral.com)
For the first time we comprehensively analyzed the transcriptome dynamics of duck subcutaneous preadipocyte proliferation and differentiation. (biomedcentral.com)
Recent advances in live imaging and genetics of mammalian division, movement and cell differentiation leading to development which integrate observations of biochemical tissue formation [14 ]. (lu.se)

ACVR2-restored cells showed decreased growth and reduced S phase but increased cellular migration following activin treatment. (nih.gov)
ACVR2-complemented MSI-H colon cancers restore activin-SMAD signaling, decrease growth, and slow their cell cycle following ligand stimulation but show increased cellular migration. (nih.gov)
CLA-coated PTX-SPIONs@HRH exhibited high PTX loading efficiency (98.5%) and sustained release in vitro, with a marked dose dependent anti-proliferative activity in A549 lung adenocarcinoma cells, complimented by an enhanced cellular uptake. (bvsalud.org)
Chlamydia trachomatis manipulates host cellular pathways to ensure its proliferation and survival. (duke.edu)
This triggered an increase in paracellular permeability via cellular redistribution of claudin 3 (CLDN3) from TJs into cell nuclei followed by disruption of epithelial integrity and formation of epithelial lesions. (springer.com)
Cu is not only involved in regulatory cell death (RCD), but also in exogenous factors that induce cellular responses and toxic outcomes. (ijbs.com)
Phosphoinositide 3-kinase (PI3K) signaling contributes to a variety of processes, mediating many aspects of cellular function, including nutrient uptake, anabolic reactions, cell growth, proliferation, and survival. (mdpi.com)
Emerging evidence suggests that lysosomes may also be the cellular center for intracellular transport (Fig. 1 ), signaling (Fig. 2 ), and metabolism. (biomedcentral.com)
Amino acids are essential for cellular homeostasis, growth and proliferation via their contribution to a diverse range of cellular processes. (spandidos-publications.com)
Three areas of physiological engagement of sPLA 2 -BPs have appeared most clearly: cellular transport and signalling, and regulation of the enzymatic activity of sPLA 2 s. (ijbs.com)
We measure cellular forces in cells and tissues with high spatial resolution using arrays of vertical nanowires. (lu.se)
Although older chemotherapeutic drugs are often toxic to normal cells, advances in genetics and cellular and molecular biology have led to development of more selective drugs. (msdmanuals.com)
These results demonstrate differential sensitivity of standard cytotoxicity assessments on the PPP, thus (1) decoupling 'mitochondrial activity' as an interpretation of cellular formazan and Alamar Blue metabolism, and (2) demonstrating the implicit requirement for investigators to sufficiently verify interaction of these methods in routine cytotoxicity and proliferation characterization. (cdc.gov)

One of the most important regulators of p53 is MDM2, a RING domain E3 ligase that ubiquitinates p53, leading to both proteasomal degradation and relocation of p53 from the nucleus to the cytoplasm. (nih.gov)
In the cytoplasm, Abl plays a role in cell proliferation and survival. (umbc.edu)
In addition, baicalin activated the p53 signaling pathway and promoted the expression and transport of p53 through the cytoplasm to nucleus pursuing MEG3 knockdown in ox-LDL-treated HA-VSMCs. (researchensemble.com)

At molecular level, these processes may be triggered by epithelial-mesenchymal transition (EMT) and necessitates specific alterations in cell metabolism. (biomedcentral.com)
In addition, previous studies have shown that lysosomes may play important roles in cancer development and progression through the abovementioned biological processes and that the functional status and spatial distribution of lysosomes are closely related to cancer cell proliferation, energy metabolism, invasion and metastasis, immune escape and tumor-associated angiogenesis. (biomedcentral.com)

ZNF513 combined with KIF3C regulates gingival fibroblast proliferation, migration, and fibrosis response via the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK pathways. (nature.com)
Myosin 1b promotes cell proliferation, migration, and invasion in cervical cancer. (nih.gov)
The endocytic pathway is the gateway between cells and their environment, and promotes diverse events such as nutrient uptake and cell migration. (royalsociety.org)
We investigate immortalized cells in terms of migration, proliferation, stress and membrane conformation on the nanowires. (lu.se)

Many molecular pathways in eukaryotic cells are modulated by specific signaling proteins that are controlled, by phosphorylation and dephosphorylation, through the activity of kinase and phosphatase enzymes. (biomedcentral.com)
The regulation of complex and dynamic signal transduction proteins contributes to the destination of targeting proteins and the signal transduction of cell growth, and exposure to parasites can also influence signaling pathways. (biomedcentral.com)
Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase through different pathways, resulting in a decrease in antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells, ultimately leading to oxidative cell death. (nature.com)
NF-κB pathways are associated with immunity, inflammation and cell survival. (springer.com)
Studies of cells that are functionally mGluR defective in different components of the DDR pathways}, reduced ability to repair damaged DNA and a heightened sensitivity to IR and other DNA damaging agents. (hdacassay.com)
Furthermore, the Wnt/β-catenin can crosstalk with other signaling pathways including Notch, FGF, Hedgehog, and TGF-β/BMP signaling cascades to form a signaling network to regulate the survival and progression of cancer cells ( 14 - 16 ). (frontiersin.org)

Upregulation of HK3 is associated with EMT in CRC and may be a crucial metabolic adaptation for rapid proliferation, survival, and metastases of CRC cells. (biomedcentral.com)
CP466722 is just a fast reversible inhibitor of ATM function and transient coverage used in clonogenic survival assays suggests that temporary inhibition of ATM function is enough to sensitize cells to IR. (hdacassay.com)

The resulting BCR-Abl fusion protein is constitutively active and associates into tetramers, resulting in a hyperactive kinase sending a continuous signal. (umbc.edu)
E-cadherin is a well-known tumor suppressor protein and loss of its expression in tumor cells is associated with increased tumor invasiveness and metastasis [ 18 , 19 ]. (biomedcentral.com)
Upon phosphorylation, R-SMADs recruit the co-SMAD SMAD-4 to form protein complexes that translocate into the nucleus and exhibit transcriptional activity. (springer.com)
The current study indicated that downregulated expression of MEG3 increased cell cycle-associated protein expression. (researchensemble.com)
We found that TRIM13 mRNA and protein expression was reduced in NSCLC tissues and cell lines in comparison to paired non-cancerous tissues and a human normal bronchial epithelial cell line, respectively. (cancerindex.org)
Signaling is initiated when the Wnt ligand binds to the Frizzled receptor on the cell membrane and the LDL receptor-associated protein 5/6 (LRP5/6) co-receptor. (frontiersin.org)
In addition HIV-1 Vpr protein alters the cell-cycle regulation by hijacking centrosome functions. (biomedcentral.com)
In this study we used phosphorylation of the transcription factor cAMP response element-binding protein as a functional readout to identify cells responding to EGF and FGF-2. (beauty104.com.tw)
Unfortunately, protein and some elements in existing dispersion media are suboptimal for potential nose-to-brain transport of nanomaterials because olfactory transport has size- and ion-composition requirements. (cdc.gov)
Therefore, we designed a protein-free dispersion media containing phospholipids and amino acids in an isotonic balanced electrolyte solution, a solution for nasal and olfactory transport (SNOT). (cdc.gov)

Pulsating tandem microbubble for localized and directional single-cell membrane poration. (duke.edu)
Borax entering the body in the ROS form will cause several responses, i.e. borax will seek ion pairs that might cause damage to the cell membrane and activate the Kupffer cell and TLR4 as pro-inflammatory to express IL-2 [ 2 ]. (jmchemsci.com)
5) Lysosomes can also fuse with the plasma membrane to mediate membrane repair or discharge contents outside the cell, such as cathepsins or immune factors. (biomedcentral.com)
The transport of serum amino acids into cells is an active process that is facilitated by plasma membrane-localized amino acid transporters. (spandidos-publications.com)
Specific recent and current research topics that contribute to the synthetic biology toolbox for development of artificial cells include membrane texturing through phase separation, artificial DNA adhesion receptors, hybrid lipid-polymer membrane systems for enhanced stability and lifetime, encapsulation of feedback-responsive systems and controlled generation of eukaryote-like membrane architectures. (royalsociety.org)
In order to deepen our understanding of the interactions between the cell membrane and nanostructures, we perform STED microscopy live imaging of the membrane of cells cultured on nanostructures. (lu.se)
For chemotherapy drugs, one of the best characterized resistance mechanisms is overexpression of MDR1 , a cell membrane transporter that causes efflux of certain drugs (eg, vinca alkaloids, taxanes, anthracyclines). (msdmanuals.com)

We identified a novel nuclear transport pathway involving calmodulin. (nih.gov)
CCND1-associated ceRNA network reveal the critical pathway of TPRG1-AS1-hsa-miR-363-3p-MYO1B as a prognostic marker for head and neck squamous cell carcinoma. (nih.gov)
As an agonist of the retinoic-X receptor (RXR) pathway, Bxt notably increased the nuclear expression of the RXRα throughout transcriptionally active euchromatin domains. (frontiersin.org)
The ATM signal transduction was also inhibited by the compound pathway in cells, disturbed cell cycle checkpoint function and sensitive tumefaction cells to IR. (hdacassay.com)
Abnormally activated Wnt/β-catenin signaling pathway plays a crucial role in promoting malignant tumor occurrence, development, recurrence, and metastasis, particularly in cancer stem cells. (frontiersin.org)
Studies have shown that the Wnt/β-catenin signaling pathway controls cell fate and function through the transcriptional and post-translational regulation of omics networks. (frontiersin.org)
This suggests the possibility that strictly regulated self-renewal mediated by Wnt signaling in cancer cells may be disturbed by the SUMOylation pathway to allow more malignant proliferation. (frontiersin.org)
The current investigation aimed to demonstrate how interpretation of results from several standard cytotoxicity and proliferation assays vary in dependence on contributions from the pentose phosphate pathway (PPP). (cdc.gov)

The binding of calcitriol to the VDR allows the VDR to act as a transcription factor that modulates the gene expression of transport proteins (such as TRPV6 and calbindin), which are involved in calcium absorption in the intestine. (wikipedia.org)
INTRODUCTION: Proteins that undergo receptor-mediated endocytosis are subject to lysosomal degradation, requiring radioiodination methods that minimize loss of radioactivity from tumor cells after this process occurs. (duke.edu)
These findings suggest that parasite proteins are able to inhibit erythroid cell growth by down-regulation of ezrin phosphorylation, leading to ineffective erythropoiesis ultimately resulting in severe malarial anaemia. (biomedcentral.com)
The nuclear pore complex (NPC) mediates the transport of mRNA and proteins across the nuclear envelope. (nih.gov)
However, treatment with baicalin inhibited the expression of cell-cycle associated proteins in HA-VSMCs with MEG3 knockdown. (researchensemble.com)
Tripartite Motif Containing 13 (TRIM13), a member of TRIM proteins, is deleted in multiple tumor types, especially in B-cell chronic lymphocytic leukemia and multiple myeloma. (cancerindex.org)
Cuproptosis causes proteotoxic stress and ultimately results in cell death by the binding of Cu ions to lipid-acylated proteins during the tricarboxylic acid cycle of mitochondrial respiration. (ijbs.com)
Post-translational modifications (PTMs) of proteins, including phosphorylation, acetylation, ubiquitination, and SUMOylation, can regulate the function of proteins, determine the active state and subcellular location of proteins, and dynamically interact with other proteins related to carcinogenesis and progression ( 17 - 20 ). (frontiersin.org)
Proteins that act both at the cell surface and intracellularly will be discussed in this thesis, with particular emphasis on the fibroblast growth factors. (beauty104.com.tw)
The FGFs are heparin -binding proteins and interactions with cell-surface associated heparan sulfate proteoglycans has been shown to be essential for FGF signal transduction. (beauty104.com.tw)
Myelinating Schwann cells form a myelin sheath around a single axon and express high levels of myelin-related proteins and messenger RNA (mRNA). (medscape.com)

One of the most important functions of bFGF is the promotion of endothelial cell proliferation and the physical organization of endothelial cells into tube-like structures. (beauty104.com.tw)

The lesions responsible for the disruption of ADH synthesis or secretion in hypophyseal diabetes insipidus include large pituitary neoplasms (endocrinologically active or inactive), a dorsally expanding cyst or inflammatory granuloma, and traumatic injury to the skull, with hemorrhage and glial proliferation in the neurohypophyseal system. (merckvetmanual.com)
We also use primary retinal cells to investigate the effects of nanowires on different cell types, in particular neurons compared to glial cells. (lu.se)

p53 functions to prevent malignant progression, in part by inhibiting proliferation or inducing the death of potential tumour cells. (nih.gov)

Nutrient-Driven O-GlcNAcylation Controls DNA Damage Repair Signaling and Stem/Progenitor Cell Homeostasis. (nih.gov)
Regulated Cell Death (RCD) is a universal process in living organisms essential for maintaining tissue homeostasis and responding to various stressors. (ijbs.com)
RCD is critical for cell homeostasis, tissue remodeling, and disease processes. (ijbs.com)

check the tag ADOLESCENCE HN - 2008 BX - Nutrition in Adolescence FX - Adolescent Nutrition Physiology MH - Peritoneal Stomata UI - D054048 MN - A01.047.025.600.700 MN - A10.810 MS - Natural openings in the subdiaphragmatic lymphatic plexus in the PERITONEUM, delimited by adjacent mesothelial cells. (bvsalud.org)
We strive for a detailed understanding of the interactions between cells and nanostructures with respect to cell behavior, cell physiology and cell mechanics. (lu.se)
Our goal is to understand in detail the interactions between cells and nanostructures such as nanowires and nanotubes with respect to cell behavior, cell physiology and cell mechanics. (lu.se)

As dependence on iron is a key feature of tumor cells, using chelators to reduce iron represents an opportunity to improve conventional GBM therapies. (biomedcentral.com)

Deferiprone, a bidentate iron chelator, has been shown to have antiproliferative and cytotoxicity activities in neuroblastoma cell lines [ 7 ]. (biomedcentral.com)
The addition of essential amino acids, but not non-essential amino acids to the cell culture medium resulted in the cancellation of this pronounced cytotoxicity. (spandidos-publications.com)
Autophagic cell death was excluded as the inhibition of autophagy did not attenuate the cytotoxicity. (spandidos-publications.com)
However, potentially erroneous characterization of cytotoxicity and cell proliferation can arise if verification of baseline interaction of test article with method employed is neglected. (cdc.gov)
Non-tumorigenic Beas-2B cells were treated with graded concentrations of benzo[a]pyrene (B[a]P) for 24 and 48h prior to cytotoxicity and proliferation assessment with commonly used MTT, MTS, WST1, and Alamar Blue assays. (cdc.gov)

Activation of the Cyclin B/Cdc2 kinase complex triggers entry into mitosis in all eukaryotic cells. (duke.edu)
Macroautophagy (thereafter designated as autophagy) is a self-digestive system conserved in all eukaryotic cells. (spandidos-publications.com)

Epidermal growth factor (EGF) and fibroblast growth factor 2 (FGF-2) induce the proliferation of neural precursor cells isolated from specific regions of the embryonic and adult brain. (beauty104.com.tw)

Targeting MYO1B impairs tumorigenesis via inhibiting the SNAI2/cyclin D1 signaling in esophageal squamous cell carcinoma. (nih.gov)

Overexpression of TRIM13 in NCI-H1975 and SPC-A-1 cells hampered cell proliferation. (cancerindex.org)

Our laboratory focuses on (1) the molecular features of a novel, glycan-dependent, signal transduction cascade and (2) the mechanism of nuclear transport. (nih.gov)
MW) chemicals interact with host cells and molecules and In our daily life, we are confronted with a plethora of natural influence biologic processes such as signal transduction. (cdc.gov)

In addition, Wnt/β-catenin has emerged as a critical regulator of cancer stem cells (CSCs), which is considered one of the root causes of cancer recurrence and metastasis because of their heterogeneity and plasticity ( 13 ). (frontiersin.org)

MEG3 knockdown increased the expression of proliferating cell nuclear antigen (PCNA), cyclin A and E. However, following treatment of HA-VSMCs with different concentrations baicalin, expression of PCNA, cyclin A and E was inhibited in cells with MEG3 knockdown. (researchensemble.com)

The anticancer activities of iron depletion are based on the fact that neoplastic cells require more iron than normal cells for proliferation [ 2 ]. (biomedcentral.com)
The posterior lobe, infundibular stalk, and hypothalamus are compressed or disrupted by neoplastic cells. (merckvetmanual.com)

The phosphorylation of the sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) plays a key role in the regulation of renal phosphate transport by parathyroid hormone (PTH) and dopamine. (duke.edu)

Following the sensitization of recipient mice with OVA, the proportion of CD4 + Foxp3 + cells of donor origin significantly increased in recipients of CD4 + CD25 + cells from the SDLN of 1,25(OH) 2 D 3 -treated mice, indicating that these regulatory T cells can expand in vivo with antigenic stimulation. (aai.org)

How to intervene in the occurrence and development of related diseases by regulating cell ferroptosis has become a hotspot and focus of etiological research and treatment, but the functional changes and specific molecular mechanisms of ferroptosis still need to be further explored. (nature.com)
Cells use a number of mechanisms to sense and maintain their homeostatic levels. (spandidos-publications.com)
of the most critical events which lead to tissue patterning involves mechanisms going beyond single cells. (lu.se)

Instead it can be considered a hormone, with activation of the vitamin D pro-hormone resulting in the active form, calcitriol, which then produces effects via a nuclear receptor in multiple locations. (wikipedia.org)
The active vitamin D metabolite calcitriol mediates its biological effects by binding to the vitamin D receptor (VDR), which is principally located in the nuclei of target cells. (wikipedia.org)
The vitamin D receptor belongs to the nuclear receptor superfamily of steroid/thyroid hormone receptors, and VDRs are expressed by cells in most organs, including the brain, heart, skin, gonads, prostate and breast. (wikipedia.org)
A putative transmembrane receptor may be responsible for nongenomic effects leading to rapid influx of calcium within muscle cells. (hindawi.com)
This can either occur by cell surface receptor interactions, as in the case with peptide growth factors, or by interactions with intracellular molecules, as in the case with steroid hormones. (beauty104.com.tw)
This receptor complex has increased VEGF signalling activity in endothelial cells. (vegfr-3inhibitor.com)

It is important to note that not all ERs are found in the nucleus: some ERs are found on cell membranes. (clinicalgate.com)

Identification of CP466722 Urogenital pelvic malignancy supplies a new chemical structure that inhibits ATM function in cells and may now be modified to generate more potent and specific agencies that could possibly be able to enhancing cyst cell killing in vivo. (hdacassay.com)

May be involved in the regulation of dopamine release and transport. (abcam.com)
In this study, a phosphoproteomic approach was performed to dissect the molecular mechanism of phosphoprotein regulation, which is involved in the inhibitory effect of parasites on erythroid cell development. (biomedcentral.com)
This result suggests that phospho-ezrin is important for actin cytoskeleton regulation during erythroid cell growth and division. (biomedcentral.com)
This regulation was lost upon removal of CD4 + CD25 + cells. (aai.org)

ACVR2 small interfering RNA reversed these effects in complemented cells. (nih.gov)
Calcitriol also has other effects, including some on cell growth, neuromuscular and immune functions, and reduction of inflammation. (wikipedia.org)
Despite some controversies in the interpretation of meta-analysis, a reduced risk of falls has been attributed to vitamin D supplementation due to direct effects on muscle cells. (hindawi.com)
This leads to uncontrolled proliferation, morphological transformation and anti-apoptotic effects. (umbc.edu)
Herein we elaborated effects of TGF-β1 on TJs of primary human bronchial epithelial cells. (springer.com)
The abolition of the antineoplastic DFX effects when cells were co-treated with ferric ammonium sulfate supports the hypothesis that its effects result from its ability to chelate iron. (biomedcentral.com)
The immunomodulatory effects of vitamin D have been described following chronic oral administration to mice or supplementation of cell cultures with 1,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ), the active form of vitamin D. In this study, topically applied 1,25(OH) 2 D 3 , enhanced the suppressive capacity of CD4 + CD25 + cells from the draining lymph nodes. (aai.org)
The ideal drug would target only cancer cells and have no adverse effects on normal cells. (msdmanuals.com)

This enzyme is expressed as differentially targeted isoforms in man and is localized to both the nucleus and the mitochondria. (nih.gov)

In primary cultures of mouse embryonic day 14 (E14) striatum, maintained in vitro for 24 hr, 12% of the cells responded to FGF-2, whereas no response to EGF could be detected. (beauty104.com.tw)

CD4 + cells from the skin-draining lymph nodes (SDLN) of either 1,25(OH) 2 D 3 -treated or UVB-irradiated mice had reduced capacity to proliferate to Ags presented in vitro, and could suppress Ag-specific immune responses upon adoptive transfer into naive mice. (aai.org)
Furthermore, purified CD4 + CD25 + cells from the SDLN of 1,25(OH) 2 D 3 -treated or UVB-irradiated mice compared with equal numbers of CD4 + CD25 + cells from control mice had increased capacity to suppress immune responses in both in vitro and in vivo assay systems. (aai.org)
Priming of striatal cells for 24 hr with FGF-2 but not with EGF was sufficient to induce the appearance of EGF- and FGF-2 responsive cells after only 2 d in vitro. (beauty104.com.tw)
Thus, neural precursor cells from the mouse E14 striatum initially responding to FGF-2 only acquire EGF responsiveness later during in vitro development. (beauty104.com.tw)

Cell Death Dis, 2022 Nov 8. (nih.gov)
J Cell Physiol, 2022 Sep. (nih.gov)

Particularly affected was ezrin (phosphorylated at Thr567), which is normally localized to gEC cell extension peripheral processes. (biomedcentral.com)

EMT is the conversion of epithelial cells into cells with a mesenchymal phenotype, which is accompanied by a decrease in cell-cell cohesion and fundamental reorganization of the cytoskeleton. (biomedcentral.com)
A hallmark feature of EMT is the downregulation of E-cadherin, a cell-cell adhesion molecule localized on the surface of epithelial cells [ 17 ]. (biomedcentral.com)
Lung epithelial cells form a barrier that lines airway and alveolar surfaces and constitute an air-liquid interface. (springer.com)

Consequently, most cyclin-dependent kinase (Cdk)/cyclin complexes are localized to the nucleus when active. (duke.edu)

The aim of the present study was, therefore, to investigate the cytostatic and cytotoxic impact of the new iron chelator deferasirox (DFX) on human GBM cells in well-defined clinical situations represented by radiation therapy and mild-hypoxia. (biomedcentral.com)
This latter observation highlights components of these DDR paths as possible therapeutic targets for the development of small molecule inhibitors that could enhance the sensitivity of tumefaction cells to the cytotoxic ramifications of radio /chemo therapeutic agents. (hdacassay.com)
Cytotoxic drugs damage DNA and kill many normal cells as well as cancer cells. (msdmanuals.com)

Retinal degeneration is progressive deterioration of the retinal cells, eventually culminating in their death. (molvis.org)

In 2012, Dixon 1 first proposed the concept of ferroptosis, an iron-dependent, non-apoptotic mode of cell death characterized by the accumulation of lipid reactive oxygen species (ROS). (nature.com)

SDF-1alpha/CXCL12 enhances GABA and glutamate synaptic occupation at serotonin neurons in the rat dorsal raphe nucleus. (wgc2010.sk)
Seventy-five percent of these FGF-2-responsive cells were beta tubulin III (TuJ1)-positive neurons, and 25% expressed nestin, a marker for neuroepithelial precursors. (beauty104.com.tw)

This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. (cancerindex.org)
The usage of vector modified hematopoietic stem cell therapy by which myelocytotoxic and IS drugs are given to the host to create space in the bone marrow for the homing and development of gene adjusted cells will not be examined. (hdacassay.com)
Significantly, photosynthetic capacity (CO2 assimilation at varying light and CO2 and quantum yield of PSII electron transport) per unit leaf area and per leaf dry weight were increased in lines of N. tabacum transformed with the E. coli gene otsA, which encodes trehalose phosphate synthase. (rothamsted.ac.uk)

Calcifediol is further hydroxylated by the kidneys and some of the immune system cells to form calcitriol (1,25-dihydroxycholecalciferol), the biologically active form of vitamin D. Calcitriol circulates as a hormone in the blood, having a major role regulating the concentration of calcium and phosphate, and promoting the healthy growth and remodeling of bone. (wikipedia.org)
10,11] Part of the calcidiol is converted by the kidneys to calcitriol, the biologically active form of vitamin D.[12] Calcitriol circulates as a hormone in the blood, regulating the concentration of calcium and phosphate in the bloodstream and promoting the healthy growth and remodeling of bone. (truthwiki.org)

Ferroptosis is a new type of programmed cell death, which occurs with iron dependence. (nature.com)

The nuclear transport of transcription factors, nuclear kinases, steroid hormone receptors, and replication factors often serves a critical regulatory function. (nih.gov)
The immune systems a reaction to antigen depends on the relative frequencies of responding T and Caspase inhibition B cells and on the thresholds of binding affinity that their receptors display, the quantities of antigen present, and the period when the antigen stays in secondary lymphoid tissue, where primary immune responses are initiated. (hdacassay.com)
Like other steroidal hormones (e.g., testosterone, cortisol), estrogen acts primarily through receptors in the cell nucleus, not on the cell surface. (clinicalgate.com)

While the LAP peptides confer latency, LTBP is needed to release active TGF-β1 ligand from the L-TGF-β1 complex upon appropriate stimuli [ 4 ]. (springer.com)

Not long after FGF1 and FGF2 were isolated, another group isolated a pair of heparin -binding growth factors which they named HBGF-1 and HBGF-2, whilst a third group isolated a pair of growth factors that caused proliferation of cells in a bioassay containing blood vessel endothelium cells which they called ECGF-1 and ECGF-2. (beauty104.com.tw)
Kaposi sarcoma is seen commonly in patients who are infected with HIV, where 3 histologic types of tumors have been described based on appearance of the vascular endothelium and the number of spindle cells. (medscape.com)

Its primary function is to eliminate non-functional or potentially harmful cells, contributing to overall biological equilibrium. (ijbs.com)
We will address how repurposing of biological and synthetic components can be used to create artificial cells for development in areas such as fuel production, drug delivery and environmental remediation. (royalsociety.org)

Whether under physiological or pathological conditions, cell death is an unavoidable and important link in the process of life and marks the end of the life of a cell. (nature.com)
It operates during both physiological conditions, such as embryonal development (referred to as 'programmed' cell death), and pathological conditions like infection. (ijbs.com)

Electron microscopy demonstrated that the CAL 27 cells treated with GEF under AAS culture conditions exhibited swelling of the cytosol and organelles with an increased number of autophagosomes and autolysosomes, but without chromatin condensation and nuclear fragmentation. (spandidos-publications.com)

Involved in actin filament organization and post-Golgi vesicle-mediated transport. (nih.gov)

TGF-β1 activated accumulation of phosphorylated SMAD2 (pSMAD2-C) at centrioles of motile cilia and at cell nuclei. (springer.com)
In G1 phase, cells have a single centrosome consisting of two centrioles joined by cohesion fibers. (biomedcentral.com)

We developed and characterized a cell model in which we studied how activin signaling affects growth. (nih.gov)
Loss of epithelial and gain of dedifferentiated mesenchyme-like phenotype enable CRC cells to develop invasive and metastatic growth characteristics [ 22 ]. (biomedcentral.com)
Lysed IE significantly inhibited gEC growth at 48 and 72 h and cell division resulting in the accumulation of cells in G0 phase. (biomedcentral.com)
T and B cell tolerance can be recognized or damaged either centrally, at the website of primary lymphocyte growth in the thymus or bone marrow, or peripherally in the lymphoid tissue where antigen recognition and processing occur. (hdacassay.com)
After growth factor treatment for 6 d, a population of nestin-positive cells responding to both EGF and FGF-2 were identified. (beauty104.com.tw)

Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. (abcam.com)

however, nuclear accumulations of pSMAD2-C and CLDN3 redistribution were observed with similar time course in ciliated and non-ciliated cells. (springer.com)

They localize in close proximity to the nucleus for the duration of interphase and play major roles in numerous cell functions. (biomedcentral.com)
Although the LAT family plays important roles in the development and function of normal tissues, they are frequently increased in cancer cells ( 3 ). (spandidos-publications.com)

Anatomy54

Organisms18

Diseases1

Chemicals and Drugs103

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes61

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Information Science3

Health Care1

Apoptosis16

Differentiation13

Cellular13

Cytoplasm3

Metabolism2

Migration4

Pathways6

Survival2

Protein10

Membrane7

Pathway8

Proteins11

Endothelial cell1

Glial2

Progression1

Homeostasis3

Physiology3

Tumor cells1

Cytotoxicity5

Eukaryotic cells2

Fibroblast1

Esophageal1

Overexpression1

Signal transduction2

Metastasis1

Proliferating cell nu1

Neoplastic2

Phosphorylation1

Stimulation1

Mechanisms3

Receptor6

Membranes1

Inhibits1

Regulation4

Effects8

Mitochondria1

Maintained in vitro1

Vitro4

20222

Processes1

Epithelial cells3

Complexes1

Cytotoxic3

Retinal cells1

Lipid1

Neurons2

Gene3

Form of vitamin2

Dependence1

Receptors3

Ligand1

Endothelium2

Biological2

Pathological conditions2

Chromatin condensation1

Organization1

Centrioles2

Growth5

Knockout1

Nuclear1

Roles2