• In a comprehensive review of the subject published in 2006, Martin Embley and William Martin (6) concluded bleakly that the evolutionary gap between prokaryotes and eukaryotes is now deeper, and the nature of the host that acquired the mitochondrion more obscure, than ever before . (asmblog.org)
  • By the 1960's, microscopists had determined that the world of living things could be divided into two separate groups -eukaryotes and prokaryotes, depending on the structure of the cells that composed them. (biologyjunction.com)
  • DNA sequences encoding 2 essential cellular proteins agreed that the last common ancestor spawned both the true bacteria and archaic bacteria and then the eukaryotes (with a nucleus) branched from the archaic. (biologyjunction.com)
  • Sequencing the genomes of multiple, taxonomically diverse eukaryotes enables in-depth comparative-genomic analysis which is expected to help in reconstructing ancestral eukaryotic genomes and major events in eukaryotic evolution and in making functional predictions for currently uncharacterized conserved genes. (biomedcentral.com)
  • One was that the "three domains tree of life" was an accurate description of the relationships between eukaryotes and prokaryotes (you can see the tree here ). (ncl.ac.uk)
  • Thus, it is now thought that all eukaryotes contain an organelle related to mitochondria, and its most conserved function is in Fe/S protein biogenesis, not ATP production. (ncl.ac.uk)
  • In the eocyte tree, eukaryotes originate from within the Archaea, suggesting that eukaryotes are not a primary domain of life like Archaea and Bacteria, but are instead a product of genetic and cellular contributions from both prokaryote domains. (ncl.ac.uk)
  • With shotgun metagenomic datasets covering an ever widening range of biomes, multiple studies have been conducted with the aim of recovering the genomes of prokaryotes, viruses and more recently eukaryotes 7 . (researchsquare.com)
  • To address this analysis gap and achieve our goal of searching for eukaryotes, we downloaded all available assemblies in April 2021 (19,800 in total) from MGnify and screened each assembly using EukRep 11 , retaining only those assemblies estimated to contain at least 5Mb eukaryotic DNA (6,430 assemblies). (researchsquare.com)
  • The N- glycosylation is an essential protein modification taking place in the membranes of the endoplasmic reticulum (ER) in eukaryotes and the plasma membranes in archaea. (biomedcentral.com)
  • The peptidyl-prolyl cis / trans isomerase (PPIase) class of proteins is present in all known eukaryotes, prokaryotes, and archaea, and it is comprised of three member families that share the ability to catalyze the cis / trans isomerisation of a prolyl bond. (biomedcentral.com)
  • The significant conflict between eukaryotic phylogenies inferred from MATX and SSU rDNA data represents strong evidence that MATX paralogues have undergone horizontal gene transfer across the tree of eukaryotes. (biomedcentral.com)
  • Multiple sequence alignments of MAT genes from a wide diversity of eukaryotes demonstrated a paralogue of MAT, named MATX, with distinctive features that are absent in all other eukaryotic MATs. (biomedcentral.com)
  • The origins and evolution of prokaryotes and eukaryotes. (web.app)
  • The defining difference between prokaryotes and eukaryotes is the presence of membrane structures in the cytoplasm of eukaryotes, specifically, a. (web.app)
  • However, there are some microbial organisms that appear to be intermediates between prokaryotes and eukaryotes they possess a nucleus but do not have mitochondria or chloroplasts, an example. (web.app)
  • Establishing the root of the tree of life has shown that prokaryotes in fact consist of two domains, the archaea and bacteria, that the last universal common ancestor luca of all extant life lived at extremely high temperatures and that the eukaryotes emerged from the. (web.app)
  • The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes. (lookformedical.com)
  • They proposed basing family trees on differences in the building block sequences for genes and proteins. (biologyjunction.com)
  • Their approach is known as molecular phylogeny, and it states that individual genes are composed of unique sequences of nucleotides that typically serve as the blueprint for making specific proteins. (biologyjunction.com)
  • Distel, D. L., DeLong, E. F., and Waterbury, J. Epub … Bacterial Identification by 16S rRNA Gene Sequence Analysis Background All bacteria contain 16S ribosomal RNA (rRNA) genes of approximately 1500 base pairs (bp) in length. (printerresource.com)
  • rRNA genes contain regions of variable DNA sequence that are unique to the species carrying the … Ribosomal RNA is transcribed from ribosomal DNA (rDNA) and then bound to ribosomal proteins to form small and large ribosome subunits. (printerresource.com)
  • These conserved KOGs are often essential for survival and might approximate the minimal set of essential eukaryotic genes. (biomedcentral.com)
  • Other KOGs show a variety of phyletic patterns, which points to major contributions of lineage-specific gene loss and the 'invention' of genes new to eukaryotic evolution. (biomedcentral.com)
  • The KOG analysis reveals a conserved core of largely essential eukaryotic genes as well as major diversification and innovation associated with evolution of eukaryotic genomes. (biomedcentral.com)
  • Also, comparative genomics have shown that many eukaryotic operational (metabolic) genes are closely related to bacterial homologues, while informational genes are more similar to archaeal ones [ 12 ]. (biomedcentral.com)
  • To identify YpdB-regulated genes, we compared the transcriptomes of E. coli cells overproducing either YpdB or a control protein. (cipsm.de)
  • Three of the six up-regulated genes encode potential zinc transporter proteins (ZnuA1, ZnuB1, ZnuC1) suggesting involvement of s479 in regulation of zinc transport. (uni-stuttgart.de)
  • Interestingly, s479 is not only encoded next to CRISPR-cas genes but the mature s479 contains a crRNA-like 5´ handle and experiments with Cas protein deletion strains indicate maturation by Cas6 and interaction with Cas proteins. (uni-stuttgart.de)
  • The first is that ATP production, coupled to electron transport, and translation of mitochondrial proteins represent the essence of mitochondrial function: these functions are common to all mitochondrial genomes and can be traced unambiguously and directly to an α-proteobacterial ancestor. (biomedcentral.com)
  • The results provide quantitative support for major trends of eukaryotic evolution noticed previously at the qualitative level and a basis for detailed reconstruction of evolution of eukaryotic genomes and biology of ancestral forms. (biomedcentral.com)
  • Using these approaches we identified 99,073 prokaryotic and 751 eukaryotic genomes, and propose a method for reducing the redundancy of single-celled eukaryotic MAGs at the species level. (researchsquare.com)
  • However as eukaryotic genomes are generally larger and lower in abundance in shotgun metagenomic datasets, they often go unreported. (researchsquare.com)
  • ISWI slides nucleosomes along DNA, enabling the structural changes of chromatin required for the regulated use of eukaryotic genomes. (cipsm.de)
  • Until about a decade ago, the general presumption was that the essential features of eukaryotic organization evolved autogenously in a proto-eukaryotic lineage, without contributions from other organisms. (asmblog.org)
  • The 50S subunit is primarily composed of proteins but also contains single-stranded RNA known as ribosomal RNA (rRNA). (wikipedia.org)
  • At this same time, Carl R. Woeses of the University of Illinois was turning his attention to a powerful new yardstick for evolutionary distances - a small molecular subunit known as ribosomal RNA. (biologyjunction.com)
  • Erko had worked with Carl Woese in pioneering the use of ribosomal RNA sequences to investigate evolutionary relationships among prokaryotes. (ncl.ac.uk)
  • Despite having the same sedimentation rate, bacterial and archaeal ribosomes can be quite different. (wikipedia.org)
  • Due to the differences, archaeal 50S are less sensitive to some antibiotics that target bacterial 50S. (wikipedia.org)
  • Here we report the temporal measurements of absolute RNA and protein levels per gene within a mixed bacterial-archaeal consortium. (nature.com)
  • Our analysis of this data reveals an absolute protein-to-RNA ratio of 10 2 -10 4 for bacterial populations and 10 3 -10 5 for an archaeon, which is more comparable to Eukaryotic representatives' humans and yeast. (nature.com)
  • Indeed, the protein-to-RNA ratio per sample of the bacterial populations matched previous calculations for the existing example from axenically cultured E. coli 2 . (nature.com)
  • Here, we address this challenge by establishing a bacterial cell-free protein synthesis platform that enables rapid production of a variety of OSTs in their active conformations. (biorxiv.org)
  • Here, a phylogenomic analysis was carried out to examine the validity of rival hypotheses suggesting alternative archaeal or bacterial origins to the eukaryotic N- glycosylation pathway. (biomedcentral.com)
  • The only known exception to this is the 23S ribosomal RNA in the bacterial ribosome which catalyzes peptide bond formation. (jove.com)
  • No one disputes that mitochondria derive from free-living bacteria that established an intimate symbiotic relationship with a host of some kind and progressively turned into organelles, workhorses of metabolism, and a hallmark of eukaryotic organization. (asmblog.org)
  • Eventually most scientists accepted this hypothesis because the overall structures of certain molecules in archaeal species of bacteria. (biologyjunction.com)
  • Similarly, the archaeal proteins responsible for several crucial cellular processes have a distinct structure from the proteins that do the same tasks in more modern bacteria. (biologyjunction.com)
  • Once scientists accepted the idea of 3 domains of life instead of two, they naturally wanted to know which of the 2 structurally primitive groups - true bacteria or archaic- gave rise to the first eukaryotic cell. (biologyjunction.com)
  • 6. I want to study ribosomal RNA expression and potential processing sites in bacteria. (printerresource.com)
  • A., 1992, The use of 16S ribosomal RNA targeted oligonucleotide probes to study competition between ruminai fibrolytic bacteria. (printerresource.com)
  • The origin of the eukaryotic N- glycosylation pathway is not unique and less straightforward than previously thought: some basic components likely have proteoarchaeal origins, but the pathway was extensively developed before the eukaryotic diversification through multiple gene duplications, protein co-options, neofunctionalizations and even possible horizontal gene transfers from bacteria. (biomedcentral.com)
  • EF-P is present in all bacteria and orthologous to archaeal and eukaryotic initiation factor 5A, yet the biological function has so far remained enigmatic. (cipsm.de)
  • Once regarded as plants constituting the class Schizomycetes , bacteria are now classified as prokaryotes . (alchetron.com)
  • Although the term bacteria traditionally included all prokaryotes, the scientific classification changed after the discovery in the 1990s that prokaryotes consist of two very different groups of organisms that evolved from an ancient common ancestor . (alchetron.com)
  • While workflows for the recovery of prokaryotic MAGs are established, MAGs of eukaryotic species are seldom reported. (researchsquare.com)
  • To address this, we developed new approaches to improve the recovery of eukaryotic MAGs and applied these to large collections of assembled metagenomes in an effort to systematically identify both prokaryotic and eukaryotic MAGs. (researchsquare.com)
  • In this study we report a workflow for the recovery of eukaryotic and prokaryotic MAGs from public data covering a range of biomes. (researchsquare.com)
  • Prokaryotic and eukaryotic cell free download as powerpoint presentation. (web.app)
  • The big picture the deepest divisions of life are very old the ancestors of all current diversity were singlecelled and prokaryotic prokaryotes had evolved by 3. (web.app)
  • The model of Hm 50S, determined in 2000 by Nenad Ban and colleagues in the laboratory of Thomas Steitz and the laboratory of Peter Moore, includes 2711 of the 2923 nucleotides of 23S rRNA, all 122 nucleotides of its 5S rRNA, and structure of 27 of its 31 proteins. (wikipedia.org)
  • The most widely understood role of RNA is in protein synthesis, which includes messenger RNA (mRNA), transfer RNA (tRNA) and ribosomal RNA (rRNA) (see Chapter 2). (printerresource.com)
  • Base modifications occur primarily in tRNA and ribosomal RNA (rRNA), and occur after the RNA is transcribed. (printerresource.com)
  • The amino group of an aminoacyl-tRNA (binds to A site) attacks the carbon of a carbonyl group of a peptidyl-tRNA (binds to P site) and finally yields a peptide extended by one amino acid esterified to the A site tRNA bound to the ribosomal A site and a deacylated tRNA in the P site. (wikipedia.org)
  • After initiation, elongation, and termination, there is a fourth step of the disassembly of the post-termination complex of ribosome, mRNA, and tRNA, which is a prerequisite for the next round of protein synthesis. (wikipedia.org)
  • Introns are categorized into five distinct classes - nuclear mRNA, nuclear tRNA, archaeal, group one, and group two introns. (jove.com)
  • 50S, roughly equivalent to the 60S ribosomal subunit in eukaryotic cells, is the larger subunit of the 70S ribosome of prokaryotes. (wikipedia.org)
  • The large ribosomal subunit (50S) is approximately twice as massive as the small ribosomal subunit (30S). (wikipedia.org)
  • Specifically, by using lipid nanodiscs as cellular membrane mimics, we obtained yields of up to 440 µg/mL for the single-subunit OST enzyme, 'Protein glycosylation B' (PglB) from Campylobacter jejuni , as well as for three additional PglB homologs from Campylobacter coli, Campylobacter lari , and Desulfovibrio gigas . (biorxiv.org)
  • The 48 kDa subunit, RETINOBLASTOMA-BINDING PROTEIN 4, is also a component of several other protein complexes involved in chromatin remodeling. (lookformedical.com)
  • Although initially discovered as a retinoblastoma binding protein it has an affinity for core HISTONES and is a subunit of chromatin assembly factor-1 and polycomb repressive complex 2. (lookformedical.com)
  • It is found as a subunit of protein complexes that are in involved in the enzymatic modification of histones including the Mi2 and Sin3 histone deacetylase complexes and the polycomb repressive complex 2. (lookformedical.com)
  • but if you are curious about the origin of mitochondria and their place in the history of the eukaryotic cell, you will find here an evidence-based summary of where that inquiry stands. (asmblog.org)
  • The strong implication is that mitochondria are not an optional accessory to eukaryotic cells but part of their basic fabric. (asmblog.org)
  • The symbionts that eventually became mitochondria would have been acquired, probably by phagocytosis, by a host that already possessed the essential characteristics of eukaryotic cells including a nucleus, endomembranes and a cytoskeleton (1, 4, 11). (asmblog.org)
  • The endosymbiont hypothesis proposes that mitochondria formed after a prokaryote that had evolved into an early eukaryote engulfed and then kept one or more alpha-proteobacteria cell. (biologyjunction.com)
  • Is the amitochondrial condition in these organisms a secondary adaptation or is it evolutionarily primitive - or, in other words, did any organisms diverge from the main line of eukaryotic evolution before the advent of mitochondria? (biomedcentral.com)
  • Whereas the issue of how the eukaryotic cell arose remains controversial [ 8 , 9 ], current genomic data do allow us to make a number of reasonably compelling inferences about how mitochondria themselves originated and have since evolved. (biomedcentral.com)
  • Endosymbiosis was certainly an important contributor to eukaryogenesis, for at least the mitochondria are known to have evolved from an alpha-proteobacterium that was engulfed prior to the last eukaryotic common ancestor (LECA) [ 1 , 2 ]. (biomedcentral.com)
  • Group one and two introns are large ribozymes that are several hundred nucleotides long and are found in fungal and plant mitochondria, chloroplasts, bacteriophages, and eukaryotic viruses. (jove.com)
  • Expression of the Escherichia coli tryptophanase operon depends on ribosome stalling during translation of the upstream TnaC leader peptide, a process for which interactions between the TnaC nascent chain and the ribosomal exit tunnel are critical. (cipsm.de)
  • We determined subnanometer-resolution cryo-electron microscopy structures of eukaryotic ribosome-Sec61 complexes. (cipsm.de)
  • The naturally available ribozymes are known to catalyze a narrow range of reactions such as phosphoryl transfer in nucleic acids and peptide bond formation in proteins. (jove.com)
  • Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus. (lookformedical.com)
  • A comparison of their known functions has identified, besides a common role within protein folding, multiple roles for the cyclophilins within pre-mRNA splicing and cellular signalling, and within transcription and cell cycle regulation for the parvulins. (biomedcentral.com)
  • It is the process in which the protein is synthesized from the information contained in a molecule of messenger rna mrna. (web.app)
  • 50S includes the activity that catalyzes peptide bond formation (peptidyl transfer reaction), prevents premature polypeptide hydrolysis, provides a binding site for the G-protein factors (assists initiation, elongation, and termination), and helps protein folding after synthesis. (wikipedia.org)
  • The involvement of RNA in such fundamental processes as protein synthesis and RNA processing has led to the idea that ribozymes were more common in early life. (printerresource.com)
  • These modifications are essential for their proper function in protein translation (see Chapter 13: Protein Synthesis). (printerresource.com)
  • A particular challenge is the synthesis of oligosaccharyltransferases (OSTs), which catalyze the attachment of glycans to specific amino acid residues in target proteins. (biorxiv.org)
  • Specific modifications commonly found at the junction of the stems of the cloverleaf structure (Figure 1), referred to as the core, elbow or hinge in the three-dimensional structure of most tRNAs, are often associated with functional folding, allowing tRNAs to fold into the common L-shape form critical to ribosomal protein synthesis. (datexis.com)
  • Candidatus Nanohaloarchaeota, an archaeal phylum within the DPANN superphylum, is characterized by limited metabolic capabilities and limited phylogenetic diversity and until recently has been considered to exclusively inhabit hypersaline environments due to an obligate association with Halobacteria . (biomedcentral.com)
  • Molecular phylogenetic analyses clearly showed that MATX is related to other eukaryotic MATs, but it forms a long branch in the eukaryotic subtree [ 8 ]. (biomedcentral.com)
  • A. Ribosomal RNA analysis StructRNAfinder - predicts and annotates RNA families in transcript or genome sequences. (printerresource.com)
  • Parsimonious scenarios of eukaryotic genome evolution and gene sets for ancestral eukaryotic forms were reconstructed. (biomedcentral.com)
  • The gene set of the last common ancestor of the crown group consists of 3,413 KOGs and largely includes proteins involved in genome replication and expression, and central metabolism. (biomedcentral.com)
  • This threshold was used to enrich for assemblies most likely to have sufficient DNA to recover a eukaryotic genome. (researchsquare.com)
  • Nearly all these proteins are subunits of known or predicted multiprotein complexes, in agreement with the balance hypothesis of evolution of gene copy number. (biomedcentral.com)
  • The sRNA gene is encoded between a CRISPR RNA locus and the Cas protein gene cluster, the s479 deletion strain is viable and was characterized in detail. (uni-stuttgart.de)
  • Its six backbone torsion angles and glycosidic bond between base and ribose provide conformational dynamics not afforded by the peptide bond of proteins and more flexibility than the DNA backbone. (datexis.com)
  • The peptidyl-prolyl cis / trans isomerase (PPIase) class of proteins is traditionally comprised of three distinct protein families, the cyclophilins (cyclosporin A binding proteins), FKBPs (FK506 binding proteins) and parvulins, that are linked by their shared ability to catalyse the bond preceding a proline residue between its cis and trans forms. (biomedcentral.com)
  • Eukaryotic cells have important cytological specificities, such as nuclei, organelles and other cellular processes. (biomedcentral.com)
  • Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. (lookformedical.com)
  • The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. (lookformedical.com)
  • A family of cellular proteins that mediate the correct assembly or disassembly of polypeptides and their associated ligands. (lookformedical.com)
  • Concerning the origin of eukaryotic cells, much has been written but almost everything remains to be settled. (asmblog.org)
  • the nature of that host, the timing and circumstances of the partnership, and its role in generating the conspicuous complexity of eukaryotic cells all remain elusive and entangled in controversy. (asmblog.org)
  • While it is routine to detect structural viral proteins in vitro for diagnostic purposes, it previously remained impossible to directly and dynamically visualize HIV in living cells without genetic modification of the virus. (cipsm.de)
  • in eukaryotic cells the most important of these proteins are the histones . (wikipedia.org)
  • Archaeal and eubacterial cells generally lack internal structural organization with a few notable exceptions, like the cyanobacteria. (web.app)
  • Thus, eukaryotic cells can perform a wider range of functions. (web.app)
  • Ribozymes have been found in all types of organisms and are similar to protein-based enzymes, as they both increase the rate of reactions. (jove.com)
  • Eukaryotic organisms may be multicellular or singlecelled organisms. (web.app)
  • Identify reliable resources for eukaryotic taxonomic classification. (web.app)
  • Taxonomic distribution of proteins containing ZnF_C2H2 domain. (embl.de)
  • The complete taxonomic breakdown of all proteins with ZnF_C2H2 domain is also avaliable . (embl.de)
  • Click on the protein counts, or double click on taxonomic names to display all proteins containing ZnF_C2H2 domain in the selected taxonomic class. (embl.de)
  • This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS. (lookformedical.com)
  • The diversity of eukaryotic energy metabolism is extremely limited, much narrower than that of prokaryotes. (asmblog.org)
  • the participating enzymes represent a sub-set of a eukaryotic complement that was probably already present in LECA, the last eukaryotic common ancestor. (asmblog.org)
  • Following the success of comparative analyses to trace back particular machineries to LECA [ 25 - 32 ], the origin and evolution of the eukaryotic N- glycosylation pathway will be studied here. (biomedcentral.com)
  • For example, when Escherichia coli is grown axenically in steady state, we can expect that each RNA molecule corresponds to 10 2 -10 4 of the matching protein (absolute protein-to-RNA ratio, hereafter referred protein-to-RNA ratio) and the variation in the level of cellular RNA explains ~29% of the variation in the amount of detectable protein 2 . (nature.com)
  • The comparison of several polyisoprenol-based glycosylation pathways from the three domains of life shows that most of the implicated proteins belong to a limited number of superfamilies. (biomedcentral.com)
  • ADP-ribosylation is a post-translational modification of proteins that occurs mostly in response to cellular stress and is catalysed by members of the diverse poly-ADP-ribose (PAR) polymerase (PARP/ARTD) family. (cipsm.de)
  • 6. Miller J, Mc Lachlan AD, Klug A. Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes. (ac.ir)
  • 8. Wolfe SA, Nekludova L, Pabo CO. DNA recognition by Cys2His2 zinc finger proteins. (ac.ir)
  • Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. (embl.de)
  • In this context, the exploration of temporal interplay between populations with different lifestyles (comprising metabolism, motility, sporulation, etc.) becomes of primary importance to interpret the changes in fundamental quantities in a microbial community, such as the protein-to-RNA ratio that ultimately impacts the overarching community phenotype(s). (nature.com)
  • A retinoblastoma-binding protein that is involved in CHROMATIN REMODELING, histone deacetylation, and repression of GENETIC TRANSCRIPTION. (lookformedical.com)
  • The repeating structural units of chromatin, each consisting of approximately 200 base pairs of DNA wound around a protein core. (lookformedical.com)
  • At an early stage in the evolution of what would become the eukaryotic cell, a facultative bacterium akin to today's alpha-proteobacteria forged an intimate association with a host whose nature is left open (but see below). (asmblog.org)
  • While the field of microbiology has adapted to the study of complex microbiomes via modern meta-omics techniques, we have not updated our basic knowledge regarding the quantitative levels of DNA, RNA and protein molecules within a microbial cell, which ultimately control cellular function. (nature.com)
  • Furthermore, we demonstrate the ability of cell-free synthesized OSTs to glycosylate multiple target proteins with varying N -glycosylation acceptor sequons. (biorxiv.org)
  • Preexisting antivector immunity can severely compromise the ability of Salmonella enterica serovar Typhimurium live vaccines to induce protective CD8 T-cell frequencies after type III secretion system-mediated heterologous protein translocation in orally immunized mice. (cipsm.de)
  • These debates have posed such questions as the following: Did the mitochondrion arise at the same time as, or subsequent to, the rest of the eukaryotic cell? (biomedcentral.com)
  • Animations provided deal with topics such as protein purification, transcription, splicing reactions, cell division and DNA replication and SDS-PAGE. (vet-ebooks.com)
  • Antibiotics in current use target a surprisingly small number of cellular functions: cell wall, DNA, RNA, and protein biosynthesis. (biomedcentral.com)
  • Proteins that control the CELL DIVISION CYCLE. (lookformedical.com)
  • A retinoblastoma-binding protein that has an affinity for core HISTONES. (lookformedical.com)
  • These proteins, aided by chaperone proteins , bind to and condense the DNA molecule to maintain its integrity. (wikipedia.org)
  • Proteins which bind to DNA. (lookformedical.com)
  • They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. (embl.de)
  • Here we demonstrate that PSRP1 is not a bona fide ribosomal protein, but rather a functional homologue of the Escherichia coli cold-shock protein pY. (cipsm.de)
  • The trimeric Sec61/SecY complex is a protein-conducting channel (PCC) for secretory and membrane proteins. (cipsm.de)
  • the next seven years showing that the mitosome functions in the biosynthesis of essential cytosolic and nuclear Iron/Sulphur (Fe/S) proteins . (ncl.ac.uk)
  • Not only does RNA translate the genetic code decoding it into protein, but it also has various catalytic and regulatory functions yet to be completely elucidated. (datexis.com)
  • Protein glycosylation, or the attachment of sugar moieties (glycans) to proteins, is important for protein stability, activity, and immunogenicity. (biorxiv.org)
  • RNA versatility and the complex roles which it plays in cellular life and function are possible through its extensive variation in length from microRNAs and transfer RNAs (tRNAs) of less than 100 nucleosides in length, to long non-coding RNAs (lncRNAs), messenger RNAs (mRNAs) and ribosomal RNAs (rRNAs) of 1000s of nucleosides in length. (datexis.com)