• Vertebrate Wnt pathways can be functionally separated into two classes, the canonical Wnt/beta-catenin pathway and the non-canonical Wnt/Ca 2+ pathway. (biomedcentral.com)
  • Long non-coding RNAs (lncRNAs) have shown promise as biomarkers in other cancer types and in some cases functionally contribute to tumor development and progression. (biomedcentral.com)
  • The present invention relates to compositions and methods for treating cancerous tumors, including naïve, metastatic and recurrent cancers. (justia.com)
  • The antibodies can be used to target carcinomas in the brain, skin and bone, as well as cancers of the lungs, esophagus or stomach, liver, gallbladder, pancreas. (patentpc.com)
  • CONCLUSION: Our results confirm that increased nuclear expression of MAGE-A2 has a clinical significance in embryonal carcinomas and is associated with progression of disease. (bvsalud.org)
  • We speculate that precancerous stem cells (pCSCs) arise during the evolution of carcinomas based on long-term experimental findings, published literature, and the cancer stem cell (CSC) theory, wherein pCSCs exist in precancerous lesions and have characteristics of both CSCs and normal stem cells. (biomedcentral.com)
  • AFP is a glycoprotein produced by fetal yolk sac elements and is produced by a wide range of cancers , including gastric , liver, and colon adenocarcinoma , as well as extracranial germ cell tumors. (medscape.com)
  • The observation that one inch of cancerous liver tissue can have more than 100 000 000 mutations and an identical mutation can result in different phenotypes, depending on the environment surrounding that mutation, makes it very unlikely that mutations by themselves are causative of most cancers. (4open-sciences.org)
  • According to the American Cancer Society (ACS), the 5-year relative survival rate differs significantly according to cancer type with higher rates ≥90% for prostate cancer, melanoma, skin and female breast cancer compared to lower rates ≤18% in liver, lung, and pancreatic cancer [ 1 ]. (4open-sciences.org)
  • Analysis of TCGA pan-cancer data revealed significant overexpression of CASC9 across different other entities including bladder, liver, lung and stomach cancers and especially in squamous cell carcinoma (SCC) of the lung. (biomedcentral.com)
  • Methods A total of 1,490 cancer patients (lung/gastric/liver/: 550/460/480) and 800 controls were recruited in this case-control study. (besjournal.com)
  • Results The results of this study showed that in the Hubei Han Chinese population, the rs10754339 gene was significantly associated with the risk of lung and gastric cancer but not liver cancer, and the rs12976445 gene was significantly associated with the risk of lung cancer but not liver or gastric cancer. (besjournal.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Objective To investigate the effects of the B7-H4 gene rs10754339 and miR‐125a gene rs12976445 on cancer susceptibility through a case-control study and meta-analysis. (besjournal.com)
  • The meta-analysis results indicated that rs10754339 and rs12976445 contributed to cancer susceptibility in the Chinese population and also revealed a significant association between rs10754339 and breast cancer risk, as well as between rs12976445 and lung cancer risk. (besjournal.com)
  • Conclusion The B7-H4 gene rs10754339 and miR‐125a gene rs12976445 may be the potential genetic markers for cancer susceptibility in the Chinese population, which should be validated in future studies with larger sample sizes in other ethnic populations. (besjournal.com)
  • CR-1 high cells isolated from ESCC cells possess cancer stem-like cells (ECSLC) properties. (cusabio.com)
  • These Wnts were chosen since previous studies suggest that C57mg cells respond differently to these Wnts, and since these Wnts can activate different signaling pathways in other systems. (biomedcentral.com)
  • We then focused on two genes previously linked to various cancers, mesothelin and stromelysin-1, which are respectively up-regulated by Wnt-1 and Wnt-5a in C57mg cells. (biomedcentral.com)
  • Cancer stem cells (CSCs) play an important role during metastasis, but the dynamic behavior and induction mechanisms of CSCs are not well understood. (nature.com)
  • Mechanistically, stemness is induced in non-stem cancer cells upon their direct contact with macrophages via Notch-Jagged signaling. (nature.com)
  • In breast cancers from patients, the density of TMEM doorways correlates with the proportion of cancer cells expressing stem cell markers, indicating that in human breast cancer TMEM doorways are not only cancer cell intravasation portals but also CSC programming sites. (nature.com)
  • At the apex of the hierarchy are the cancer stem cells (CSCs). (nature.com)
  • Targeted therapies specifically target cancer cells while sparing healthy cells, leading to fewer side effects and improved patient outcomes. (patentpc.com)
  • Immunotherapies harness the body's immune system to recognize and destroy cancer cells, offering a novel and effective treatment option. (patentpc.com)
  • Therefore, investigations on testing and maintaining the integrity of genomic DNA within precancerous stem cells (pCSCs), which are within the framework of the cancer stem cell (CSC) hypothesis, are necessary. (biomedcentral.com)
  • Cancer stem cells (CSCs) are considered to be critically involved in the recurrence and metastasis of NB and are isolated as NB spheres. (oncotarget.com)
  • Accumulating evidence has shown that cancer stem cells (CSCs) are a small subpopulation of tumor cells that exhibit the properties of self-renewal, differentiation into various tumor cell types, tumorigenicity, and chemo/irradiation resistance [ 1 ]. (oncotarget.com)
  • Therefore, CSCs have become promising target cancer cells for preventing cancer relapse and improving the prognosis of tumor patients [ 3 ]. (oncotarget.com)
  • The following text points out several possibilities and chemical pathways in which "Intume" chlorine dioxide intervention can destroy tumors and prevent proliferation of cancer cells. (justia.com)
  • Cancer cells are rich in polyamines which is necessary for survival and growth of tumors. (justia.com)
  • ix Capacity of cancer tissue to produce abundant PA likely contributes to cancer cell's higher growth rates.ix ,x High concentrations of PA enhance cancer cells to invade, and is associated with less apoptosis and increased expression of the genes affecting metastasis.ix ,xi The association of increased polyamine synthesis and cancer was first reported in the late 1960s. (justia.com)
  • Gas7 and Circzfp644 functions were determined by miRNA-mimics and inhibitors in mouse teratocarcinoma cells (F9 cells), and luciferase gene reporter assay was assessed in the F9 cells. (besjournal.com)
  • Because in order to avoid renal injury, the recovery of affected cells is as significant as preventing its progression towards end stage renal disease [ 1 ]. (biomedcentral.com)
  • Wnt ligands are secreted glycoproteins that function in intracellular signaling pathways to regulate a variety of developmental processes including cell growth, cell differentiation, cell polarity, and apoptosis. (biomedcentral.com)
  • Thus, a better understanding of the in vivo mechanisms that regulate CSCs is essential for the development of more effective anti-cancer therapies. (nature.com)
  • Targeting the Cripto-1/TAK-1/NF-kappaB/Survivin pathway may be an effective approach to combat apoptosis resistance in cancer. (cusabio.com)
  • Interest in targeting polyamine metabolism as a potential strategy for cancer chemotherapy was stimulated in the early 1970s. (justia.com)
  • INTRODUCTION: Melanoma-associated antigen A2 (MAGE-A2) is a member of the cancer-testis antigen family differentially overexpressed in a variety of malignancies and is associated with tumor development. (bvsalud.org)
  • In contrast, little is known about the Wnt/Ca 2+ pathway and whether it regulates gene expression. (biomedcentral.com)
  • Many downstream gene targets of the canonical Wnt/beta-catenin pathway have been identified http://www.stke.org . (biomedcentral.com)
  • Compositions such as targeted therapies, immunotherapies, and precision medicine have emerged as promising approaches in the fight against cancer. (patentpc.com)
  • The development of novel therapies and diagnostic tools holds great promise in improving patient outcomes and ultimately eradicating cancer. (patentpc.com)
  • The methods of use are not limited to cancer diagnostics and therapies. (patentpc.com)
  • A vast amount of research exists on the possible molecular mechanisms through which vitamin D affects cancer cell proliferation, cancer progression, angiogenesis, and inflammation. (mdpi.com)
  • Accurate assessment of the carcinogenic potential of oral mucosal diseases can significantly reduce the prevalence of oral cancer. (biomedcentral.com)
  • While more advanced cancer stages reveal significantly lower survival rates [ 1 ] they may just represent clinical empiricism [ 4 , 5 ] and do not explain the origin of cancer. (4open-sciences.org)
  • Epidemiologic evidence indicates that lower circulating vitamin D levels are associated with a higher risk of ovarian cancer and that vitamin D supplementation is associated with decreased cancer mortality. (mdpi.com)
  • We conducted a systematic review of the literature on the effects of vitamin D on ovarian cancer cell. (mdpi.com)
  • CFC1 inhibited Activin A-induced NB cell differentiation and Smad2 phosphorylation in NB cell lines, indicating its involvement in tumorigenesis related to EGF-CFC co-receptor family molecule pathways. (oncotarget.com)
  • Macrophages are emerging as major cellular factors in the tumor ecosystem that can influence the stem phenotype and cancer progression. (nature.com)
  • The market for compositions for the treatment and detection of cancer has witnessed significant growth in recent years. (patentpc.com)
  • Compositions for the treatment and detection of cancer play a crucial role in improving patient outcomes and saving lives. (patentpc.com)
  • As a result, there is a pressing need for advanced compositions that can effectively treat and detect cancer at an early stage. (patentpc.com)
  • The market for compositions for the treatment and detection of cancer is also driven by increased research and development activities. (patentpc.com)
  • Pharmaceutical and biotechnology companies are investing heavily in developing innovative compositions that can effectively target and treat various types of cancer. (patentpc.com)
  • Furthermore, the growing importance of early cancer detection has contributed to the demand for compositions that can accurately diagnose cancer at its earliest stages. (patentpc.com)
  • Compositions such as liquid biopsies, molecular diagnostics, and imaging techniques have shown great promise in detecting cancer at its earliest stages, enabling timely intervention and treatment. (patentpc.com)
  • The market for compositions for the treatment and detection of cancer is highly competitive, with numerous players vying for market share. (patentpc.com)
  • These companies are constantly striving to develop innovative compositions that can address the unmet needs of cancer patients. (patentpc.com)
  • In conclusion, the market for compositions for the treatment and detection of cancer is witnessing significant growth due to the rising incidence of cancer, advancements in technology, increased research and development activities, and the growing importance of early cancer detection. (patentpc.com)
  • As the global burden of cancer continues to increase, the demand for effective and innovative compositions will only continue to rise. (patentpc.com)
  • These results highlight a functional role for CRIPTO and GRP78 in prostate cancer metastasis and suggest that targeting CRIPTO/GRP78 signaling may have significant therapeutic potential. (cusabio.com)
  • Although colorectal cancer outcomes in England are improving, they remain poorer than many comparable countries. (envite.org)
  • From a "birds-eye" view, it may appear that we have made little progress in eradicating cancer and that outcomes are largely based on the merits, or lack thereof, of any selected therapy " meaning to reach the proposed vision " Imagine a world without cancer " [ 6 ], we need to work much harder to understand the as yet unanswered questions that surround the origins of most cancers. (4open-sciences.org)
  • Further, high level nuclear expression of MAGE-A2 had shorter disease-specific survival (DSS) or progression-free survival (PFS) compared to patients with moderate and low expression of MAGE-A2, however, without a statistically significant association. (bvsalud.org)
  • The Wnt signal transduction pathway is important in a wide variety of developmental processes as well as in the genesis of human cancer. (biomedcentral.com)
  • Notch signaling has been implicated in many microenvironmental processes associated with cancer progression such as vascular remodeling, immunosuppression, epithelial to mesenchymal transition (EMT), as well as maintenance of the CSC pool 21 . (nature.com)
  • With the increasing prevalence of cancer worldwide, there is a growing need for innovative and effective solutions to combat this deadly disease. (patentpc.com)
  • The increasing prevalence of risk factors such as tobacco use, unhealthy diets, physical inactivity, and exposure to carcinogens has contributed to the growing burden of cancer. (patentpc.com)
  • 90% of cancer-related deaths, is a multi-step process involving cancer cell intravasation into the bloodstream, dissemination to distant sites, and seeding in new organs 1 . (nature.com)
  • The antibodies disclosed herein can bind certain cancer cell surface. (patentpc.com)
  • Long non-coding RNAs (lncRNAs) have moved into the focus of cancer research as good candidates for tumor biomarkers and as regulators of various neoplastic cell properties. (biomedcentral.com)
  • Two independent HNSCC tissue sets and a bladder cancer tissue set were analyzed by RT-qPCR. (biomedcentral.com)
  • There is a kind of zeitgeist that findings in genetics, namely somatic mutations, are reflexively viewed as being causative for carcinogenesis, although some 80% of all cancers are presently termed "sporadic" (i.e., with no proven cause). (4open-sciences.org)
  • We hope that our study will increase attention to pCSC research and lead to the development of novel strategies for the prevention and treatment of oral cancer by identifying pCSC markers. (biomedcentral.com)
  • While regularly overexpressed, however, this lncRNA does not seem to act as a major driver of development or progression in this tumor. (biomedcentral.com)
  • Dysregulation of lncRNA expression has been reported for different cancer types and may contribute to tumor development and progression [ 2 , 3 ]. (biomedcentral.com)
  • Presently, the likelihood of an oral potentially malignant disorder (OPMD) progressing to oral cancer is determined according to histopathological findings, which are susceptible to inadequate and/or subjective qualitative interpretations [ 5 ]. (biomedcentral.com)
  • Wnts in this functional class activate the canonical Wnt/beta-catenin pathway (Wnt-1, -3A, and -8). (biomedcentral.com)
  • Early detection plays a crucial role in improving survival rates and reducing the burden of cancer. (patentpc.com)
  • Despite success in some cancer survival rates, these numbers differ by race, ethnicity, socioeconomics, health policy, geography, and age so the overall survival numbers ignore the large variations within any given group. (4open-sciences.org)
  • Epidemiologically, cancer is an age-related disease which will be a major burden to healthcare worldwide along with neurologic, cardiovascular diseases, and diabetes [ 3 ]. (4open-sciences.org)
  • Wnts in this class have been shown to signal in a non-canonical Wnt signaling pathway, the Wnt/Ca 2+ pathway (Wnt-5a, -4, -11). (biomedcentral.com)
  • identified using whole-genome sequencing (WGS), cytogenetic analysis, and structural modeling that extrachromosomal circular DNA is highly amplified and common in various types of cancers. (wikipedia.org)
  • There is a large family of Wnt ligands and not all Wnts are thought to function in the same pathway. (biomedcentral.com)
  • Advancements in technology have revolutionized the field of cancer treatment and detection. (patentpc.com)
  • Increased nuclear expression of MAGE-A2 was observed to be associated with more aggressive behaviors and tumor progression rather than cytoplasmic expression in these cases. (bvsalud.org)