• OBJECTIVES: I. Determine the maximum tolerated dose of interleukin-12 (IL-12) in patients with AIDS-associated Kaposi's sarcoma. (knowcancer.com)
  • After much investigation a diagnosis of AIDS-related kaposi's sarcoma with visceral manifestations was made. (webmedcentral.com)
  • New findings just published in the Proceedings of the National Academy of Sciences by University of Miami Miller School of Medicine researchers suggest that antioxidant therapy could help prevent and treat Kaposi's sarcoma, a major AIDS-related malignancy. (univmiami.net)
  • Even though the number of cases has gone down with the use of highly active antiretroviral therapy, Kaposi's sarcoma still has a high death rate, particularly in Sub-Saharan Africa. (univmiami.net)
  • Scientists at the University of Miami Miller School of Medicine's Sylvester Comprehensive Cancer Center and other collaborating universities have been able to reproduce Kaposi's sarcoma in mice by overexpressing a single protein from the Rac1 gene. (univmiami.net)
  • The researchers found that as mice age, overexpression of Rac1, in a form that is constitutively activated, triggers the development of a tumor that has all the scientific characteristics of human Kaposi's sarcoma. (univmiami.net)
  • They study a mouse gammaherpesvirus called MHV68, a relative of several human cancer-promoting viruses that include Kaposi's sarcoma herpesvirus. (medicalxpress.com)
  • Kaposi's sarcoma (KS) - currently the most common tumour observed with an estimated incidence of 15 - 20% - represents the first manifestation of AIDS in 30 - 40% of patients. (sun.ac.za)
  • Common oral symptoms of HIV fall into several categories: fungal, viral and bacterial infections, and neoplasms (such as the oral lesions of Kaposi's sarcoma and large, ulcerated masses on the palate or gums that typifies non-Hodgkin's lymphoma). (realhealthmag.com)
  • Kaposi's sarcoma is a neoplasm of vascular endothelium that is characterized by proliferation of spindle cells, neoangiogenesis, inflammation and edema 17 . (bvsalud.org)
  • The endemic form of Kaposi's sarcoma, present in Africa (mainly in the south of the Sahara Desert), is relatively rare, but more aggressive. (bvsalud.org)
  • Stage-stratified treatment greatly reduces the need for chemotherapy in patients with early-stage HIV-related Kaposi's sarcoma (KS), leading to high overall survival rates in patients with early and advanced disease. (medscape.com)
  • Kaposi's sarcoma or lymphomas for example. (stackexchange.com)
  • Does the Kaposi's sarcoma virus speed up progression of infection with HIV to AIDS? (ichacha.net)
  • Does the Kaposi's sarcoma virus suppress the immune system independently of the AIDS virus? (ichacha.net)
  • Does the Kaposi's sarcoma virus infect many people but cause disease in only a few? (ichacha.net)
  • The study was too limited in scope to prove that Kaposi's sarcoma virus causes myeloma. (ichacha.net)
  • The Columbia researchers said they began hunting for a Kaposi's sarcoma virus about 18 months ago. (ichacha.net)
  • The Los Angeles scientists found the Kaposi's sarcoma virus in two of eight patients with the gammopathy condition. (ichacha.net)
  • Kaposi's sarcoma-associated herpesvirus (KSHV) is the infectious etiologic agent associated with Kaposi's sarcoma (KS), primary effusion lymphoma, and multicentric Castleman disease. (virosin.org)
  • Spectrum of Kaposi's sarcoma-associated herpesvirus, or human herpesvirus 8, diseases. (virosin.org)
  • 2001. Seroprevalence of Kaposi's sarcoma-associated herpesvirus infection among blood donors from Texas. (virosin.org)
  • 2001. Epidemiology and pathogenesis of Kaposi's sarcoma-associated herpesvirus. (virosin.org)
  • Purpose: Paclitaxel, a cytotoxic agent metabolized by cytochrome P450 hepatic enzymes, is active for the treatment of human immunodeficiency (HIV) associated Kaposi's sarcoma. (elsevierpure.com)
  • An individual exposed to KSHV may develop Kaposi's sarcoma and lymphoma. (sciencious.com)
  • Despite the disease being common in men, Kaposi's sarcoma is usually transmitted through saliva rather than semen. (sciencious.com)
  • The pattern of Non-Hodgkin's lymphoma and aggressive Kaposi's sarcoma is known to have changed in some countries as the prevalence of the acquired immunodeficiency syndrome increases. (pubpub.org)
  • A retrospective analysis of histologically verified cancers in southern Ethiopia during the period 1963-86 did not demonstrate any change in the pattern of aggressive Kaposi's sarcoma nor of Non-Hodgkin lymphomas, suggesting that the HIV epidemic did not start before the mid-1980s. (pubpub.org)
  • Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent of several human cancers, including Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL), which preferentially arise in immunocompromised patients while lack of effective therapeutic options. (bvsalud.org)
  • Although Kaposi's sarcoma-associated herpesvirus (KSHV) has been reported to cause several human cancers including Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL), the mechanisms of KSHV-induced tumorigenesis, especially virus-host interaction network, are still not completely understood, which therefore hinders the development of effective therapies. (bvsalud.org)
  • Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor. (gutkindlab.org)
  • The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's Sarcoma Associated Herpesvirus G Protein-Coupled Receptor. (gutkindlab.org)
  • Researchers evaluated the development of Kaposi's sarcoma-associated herpesvirus (KHSV) after treatment with CBD in human dermal microvascular endothelial cells. (plantsbeforepills.com)
  • The inflammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells. (bnwax.com)
  • Lesional skin tissue was obtained from 34 Kaposi's sarcoma-negative, immunocompetent patients with typical acute phase pityriasis rosea. (medicaljournals.se)
  • Kaposi sarcoma (KS) is a low-grade vascular tumor associated with kaposi sarcoma herpesvirus/human herpesvirus 8 (KSHV/HHV8) infection. (webmedcentral.com)
  • Kaposi sarcoma-associated herpesvirus (KSHV), another name for HHV-8, is the etiologic agent of all clinical forms of KS and several other lymphoproliferative diseases, including primary effusion lymphoma (PEL) and multicentric Castleman disease (MCD). (unboundmedicine.com)
  • Papilloma viruses (HPV), hepatitis B- (HBV) and C-viruses (HCV), Epstein-Barr virus (EBV), Kaposi sarcoma virus (KSHV), human T-cell-leukemia virus (HTLV) may contribute to the pathogenesis of as much as 15-20% of all human cancers. (ki.se)
  • Kaposi sarcoma-associated herpesvirus (KSHV). (sciencious.com)
  • We determined that histamine treatment promoted KSHV-infected lymphoma progression in immunocompromised mice models. (bvsalud.org)
  • The seroprevalence of human herpesvirus-8 (HHV-8)-also known as Kaposi sarcoma-associated herpesvirus (KSHV)-varies worldwide and is estimated to be 1% to 5% in the general U.S. population 1,2 compared with 10% to 20% in certain Mediterranean countries and 30% to 80% in parts of sub-Saharan Africa. (hiv.gov)
  • In the paper, investigators say more research is needed diagnosis of Kaposi sarcoma in related to anti-retroviral therapies, loss of immunity to the KS-associated herpesvirus, where prevalence is high among children in sub-Saharan Africa and in men who have sex with men. (drugtopics.com)
  • Six human viruses, including high-risk alpha human papillomaviruses (HPV), hepatitis B (HBV) and C (HCV) viruses, human T-cell lymphotropic virus 1 (HTLV-1), Epstein-Barr virus (EBV), and Kaposi sarcoma-associated herpesvirus (HHV-8), have been classified as class 1 carcinogens by the International Agency for Research on Cancer. (biomedcentral.com)
  • For more than a century, since first described in 1872 by Moritz Kaposi* as "idiopathic multiple pigmented sarcoma," dermatologists focused on classical Kaposi sarcoma (KS) - violaceous patches, plaques, and tumors on the lower extremities of elderly men of either Mediterranean or Eastern European (Ashkenazi Jewish) descent. (aad.org)
  • Moritz Kaposi, a Hungarian dermatologist in 1872, first described it. (bvsalud.org)
  • In his original article entitled "Idiopathic multiple sarcoma of the skin", Moritz Kaposi described the indolent and rare disease that is known as classic or sporadic Kaposi sarcoma. (bvsalud.org)
  • Kaposi sarcoma (KS) was originally described in 1872 by a Hungarian dermatologist named Moritz Kaposi. (unboundmedicine.com)
  • Kaposi sarcoma, primary effusion viruses, HIV, human T-lymphotropic and Burke A. Cunha lymphoma, and multicentric Castle- viruses I and II, Treponema pallidum, Author affi liations: Winthrop-University Hos- man disease. (cdc.gov)
  • With a five-year, $6 million grant from the NIH's National Cancer Institute, the research consortium will look at screening and diagnosing innovations for three cancers common to people with HIV: Kaposi sarcoma, cervical cancer and lymphoma. (unclineberger.org)
  • People with HIV have a high risk of developing certain types of cancers, including Kaposi sarcoma, non-Hodgkin lymphoma, and cancers of the cervix, lung, liver, and anus. (cancer.gov)
  • Introduced in the mid-1990s, highly active antiretroviral therapy (HAART) was discovered to lessen the occurrence of cancer- specifically Kaposi sarcoma and non-Hodgkin lymphoma. (sciencious.com)
  • In many other countries, the number of Non-Hodgkin's lymphoma (NHL), which is the cancer of the immune system, and Kaposi sarcoma, which is the cancer of the skin or lining of mucous membranes, increased alongside the incidence of AIDS. (pubpub.org)
  • HHV-8 is etiologically associated with all forms of Kaposi sarcoma (KS) including classic, endemic, transplant-related, and AIDS-related, as well as rare neoplastic disorders (primary effusion lymphoma [PEL] and solid organ variants) and the lymphoproliferative disorder known as multicentric Castleman's disease (MCD). (hiv.gov)
  • The dermatology team carried out a punch biopsy which was positive for HHV-8 in keeping with the diagnosis of cutaneous kaposi Sarcoma. (webmedcentral.com)
  • Development of Kaposi sarcoma in the oral cavity also has prognostic implications for untreated HIV patients, who are found to have higher death rates than patients affected only by cutaneous disease. (bvsalud.org)
  • The primary therapeutic goal is to control the HIV infection through adherence to HAART, as this significantly improves immune function and helps control KS progression. (alliedacademies.org)
  • A CT/High-Resolution CT was performed which showed mediastinal lymphadenopathy, lungs nodularity and patchy opacity which might represent part of the kaposi sarcoma and features of superadded infection/atypical infection were also seen. (webmedcentral.com)
  • This activation of SINE expression is a biphasic response, with an initial phase arising as a result of either viral attachment or entry in to cells, and a second wave that requires progression of the infection past entry and expression of immediate early and early viral genes. (medicalxpress.com)
  • This is because oral problems are often the first symptom of HIV infection and may signal clinical progression of the disease. (realhealthmag.com)
  • Kaposi sarcoma is rare in HIV negative patients and it is associated with HHV-8 infection. (bvsalud.org)
  • Kaposi sarcoma is one of the first recognized opportunistic diseases in HIV infection and is still the most common malignancy associated with AIDS 32 . (bvsalud.org)
  • HIV infection may promote KS progression by inducing cytokines and impairing host immunity. (unboundmedicine.com)
  • Kaposi sarcoma (KS) was the first reported malignancy associated with HIV infection and was first documented in 1981 from reports in New York, Los Angeles, and San Francisco. (medscape.com)
  • 28 Immunocompetent children and organ transplant recipients infected with HHV-8 may develop a primary infection syndrome consisting of fever, rash, lymphadenopathy, bone marrow failure, and occasional rapid progression to KS. (hiv.gov)
  • Our results identify a novel model of intercellular crosstalk following SARS-CoV-2 infection that evoke immune responses positioned to contribute to elevated cytokine production associated with COVID-19 progression, severity, and long-haul symptoms. (wphobby.com)
  • Kaposi sarcoma lesions predominantly present at mucocutaneous sites, but may involve all organs and anatomic locations, with the gastrointestinal tract and lungs being commonly affected. (webmedcentral.com)
  • Lesions appear in different areas of the body and have a different clinical progression 18,30 . (bvsalud.org)
  • The workshop highlighted the state of four different cancers associated with HIV: Kaposi sarcoma (KS), cervical, lung and anal cancer. (drugtopics.com)
  • Patients suffering with AIDS are more likely to develop these cancers and are more severely affected, so researchers can use cancer medical records as a way to track the start and progression of the AIDS epidemic. (pubpub.org)
  • Based on these results differentials included atypical infections, tuberculosis, haematological malignancies and HIV associated pneumocystis pneumonia and kaposi Sarcoma. (webmedcentral.com)
  • In addition, CBD slowed the progression of KHSV-related malignancies in healthy cells. (plantsbeforepills.com)
  • AIDS-related Kaposi sarcoma (KS) after failure of highly active antiretroviral therapy. (drugguide.com)
  • Patients with HIV/AIDS are also at increased risk of developing Kaposi sarcoma. (bvsalud.org)
  • The aim of this article is to present two cases of Kaposi sarcoma in the hard palate of HIV/AIDS male patients. (bvsalud.org)
  • Kaposi sarcoma should be considered in the differential diagnosis of any AIDS patient who presents with bluish, smooth, firm, nonpulsatile macule or nodule in the region of the hard palate. (bvsalud.org)
  • About 15% of all diagnosed cases of AIDS have associated Kaposi sarcoma 4 . (bvsalud.org)
  • In 1978, the number of people who had Kaposi sarcoma was high, but likely not related to AIDS because the patients did not seem to be as severely affected as AIDS patients usually are. (pubpub.org)
  • The progression from HIV to AIDS is caused by the destruction of a type of white blood cell known as CD4 T cell. (bajajallianz.com)
  • these immunologic parameters remained stable for 8 to 24 months of follow-up, without disease progression. (aad.org)
  • Patients with stable or better disease continue IL-12 treatment in the absence of disease progression or unacceptable toxicity. (knowcancer.com)
  • Thirty years of intensive research have revealed a highly complex disease dynamics, calling for quantitative approaches to interpret the experimental data and to aid the understanding of the underlying processes that govern the dynamics and progression of the disease. (mdpi.com)
  • For Kaposi sarcoma, the researchers will study the impact of different therapies on the disease's progression and will seek to develop prognostic biomarkers of the disease. (unclineberger.org)
  • Most Kaposi sarcoma cases are in sub-Saharan Africa, where it is often late in the disease progression when diagnosed. (drugtopics.com)
  • The management of Kaposi Sarcoma in the HAART era involves a multidisciplinary approach, with collaboration between oncologists, infectious disease specialists, and HIV clinicians. (alliedacademies.org)
  • An estimated 30 - 40% of HIV-infected patients are likely to develop cancer during the progression of their disease. (sun.ac.za)
  • In non HIV patients, known as Classical Kaposi sarcoma, it is generally localized disease and is very slow growing. (shyamhemoncclinic.com)
  • Proliferation of HIV specific cells, particular CD8, is associated with delayed disease progression or control. (stackexchange.com)
  • Elevated serum cytokine production in COVID-19 patients is associated with disease progression and severity. (wphobby.com)
  • Many conservative therapies seem to have only a supportive character and do not prevent progression of the disease. (medicaljournals.se)
  • Her research is mainly focused on understanding how the inflammasome and complement pathways are activated and their impact in the progression of different inflammatory conditions, including Tuberculosis (TB) immune reconstitution inflammatory syndrome (IRIS), Kaposi sarcoma. (nih.gov)
  • Rates of Kaposi sarcoma, a cancer of the skin, lymph nodes and organs that is associated with HIV, have declined as treatment options for HIV have increased. (drugtopics.com)
  • Kaposi sarcoma is a vascular neoplasm composed of endothelium-lined vascular spaces and spindle-shaped cells. (bvsalud.org)
  • The purpose of this paper is to present two cases of Kaposi sarcoma in its epidemic form in HIV positive patients. (bvsalud.org)
  • Of the 20 patients assessable for response, 6 (30%) had an objective response and median progression-free survival was 7.8 months (95% confidence interval, 5.6, 21.0 months). (elsevierpure.com)
  • RÉSUMÉ La présente étude visait à dresser le profil épidémiologique de patients atteints de leishmaniose cutanée américaine dans 34 municipalités de la vallée du Jequitinhonha, dans l'État du Minas Gerais (Brésil), enregistrés entre 2005 et 2010 auprès de la Surintendance régionale de la santé, en utilisant les données du système brésilien de notification des maladies. (who.int)
  • Furthermore, recent findings showed the intriguing effects of microbiota in cancer susceptibility, neoplastic progression, co-infections with carcinogenic agents, and response to therapy. (biomedcentral.com)
  • There was no significant difference in overall survival or progression-free survival between these 2 cART treatment regimens (log-rank P = .37). (medscape.com)
  • Progression-free survival in this group was 77% at 5 years and 76% at 10 years. (medscape.com)
  • Decreased progression of multiple myeloma and KS. (drugguide.com)
  • It induces c-kit expression and produces the spindled morphology of Kaposi sarcoma cells from their original cuboidal monolayer. (aad.org)