Progression myeloid cell leukemia sequence 1 protein. Medical search. Frequent questions

Induced myeloid leukemia cell differentiation protein Mcl-1 is a protein that in humans is encoded by the MCL1 gene. (wikipedia.org)
DNMT3A is a critical regulator of hematopoietic stem cell (HSC) differentiation and somatic DNMT3A mutations are frequent in hematologic malignancies and clonal hematopoiesis. (haematologica.org)
To evaluate the leukemogenic role of RUNX1-MT in ASXL1 -mutated cells, we co-expressed RUNX1 -MT (R135T) and ASXL1 -MT (R693X) in different cell lines and performed immunoblot, co-immunoprecipitation, gene expression microarray, quantitative RT-PCR, cell proliferation, differentiation, and clonogenic assays for in vitro functional analyses. (biomedcentral.com)
The expression of RUNX1 mutant in ASXL1 -mutated myeloid cells augmented proliferation, blocked differentiation, and increased self-renewal activity. (biomedcentral.com)
The integrin CD49a marks highly cytotoxic epidermal-tissue-resident memory (TRM) cells, but their differentiation from circulating populations remains poorly defined. (scilifelab.se)
Together, our results indicate that combined RUNX2 and RUNX3 activity promotes the differentiation of cytotoxic CD8+CD103+CD49a+ TRM cells, providing immunosurveillance of infected and malignant cells. (scilifelab.se)
RUNX1‑RUNX1T1 suppression supported myeloid differentiation by the differential expression of CEBPA, CEBPE, ID2, JMJD6, IKZF1, CBFB, KIT and CDK6, while MAPK1 depletion inhibited the differentiation of t(8;21) cells by elevated expression of ADA and downregulation of JUN. (prinsesmaximacentrum.nl)
Taken together, the current results demonstrate that MAPK1 promotes myeloid cell proliferation and differentiation simultaneously by cell cycle progression while suppresing apoptosis. (prinsesmaximacentrum.nl)
Semaphorin 4D (Sema4D) belongs to the semaphorin family, which binds to receptors such as Pleixn-B1 (transmembrane structure receptor), CD72 (cluster of differentiation antigen 72, mainly expresses on lymphocyte cells), then activates downstream signaling molecules. (jcancer.org)
Our scientists have developed a wide array of stem cell-focused reagents and resources for many applications including flow cytometry , western blotting , ELISAs , and recombinant proteins for cell differentiation. (biolegend.com)
RUNX1 is also required for the differentiation of CD8+, Th17, and regulatory T cells. (biolegend.com)
These findings revealed that RUNX1 acts as a tumor suppressor for myeloid leukemia and is crucial for the development and terminal differentiation of several blood cell lineages 2,3 . (biolegend.com)
STAT3 protein belongs to a group of intracellular transcription factors that mediate a variety of functions such as cellular differentiation, proliferation, and apoptosis. (biolegend.com)
Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. (lu.se)
Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
In this study, highly purified, flow-cytometry sorted, classified in relation to normal B-cell differentiation [1]. (lu.se)

This suggests the possibility that strictly regulated self-renewal mediated by Wnt signaling in cancer cells may be disturbed by the SUMOylation pathway to allow more malignant proliferation. (frontiersin.org)
The most remarkable function of TNFRSF4 is to enhance division, proliferation, survival and cytokine production of T cells by activating the pathways described above. (biomedcentral.com)
As they reported in Cell on Tuesday, the researchers relied on a series of genome-wide CRISPR-interference screens using growth analyses and high-throughput sequencing to search for loss-of-function changes affecting the proliferation of human or chimp pluripotent stem cells. (genomeweb.com)
DHX15 silencing greatly inhibited leukemia cell proliferation and induced cell apoptosis and G1-phase arrest. (oncotarget.com)
The present study demonstrates that HBx promotes HCC cell proliferation via the C-X-C motif chemokine ligand 12-C-X-C chemokine receptor type 4 (CXCL12-CXCR4) axis. (techscience.com)
BeadChip microarray and gene ontology analysis revealed that RUNX1‑RUNX1T1 and MAPK1 suppression reduced the proliferation rate of the t(8;21) cells with deregulated expression of several classical positive regulator genes that are otherwise known to enhance cell proliferation. (prinsesmaximacentrum.nl)
Knockdown of TUG1 significantly promoted the proliferation of NSCLC cells. (biomedcentral.com)
In previous research, the authors demonstrated that the methanol extract of Artemisia vulgaris (AVM) has the ability to inhibit chronic myeloid leukemia (CML) cell proliferation. (spandidos-publications.com)
Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a myeloproliferative disorder characterized by increased proliferation of the granulocytic cell line without the loss of their capacity to differentiate. (medscape.com)

Scope includes mutations and abnormal protein expression. (cancerindex.org)
In the age of personalized cancer therapy, genetic sequencing technologies allow clinicians to rapidly pinpoint mutations likely involved in driving patient-specific tumorigenesis and disease progression. (cancer.gov)
A hypothetical model in which nonpathogenic somatic mutations (1-3) acquired over the lifespan of a stem cell are propagated in the malignant clone after it acquires a critical initiating mutation (4). (wustl.edu)
Somatic TP53 mutations have been observed in patients with SDS who develop MDS 13 , raising the possibility that next-generation sequencing could be integrated into surveillance for somatic clones with enhanced leukemia potential. (nature.com)
Additional sex combs-like 1 ( ASXL1 ) mutations have been described in all forms of myeloid neoplasms including chronic myelomonocytic leukemia (CMML) and associated with inferior outcomes, yet the molecular pathogenesis of ASXL1 mutations ( ASXL1 -MT) remains poorly understood. (biomedcentral.com)
Previously, we observed that transcription factor RUNX1 mutations ( RUNX1 -MT) coexisted with ASXL1 -MT in CMML and at myeloid blast phase of chronic myeloid leukemia. (biomedcentral.com)
The contribution of RUNX1 mutations in the pathogenesis of myeloid transformation in ASXL1 -mutated leukemia, however, remains unclear. (biomedcentral.com)
Co-expression of two mutant genes increased myeloid stem cells in animal model, suggesting that cooperation of RUNX1 and ASXL1 mutations played a critical role in leukemia transformation. (biomedcentral.com)
Mice transduced with both ASXL1 and RUNX1 mutations enhanced inhibitor of DNA binding 1 (ID1) expression in the spleen, liver, and bone marrow cells. (biomedcentral.com)
The findings build on prior research looking at rare, large-effect mutations that distinguish humans and nonhuman primates, Pollen explained, noting that the current analyses focused on more subtle, "long tail" mutations with species-specific effects in the pluripotent stem cell type considered. (genomeweb.com)
Recently, massively parallel sequencing has identified recurrent mutations in the SKI domain of SETBP1 in a variety of myeloid disorders, including JMML (Piazza et al Nat Genet 2012, Makishima et al Nat Genet 2013, Sakaguchi et al Nat Genet, 2013). (ashpublications.org)
These and other data suggested that SETBP1 mutations contribute to disease progression rather than initiation. (ashpublications.org)
RNA sequences, somatic mutations, and clinicopathological features of 33 cancers were downloaded from The Cancer Genome Atlas (TCGA) database. (hindawi.com)
Recurrent hotspot mutations of U2AF1 encoding a protein belonging to the spliceosome were detected in 15% of vHCL. (fortuneonline.org)
Bioinformatics analysis of mutations sheds light on the evolution of Dengue NS1 protein with implications in the identification of potential functional and druggable sites. (ncbs.res.in)
mutations high frequency of IDH1/2 mutations in oligodendrogliomas, astrocytomas and in alteRations in the RB1 pathway in The TET2 gene encodes the -KG- secondary glioblastomas derived thereof low-gRade diffuse gliomas lacking dependent enzyme that catalyses suggests that these tumours share a common genetic alteRations the conversion of 5-methylcytosine to common progenitor cell population. (who.int)
Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. (thermofisher.com)
U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies. (cancer-genetics.org)
Spliceosome mutations are common in myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML), but the oncogenic changes due to these mutations have not been identified. (cancer-genetics.org)
Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia. (lu.se)
Identification of Bruton tyrosine kinase mutations in 12 Chinese patients with X-linked agammaglobulinaemia by long PCR-direct sequencing. (lu.se)
Acquisition of JAK2, PTPN11, and RAS mutations during disease progression in primary myelodysplastic syndrome. (lu.se)
PTPN11, RAS and FLT3 mutations in childhood acute lymphoblastic leukemia. (lu.se)

To understand the mechanisms that mediate germline genetic leukemia predisposition, we studied the inherited ribosomopathy Shwachman-Diamond syndrome (SDS), a bone marrow failure disorder with high risk of myeloid malignancies at an early age. (nature.com)
Hepatocellular carcinoma (HCC), one of the most common malignancies, ranks second among the leading causes of cancer-related death globally [ 1 ]. (hindawi.com)
The present study demonstrated the biological and functional evidence for the critical role of RUNX1 -MT in ASXL1 -mutated leukemia in the pathogenesis of myeloid malignancies. (biomedcentral.com)
Our study describes the sequence characteristics of 5' non-coding region of Sema4D, enhances our understanding of the regulatory mechanism of Sema4D and benefits the development of a possible anti-angiogenesis therapeutic strategy for malignancies. (jcancer.org)
Antibody binding and neutralization of live SARS-CoV-2 variants including BA.4/5 following booster vaccination of patients with B-cell malignancies. (cdc.gov)

El-Masry OS, Alamri AM, Alzahrani F, Alsamman K. ADAMTS14 , ARHGAP22 , and EPDR1 as potential novel targets in acute myeloid leukaemia. (ajmc.com)
The t(8;21) translocation is one of the most frequent chromosome abnormalities associated with acute myeloid leukaemia (AML). (prinsesmaximacentrum.nl)

The protein encoded by this gene belongs to the Bcl-2 family. (wikipedia.org)
The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing. (wikipedia.org)
Loss of the Mcl-1 gene results in embryo death when the embryo is only around 3.5 days old, before it has even implanted. (wikipedia.org)
What does this gene/protein do? (cancerindex.org)
What pathways are this gene/protein implicaed in? (cancerindex.org)
Tumor-infiltrated macrophages were isolated from human GC tissues using magnetic beads, gene transcription was determined by real-time PCR, protein expression was monitored using western blots, metabolites were determined using HPLC, and transcriptional regulation was analyzed by the luciferase-based reporter gene system. (cancerindex.org)
The protein produced from the BCR-ABL1 gene signals cells to continue dividing abnormally and prevents them from self-destructing, which leads to overproduction of the abnormal cells. (medlineplus.gov)
Targeting AML cells is difficult despite advances in the understanding of its genetic alterations, so a recent study aimed to add potential novel therapeutic targets and gene variants based on RNA sequencing. (ajmc.com)
The lab established that the initiating event for Acute Promyelocytic Leukemia is the PML-RARA fusion gene created by the t(15;17) that is found in nearly all patients with this disease. (wustl.edu)
This gene encodes the GA-binding protein transcription factor, beta subunit. (nih.gov)
Moreover, the RUNX1 mutant protein was more stable than WT and increased HIF1-α and its target ID1 gene expression in ASXL1 mutant cells. (biomedcentral.com)
Based on 16 CRISPR interference screens and essential and nonessential gene Dependency Map analyses, they went on to uncover 75 genes with species-specific growth effects in stem cells. (genomeweb.com)
With a series of follow-up analyses, including additional gene knockdown, copy number variant, and RNA sequencing analyses on pluripotent stem cells from orangutans and from several human and chimpanzee representatives, the team found that genetic differences tended to fall on pathways involved in lysosomal signaling and cell-cycle progression. (genomeweb.com)
In cancer, genomic rearrangements can create fusion genes that either combine protein-coding sequences from two different partner genes or place one gene under the control of the promoter of another gene. (biomedcentral.com)
We have tested it on matched RNA-Seq and WGS data for both tumors and cancer cell lines and show that it can be used to validate both new predicted gene fusions and experimentally validated fusion events. (biomedcentral.com)
In cancer, gene fusions occur frequently due to the genetic instability of cancer cells. (biomedcentral.com)
Gene fusions are commonly detected in RNA sequencing (RNA-Seq) data in the form of chimeric fusion transcripts. (biomedcentral.com)
Deformed epidermal autoregulatory factor-1 (DEAF-1) is a transcription factor that was originally shown to bind the autoregulatory enhancer of the Deformed ( Dfd ) Hox gene, which is activated in embryonic head segments of Drosophila (Gross, 1996). (sdbonline.org)
DEAF-1 recognizes several TTCG motifs within the portion of the Dfd autoregulatory region termed 'module E.' In addition, DEAF-1 binds several similar motifs within a Dfd response element ( DRE ) from the 1.28 gene that enhances maxillary gene expression during embryogenesis (Pederson, 2000). (sdbonline.org)
It is well-known in clinics that different oncological subjects respond differently to the same drug, due to the wide number of specific gene sequence of proteins involved in the response to drug therapy. (techscience.com)
Therefore, the aim of the present study was to investigate the gene expression patterns following siRNA‑mediated suppression of RUNX1‑RUNX1T1 and MAPK1 in Kasumi‑1 and SKNO‑1 cells and to determine the differentially expressed genes in enriched biological pathways. (prinsesmaximacentrum.nl)
RUNX1‑RUNX1T1 suppression exerted an anti‑apoptotic effect through the overexpression of BCL2, BIRC3 and CFLAR genes, while MAPK1 suppression induced apopotosis in t(8;21) cells by the apoptotic mitochondrial changes stimulated by the activity of upregulated TP53 and TNFSF10, and downregulated JUN gene. (prinsesmaximacentrum.nl)
Long noncoding RNAs (lncRNAs) play crucial roles in tumorigenesis, and lncRNA taurine-upregulated gene 1 ( TUG1 ) has been proven to be associated with several human cancers. (biomedcentral.com)
The lncRNA taurine-upregulated gene 1 ( TUG1 ) is a nonprotein-coding gene located on chromosome 22q12.2 that transcribes to a 6.7-kilobase-long, spliced, and polyadenylated RNA. (biomedcentral.com)
The capability of these cells to differentiate depends on the stem cell type, the regulation of gene expression by various transcription factors and interaction with the stem cell niche 1,4 . (biolegend.com)
RUNX1 regulates CD4 gene transcription during multiple stages of T cell development and represses the CD4 gene in CD4-CD8- (double negative) T cells. (biolegend.com)
The encoded protein contains two different binding sites that are known to bind DNA and function as a regulator of gene transcription. (biolegend.com)
KMT2A gene consists of 37 exons encoding a 3969 amino-acid nuclear protein with a molecular weight of nearly 431 kDa. (atlasgeneticsoncology.org)
FLNA gene consists of 48 exons encoding a 2647 amino-acid protein with a molecular weight of 280739 Da. (atlasgeneticsoncology.org)
Numerous cellular proteins detect DNA damage and induce senescence , a permanent change of state characterized by morphological and gene expression changes. (massgenomics.org)
An abnormal chromosomal translocation known as t(9;22) results in the establishment of the Philadelphia chromosome, which contains the BCR-ABL gene, culminating in the development of this syndrome ( 1 ). (spandidos-publications.com)
Combined with miRNAs-based transcriptome sequencing assay, it was found that Tanshinone IIA downregulated miR-125b level and upregulated its target gene STARD13 (StAR-related lipid transfer protein 13) level, thus inactivating the miR-125b/STARD13 axis, which had been previously confirmed to promote breast cancer progression. (biomedcentral.com)
This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. (thermofisher.com)
This gene encodes subunit 1 of the splicing factor 3b protein complex. (cancer-genetics.org)

Recent reports based on proteomic studies have identified many SUMOylated substrates that play important roles in the development and progression of cancer. (frontiersin.org)
However, current understanding of the molecular mechanisms underlying the development and progression of AML is limited, and early diagnosis remains difficult, which may lead to treatment delays. (biomedcentral.com)
It is likely that a loss of one or more of these genes plays a role in the early development and progression of bladder cancer. (medlineplus.gov)
In-frame fusions that produce chimeric proteins often drive cancer development and progression via dysregulation of signaling pathways related to the fusion genes. (biomedcentral.com)
Therefore, dysregulation of the angiogenic process has been linked to tumour development and progression [ 1 ]. (hindawi.com)

Furthermore, the Wnt/β-catenin can crosstalk with other signaling pathways including Notch, FGF, Hedgehog, and TGF-β/BMP signaling cascades to form a signaling network to regulate the survival and progression of cancer cells ( 14 - 16 ). (frontiersin.org)
For instance, CSC maintenance in glioblastoma, colon cancer, gastric cancer, and prostate cancer is regulated by CD133-mediated AKT, leucine-rich G-protein-coupled receptor 5 (LGR5)-mediated Wnt/β-catenin and speckle-type POZ protein (SPOP)-mediated Nanog pathways [ 4 - 8 ] . (oaepublish.com)
In contrast, regulation of breast cancer CSCs (BCSCs) occurs by CD44 standard splice isoform (CD44s)-activated platelet-derived growth factor receptor b (PDGFRb)/signal transducer and activator of transcription 3 (STAT3), forkhead box C1 (FOXC1)-activated sonic hedgehog (SHH), and sphingosine-1-phosphate (S1P)/S1PR3-activated NOTCH pathways [ 10 - 13 ] . (oaepublish.com)
1 The BCR-ABL1 fusion protein is a constitutively active tyrosine kinase and triggers a cascade of aberrant downstream signaling pathways leading to clonal outgrowth of CML cells and subsequent disease manifestation. (haematologica.org)
They can act as signalling molecules that regulate a number of life and death pathways in cells, and they are generated by the immune system to fight microbes. (otago.ac.nz)
Prof Hampton's research is focused on how understanding how cells sense and respond to oxidants, and how these pathways might be modulated to prevent and treat human disease. (otago.ac.nz)
Our findings demonstrate that human stem cells have evolved a distinct reliance on several cellular pathways, including increased dependence on genes mediating lysosomal signaling and increased robustness to re-enter cell cycle," senior and co-corresponding author Alex Pollen, a regeneration medicine, stem cell, and neurology researcher with UCSF, said in an email. (genomeweb.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
With the advancement and affordability of new generation sequencing and molecular signaling monitoring, an ever increasing number of cancer pathways are nowadays under scrutiny. (techscience.com)
In their review " Natural and Adaptive Immunity to Cancer ", Vesely and colleagues draw from recent mouse models of cancer and human clinical data to describe how cells, effector molecules, and pathways of the immune system act to suppress and control tumor cells. (massgenomics.org)

Studies in other cancer types have also highlighted ADAMTS14 as a potential player in disease progression , which authors of the current study suggest as a potential novel target in AML. (ajmc.com)
Several lncRNAs are involved in the carcinogenesis, disease progression, or metastasis of human cancers (e.g. (biomedcentral.com)
Poor prognosis (see Table 1): all described patients died either from the disease progression (De Braekeleer et al. (atlasgeneticsoncology.org)
and he died 2 months after diagnosis of disease progression. (atlasgeneticsoncology.org)
a bone marrow transplantation (BMT) 8 months after diagnosis from MUD, but the patient died on day +100 after BMT of disease progression. (atlasgeneticsoncology.org)

We detected all 3 genomic targets: the nucleoprotein, hemagglutinin, and large protein genes. (cdc.gov)
Chromosome 9 likely contains 800 to 900 genes that provide instructions for making proteins. (medlineplus.gov)
Research shows that several genes that control cell growth and division are located on chromosome 9. (medlineplus.gov)
Many of these genes are tumor suppressors, which means they normally help prevent cells from growing and dividing in an uncontrolled way. (medlineplus.gov)
RNA sequencing of the patient's sample showed a significant number of genes upregulated (2539) versus downregulated (252) compared with the control genetic profile-a difference study authors described as "remarkable. (ajmc.com)
The top 8% of upregulated genes shown in RNA sequencing included ADAMTS14 , ARHGAP22 , and EPDR1 , which was also reflected in real-time quantitative polymerase chain reaction (qPCR) results. (ajmc.com)
Novel INDEL and SNP variants were identified, and ARHGAP22 and other genes in its family of proteins may play roles in other cancer types such as melanoma and chronic lymphocytic leukemia. (ajmc.com)
This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. (nih.gov)
Immune cell analysis revealed that the genes in the signature were correlated with B cell, CD4 T cell, CD8 T cell, dendritic cell, macrophage, and neutrophil. (hindawi.com)
In particular, human cells seemed able to withstand the loss of three genes - CDK2, CCNE1, and CDK4 - that are essential to cell cycle function in chimps in pluripotent stem cells and in neural progenitor cells. (genomeweb.com)
DEAF-1 activates the expression of Mtk and Drs promoter-luciferase fusion genes in S2 cells. (sdbonline.org)
According to the bioinformatic analysis result of TUG1 4C sequencing data, 83 candidate genes and their interaction regions were identified. (biomedcentral.com)
Among these candidate genes, CUGBP and Elav-like family member 1 ( CELF1 ) are potential targets of TUG1 in-trans regulation. (biomedcentral.com)
Transcription factors are proteins that regulate the transcription of genes, or the production of mRNA from DNA. (biolegend.com)
The underphosphorylated, active form of Rb interacts directly with E2F1 , leading to cell cycle arrest, while the hyperphosphorylated form decouples from E2F1, thus promoting the transcription of genes promoting entry into the S phase. (biolegend.com)
Genes Chromosomes Cancer 2008(1): 26-33 [ PubMed abstract ]. (lu.se)

Conditional deletion of Mcl-1 depletes a wide variety of cells, including hematopoietic stem cells, B cell-committed progenitors, T cell-committed progenitors, antibody-secreting plasma cells, cardiac muscle cells, and neurons. (wikipedia.org)
DHX15 was highly expressed in hematopoietic stem cells and leukemia cells but was lowly expressed in mature blood cells. (oncotarget.com)
RUNX1-deficient mice fail to generate hematopoietic stem cells. (biolegend.com)

Deletion of Mcl-1 in hepatocytes causes apoptosis and aberrant polyploidization but improves liver regeneration after surgery. (wikipedia.org)
Substantial data have provided convincing evidence establishing that human cancers emerge from cancer stem cells (CSCs), which display self-renewal and are resistant to anticancer drugs, radiation, and apoptosis, and express enhanced epithelial to mesenchymal progression. (oaepublish.com)
In contrast, the restoration of DHX15 expression rescued cell viability and reduced cell apoptosis. (oncotarget.com)
overexpression of DHX15 caused dramatic resistance to ATO-induced cell apoptosis, suggesting an important role for DHX15 in cell apoptosis. (oncotarget.com)
Alternatively, cells that sense injury or loss of mitochondrial integrity may undergo programmed cell death (apoptosis). (massgenomics.org)
AVM induced the release of cleaved PARP and cleaved caspase‑3 caused apoptosis and inhibited the viability of these cells. (spandidos-publications.com)

Aberrantly expressed cytokines in the bone marrow (BM) niche are increasingly recognized as critical mediators of survival and expansion of leukemic stem cells. (haematologica.org)
2 1 There is growing evidence to suggest that primitive CML cells affect the bone marrow (BM) niche, contributing to deregulated cytokine levels. (haematologica.org)
Acute myeloid leukemia (AML) is a heterogenous and hematologic malignant disease which is characterized by infiltration of the bone marrow, blood, and other tissues by proliferative, clonal, abnormally differentiated, and occasionally poorly differentiated cells of the hematopoietic system [ 1 ]. (biomedcentral.com)
Adult acute myeloid leukemia (AML) is a cancer of the blood and bone marrow. (cancer.gov)
Current surveillance strategies for patients with SDS and other leukemia predisposition syndromes rely on monitoring hematologic status by serial peripheral blood counts to identify worsening cytopenias and bone marrow examinations to identify morphologic changes or development of clonal chromosomal abnormalities 11 . (nature.com)
A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy. (genomeweb.com)
The diagnosis of Hairy Cell Leukemia and HCL-like diosrders, including HCL variant (vHCL) and Splenic Diffuse Red Pulp Lymphoma (SDRPL), is based on the examination of the peripheral blood and bone marrow smears allowing the identification of hairy cells and the flow cytometric analysis. (fortuneonline.org)
An accurate diagnosis is necessary given that different clinical management is required: the first step in a definitive diagnosis is based on the examination of the peripheral blood and bone marrow smears allowing the identification of hairy cells and a specific Flow Cytometric Analysis (FCA). (fortuneonline.org)
Chronic myeloid leukemia (CML) is a malignancy of the blood and bone marrow that affects children and adults. (spandidos-publications.com)

Acute myeloid leukemia is a complicated heterogenous hematological cancer with a poor prognosis, but novel targets may lead to improved treatment and outcomes going forward. (ajmc.com)
Patients with acute myeloid leukemia (AML) currently face a poor prognosis and complicated disease classification due to the disease's complex genetic makeup. (ajmc.com)
Methyltransferase-like 3 (METTL3) correlates with the poor prognosis of HCC and promotes the progression of HCC [ 11 ]. (hindawi.com)
Wilms tumor 1-associated protein (WTAP) was investigated to be a poor prognosis factor and contributed to the progression of HCC via the HuR-ETS1-p21/p27 axis [ 14 ]. (hindawi.com)
Survival analysis revealed that a low NRP1 expression in adrenocortical carcinoma (ACC), cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), low-grade glioma (LGG), and stomach adenocarcinoma (STAD) was associated with poor prognosis. (hindawi.com)
A high NRP2 expression in bladder urothelial carcinoma (BLCA), kidney renal papillary cell carcinoma (KIRP), and mesothelioma (MESO) was associated with poor prognosis. (hindawi.com)

The biological importance of activation targets of Nanog, Oct4, SOX-2, and c-Myc in CSCs, which are more frequently overexpressed in poorly differentiated tumors than in well-differentiated tumors, has been shown by correlating signature characteristics of these cells and poor survival [ 3 ] . (oaepublish.com)
Survival of patients with SDS who develop myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) is poor 10 . (nature.com)
Previous studies have juxtaposed and analyzed immune cell compartments between different CCA categorizations such as short or long-term overall survival (OS) [ 16 ]. (springer.com)
Juvenile Myelomonocytic Leukemia (JMML) is an aggressive myeloproliferative neoplasm of childhood with a 5-year event free survival of 52% after hematopoietic stem cell transplantation (HSCT). (ashpublications.org)
In melanoma patients, high RUNX2, but not RUNX3, transcription correlated with a cytotoxic CD8+CD103+CD49a+ TRM cell signature and improved patient survival. (scilifelab.se)
in 2004, the overall 5-year survival rate at all stages was 16.8 % [ 1 ]. (biomedcentral.com)
Rb homeostasis is also essential for self-renewal and survival of human embryonic stem cells 10 . (biolegend.com)
[ 6 ] Additionally, a follow-up study showed significant improvement in 8-year event survival, freedom from progression to accelerated phase or blast phase, and overall survival. (medscape.com)

Abnormally activated Wnt/β-catenin signaling pathway plays a crucial role in promoting malignant tumor occurrence, development, recurrence, and metastasis, particularly in cancer stem cells. (frontiersin.org)
In addition, Wnt/β-catenin has emerged as a critical regulator of cancer stem cells (CSCs), which is considered one of the root causes of cancer recurrence and metastasis because of their heterogeneity and plasticity ( 13 ). (frontiersin.org)
A pro-inflammatory environment is thought to provide a selective advantage for the leukemic stem cells (LSC). (haematologica.org)
Cancer stem cells (CSCs) are thought to the underlying reason for cancer initiation, metastasis, and relapse. (springer.com)
Cancer stem cells (CSCs) represent a small subset of the tumor population and reside at the apex of the hierarchy [ 9 ]. (springer.com)
NEW YORK - A team led by investigators at the University of California, San Francisco has combined loss-of-function screening and comparative genomics to tease out genetic dependencies that distinguish human stem cells from those in nonhuman primates. (genomeweb.com)
Moreover, the team noted that the cell-cycle pathway changes unearthed in the CRISPR-based stem cell screen involved genetic shifts that appeared to be evolutionarily derived in humans relative to the ancestral forms found in chimp and orangutan stem cells. (genomeweb.com)
Stem Cells Transl Med. (uniklinikum-dresden.de)
Stem cells are unique due to their ability to limitlessly self-renew and differentiate into each cell type in the adult body. (biolegend.com)
And a recent study demonstrates that Tanshinone IIA restrains migratory and invasive ability of cervix carcinoma stem cells by suppressing the transcriptional activity of YAP (Yes-associated protein) [ 11 ]. (biomedcentral.com)
A study by Tang et al determined that long-term TKI therapy may reduce the abundance of leukemic stem cells in select patients. (medscape.com)

We aimed to determine the signaling pathway regulating cell metabolism and the mechanism related to the regulation of human tumor-associated macrophages (TAMs) in gastric cancer (GC). (cancerindex.org)
The cancer stem cell (CSC) paradigm emerged from investigating a subpopulation of less-differentiated CD34+/CD38- cells possessing stem cell-like renewal ability and robust malignant-initiating capacity in acute myeloid leukemia (AML) [ 1 ] . (oaepublish.com)
In this work, lycorine hydrochloride (LH) and magnetic iron oxide nanoparticles coated with a colorectal cancer (CRC) cell membrane (LH-Fe3O4@M) were prepared, for homologous targeting, magnetic resonance imaging (MRI), and chemotherapy. (bvsalud.org)
Results showed that the LH-Fe3O4@M and Fe3O4@M intensity at HT29 tumor was significantly higher than that Fe3O4@PEG, proving the superior selectivity of cancer cell membrane-camouflaged nanomedicine for homologous tumors and the MRI effect of darkening contrast enhancement were remarkable at HT29 tumor. (bvsalud.org)
Cell counting kit-8 (CCK-8) and ex vivo experiments were performed to investigate the immunoprotective effects of ginsenoside Rg1 on the anti-cancer function of granulocytes inhibited by NA. (bvsalud.org)
Transcriptome sequencing analysis and qRT-PCR showed that NA elevated the mRNA expression of ARG2, MMP1, S100A4, and RAPSN in granulocytes, thereby reducing the anti-cancer function of granulocytes. (bvsalud.org)
Bladder cancer is a disease in which certain cells in the bladder become abnormal and multiply uncontrollably to form a tumor. (medlineplus.gov)
These chromosomal changes are seen only in cancer cells. (medlineplus.gov)
A rearrangement (translocation) of genetic material between chromosomes 9 and 22 causes a type of cancer of blood-forming cells called chronic myeloid leukemia. (medlineplus.gov)
This slow-growing cancer leads to an overproduction of abnormal white blood cells. (medlineplus.gov)
CD66 and CD49f expressing cells are associated with distinct neoplastic phenotypes and progression in human cervical cancer. (ncbs.res.in)
2017. Oestrogen Receptor-α binds the FOXP3 promoter and modulates regulatory T-cell function in human cervical cancer. . (ncbs.res.in)
A SUV39H1-low chromatin state characterises and promotes migratory properties of cervical cancer cells. (ncbs.res.in)
Earlier this year, a team from the European Cancer Moonshot Lund Center at Lund University published proteomics and corresponding proteogenomic integration studies for malignant melanomas (MM). The twin publications represent an effort to map protein. (cancer.gov)
It is a category that includes many different kinds of cancer and is dominated by renal cell carcinoma. (cancer.gov)
Next-generation sequencing of cancer genomes: back to the future. (wustl.edu)
However, due to their elusive character and differences in identification among different types of cancer, it remains a challenge to study such cells. (springer.com)
Here, we employ a fluorescent reporter system to track and isolate stem-like cancer cells of cholangiocarcinoma cell lines. (springer.com)
The study of this discipline not only is constantly unveiling specific molecular signaling which the onset and progression of cancer can be advocate for, but also offer the tremendous opportunity for a pharmacogenomics-driven specific approach. (techscience.com)
This has resulted in an extraordinary history of clinically actionable benefits to patients-from understandings of HIV-1 infection to auto-immune processes and cancer immunotherapy to name a few. (nature.com)
Sequencing and alignment of this region in 11 cancer cell lines and 4 normal cell lines were also performed, followed by cloning, mutation and luciferase assay analysis. (jcancer.org)
There were three nucleotide variants (T471C/A600G/C862T) frequently detected in cancer cell lines. (jcancer.org)
The site variation rates of T471C/A600G/C862T were 72.7%, 18.2%, and 72.7% in cancer cells respectively. (jcancer.org)
A previous study showed that Sema4D could be a pro-vascular element in cancer ( 1 - 3 ). (jcancer.org)
Sema4D is regulated by HIF-1 and plays a role in tumor-associated macrophage-induced metastatic behavior and is clinically significant in colon cancer ( 9 ). (jcancer.org)
Hypoxia is the most common characteristic in the microenvironment of solid tumors because tumor progression and metastasis depend on the ability of cancer cells to initiate angiogenesis and ensure the delivery of oxygen and nutrients ( 11 , 12 ). (jcancer.org)
We examined the expressions of TUG1 in a cohort of 89 patients with non-small cell lung cancer (NSCLC) to determine the association between TUG1 expression and clinical parameters. (biomedcentral.com)
As a leading cause of cancer-related mortality worldwide, lung cancer has been investigated in numerous molecular genetic studies aimed at developing new treatment strategies [ 1 ]. (biomedcentral.com)
Lung cancer is classified into two types according to biological characteristics: non-small cell lung cancer (NSCLC) (accounting for approximately 85 % of cases), and small cell lung cancer (SCLC) [ 2 ]. (biomedcentral.com)
The Part 1 post in this series is concerned principally with anti-cancer interventions that address the mTOR pathway, a growth pathway also of great interest from the viewpoint of longevity. (anti-agingfirewalls.com)
In vitro mammary spheroid formation, flow cytometry assay on CD24 − /CD44 + sub-population, ALDH activity detection, cell viability assay and western blot analysis, and in vivo tumor-initiating analysis were performed to examine the effects of Tanshinone IIA on the stemness of breast cancer cells. (biomedcentral.com)
Tanshinone IIA attenuated the stemness of breast cancer cells, evident by downregulating the expression of stemness markers, hindering the capacity of spheroid formation, decreasing the CD24 − /CD44 + sub-population in a concentration-dependent manner and reducing the tumor-initiating ability of breast cancer cells. (biomedcentral.com)
Additionally, Tanshinone IIA enhanced adriamycin sensitivity and attenuated adriamycin resistance of breast cancer cells. (biomedcentral.com)
Notably, miR-125b overexpression enhanced the stemness of breast cancer cells, and miR-125b overexpression or STARD13 knockdown impaired the inhibitory effects of Tanshinone IIA on the stemness of breast cancer cells. (biomedcentral.com)
The previous work has shown that Tanshinone IIA could ameliorate inflammation microenvironment in colorectal cancer via repressing miRNA-155 expression ( 8 ) and exert an anti-angiogenic effect in vascular endothelial cells via inhibiting the VEGF/VEGFR2 pathway [ 9 ]. (biomedcentral.com)
The study has previously revealed that miR-125b faciliates cell migratory ability breast cancer via targeting STARD13 (StAR-related lipid transfer protein 13) [ 20 ]. (biomedcentral.com)
Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. (lu.se)
At the end of 2023, researchers at Lund Stem Cell Center received funding amounting to SEK 77.5 million from the Swedish Research Council, the Swedish Cancer Society, and the Swedish Childhood Cancer Fund. (lu.se)
The project funded by Cancerfonden, will focus on using exhaled breath particles as a non-invasive method for diagnosing and monitoring non-small-cell lung cancer. (lu.se)

Proteins associated with the Wnt/β-catenin pathway have been identified as SUMOylated substrates, and evidences suggested that the initiation and progression of cancers depended on the function of the SUMOylation ( 23 ). (frontiersin.org)
See Chronic Leukemias: 4 Cancers to Differentiate, a Critical Images slideshow, to help detect chronic leukemias and determine the specific type present. (medscape.com)

The infection was confirmed by whole-genome RNA sequencing of measles virus from brain tissue. (cdc.gov)
We describe a method for validation of fusion transcripts detected by RNA-Seq in matched whole-genome sequencing (WGS) data. (biomedcentral.com)
Whole-genome sequencing (WGS) has the advantage of being able to detect structural variants at a genomic scale, but it is challenging to assess whether a fusion event found purely at the DNA level has the potential to be processed into a functional transcript. (biomedcentral.com)
Evaluation of In-Hospital Cluster of COVID-19 Associated With a Patient With Prolonged Viral Shedding Using Whole-Genome Sequencing. (cdc.gov)

There is a strong link between neural stem/progenitor cells (NSPCs) and endothelial cells (ECs) [ 7 ]. (hindawi.com)
Early fate decisions in hematopoietic stem and progenitor cells. (lu.se)

2022. Immune profile and responses of a novel Dengue DNA vaccine encoding EDIII-NS1 consensus design based on Indo-African sequences. . (ncbs.res.in)
2022. Snail maintains the stem/progenitor state of skin epithelial cells and carcinomas through the autocrine effect of matricellular protein Mindin. . (ncbs.res.in)
As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. (oncotarget.com)
Clinical lymphoma, myeloma & leukemia 2022 0 0. (cdc.gov)

These signs and symptoms include delayed development, intellectual disability, certain physical abnormalities, and the characteristic features of a genetic condition called Gorlin syndrome (also known as nevoid basal cell carcinoma syndrome). (medlineplus.gov)
AML is a hematological malignancy with a complicated genetic landscape, and previous studies have conducted large-scale genetic sequencing to further understand it. (ajmc.com)
One study stratified AML's genetic alterations into 4 main categories: coding region changes, splice variants, genomic regulatory regions, and non-repetitive sequences. (ajmc.com)
These results mechanistically link leukemia predisposition to germline genetic constraints on cellular fitness, and provide a rational framework for clinical surveillance strategies. (nature.com)
Genetic predisposition to myeloid malignancy comprises a separate disease entity in the WHO classification 1 . (nature.com)

Four months after her initial acute myeloid leukemia diagnosis, the patient received a paternal haploidentical stem cell transplant. (cdc.gov)
Diagnosis of leukemia predisposition provides potential opportunities for early intervention, but data to guide precision medicine approaches to clinical surveillance are lacking. (nature.com)
Based on these data, we tested the hypothesis that rare SETBP1 mutant clones exist at diagnosis in many patients who relapse, and that these rare cells undergo positive selection during treatment. (ashpublications.org)

Chromosome 9 is made up of about 141 million DNA building blocks (base pairs) and represents approximately 4.5 percent of the total DNA in cells. (medlineplus.gov)
9q22.3 microdeletion is a chromosomal change in which a small piece of the long (q) arm of chromosome 9 is deleted in each cell. (medlineplus.gov)
We used circular chromosome conformation capture (4C) coupled with next-generation sequencing to explore the genome regions that interact with TUG1 and the TUG1 -mediated regulation. (biomedcentral.com)

Post-translational modifications (PTMs) of proteins, including phosphorylation, acetylation, ubiquitination, and SUMOylation, can regulate the function of proteins, determine the active state and subcellular location of proteins, and dynamically interact with other proteins related to carcinogenesis and progression ( 17 - 20 ). (frontiersin.org)
Furthermore, we show expression of MSTN by CML mesenchymal stromal cells, and that myostatin propeptide has a direct and instant effect on CML cells, independent of myostatin, by demonstrating binding of myostatin propeptide to the cell surface and increased phosphorylation of STAT5 and SMAD2/3. (haematologica.org)

However, the molecular pathogenesis of the progression of CMML to sAML remains unclear. (biomedcentral.com)
NGI now offers High Molecular Weight (HMW) DNA extraction as a service for sequencing projects at or in collaboration with NGI and SciLifeLab. (scilifelab.se)
Molecular studies are usually needed, particularly in complex cases, including cases with transformation and/or progression. (fortuneonline.org)
CML-466 Asciminib Provides Durable Molecular Responses in Patients With Chronic Myeloid Leukemia in Chronic Phase (CML-CP) With the T315I Mutation: Updated Efficacy and Safety Data From a Phase I Trial. (cdc.gov)

The goals for advances in flow cytometry are clear: measure as many relevant target molecules per cell as quickly as possible. (nature.com)
Fluorescence and isotope tagging are the principal means for measuring antibody binding to cells in flow cytometry. (nature.com)
GEP analyses were performed on highly purified, flow-cytometry sorted tumor-cells from eight subgroups of BCLs. (lu.se)

We sequenced samples on the NovaSeq 6000 system (Illumina, https://www.illumina.com ) using 150-nt paired-end sequencing and aligned them to the MV vaccine complete genome (GenBank accession on. (cdc.gov)
Recovery of Five Complete Influenza A(H1N1)pdm09 Genome Sequences from the 2015 Influenza Outbreak in India by Metagenomic Sequencing. (ncbs.res.in)
2019. Complete assembly of a dengue virus type 3 genome from a recent genotype III clade by metagenomic sequencing of serum. . (ncbs.res.in)
Genome-wide association analysis revealed that the NRP1 expression was strongly associated with kidney renal clear cell carcinoma (KIRC), whereas the NRP2 expression was closely associated with BLCA. (hindawi.com)
Genome-wide single-nucleotide polymorphism analysis in juvenile myelomonocytic leukemia identifies uniparental disomy surrounding the NF1 locus in cases associated with neurofibromatosis but not in cases with mutant RAS or PTPN11. (lu.se)

Macrophages are essential inflammatory cells which regulate the features of immune reactions within tumors. (cancerindex.org)
DETECTing Merkel Cell Polyomavirus in Merkel Tumors. (ncbs.res.in)
B-cell lymphomas (BCLs) constitute a diverse set of tially identify new functional, diagnostic, and therapeutic tumors, both morphologically and clinically, that are mainly targets. (lu.se)

MiRNAs-based transcriptome sequencing and data analysis, online dataset analysis, luciferase reporter assay combined with rescuing experiments were constructed to explore the underlying mechanisms. (biomedcentral.com)
LINE-1 retrotransposons drive human neuronal transcriptome complexity and functional diversification. (lu.se)

[ 4 ] or as a late event in patients previously treated for leukemia. (medscape.com)
Patients can be expected to develop complications secondary to decreased production of functional white blood cells (infection), decreased numbers of red blood cells (anemia), and decreased numbers of platelets (bleeding). (medscape.com)
Therefore, a central goal in clinical care of SDS patients is to identify incipient leukemic transformation and initiate pre-emptive treatment with allogeneic stem cell transplantation. (nature.com)
Analysis of mononuclear cell extracted DNA from serial samples of two patients who relapsed revealed an increase in the SETBP1 mutant allele frequency over time ( Figure 1 ). (ashpublications.org)
DHX15 was down-regulated when AML patients achieved disease remission or when leukemia cell lines were induced to differentiate. (oncotarget.com)
What Do the Elevated Protein Levels Mean in My Patients with Myeloma, Amyloidosis, and Related Disorders? (wustl.edu)
Functional humoral and cellular response of monovalent COVID-19-vaccines against Omicron BA.2 variant of SARS-CoV-2 in patients with chronic lymphocytic leukemia. (cdc.gov)
SARS-CoV-2 Omicron Variant in Patients With Chronic Lymphocytic Leukemia: Case Series. (cdc.gov)
CLL-515 Antibody Responses Against SARS-CoV-2 Variants after Booster Vaccination in Patients With B Cell Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia. (cdc.gov)
A Case Series of SARS-CoV-2 Omicron Variant in Patients With Acute Leukemia. (cdc.gov)
Humoral Responses Against SARS-CoV-2 and Variants of Concern After mRNA Vaccines in Patients With Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia. (cdc.gov)
SARS-CoV-2 Omicron Variant in Patients With Chronic Myeloid Leukemia: A Retrospective Study. (cdc.gov)
Rapid detection of intracellular SH2D1A protein in cytotoxic lymphocytes from patients with X-linked lymphoproliferative disease and their family members. (lu.se)
In addition, patients receiving nilotinib demonstrated a lower rate of progression to the accelerated or blast stage of CML. (medscape.com)

The possible hypoxia response element (HRE) sequences in 5' non-coding Region before ATG start codon of Sema4D were screened, followed by point mutagenesis and luciferase assay analysis. (jcancer.org)

Immunosurveillance , in which transformed cells are identified and destroyed before they can establish malignancy. (massgenomics.org)

In previous research, the authors demonstrated that the methanol extract of A. vulgaris (AVM) has the ability to inhibit the viability of CML cells ( 10 ). (spandidos-publications.com)

Signaling is initiated when the Wnt ligand binds to the Frizzled receptor on the cell membrane and the LDL receptor-associated protein 5/6 (LRP5/6) co-receptor. (frontiersin.org)
Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), as known as OX40 or CD134 is expressed primarily on activated T cells [ 12 ]. (biomedcentral.com)
Interleukin-1 receptor-associated kinase 4 (IRAK4) was the dominant alternatively spliced isoform in MDS and AML and is characterized by a longer isoform that retains exon 4, which encodes IRAK4-long (IRAK4-L), a protein that assembles with the myddosome, results in maximal activation of nuclear factor kappa-light-chain-enhancer of B cells (NF-κB) and is essential for leukaemic cell function. (cancer-genetics.org)

Leukemia & lymphoma 2023 0 0. (cdc.gov)

SUMOylation of proteins is an important mechanism in cellular responses to environmental stress ( 21 , 22 ). (frontiersin.org)
CSCs represent a heterogeneous tumor cell population and lack specific cellular targets, which makes it a great challenge to target and eradicate them. (oaepublish.com)
Single-cell omics provide insight into cellular heterogeneity and function. (nature.com)

In brief, we converted 5 μL of extracted total nucleic acids to complementary DNA and prepared sequencing libraries using the NEBNext RNA ULTRA II kit (New England Biolabs, https://www.neb.com ) according to manufacturer instructions. (cdc.gov)
Both technologies have been primarily focused on measurement of protein epitopes, but have been used to measure nucleic acids such as targeted mRNA 11 , 12 . (nature.com)
Antibodies recognize specific configurations (epitopes, or antigenic determinants) on the surfaces of antigens (eg, proteins, polysaccharides, nucleic acids). (msdmanuals.com)

The SBDS protein promotes formation of the mature, translationally active 80S ribosome by cooperating with the GTPase EFL1 to catalyze the removal of EIF6 from the 60S ribosomal subunit. (nature.com)
In SDS cells, SBDS deficiency impairs eviction of EIF6 from the nascent 60S subunit, resulting in decreased ribosomal subunit joining and reduced translation efficiency 6 . (nature.com)
Knockdown of DHX15 inhibited the nuclear translocation and activation of the NF-kB subunit P65 in leukemia cells. (oncotarget.com)
It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. (thermofisher.com)
The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. (cancer-genetics.org)

MiRNA182 regulates percentage of myeloid and erythroid cells in chronic myeloid leukemia. (ncbs.res.in)

MCL1 has been identified as a resistance factor for BCL-2 inhibitor venetoclax in lymphoma cells. (wikipedia.org)
Leukemia and Lymphoma. (elsevierpure.com)
Splenic marginal zone lymphoma with circulating villous lymphoid cells (SMZL) is a distinct and very different pathological entity since the WHO 2008 classification: it is characterized by an expansion of the splenic white pulp with the infiltration of the red pulp. (fortuneonline.org)
Simultaneous manifestation of fulminant infectious mononucleosis with haemophagocytic syndrome and B-cell lymphoma in X-linked lymphoproliferative disease. (lu.se)
This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). (lu.se)

CDK4 is a member of the Ser/Thr protein kinase family. (thermofisher.com)

Expression of IRAK4-L is mediated by mutant U2 small nuclear RNA auxiliary factor 1 (U2AF1) and is associated with oncogenic signalling in MDS and AML. (cancer-genetics.org)

Note: In August, 2008, the nomenclature of the GA binding protein transcription factors was clarified. (nih.gov)
Transcription factors have an important role in the ability of a cell to self-renew and also differentiate into most cell types, also known as pluripotency 1 . (biolegend.com)

Here, we summarize the different types of epigenetic enzymes which target corresponding protein domains, emphasize DNA methylation , histone modifications, and microRNA-mediated cooperation with epigenetic modification, and highlight recent achievements in developing targets for epigenetic inhibitor therapy. (frontiersin.org)

FOXC1 silencing inhibits the epithelial‑to‑mesenchymal transition of glioma cells: Involvement of β‑catenin signaling. (cancerindex.org)

Moreover, subsequent experiments showed that TUG1 RNA could bind to PRC2 in the promotor region of CELF1 and negatively regulate CELF1 expressions in H520 cells. (biomedcentral.com)

Additionally, characterization of the tumor microenvironment such as interactions with immune cells remain largely unknown. (springer.com)
Characterization of acute myeloid leukemia with PTPN11 mutation: the mutation is closely associated with NPM1 mutation but inversely related to FLT3/ITD. (lu.se)

To identify regulators of primitive chronic myeloid leukemia (CML) cells, we performed a high-content cytokine screen using primary CD34 + CD38 low chronic phase CML cells. (haematologica.org)
Treatment protocols for chronic myelogenous leukemia (CML) are provided below for chronic phase, accelerated phase, and blast phase. (medscape.com)

We then performed metagenomic RNA sequencing as described elsewhere ( 9 ). (cdc.gov)

In summary, we identify myostatin propeptide as a novel positive regulator of primitive CML cells and corresponding normal hematopoietic cells. (haematologica.org)

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm caused by an acquired 9;22-chromosomal translocation in a hematopoietic stem cell (HSC) resulting in the expression of the BCR-ABL1 fusion protein. (haematologica.org)

Studies have shown that the Wnt/β-catenin signaling pathway controls cell fate and function through the transcriptional and post-translational regulation of omics networks. (frontiersin.org)
SUMOylation is a post-translational modification of proteins that has been found to play a major role in the Wnt/β-catenin signaling pathway. (frontiersin.org)

Furthermore, studies have shown HIF-mediated Sema4D induction in the generation of the pro-angiogenic phenotype in oral squamous cell carcinoma (OSCC) and have determined its biological significance for tumor growth and vascularity ( 10 ). (jcancer.org)

Cells already have an array of intrinsic defense mechanisms that halt the transformation process. (massgenomics.org)
There are still other, non-apoptotic paths to cell death (necrosis, autophagy, mitotic catastrophe) that are gaining attention as barriers to transformation. (massgenomics.org)

Anatomy1

Diseases3

Chemicals and Drugs2

Phenomena and Processes1

Differentiation16

Proliferation9

Mutations23

Malignancies5

Acute myeloid l2

Gene34

Development and progression5

Pathways10

Disease progression5

Genes16

Hematopoietic stem3

Apoptosis6

Bone marrow9

Poor prognosis6

Survival8

Stem cells11

Cancer39

Cancers2

Whole-genome4

Progenitor cells2

20224

Genetic5

Diagnosis3

Chromosome3

Phosphorylation2

Molecular4

Flow cytometry3

Genome5

Tumors3

Transcriptome2

Patients14

Assay1

Malignancy1

Inhibit1

Receptor3

20231

Cellular3

Nucleic acids3

Subunit5

Regulates1

Lymphoma5

Kinase1

Oncogenic1

Transcription Factors2

Targets1

Mesenchymal1

Regulate1

Characterization2

Chronic phase2

Metagenomic1

Normal hematopoietic1

Myeloproliferative neoplasm1

Pathway2

Squamous cell carc1

Transformation2