Progression chromosome cell cycle. Medical search. Frequent questions

The 82nd Cold Spring Harbor Symposium focused on Chromosome Segregation & Structure and addressed the enormous progress in our understanding of the nature and behavior of chromosomes during the life cycle of the cell. (cshlpress.com)
Biogenesis of the cell division center is of clear biomedical importance because it regulates the timing of the cell cycle as well as progression through the steps of normal chromosome segregation. (heartland.org)
This maintenance is accomplished through major cell cycle events such as chromosome replication, segregation, and proper timing of cytokinesis. (illinois.edu)
Using a systemic approach, we have identified new communicative processes that keep the onset of chromosome replication and the onset of chromosome segregation highly interconnected. (illinois.edu)
We have shown that a key regulator of chromosome replication can promote segregation independently of chromosome replication. (illinois.edu)
A key regulator of chromosome segregation can also promote the onset of replication independently of chromosome segregation. (illinois.edu)
In eukaryotes, DNA replication is separated in time from chromosome segregation. (rupress.org)
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. (antikoerper-online.de)
The structural maintenance of chromosomes (SMC) proteins form distinct complexes that maintain genome stability during chromosome segregation, homologous recombination, and DNA replication. (uni-koeln.de)
In the course of my postdoctoral work I came to appreciate the beauty and sophistication of the intricate regulatory mechanisms that drive cell cycle progression in general, and chromosome segregation in particular, and I decided to continue this line of research in my own lab. (unt.edu)

Beyond their nutritional impact, clear evidence is beginning to link modifications in chromatin structure induced by butyrate to cell cycle progression, DNA replication and overall chromosome stability. (usda.gov)
This is the process we have studied most intensively, but we are also interested in an alternative process known as break-induced replication (BIR), where only one end of a chromosome break locates a template sequence and assembles a complete replication fork and can copy sequences to the end of a chromosome, producing a nonreciprocal translocation. (brandeis.edu)
however, chromosome replication begins immediately in the daughter cell with the stalk and when the swarmer loses its tail (Stanford). (kenyon.edu)
Throughout the cell cycle, the chromosome progressively goes from being fully methylated to hemimethylated during DNA replication - this results in differential binding of regulatory proteins to activate or repress transcription. (kenyon.edu)
We have found that cell size regulation and timing of chromosome replication are interconnected, a connection that is influenced by nutrient availability. (illinois.edu)
It is well known that the products of chromosome replication are paired to ensure that the sisters segregate away from each other during mitosis. (rupress.org)
For instance, DNA replication and DNA damage checkpoints delay cell cycle progression until each chromosome is fully replicated and physically intact. (rupress.org)
Thus, the products of chromosome replication (sister chromatids) generated during S-phase must be identified over time until mitosis when sisters associate with the mitotic spindle and segregate away from each other into the newly forming daughter cells. (rupress.org)
We applied an assay that measures the stability of maintenance of an episomal plasmid in human tissue culture cells to screen for new DNA replication factors. (aacrjournals.org)
We identify an important role for DDX5 in G 1 -S-phase progression where it directly regulates DNA replication factor expression by promoting the recruitment of RNA polymerase II to E2F-regulated gene promoters. (aacrjournals.org)
DDX5 is required for cell proliferation by controlling the transcription of genes expressing DNA replication proteins in cancer cells in which the DDX5 locus is amplified, and this has uncovered a dependence on DDX5 for cell proliferation. (aacrjournals.org)
Defects in the control of cell proliferation are a hallmark of cancer, and DNA replication is a key process for cell proliferation. (aacrjournals.org)
Understanding how DNA replication is regulated in human cells can provide insight into cancer development and may reveal vulnerabilities that can be exploited therapeutically. (aacrjournals.org)
Germ cells of smc-5-defective animals show reduced proliferation, sensitivity to perturbed replication, chromatin bridge formation, and accumulation of RAD-51 foci that indicate the activation of homologous recombination at DNA double-strand breaks. (uni-koeln.de)

Ki-67 protein plays an essential role in ribosomal RNA transcription and cell proliferation. (biolegend.com)
Butyrate-induced biological effects in bovine cells provide an example of epigenetic regulation and provide a basis for understanding the full range of the biological roles and molecular mechanisms that butyrate may have in animal cell growth, proliferation and energy metabolism. (usda.gov)
Sex steroid receptors (SSRs), which are involved in BC etiology and progression, promote BCSC proliferation, dedifferentiation and migration. (wjgnet.com)
Clinical efficacy was associated with decreased proliferation of immune cells, characterized by nuclear accumulation of cell cycle inhibitors, and preservation of cytoskeletal integrity even in demyelinated axons. (nih.gov)
Our results show a novel role for DDX5 in cancer cell proliferation and suggest DDX5 as a therapeutic target in breast cancer treatment. (aacrjournals.org)
This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. (microarraystation.com)
Our study demonstrates that survivin and APE1/Ref-1 are significantly higher in human prostate cancer specimens compared to noncancerous controls and that APE1/Ref-1 redox-specific inhibition with small molecule inhibitor, APX3330 and a second-generation inhibitor, APX2009, decreases prostate cancer cell proliferation and induces cell cycle arrest. (oncotarget.com)
Because colorectal cancer's migration and invasion are one of main factors to the severity of the disease, exploring the molecular mechanisms of proliferation, migration and invasion of CRC cells will contribute to the development of targeted therapy [ 5 ]. (aging-us.com)
MicroRNAs control the levels of numerous cell cycle regulators that controls cell proliferation. (ukessays.com)
ABSTRACT This study examined haematopoietic stem cells of 19 high-risk cases of myelodysplastic syndrome (MDS) for apoptotic and anti-apoptotic signals and cellular proliferation and correlated these with clinical and cytogenetic subtypes, particularly trisomy 8. (who.int)
or physiological or as a description of key events and processes starting toxic effects that affect cell proliferation. (cdc.gov)

Progression of the mammalian cell cycle is primarily regulated by phosphorylation/dephosphorylation and synthesis/degradation of many key proteins. (bdbiosciences.com)
In mammalian cells the inactivation of these surveillance mechanisms can lead to cancer. (unt.edu)
One vial containing 420 mg of trastuzumab, a humanised IgG1 monoclonal antibody produced by mammalian (Chinese hamster ovary) cell suspension culture and purified by chromatography including specific viral inactivation and removal procedures. (who.int)

S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. (cancerindex.org)
The genome of Caulobacter crescentus is structured in a circular chromosome and is comprised of 4,016,942 bp encoding for 3,767 genes. (kenyon.edu)
Each chromosome harbors essential genes. (rupress.org)
DEAF-1 activates the expression of Mtk and Drs promoter-luciferase fusion genes in S2 cells. (sdbonline.org)
We integrated chromosome 5 genomic copy number and gene expression data to identify key target over expressed genes as a consequence of 5p gain. (columbia.edu)
In humans, the CRYAA gene encodes a 173 amino acid residue protein by single copy genes located on chromosome 21. (molvis.org)
Male-less (mle), a Drosophila protein required in males, for dosage compensation of X chromosome linked genes. (expasy.org)

S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. (cancerindex.org)
It was found that the C . crescentus genome encodes for more two-component signal transduction proteins that assist in cell cycle progression than any other bacterial genome sequenced so far. (kenyon.edu)
Several two-component signal transduction proteins are involved in the cell cycle progression by accumulating at one or both poles "in a spatial and temporal pattern that is reproduced during each cycle" (Jacobs-Wagner 2003). (kenyon.edu)
Lymph accumulates in the tiny spaces between tissue cells and contains proteins, fats, and certain white blood cells known as lymphocytes. (rarediseases.org)
A key feature of prostate cancer progression is the induction and activation of survival proteins, including the Inhibitor of Apoptosis (IAP) family member survivin. (oncotarget.com)
T he presence and activity of various proteins are required in the cell cycle progression. (ukessays.com)
Regulation can occur through modification of the p27 protein's structure, its interaction with other proteins, or its localization within the cell. (medlineplus.gov)

All somatic eukaryotic cells arrest progression through the cell cycle when their DNA is damaged, presumably because optimal repair of the damage would be a mechanistic challenge if the cell continued to replicate DNA or segregate chromosomes. (the-scientist.com)
The data indicate that a spindle checkpoint, providing surveillance of misaligned chromosomes, was overridden or compromised by the incompatibility between somatic chromosomes and meiotic spindles during the first meiotic division. (ox.ac.uk)

The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. (antikoerper-online.de)
Interactions of the meiotic spindle with mitotic chromosomes in GV mouse oocytes. (ox.ac.uk)
During mitosis, a spindle checkpoint detects chromosome misalignment and halts the cell cycle progression. (ox.ac.uk)
This research employed a unique model in the mouse, mitotic chromosomes transferred to meiotic cytoplasts to investigate whether a meiotic oocyte's microtubule apparatus can effectively separate mitotic metaphase chromosomes, and whether a spindle checkpoint exists during its division. (ox.ac.uk)
The spindle formation and polar body extrusion suggest that the first meiotic spindle was functional, and the chromosome misalignment did not prevent the onset of anaphase. (ox.ac.uk)

Shugoshin-2 is essential for the completion of meiosis but not for mitotic cell division in mice. (nature.com)

Caulobacter crescentus is a single-celled, small bacterium that divides asymmetrically producing cells that differ in structure and function - it is an ideal model system for the mechanisms of asymmetric cell division and has been studied thoroughly. (kenyon.edu)

Let-7 Let-7 has an essential role in cell cycle and the differentiation of cell cycle terminals. (ukessays.com)
therefore, definitive differentiation of Hürthle cell carcinoma from Hürthle-cell adenoma is based on vascular invasion and/or capsular invasion, as well as on permanent histologic sections or extrathyroidal tumor spread and lymph node and systemic metastases. (medscape.com)
Studies suggest that p27 is also involved in controlling cell differentiation, which is the process by which cells mature to carry out specific functions. (medlineplus.gov)

Within cells, p27 is located primarily in the nucleus, where it plays a critical role in controlling cell growth and division. (medlineplus.gov)
For example, when p27 is held (sequestered) in the fluid that surrounds the nucleus (the cytoplasm) instead of being transported into the nucleus, the protein is unavailable to block cell cycle progression. (medlineplus.gov)
All of these mutations reduce the amount of functional p27 that is available in the nucleus to regulate the cell cycle. (medlineplus.gov)

It also directly binds to BubR1, a kinetochore-associated kinase implicated in the mitotic checkpoint, the major cell cycle control pathway in which unattached kinetochores prevent anaphase onset. (rupress.org)

consequently cells have evolved a variety of mechanisms to repair double-strand breaks (DSBs). (brandeis.edu)
Thus, we must rely on the elegant mechanisms our cells have developed to repair damage. (the-scientist.com)
Single-strand breaks are easily fixed, but double-strand breaks require the complex mechanisms of nonhomologous end-joining and homologous recombination, the latter only being useful in late S, G 2 or M phases of the cell cycle, when homologous chromosomes are present in the cell. (the-scientist.com)
3 Such cellular-suicide mechanisms can eliminate cells that could present problems for the whole organism because of alterations in the DNA or difficulties in dealing with stressful stimuli. (the-scientist.com)
In order to analyze the cell cycle regulatory mechanisms and other mechanisms of Caulobacter , many mutant strains have been made and studied. (kenyon.edu)
In particular we are interested in regulatory pathways that drive cell division and in surveillance mechanisms, also known as checkpoint pathways, that stop cell cycle progression when cellular components malfunction or become damaged. (unt.edu)
Human T-lymphotropic virus 1 (HTLV-1) infected individuals remain as asymptomatic carriers (ACs) or can develop the chronic neurological disorder HTLV-1-associated myelopathy/Tropical Spastic Paraparesis (HAM/TSP) or the adult T-cell leukemia/lymphoma (ATLL), and the immunological mechanisms involved in this pathologies need to be elucidated. (bvsalud.org)
In contrast to its normal counterparts, the initiated cell can escape from cellular control mechanisms when responding to external or intercellular signals 5 . (bvsalud.org)

Recombination between homologous sequences is a fundamentally important process both in meiosis and in mitotic cells. (brandeis.edu)

Regulation of gene expression gives control over the timing, location, and amount of a given gene product (protein or ncRNA) present in a cell and can have a profound effect on the cellular structure and function. (wikipedia.org)
Thus, our results identify an unexpected function of SGO2 in mitotically dividing cells and a mechanism of separase regulation that is independent of securin but still supervised by the SAC. (nature.com)
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. (cancerindex.org)
We have shown that this regulation involves the action of a small Recombination Enhancer (RE) sequence that enables a donor on the left chromosome arm to recombine preferentially in MATa cells. (brandeis.edu)
This is interesting because the molecular factors responsible for regulating cell size in bacteria and the mechanism that coordinate cell size regulation with the progression of the cell cycle remain unclear. (illinois.edu)
We are currently working out the molecular network that links cell shape regulation and ability to resist toxic compounds. (illinois.edu)
Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (affbiotech.cn)
1) The regulation of these protein levels is vital for the understanding of the cell cycle control and its dysregulation. (ukessays.com)
1) For example, the down-regulation of miR15s and miR - 16 - 1 in chronic lymphocytic leukaemia, prostate cancer and pituitary tumours, leading to the inhibition of tumour growth and induce cell cycle arrest at the G 1 - phase by target cell cycle regulators ( cyclin D1, cyclin E1, cyclin D3 and CDK6). (ukessays.com)
Main focus: Cell cycle regulation in budding yeast. (unt.edu)
My lab works on cell cycle regulation in budding yeast. (unt.edu)

High-risk types (e.g., types 16 and 18) can cause low-grade cervical cell abnormalities, high-grade cervical cell abnormalities that are precursors to cancer, and cancers ( 5 - 7 ). (cdc.gov)
It is rare to find such a wide-ranging perspective on this topic in one volume and this collection of papers will be valuable to investigators interested in many aspects of cell biology, genetics, and cancer. (cshlpress.com)
GTF2IRD1 overexpression promotes tumor progression and correlates with less CD8+ T cells infiltration in pancreatic cancer. (nih.gov)
In this study, by comparing the activity of normal cell lines and cancer cell lines after treating with resveratrol, it was found that resveratrol has more significant cytotoxicity in cancer cell lines. (mdpi.com)
Resveratrol could play a toxic role through inducing apoptosis of the cancer cell in a time- and concentration-dependent manner. (mdpi.com)
Gain of short arm of chromosome 5 (5p) is the most frequent karyotypic change in CC. Methods: To examine the role of 5p gain, we performed a combination of single nucleotide polymorphism (SNP) array, fluorescence in situ hybridization (FISH), and gene expression analyses on invasive cancer and in various stages of CC progression. (columbia.edu)
We find that the DDX5 locus is frequently amplified in breast cancer and that breast cancer-derived cells with amplification of DDX5 are much more sensitive to its depletion than breast cancer cells and a breast epithelial cell line that lacks DDX5 amplification. (aacrjournals.org)
Given the high frequency of DDX5 amplification in breast cancer, our results highlight DDX5 as a promising candidate for targeted therapy of breast tumors with DDX5 amplification, and indeed we show that DDX5 inhibition sensitizes a subset of breast cancer cells to trastuzumab. (aacrjournals.org)
Mantle cell lymphoma (MCL) is a type of non-Hodgkin's lymphoma, which is a form of cancer that affects the lymphatic system. (rarediseases.org)
The first-line treatment typically includes chemotherapy combined with immunotherapy, which is a combination of medications that destroy the cancer cells. (rarediseases.org)
Following that, patients may be eligible for a stem cell transplant, and/or an extended course of immunotherapy that is meant to prolong cancer remission. (rarediseases.org)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Because APE1/Ref-1 is expressed and elevated in prostate cancer, we sought to characterize APE1/Ref-1 expression and activity in human prostate cancer cell lines and determine the effect of selective reduction-oxidation (redox) function inhibition on prostate cancer cells in vitro and in vivo . (oncotarget.com)
Due to the role of oncogenic transcriptional activators NFĸB and STAT3 in survivin protein expression, and APE1/Ref-1 redox activity regulating their transcriptional activity, we assessed selective inhibition of APE1/Ref-1's redox function as a novel method to halt prostate cancer cell growth and survival. (oncotarget.com)
Liu Y , Sun M , Zhang B , Zhao W , . KIF18A improves migration and invasion of colorectal cancer (CRC) cells through inhibiting PTEN signaling. (aging-us.com)
The study is designed to investigate the effect and molecular mechanism of KIF18A on the progression of colorectal cancer. (aging-us.com)
PTEN (phosphatase and tensin homolog deleted on chromosome 10) belongs to a cancer suppressor gene (one of the protein phosphatases). (aging-us.com)
BACKGROUND: Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that causes severe diseases, such as aggressive cancer or progressive neurological disease. (bvsalud.org)
Hürthle cell carcinoma of the thyroid gland is an unusual and relatively rare type of differentiated thyroid cancer. (medscape.com)
Cancer Lett, 300:215-224.doi:10.1016/j. squamous cell carcinoma in north-eastern Iran. (who.int)
99:209 -215.doi:10.1007/s11060 - 010 - 0129 -5 cell carcinoma-a population-based study in with and without cervical cancer in Tbilisi, Georgia. (who.int)
Three steps are described in the development of cancer namely initiation, promotion and progression. (bvsalud.org)

This gene may play a role in tumor development and progression. (antikoerper-online.de)
Small RNAs (sRNAs) are epigenetic regulators of essential biological processes associated with the development and progression of leukemias, including adult T-cell leukemia/lymphoma (ATLL) caused by human T-cell lymphotropic virus type 1 (HTLV-1), an oncogenic human retrovirus originally discovered in a patient with adult T-cell leukemia/lymphoma. (bvsalud.org)

For optimal responses, DNA repair must coordinate with other cellular processes, such as cell-cycle progression and programmed cell death. (the-scientist.com)
For example, neuronal cell death after stroke or in several neurodegenerative disorders likely occurs via programmed cell death responding to cellular stress signals. (the-scientist.com)
We combine bacterial genetics, biochemistry, and high-resolution imaging in order to examine the progression of the cell cycle at the molecular and cellular level. (illinois.edu)
[ 2 ] Oncocytic cells in the thyroid are often called Hürthle cells, and oncocytic change is defined as cellular enlargement characterized by an abundant eosinophilic granular cytoplasm as a result of accumulation of altered mitochondria. (medscape.com)
Unlike DNA, which is usually present as a single copy per cell, or mRNAs, which constitute the minor population of total cellular RNA, each bacterium contains hundreds to thousands of 16S rRNA molecules during the growth phase. (cdc.gov)

PTEN can inhibit cell cycle progression and induce cell death to stimulate angiogenesis [ 6 ]. (aging-us.com)

In addition cells have evolved a damage-sensing checkpoint system whereby the cells delay entry into mitosis until the break has been repaired. (brandeis.edu)
The G 2 gap phase further separates S-phase from mitosis, allowing for continued cell growth and maturation before cell division. (rupress.org)

Module analysis revealed that TAD was associated with significant pathways including cell cycle, vascular smooth muscle contraction, and adrenergic signaling in cardiomyocytes. (hindawi.com)

The intact germinal vesicle (GV) oocytes, enucleated GV cytoplasts, and enucleated GV cytoplasts at 15 h in-vitro maturation were transferred with a metaphase fibroblast cell. (ox.ac.uk)

Using synchronized cells undergoing recombination that is initiated at a specific site on a chromosome by an inducible endonuclease, we use physical monitoring techniques (Southern blots, PCR analysis) to follow the sequence of molecular events that occur in real time. (brandeis.edu)
Mark Alliegro, Ph.D., is a cell biologist with a background in biochemistry and molecular biology. (heartland.org)
As such, targeting the molecular networks involved in coordinating cell cycle events in bacteria represents an attractive target for antibiotic development. (illinois.edu)
We are interested in figuring out how bacteria integrate information from the environment into the molecular networks that drive the forward progression of the cell cycle. (illinois.edu)
Wang ZY, Qiu QQ, Seufert W. Molecular cloning of the cDNA and chromosome localization of the gene for human ubiquitin-conjugating enzyme 9. (bdbiosciences.com)

Overexpression of DEAF-1 by using a maternal driver inhibits germ-band retraction and causes defects in dorsal closure, whereas overexpression at later stages causes cell death (Reed, 2008). (sdbonline.org)

In meiosis of female germ cells, however, it is debatable whether such a checkpoint is present. (ox.ac.uk)

and Germ Cells. (cshlpress.com)

[ 5 ] The 2022 WHO classification of endocrine tumors has replaced the term Hürthle cell carcinoma with oncocytic carcinoma. (medscape.com)

We have been fascinated by the process of yeast mating-type gene switching, in which cells replace about 700 bp of Ya or Y-specific DNA sequences at the MAT locus by recombining with one of two donor loci, called HMLDescription: image3 and HMRa. (brandeis.edu)
A yeast cell cycle pulse generator model shows consistency with multiple oscillatory and checkpoint mutant datasets. (duke.edu)
Our results suggest that budding yeast has become dependent on G1 cyclin specificity to couple cell cycle progression to essential morphogenetic events. (crick.ac.uk)
Yeast CHL1 (or CTF1), which is important for chromosome transmission and normal cell cycle progression in G(2)/M. (expasy.org)

2 Cell-cycle arrest occurs at multiple stages: G 1 , S, and G 2 /M. (the-scientist.com)

Oral administration of reversible CRM1 inhibitors in preclinical murine models of demyelination significantly attenuated disease progression, even when started after the onset of paralysis. (nih.gov)

However, none of the reconstructed oocytes showed complete and accurate alignment of chromosomes, except the enucleated GV cytoplasts reconstructed after maturation. (ox.ac.uk)

Therefore, targeting drugs molecules in the PTEN signaling pathway may be another strategy to suppress tumor cells by inhibiting tumor activity [ 7 , 8 ]. (aging-us.com)
they are not inherited and are present only in tumor cells. (medlineplus.gov)

Promoting PTEN expression in CRC cell lines will stop the activation of the phosphatidylinositol-3-kinase ( PI3K )/sinkserine/threonine kinase ( Akt ) signaling pathway, which affects CRC cell growth, promotes apoptosis, and improves sensitivity to targeted therapy, immunotherapy, and conventional therapy. (aging-us.com)

To this end we have expressed the site-specific HO endonuclease in meiotic cells so that we can compare recombination events at the same loci where we have used HO to stimulate recombination in mitotic cells. (brandeis.edu)

Biotech Europe GmbH, Freiburg, Germa- cation of the virus in cells heterozygous for ny) was used to extract genomic DNA the mutation proceeded at an intermediate from white blood cells following the lysis rate [ 5 ]. (who.int)

Ki-67 is strongly expressed in proliferating cells and has been reported as a prognostic marker in various tumors. (biolegend.com)

Low-risk types (e.g., types 6 and 11) can cause benign or low-grade cervical cell changes, genital warts, and recurrent respiratory papillomatosis ( 4 ). (cdc.gov)
oxidation modification of the genetic material may also participate in the progression of benign to malignant neoplasms. (bvsalud.org)

Mantle cell lymphoma (MCL) is a lymphoproliferative disorder derived from a subset of naive pregerminal center cells localized in primary follicles or in the mantle region of secondary follicles. (medscape.com)
Mantle cell lymphoma (MCL) is recognized in the Revised European-American Lymphoma and World Health Organization classifications as a distinct clinicopathologic entity. (medscape.com)
Mantle cell lymphoma belongs to a group of diseases known as non-Hodgkin's lymphomas, which are related malignancies (cancers) that affect the lymphatic system. (rarediseases.org)

Description: A competitive ELISA for quantitative measurement of Human Anti centriole and centrosome antibody IgG in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (microarraystation.com)
Description: A competitive ELISA for quantitative measurement of Canine True insulin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (microarraystation.com)

Most cases of MCL are associated with chromosome translocation t(11;14)(q13;q32). (medscape.com)
This translocation involves the immunoglobulin heavy-chain gene on chromosome 14 and the BCL1 locus on chromosome 11. (medscape.com)

The latter mechanism facilitates a considerable degree of sister chromatid separation in securin-knockout cells that lack APC/C activity. (nature.com)
Caulobacter also uses DNA methylation as a regulatory mechanism in cell cycle progression. (kenyon.edu)

Here a DSB at the MAT locus is created by a site specific HO endonuclease, which we can induce synchronously in a large population of cells. (brandeis.edu)
We previously localized a Quantitative Trait Locus for HPFH in an extensive Asian-Indian kindred to chromosome 6q23. (biomedcentral.com)

MCL is a B-cell lymphoma that develops from malignant B-lymphocytes within a region of the lymph node known as the mantle zone. (rarediseases.org)
Permissive histologic interpretation may result in the designation of some non-neoplastic Hürthle cell lesions as malignant tumors. (medscape.com)

He is interested in the genesis of the cell division center (the centrosome in animal cells and its functional equivalents in others), both in the living cell and from an evolutionary standpoint. (heartland.org)
Functional annotation clustering showed that they belong to cell cycle, organelle or nuclear lumen, protein transport, and DNA binding and repair clusters. (molvis.org)
Cells with a shortage of functional p27 can divide too quickly or in an uncontrolled way, forming a tumor. (medlineplus.gov)
Like the mutations that cause multiple endocrine neoplasia type 4, these genetic changes reduce the amount of functional p27 available to control cell division. (medlineplus.gov)

Mistakes in this essential coordination of events can be lethal for the survival of the cell. (illinois.edu)
These bone metastases produce osteoblastic lesions that are associated with high morbidity and high mortality [ 8 ] and attempts at delaying this tumor progression with chemotherapeutic agents have only prolonged survival a few months. (oncotarget.com)
Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress. (affbiotech.cn)

This protein is found in cells and tissues throughout the body. (medlineplus.gov)

The nuclear protein Ki-67 was first identified by the monoclonal antibody Ki-67, which was generated by immunizing mice with nuclei of the L428 Hodgkin lymphoma cell line. (biolegend.com)
it was frequently categorized as diffuse small-cleaved cell lymphoma (by the International Working Formulation) or centrocytic lymphoma (by the Kiel classification). (medscape.com)

5 Conversely, p53 induction by oxidative damage may help reduce the development of atherosclerosis, perhaps by suppressing the growth or enhancing the death of cells involved in causing atherosclerotic lesions. (the-scientist.com)

[ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)

At the same time, many of the processes that drive cell cycle progression are conserved throughout evolution. (unt.edu)

J Cell Biol (2005) 169 (6): 841-846. (rupress.org)
J Cell Biol (2003) 162 (4): 551-563. (rupress.org)

Two models have been put forward for cyclin-dependent kinase (Cdk) control of the cell cycle. (crick.ac.uk)

Low levels of pyruvate induced by a positive feedback loop protects cholangiocarcinoma cells from apoptosis. (cancerindex.org)

Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. (cancerindex.org)

Full length human recombinant protein of human S100A9 produced in SF9 cell. (thermofisher.com)
The parasite intraerythrocytic cycle and human circadian cycle are coupled during malaria infection. (duke.edu)
The S100B Elisa reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (microarraystation.com)
Recently, it has been demonstrated that induced or naturally developed IgG repertoires obtained from different groups of donors, grouped by immune status, can modulate human T and B cell functions. (bvsalud.org)
Here we aimed to evaluate if the IgG obtained from HTLV-1-infected ACs, HAM/TSP, and ATLL patients can differentially modulate the production of cytokines by human T and B cells. (bvsalud.org)
Human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropic spastic paraparesis (HAM/TSP) is an insidiously progressive spinal cord disease for which there is no effective treatment. (bvsalud.org)

A single cyclin can also replace all G1 cyclins to support ordered cell cycle progression, fulfilling key predictions of the quantitative model. (crick.ac.uk)

Despite the apparently simple Mendelian inheritance of α- and β-thalassemia and sickle cell disease (SCD), a significant variation in clinical severity is observed. (biomedcentral.com)
Obviously, this factor has a major impact in interpreting the natural history of this disease and adds to the controversy about the aggressiveness of Hürthle cell carcinoma. (medscape.com)

When mitotic chromosomes were transferred into enucleated or intact mouse GV oocytes, the first bipolar meiotic spindles were established and the reconstructed oocytes were able to extrude polar bodies. (ox.ac.uk)

A key issue is how cells pair sister chromatids but preclude the catastrophic pairing of nonsister chromatids. (rupress.org)

Anatomy61

Organisms10

Diseases21

Chemicals and Drugs59

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes142

Disciplines and Occupations1

Information Science3

Segregation10

Replication14

Proliferation11

Mammalian3

Genes7

Proteins7

Somatic2

Spindle5

Mitotic cell1

Asymmetric Cell Div1

Differentiation3

Nucleus3

Anaphase1

Mechanisms8

Homologous1

Regulation11

Cancer22

Development and progression2

Cellular5

Induce cell1

Mitosis2

Pathways1

Vitro1

Molecular5

Overexpression1

Meiosis1

Germ Cells1

20221

Yeast4

Arrest1

Onset1

Maturation1

Tumor cells2

Promotes1

Recombination1

Genomic1

Prognostic marker1

Benign2

Mantle Cell Lym3

Biological2

Translocation2

Mechanism2

Locus2

Malignant2

Functional4

Survival3

Protein is found1

Lymphoma2

Lesions1

Inhibitors1

Processes1

Biol2

Kinase1

Apoptosis1

Transcription1

Human6

Quantitative1

Disease2

Meiotic1

Sister chromatids1