Cell AgingCell CycleDisease ProgressionCell Cycle ProteinsCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p21Telomerebeta-GalactosidaseTumor Suppressor Protein p53Aging, PrematureCell ProliferationTelomeraseCell Cycle CheckpointsCells, CulturedRetinoblastoma ProteinApoptosisCell Line, TumorBiological ProcessesDNA DamageAgingCell DivisionSignal TransductionFibroblastsG1 PhaseTelomere ShorteningMitosisS PhaseTime FactorsCyclinsOxidative StressCell LineReactive Oxygen SpeciesGene Expression RegulationPhosphorylationDNA-Binding ProteinsDown-RegulationBlotting, WesternFlow CytometryRNA, Small InterferingGene Expression Regulation, NeoplasticRNA InterferenceUp-RegulationEndothelial CellsPhenotypeG2 PhaseRNA, MessengerCyclin-Dependent Kinase Inhibitor p27HistonesCell DifferentiationReverse Transcriptase Polymerase Chain ReactionTOR Serine-Threonine KinasesTransfectionProtein-Serine-Threonine KinasesImmunohistochemistryG2 Phase Cell Cycle CheckpointsMenstrual CycleTumor Suppressor ProteinsMice, Inbred C57BLStem CellsMutationNuclear ProteinsMice, KnockoutMolecular Sequence DataCyclin-Dependent Kinase 2Cyclin D1Dose-Response Relationship, DrugTranscription FactorsModels, BiologicalCDC2 Protein KinaseG0 PhaseDNA ReplicationCyclin ECyclin-Dependent Kinase 4G1 Phase Cell Cycle CheckpointsCell Transformation, NeoplasticEnzyme Activationp38 Mitogen-Activated Protein KinasesTumor Cells, CulturedCyclin ABiological MarkersGenes, cdcCell NucleusCyclin BPlant LeavesGene Expression ProfilingBase SequenceCell SurvivalInterphaseAtherosclerosisEndothelium, VascularTranscription, GeneticHeLa CellsCDC2-CDC28 KinasesE2F Transcription FactorsNeoplasmsAntineoplastic AgentsAmino Acid SequenceDNAcdc25 PhosphatasesCyclin B1