E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates (PubMed:10373495, PubMed:16772533, PubMed:19204938, PubMed:19233847, PubMed:19325566, PubMed:19591933, PubMed:22645313, PubMed:24273172, PubMed:24728990). (icr.ac.uk)
E6-AP) is an important member of the ubiquitin proteasome system and a type of ubiquitin protein ligase (E3 enzyme) ( 6 ). (spandidos-publications.com)
ANXA31
Overexpression of Annexin A3 (ANXA3) increased the proportion of CD133 + cells, enhancing their tumorigenicity. (stemcellsciencenews.com)
ELISA Kit2
Description: A sandwich ELISA kit for detection of Annexin A7 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (scalegen.com)
Description: Quantitativesandwich ELISA kit for measuring Mouse Annexin A7 (ANXA7) in samples from serum, plasma, tissue homogenates. (scalegen.com)
Since externalization of PS occurs in the earlier stages of apoptosis, APC Annexin V staining can identify apoptosis at an earlier stage than assays based on nuclear changes such as DNA fragmentation. (aatbio.com)
Tumor4
It also plays a potential role in intercellular communication during tumor progression and metastasis. (wikipedia.org)
In patients with colon cancer, annexin A5 expression in cancer tissues is related to lymph node metastasis and tumor grade. (cusabio.com)
Ma, S. Lineage tracing and single-cell analysis reveal proliferative Prom1+ tumor-propagating cells and their dynamic cellular transition during liver cancer progression. (edu.hk)
Tumor microenvironment (TME) remodeling is a critical process in primary tumor progression. (nature.com)
ANXA21
We identified annexin A2 (ANXA2), N-myc downstream regulated gene 1 (NDRG1) and signal transducer and activator of transcription 1 (STAT1) as biomarkers of LACC patients' responsiveness to CRT. (biomedcentral.com)
Conjugate1
Add 200 µL PBS with 0.2% BSA into the vial of APC-Annexin V conjugate (Component A) and mix well to make 100X APC-Annexin V stock solution. (aatbio.com)
Overexpression1
Therefore is a unique marker to detect colorectal carcinomas in which overexpression have been associated with carcinogenesis, malignant potential, and progression. (neuromics.com)
Survival2
Univariate Cox regression analysis showed that Annexin A2 and S100A10 in stromal tissue correlated with shorter overall survival (OS). (cancerindex.org)
The E3 ubiquitin ligase RAD18 is well known for the maintenance of genome stability and cell survival through many DNA damage response (DDR) pathways such as translesion DNA synthesis (TLS) and homologous recombination repair (HRR) [ 4 , 5 ]. (nature.com)
Annexin A2 and S100A10 as Candidate Prognostic Markers in Epithelial Ovarian Cancer. (cancerindex.org)
The aim of this study was to examine whether Annexin A2 and S100A10 expression can be used as prognostic markers for epithelial ovarian cancer (EOC). (cancerindex.org)
Multivariate Cox regression analysis demonstrated no independent prognostic significance of stromal Annexin A2 expression. (cancerindex.org)
Lymphoma2
Also, we propose two new targets of therapy (WG2-T1), which are TCL1 and Annexin A4, respectively involved in lymphoma development and drug resistance to paclitaxel in lung cancer cells. (mutalig.eu)
In addition, numerous important cellular proteins, such as B-cell lymphoma-2 homologous antagonist/killer, Myc proto-oncogene protein, cyclin-dependent kinase inhibitor 1B, DNA replication licensing factor MCM-7, retinoblastoma 1 and Annexin A1, are degenerated through the UBE3A-mediated ubiquitin proteasome pathway ( 7 ). (spandidos-publications.com)
Tissues1
Periapical lesions are diseases resulting from contamination and necrosis of dental pulp and the progression of this infection toward the periapical tissues. (bvsalud.org)
Antibody1
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Annexin A7 (ANXA7) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (scalegen.com)
Protein1
The study shows that a plasma protein Annexin A5 decreases inflammation and modulates immune reactions to modified LDL, which creates a protective effect. (ki.se)
ANXA4 can also interact with other annexin proteins or cytoskeletal proteins, potentially contributing to its diverse cellular functions. (creativebiomart.net)
Epithelial1
Proliferation of telomerase pre malignant cells leads to telomere dysfunction and elevated genomic instability suggesting a single possi ble sequence of occasions resulting in immortalization of breast epithelial cells throughout cancer progression. (hsp70inhibitor.com)
Biotech1
Annexin Pharmaceuticals is a public clinical stage biotech company advancing a first in class biologic with a broad therapeutic potential, ANXV (a recombinant human Annexin A5). (ois.net)
Enzyme1
Disruption of normal PKB/Akt signaling has now been documented as a frequent occurrence in several human cancers and the enzyme appears to play an important role in their progression (Nicholson and Anderson, Cellular Signalling 14, 381, 2002). (justia.com)
Human2
Their role in human disease is well known for TCL1 and emerging for Annexin A4. (mutalig.eu)
Microbial infection) Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. (icr.ac.uk)
Inflammatory1
Studying the inflammatory process and immune reactions directly in cells from people with cardiovascular disease is a unique opportunity to discover the causes and new mechanisms behind the disease's progression. (ki.se)
Cellular1
S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. (cancerindex.org)
Membrane3
6. Fhit delocalizes annexin a4 from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel. (mutalig.eu)
APC Annexin V staining precedes the loss of membrane integrity which accompanies the latest stages of cell death resulting from either apoptotic or necrotic processes. (aatbio.com)
Annexin V flow cytometric analysis on adherent cells is not routinely tested since specific membrane damage may occur during cell detachment or harvesting. (aatbio.com)
Severe1
It is generally accepted that uncontrolled systemic inflammation is the hallmark of severe sepsis and the main contributor for the progression of organ dysfunction and death [ 2 ]. (springeropen.com)
Our previous study showed that it plays an essential role in the progression of multiple tumors. (nature.com)
Cancer1
Baicalein inhibits progression of gallbladder cancer cells by downregulating ZFX. (curehunter.com)
Potential1
Thus, we propose that the detected AAbs provide further insight into AMD pathogenesis and have the potential to contribute to disease biogenesis and progression. (duke.edu)
Shown1
We have shown that Annexin 5 is a possible new therapy for fighting inflammation and supports the immune defence system is a positive way. (ki.se)
Programmed cell1
Alpha v beta 5 integrin-dependent programmed cell death triggered by a peptide mimic of annexin V". Mol. (wikipedia.org)
Flow1
Monitor the fluorescence intensity of APC-Annexin V using a flow cytometer with 660/20 nm filter (APC channel). (aatbio.com)