Prognostic significance serum carcinoembryonic antigen. Medical search. Frequent questions

Prognostic biomarkers can estimate the natural course of the disease and divide the tumor into two groups: good prognosis and poor prognosis [ 3 , 4 ]. (hindawi.com)
Compared with the clinical monitoring techniques of Computed tomography (CT), Positron emission tomography computed tomography (PET-CT), and specific biomarkers, the detection of serum tumor markers was more simple, rapid and less invasive and has important clinical application value[ 6 - 9 ]. (ijpsonline.com)
The identification of putative prognostic factors in canine mammary neoplasms (CMNs) has been focused on tissue-specific biomarkers, but the serum biomarkers, including cancer antigen 15-3 (CA 15-3), c-reactive protein (CRP), and lactate dehydrogenase (LDH) have been demonstrated to display clinical application in cases of CMNs. (scielo.br)
The aim of the study was to evaluate the levels of these serum biomarkers and their association with well-established prognostic factors in CMNs. (scielo.br)
The objective of this study was to evaluate potential correlations between VS good and poor classifications, outcomes, and circulating biomarkers implicated in tumor progression and treatment resistance in pretreatment sera collected from advanced NSCLC patients treated with second line cytotoxic chemotherapy or erlotinib. (biomedcentral.com)
However, only a few systematic reviews emphasize the most relevant miRs able to contribute to the establishment of new prognostic biomarkers in CRC patients. (biorxiv.org)
Specific tissue miRs are shown to be promising prognostic biomarkers in patients with CRC, given their strong association with the prognostic aspects of these tumors, however, new studies are necessary to establish the sensibility and specificity of the miRs in order to use them in clinical practice. (biorxiv.org)
And the comparison between postoperative ePD-L1 and conventional serum biomarkers (carcinoembryonic antigen (CEA), cancer antigen 19-9 (CA19-9) and CA72-4) in prognostic of GC patients was made. (bmj.com)
Results The prognostic value of postoperative ePD-L1 is superior to that of preoperative ePD-L1 on GC patients after resection, and also superior to that of conventional serum biomarkers (CEA, CA19-9 and CA72-4). (bmj.com)
In this review we discuss the current knowledge in the area of peripheral immune-based biomarkers, drawing information from the results of recent clinical studies of a number of different immunotherapy modalities in the treatment of cancer, including checkpoint inhibitors, bispecific antibodies, chimeric antigen receptor T cells, and anti-cancer vaccines. (biomedcentral.com)

Whole blood NEAT1 expression is a novel diagnostic and prognostic biomarker of overall survival in colorectal cancer. (biomedcentral.com)
Conclusions The level of plasma postoperative ePD-L1 could be considered as a candidate prognostic biomarker of GC patients after resection. (bmj.com)
The enumeration of circulating tumor cells (CTCs) represents an effective prognostic and predictive biomarker, which is able to monitor efficacy of adjuvant therapies, detect early development of (micro)metastases and at last, assess therapeutic responses of advanced disease earlier than traditional imaging methods. (amegroups.org)

To explore the application value of tumor markers carcinoembryonic antigen and cytokeratin 19 fragment in the progression and prognosis of middle-advanced non-small cell lung cancer. (ijpsonline.com)
Previous studies have suggested that several factors are associated with recurrence or reduced survival, such as carcinoembryonic antigen, epithelial growth factor receptor, and cytokeratin-19 fragment ( 3 , 4 ). (iiarjournals.org)

0.001) and preoperative serum carcinoembryonic antigen (CEA) level (p = 0.017) are independent risk factors lymph node metastasis in cN0 NSCLC. (biomedcentral.com)
Tumor consolidation diameter and preoperative serum CEA are independent factors to predict cN0 NSCLC with tumor size ≤ 30 mm. (biomedcentral.com)
Age and sex of patients, site, gross type, size (maximum tumor diameter), preoperative serum level of carcinoembryonic antigen (CEA), depth of wall invasion, status of lymph node metastasis, histopathological differentiation, degree of lymphatic and venous invasion, and presence or absence of postoperative adjuvant chemotherapy were extracted from operation records and pathology reports. (iiarjournals.org)

69 patients with nonmetastatic colorectal cancer (non-mCRC) and 57 with metastatic CRC (mCRC) were enrolled to evaluate the prognostic value of serum albumin (ALB), serum lactate (SLA), and lactate dehydrogenase (LDH) in patients with metastatic CRC. (hindawi.com)
Circulating tumor cells (CTCs) have been accepted as a prognostic marker in patients with metastatic colorectal cancer (mCRC, UICC stage IV). (biomedcentral.com)
However, the prognostic value of CTCs in patients with non-metastatic colorectal cancer (non-mCRC, UICC stage I-III) still remains in dispute. (biomedcentral.com)
The number of metastatic lymph nodes, total number of lymph nodes examined, number of negative metastatic lymph nodes (NL), lymph node ratio (LR), and the number of apical lymph nodes (APL) were examined, and the prognostic impact of these parameters was examined in patients with colorectal cancer who underwent surgery from January 2004 to December 2011. (e-crt.org)
The studies investigated the expression of 102 different miRs associated with prognostic aspects in colorectal cancer patients. (biorxiv.org)
We evaluated the diagnostic and prognostic value, and origin of whole blood NEAT1 in colorectal cancer. (biomedcentral.com)
In the present study, we determined the diagnostic and prognostic significance and of whole blood NEAT1 in patients with colorectal cancer. (biomedcentral.com)
Although a low PNI predicts poor prognosis in patients with colorectal cancer after tumor resection, the prognostic value remains unknown in patients with stage III colon cancer undergoing curative tumor resection followed by adjuvant chemotherapy. (biomedcentral.com)
Conclusion: Lymphatic invasion in colorectal cancer correlates well with the status of lymph node metastasis and disease stage, representing an independent prognostic factor after curative resection. (iiarjournals.org)
Although the prognostic import of lymph node metastasis is widely accepted in colorectal cancer, 12 nodes or more must be examined to adequately assess the degree of lymph node metastasis ( 5 , 6 ). (iiarjournals.org)
The present study examined correlations between lymphatic invasion and lymph node metastasis or disease stage, and clarified the prognostic impact of lymphatic invasion, based on a large series and long-term follow-up of patients with colorectal cancer curatively treated. (iiarjournals.org)

Lymph node metastasis (N stage) is the single most important prognostic factor in CRC [ 2 ]. (e-crt.org)
Background: The degree of lymph node metastasis represents an important prognostic factor for cancer. (iiarjournals.org)
It is well-known that not only the presence or absence of lymph node metastasis, but also the degree of presence, is an important prognostic factor, along with depth of tumor invasion, and is useful in determining the adjuvant chemotherapy and surveillance program ( 3 , 4 ). (iiarjournals.org)

p = 0.045) remained independently significant prognostic factors. (scirp.org)
0.01) were identified as significant prognostic factors for relapse-free survival in a multivariate analysis. (researchsquare.com)
0.01), and preCRP level were significant prognostic factors for overall survival. (researchsquare.com)

However, the prognostic value of CTCs supports the use of CTCs as an indicator of metastatic disease prior to the current classification of mCRC meaning it is detectable by CT/MRI. (biomedcentral.com)
Darlix A, Lamy PJ, Lopez-Crapez E, Braccini AL, Firmin N, Romieu G, Thezenas S, Jacot W. Serum HER2 extra-cellular domain, S100ß and CA 15-3 levels are independent prognostic factors in metastatic breast cancer patients. (scielo.br)

Microsatellite instability could not predict a histopathological response to neoadjuvant radiotherapy, but was a good prognostic marker for patients without lymph node metastasis after neoadjuvant radiotherapy. (nih.gov)
Aim: To determine correlations between lymphatic invasion and lymph node metastasis or disease stage, and clarify the prognostic impact of lymphatic invasion. (iiarjournals.org)

Detection of CTCs by RT-PCR method has prognostic value for non-mCRC patients, and CTC-positive was associated with poor prognosis and poor clinicopathological prognostic factors. (biomedcentral.com)
Serum carcinoembryonic antigen and cytokeratin 19 were abnormally highly expressed in non-Small cell lung cancer patients, which are useful for clinical diagnosing, treatment planning, efficacy monitoring, and prognosis evaluation. (ijpsonline.com)
Many studies showed that the carcinoem-bryonic antigen (CEA) and human cytokeratin fragment antigen 21-1 (CYFRA21-1) has a high value in predicting tumor recurrence and judging the prognosis of patients[ 2 , 3 ]. (ijpsonline.com)
Therefore, combining the AJCC/TNM staging system with other prognostic indicators may improve the individual prognosis prediction of patients with RCC and facilitate treatment decision-making. (biomedcentral.com)
Circulating tumor cells also demonstrate prognostic value as liquid biopsies in certain tumor types such as breast and prostate, with measurement of nuclear proteins such as prostate cancer androgen receptor splice variant-7, providing additional supportive information for prognosis and therapy selection [ 6 ]. (biomedcentral.com)

The present study aimed to identify differentially expressed tissue miRs associated with prognostic factors in CRC patients, through a systematic review of the Literature. (biorxiv.org)
Using the PubMed database, Cochrane Library and Web of Science, studies published in English evaluating miRs differentially expressed in tumor tissue and significantly associated with the prognostic aspects of CRC were selected. (biorxiv.org)
Another suggestion is to have intensive postoperative follow-up which includes consultations every 4-6 months, physical examination and evaluation of serum carcinoembryonic antigen (CEA), tissue polypeptide antigen (TPA) and breast cancer-associated antigen 115 D8/DF3 (CA15.3), at each visit. (iiarjournals.org)

The recent American Joint Committee on Cancer (AJCC) manual also recognizes the following prognostic factors: preoperatively elevated serum carcinoembryonic antigen, satellite tumor deposit, tumor regression grade, circumferential resection margin, microsatellite instability, perineural invasion and KRAS mutational status [ 1 ]. (e-crt.org)

The T test, Chi square test, Kaplan-Meier survival analysis model, and Multivariate Cox proportional hazards regression model were applied to assess the prognostic significance of SLA, LDH, and serum ALB on the patients with mCRC. (hindawi.com)
Therefore, it may be a valuable prognostic factor for poor survival in CRC patients. (hindawi.com)
Methods We evaluated the prognostic value of preoperative, postoperative and change in plasma ePD-L1, as well as plasma soluble PD-L1, in short-term survival of GC patients after surgery. (bmj.com)
The levels of postoperative ePD-L1 and ePD-L1 change are independent prognostic factors for overall survival and recurrence free survival of GC patients. (bmj.com)
The prognostic nutritional index (PNI) has been widely applied for predicting survival outcomes of patients with various malignant tumors. (biomedcentral.com)
Disease-free survival (DFS) and overall survival (OS) stratified by PNI were analyzed using Kaplan-Meier method and log-rank test, and prognostic factors were identified by Cox regression analyses. (biomedcentral.com)
In this review, we highlight recent evidence related to the molecular mechanism of lncRNAs in growth, survival, invasion, metastasis, angiogenesis and apoptosis of PC cells, and discuss the potential clinical application of lncRNAs to the diagnosis, treatment and prognostic prediction of PC. (oncotarget.com)

A meta-analysis was performed to investigate the prognostic significance of CTCs detected by the RT-PCR method in patients diagnosed with non-mCRC patients. (biomedcentral.com)

There were no significant differences in terms of gender, age, tumour location or pretreatment serum carcinoembryonic antigen between the MSI-H and MSI-L + MSS groups. (nih.gov)

Here, we examined the predictive value of serum bilirubin and albumin levels in 778 gastric cancer patients from a single hospital in China who were divided among prospective training and retrospective validation cohorts. (oncotarget.com)
These results suggest that serum TBIL and albumin levels are independent predictors of OS in gastric cancer patients, and that an index that combines TBIL and albumin levels with the TNM staging system might have more predictive value than any of these measures alone. (oncotarget.com)
In this study, we extended the prognostic analysis to CRC patients with metastasis who underwent surgery in order to select the predictive factors from these available and inexpensive laboratory data. (scirp.org)

Generally, prognostic evaluations in gastric cancer are based mainly on the tumor-node-metastasis (TNM) staging system. (oncotarget.com)
Currently, detection of breast cancer metastasis relies on clinical manifestations of the spread to distant organs, biopsies of affected organs, radiological evaluations, imaging methods and serum tumor markers ( 3 , 4 ). (iiarjournals.org)

This study was conducted to investigate the clinicopathological significance and prognostic value of microsatellite instability (MSI) in locally advanced rectal cancer (LARC) following neoadjuvant radiotherapy. (nih.gov)

However, the prognostic impact of the operative invasiveness-including the postoperative inflammatory response-in NSCLC patients is uncertain. (researchsquare.com)
The prognostic value of postoperative plasma ePD-L1 has not been characterized. (bmj.com)
Therefore, it is necessary to identify prognostic factors and individualize postoperative therapy according to patient classification. (biomedcentral.com)
6 ) emphasized that the inclusion of serum tumor markers is an important factor in the postoperative monitoring of breast cancer patients ( 7 , 8 ). (iiarjournals.org)

Background The satisfactory prognostic indicator of gastric cancer (GC) patients after surgery is still lacking. (bmj.com)

Both carcinoembryonic antigen and cytokeratin 19 can be used in the diagnosis of squamous cell carcinoma and adenocarcinoma. (ijpsonline.com)
When cytokeratin 19 was positive and carcinoembryonic antigen was negative, the proportion of squamous cell carcinoma was significantly higher than that of adenocarcinoma. (ijpsonline.com)

SCC antigen is useful in the clinical management of advanced cervical cancer. (medscape.com)
Decreases in serum bilirubin and albumin levels are associated with poorer prognoses in some types of cancer. (oncotarget.com)
Di Gioia D, Blankenburg I, Nagel D, Heinemann V, Stieber P. Tumor markers in the early detection of tumor recurrence in breast cancer patients: CA 125, CYFRA 21-1, HER2 shed antigen, LDH and CRP in combination with CEA and CA 15-3. (scielo.br)
Shao Y, Sun X, He Y, Liu C, Liu H. Elevated levels of serum tumor markers CEA and CA15-3 are prognostic parameters for different molecular subtypes of breast cancer. (scielo.br)
The VeriStrat test is a serum proteomic signature originally discovered in non-responders to second line gefitinib treatment and subsequently used to predict differential benefit from erlotinib versus chemotherapy in previously treated advanced non-small cell lung cancer (NSCLC). (biomedcentral.com)
Patients with advanced pancreatic cancer and weight loss have laboratory evidence of malnutrition (eg, low serum albumin or cholesterol level). (medscape.com)
In 1995, we demonstrated the prognostic importance of lymphatic invasion in rectal cancer and advocated the subdivision of stage III (Dukes' C) tumors according to lymphatic invasion ( 12 ). (iiarjournals.org)

[ 4 ] CEA and AFP levels were inadequately able to predict any of the evaluated poor prognostic parameters and requirements for adjuvant treatment. (medscape.com)

Multivariable analysis showed the elevated LDH combined with elevated SLA (HR=2.922, 95%CI=0.971-8.793, P=0.056), the reduced ALB (HR=0.417, 95%CI=0.230-0.754, P=0.004), and the elevated CA199 (HR=2.072, 95%CI=1.125-3.816, P=0.019) were independent prognostic factors for PFS of patients with mCRC. (hindawi.com)
Taken together, our results implicate that the elevated LDH combined with elevated SLA and the reduced ALB are prognostic indicators for patients with mCRC. (hindawi.com)
Serum samples were prospectively collected from 57 patients receiving salvage chemotherapy and 70 non-EGFR mutated patients receiving erlotinib. (biomedcentral.com)
In the present study, we evaluated the prognostic impact of the operative invasiveness after surgery in NCSLC patients. (researchsquare.com)

The sample size was calculated through g power analysis with medium effect size and significance level of 0.05. (org.pk)

Renal function indexes, serum inflammatory factors, and tumor markers were evaluated. (biomedcentral.com)
Regarding the data collected, the clinical factors included the sex, age, smoking history, comorbidities, and the carcinoembryonic antigen (CEA) and preoperative CRP (preCRP) levels. (researchsquare.com)

Focal adhesion kinase is overexpressed in hepatocellular carcinoma and can be served as an independent prognostic factor. (medicalnote.jp)

Serum albumin is closely correlated with the degree of malnutrition and is a regularly used marker of nutrition status [ 8 ]. (hindawi.com)

Therefore, they can be applied to improve the efficacy of the diagnosis and prognostic evaluation in casas of CMNs. (scielo.br)

however, its' clinical significance and origin are unclear. (biomedcentral.com)

The levels of serum tumor markers were detected by electrochemiluminescence immunoassay. (ijpsonline.com)
The levels of CA 15-3, CRP and LDH were significantly higher in the serum of female dogs with CMNs compared to the healthy ones. (scielo.br)
Female dogs with CMNs were found to exhibit highest serum levels of CA 15-3, CRP, and LDH. (scielo.br)

The serum concentration of CRP was significantly higher in the open group, compared with the VATS group. (researchsquare.com)

Flow cytometric detection of intracellular antigens has become a standard method in establishing proper leukemic cell lineage affiliation. (ijpmonline.org)
Regarding the detection of intracellular antigens, standardization of the procedure remains, however, a real challenge. (ijpmonline.org)
Detection of intracellular antigens by flow cytometry (FCM) requires effective fixation and permeabilization of the cell membrane. (ijpmonline.org)

There is also a need for rational combinations beyond interleukin (IL)-2 and programmed death (PD)-1/ cytotoxic T-lymphocyte-associated antigen (CTLA)-4 immune checkpoint blockade and to combat exhaustion and restore costimulatory functions, e.g., with gene-engineered or pharmacologic agent-treated TILs. (biomedcentral.com)

The prognostic benefit of the VS test has been demonstrated with other therapies for NSCLC, including those targeting angiogenic pathways. (biomedcentral.com)

As expression of serum amyloid A, an acute phase protein, is known to play a role in the VS test classification, it is to be expected that the VeriStrat classification is associated with other proteins related to the acute response and/or chronic inflammation, as well. (biomedcentral.com)

Anatomy4

Diseases20

Chemicals and Drugs29

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes5

Disciplines and Occupations1

Information Science2

Health Care14

Biomarkers10

Biomarker3

Cytokeratin 19 fragment2

Preoperative serum3

Colorectal11

Important prognostic factor3

Significant prognostic factors3

Metastatic2

Lymph node metastasis2

Prognosis5

Tissue3

Resection1

Survival7

Performed to investigate1

Pretreatment1

Predictive3

Metastasis2

Clinicopathological1

Postoperative4

Gastric1

Squamous2

Cancer7

Parameters1

Patients4

0.051

Factors2

Factor1

Marker1

Diagnosis1

Clinical significance1

Levels3

Significantly1

Detection3

Checkpoint1

NSCLC1

Expression1